Cell Biology Cell Biology 1010

- Review- Review

Cell Biology Cell Biology 1010

- Review- Review

Sung Youn Lee, PhD. StudentSung Youn Lee, PhD. StudentVeterinary collage, Room 320Veterinary collage, Room 32002 450 3719, 016 293 605902 450 3719, 016 293 6059

leevet@paran.comleevet@paran.com

Schwann cell-PNS

Oligodendrocyte-CNS

To groove

Allowing the myosin heads to make contact with the released sites of the actin monomer

Fast axonal transport is a major form of motility for secretory and membran

ous components• Average rate ; 250~400mm/day• Membrane associated

– Plasmalema (proteins, cholesterol, phospholipids, gangliosides), synaptic vescle (neurotranmitters, neuropeptides, and enzymes), and mitochodria (50mm/day)

hsp70 released byATP hydrolysis

Positively charged, NH2-, 20-80 a.a.s

Signal peptide cleavedThen protein folds

From free ribosome

ATP hydrolysisfor protein folding

hsp70 released byATP hydrolysis

Integral Intermembrane space

Nerve growth factor• NGF binds to NGF receptors on the growth c

ones of approaching axons.• It is internalized by receptor mediated endocyt

osis and transported retrogradely to the cell body, where it undergoes lysosomal degradation.

• NGF supports the survival of cholinergic nerons.– Alzheimer disease (cholinergic neuron for memory)

Nerve growth factor• Lou Gehrig’s disease• = ALS (amyotrophic lateral sclerosis)• CNTF (ciliary neurotrophic factor)

– PNS : schwann cell– CNS : astrocyte– Cf. other neurotrophic factors are secreted by targ

et cell (muscle cell)– --> motor neuron ▽--> muscle▽

Ach

EpinehprineNorepinephrine

Ach Ach