Magnetic resonance in food science : defining food by magnetic resonance
Supplementary Information Interventional Magnetic Resonance Imaging …€¦ · ·...
10
Silvestrini et al. Novel Neurosurgical Device for Cellular Delivery 1 Supplementary Information Interventional Magnetic Resonance Imaging-Guided Cell Transplantation into the Brain with Radially Branched Deployment Matthew T. Silvestrini 1 † , Dali Yin 1 , Alastair J. Martin 3 , Valerie G. Coppes 1,4 , Preeti Mann 1,4 , Paul S. Larson 1,4 , Philip A. Starr 1 , Xianmin Zeng 5 , Nalin Gupta 1 , S. Scott Panter 1,4 , Tejal A. Desai 2 , Daniel A. Lim 1,4,6, *
Transcript of Supplementary Information Interventional Magnetic Resonance Imaging …€¦ · ·...
Silvestrini et al. Novel Neurosurgical Device for Cellular Delivery
1
Supplementary Information
Interventional Magnetic Resonance Imaging-Guided Cell Transplantation into the Brain
with Radially Branched Deployment
Matthew T. Silvestrini1 †, Dali Yin1, Alastair J. Martin3, Valerie G. Coppes1,4, Preeti Mann1,4, Paul
S. Larson1,4, Philip A. Starr1, Xianmin Zeng5, Nalin Gupta1, S. Scott Panter1,4, Tejal A. Desai2,
Daniel A. Lim1,4,6,*
Silvestrini et al. Novel Neurosurgical Device for Cellular Delivery
2
SUPPLEMENTARY FIGURE S1
Silvestrini et al. Novel Neurosurgical Device for Cellular Delivery
3
SUPPLEMENTARY FIGURE S2
Silvestrini et al. Novel Neurosurgical Device for Cellular Delivery
4
SUPPLEMENTARY FIGURE S3
Silvestrini et al. Novel Neurosurgical Device for Cellular Delivery
5
SUPPLEMENTARY TABLE S1
Supplementary Table 1: OD of commonly used cannulas for intracerebral cell transplantation or DBS
Type of Therapy Device Used O.D.
(mm) References
Cell transplantation Stablizing probe-cannula system - stablizing probe 1.8 Kondziolka et al., 2005.
Guide cannula-needle system - steel guide cannula 1.5 to 0.6 Freed et al., 2001.
Double-cannula system - guide cannula 1.00 Breeze et al., 1995.
Needle 0.91 Gupta et al., 2012
Stablizing probe-cannula system - cannula 0.9 Kondziolka et al., 2005.
Needle 0.8 Palfi et al., 1998
Needle 0.8 Peschanski e al., 1994.
Needle 0.8 Gallina et al., 2008.
Needle 0.8 Mendez et al., 2000.
Double-cannula system - tissue cannula 0.64 Breeze et al., 1995.
DBS DBS guide tube 1.7 St. Jude
DBS guide tube 1.65 ELEKTA
RBD Outer guide tube 1.57
Inner Guide tube 1.00
Delivery catheter 0.64
Plunger wire 0.38
Silvestrini et al. Novel Neurosurgical Device for Cellular Delivery
6
SUPPLEMENTARY TABLE S2
Supplementary Table 2: Precision of delivery catheter deployment
Deployment of Catheter X Distance (mm) Y Distance (mm) Z Depth (mm)
Mean S.D. Mean S.D Mean S.D
Half 0.33 0.15 4.80 0.10 5.90 0.14
Full 1.10 0.13 12.30 0.11 8.80 0.11
S.D., standard deviation, n=25 catheters
Silvestrini et al. Novel Neurosurgical Device for Cellular Delivery
7
SUPPLEMENTARY TABLE S3
Supplementary Table 3: Summary of swine study.
Sex Age
(months) weight
(kg) Target Procedure Cells or Agents used No. of Sites Delivered
F 2.5 - 3 25 Rt Striatum iMRI-guided RBD SPIO 2
F 2.5 - 3 29.5 Rt Striatum RBD hDA neurons 3
F 2.5 - 3 35 Rt Striatum RBD hDA neurons 3
F 2.5 - 3 26 Rt Striatum RBD hDA neurons with GFP 2
F 2.5 - 3 22 Rt Striatum iMRI-guided RBD hDA neurons with GFP 2
F 2.5 - 3 28 Rt Striatum iMRI-guided RBD hDA neurons with GFP 3
F 2.5 - 5 37.5 Rt Striatum iMRI-guided RBD hDA neurons with GFP 3
hDA, human dopamine neuron precursors; iMRI, interventional magnetic resonance imaging; RBD, radially branched deployment; SPIO, superparamagnetic iron oxide.
Silvestrini et al. Novel Neurosurgical Device for Cellular Delivery
8
SUPPLEMENTARY TABLE S4
Supplementary Table 4: MRI scan parameters (Siemens 1.5-T) for swine studies.
Parameter 3D T1 T2 Target Align Axi/Sag T1 Delivery Monitoring
FOV, mm 170 160 200 256 192
Matrix 384x384 384x384 128x128 256x256 192x192
Slice thick, mm 1.5 2 5 2 1
Slices, n 176 21 1 9 72
Acquisition 3D-GRE 2D-TSE 2D-TSE 2D-TSE 3D-GRE
TR, ms 14 2400 300 400 16
TE, ms 4.8 87 13 14 4.5
Flip, degrees 25 90 90 90 90
Turbo factor 1 9 7 1 1
Bandwidth, Hz/pixel 151 160 150 150 150
Axi, axial; Flip, flip angle; GRE, gradient recalled echo; FOV, field of view; Sag, sagittal;
TE, echo time; TR, repetition time; TSE, turbo spin echo; 2D, 2 dimensional; 3D, 3 dimensional.
Silvestrini et al. Novel Neurosurgical Device for Cellular Delivery
9
SUPPLEMENTARY TABLE S5
Supplementary Table 5: Summary of cadaveric head study.
Targets Procedure Agent used No. of sites delivered
Rt Putamen iMRI-guided RBD SPIO 3
Rt Hemisphere iMRI-guided RBD SPIO 6
Rt Putamen iMRI-guided RBD SPIO 6
iMRI, interventional magnetic resonance imaging. RBD, radially branched deployment;
Rt, right; SPIO, superparamagnetic iron oxide.
Silvestrini et al. Novel Neurosurgical Device for Cellular Delivery
10
SUPPLEMENTARY TABLE S6
Supplementary Table 6: MRI scan parameters (Philips Achieva 1.5-T) for human cadaveric head studies.
Parameter 3D T1 T2 Target Pivot Align Axi/Sag T1 Axi/Sag T2 Delivery Monitoring
FOV, mm 260x221 240x180 80x80 112x112 240x180 46x180 220x161
Matrix 256x192 240x240 96x96 112x112 288x240 400x216 240x240
Slice thick, mm 1.5 2 1.1 10 1.5 2 1
Slices, n 120 27 35 1 7 5 45
Acquisition 3D-GRE 2D-TSE 3D-TSE 2D-TSE 3D-TSE 3D-TSE 3D-GRE
TR, ms 20 3000 290 20 300 2000 21
TE, ms 3.1 90 66 3.7 46 80 3.9
Flip, degrees 30 90 70 30 70 90 250
Turbo factor 38 8 15 38 12 52 1 Bandwidth, Hz/pixel 280 68 817 894 817 868 115
Axi, axial; Flip, flip angle; GRE, gradient recalled echo;FOV, field of view; Sag, sagittal; TE, echo time; TR, repetition time;
TSE, turbo spin echo; 2D, 2 dimensional; 3D, 3 dimensional.
