Supplementary figure 3
description
Transcript of Supplementary figure 3
raSIRP
RIKQKKAKGSTSSTRLHEPEKNAREITQIQDTNDINDITYADLNLPKEKKPAPRVPEPNNHTEYASIETGKLPRPEDTLTYADLDMVHLNR--AQPTPKPEPSFSEYASVQVQRK 509
muSIRP
RIKQKKAKGSTSSTRLHEPEKNAREITQIQDTNDINDITYADLNLPKEKKPAPRAPEPNNHTEYASIETGKVPRPEDTLTYADLDMVHLNR--AQPAPKPEPSFSEYASVQVQRK 509
huSIRP
1 RIRQKKAQGSTSSTRLHEPEKNAREIT--QDT---NDITYADLNLPKGKKPAPQAAEPNNHTEYASIQTSPQPASEDTLTYADLDMVHLNRTPKQPAPKPEPSFSEYASVQVPRK 503
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Supplem
entary figure 3
Supplem
entary Figure 3.
Alignm
ent of the cytoplasmic S
IRP
protein sequences. Alignm
ents were perform
ed using the ClustalW
algorithm (version 1.82)
employing the follow
ing sequences: rat SH
PS
-1 (gi_6671640), mouse S
HP
S-1 (gi_1777354), and hum
an SIR
P
1 (gi_2052056). The
two proline-rich regions are overlined and the tyrosine and proline residues are highlighted in blue and red, respectively. T
he proline residues that, at least in case of the hum
an SIR
P
1, are dispensable for JAK
2 binding (42) are indicated by arrows.