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2018 RDCR Symposium

June 17-20, 2018

Agenda (DRAFT) Sunday, June 17 18:00-2100 Welcome Reception / Dinner Monday, June 18 0830-0840 Opening Remarks

Surgeon Rear Admiral Surgeon General, Norwegian Armed Forces Norway

0840 SESSION 1 Moderators:

Philip C. Spinella, MD FCCM Professor, Pediatrics Director, Translational Research Program Division of Critical Care, Department Pediatrics Washington University in St Louis, St Louis, MO USA Geir Strandenes, MD Senior Anesthetist Dept of War Surgery and Emergency Medicine Norwegian Armed Forces Medical Services Bergen, Norway

0840-0900 Introduction to THOR and RDCR

Philip C. Spinella, MD FCCM Professor, Pediatrics Director, Translational Research Program Division of Critical Care, Department Pediatrics Washington University in St Louis, St Louis, MO USA Geir Strandenes, MD Senior Anesthetist Dept of War Surgery and Emergency Medicine Norwegian Armed Forces Medical Services Bergen, Norway

0900-0920 Traumatic Hemorrhagic Shock Outcomes and Preventable Death Epidemiology COL (Ret) Brian Eastridge, MD, FACS Professor, Department of Surgery UT Health Science Center San Antonio, TX, USA

0920-0940 Preventable Death Analysis from the Paris Attacks Mathieu RAUX MD, PhD Professor of Anesthesiology and Critical Care Medicine SSPI - Accueil des Polytraumatisés Hôpital Universitaire Pitié Salpêtrière - Charles Foix France

0940-0955 BREAK

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0955 SESSION 2 Moderators:

Col Thomas Woolley, MD, FRCA, RAMC Defence Professor of Anaesthesia and Critical Care UK

Joseph F. Rappold, MD FACS Professor of Surgery Maine Medical Center Tufts University School of Medicine USA

0955-1025 The Rationale For Whole Blood And Pittsburgh Pilot Study

Jason L. Sperry, MD, MPH Assistant Professor of Surgery and Critical Care Department of Surgery, Division of Trauma and General Surgery Department of Critical Care Medicine and the Clinical and Translational Science University of Pittsburgh Pittsburgh, PA, USA

1025-1055 ABO, Rh, HLA Ab Issues With Whole Blood

Nancy M. Dunbar, MD Associate Professor, Geisel School of Medicine Department of Pathology and Laboratory Medicine Medical Director, Blood Bank Associate Medical Director, Transfusion Medicine Service Dartmouth-Hitchcock Medical Center Hanover, NH, USA

1055-1110 Whole Blood Leukoreduction Effects On Hemostasis Philip C. Spinella, MD FCCM Professor, Pediatrics Director, Translational Research Program Division of Critical Care, Department Pediatrics Washington University in St Louis, St Louis, MO USA

1110-1155 Debate: Plasma Incompatibility Risks In LTH Patients

Moderator: Einar Kristoffersen, MD, PhD (Pro) Head of Department/Professor Department of Immunology and Transfusion Medicine Haukeland University Hospital Bergen, Norway Jed Gorlin, MD, MBA Medical Director and Vice President, Quality and Regulatory Affairs Innovative Blood Resources Saint Paul, MN, USA Mark H. Yazer, MD Professor of Pathology, University of Pittsburgh Medical Director of the RBC Serology Laboratory at the Centralized Transfusion Service (a division of the Institute for Transfusion Medicine) Pittsburgh, PA, USA

1155-1215 Frozen Platelets and ABO Typing in Prehospital Setting Col Milos Bohonek,MD,PhD Head of Department of Hematology and Blood Transfusion Military University Hospital Prague Senior Consultant for Hematology and Blood Transfusion Military Medical Service Army of the Czech Republic Czech Republic

1215-1415 Lunch And Break

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1415 SESSION 3 Moderators:

COL Professor Elon Glassberg, MD, MHA Head of the Medical Department Deputy Surgeon General for Health Israel Defense Forces Medical Corps Israel Paul M. Ness, MD Director, Transfusion Medicine Johns Hopkins Medical Institutions Baltimore, Maryland USA

1415-1430 US Army Low Titer Group O Whole Blood Program

COL Audra L. Taylor, MS, MT, SBB(ASCP) Director, Army Blood Program San Antonio, TX, USA

1430-1445 US Army Cold Platelet Program LTC Jason Corley Deputy Director, Army Blood Program San Antonio, TX, USA

1445-1515 Case Presentations

Moderator: COL Professor Elon Glassberg, MD, MHA Head of the Medical Department Deputy Surgeon General for Health Israel Defense Forces Medical Corps Israel Panelists: Donald Jenkins, MD Vice Chair for Quality, Department of Surgery University of Texas Health Science Center at San Antonio San Antonio, TX USA Ernest Moore, MD Editor, Journal of Trauma Professor, Vice Chair of the Department of Surgery University of Colorado Health Sciences Center Denver, Colorado USA Geir Strandenes, MD Senior Anesthetist Dept of War Surgery and Emergency Medicine Norwegian Armed Forces Medical Services Bergen, Norway

1515-1615 Blood Center Perspective Of Whole Blood Roundtable Moderator: Paul M. Ness, MD Director, Transfusion Medicine Johns Hopkins Medical Institutions Baltimore, Maryland USA

Panelists: Heidi Doughty, MD Civilian Defence Consultant Adviser Transfusion Medicine Headquarters Surgeon General United Kingdom

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Einar Kristoffersen, MD, PhD (Pro) Head of Department/Professor Department of Immunology and Transfusion Medicine Haukeland University Hospital Bergen, Norway

Prof. Eilat Shinar, MD Director, Blood Services Magen David Adom Israel Jed Gorlin, MD, MBA Medical Director and Vice President, Quality and Regulatory Affairs Innovative Blood Resources Saint Paul, MN, USA Elizabeth Waltman Chief Operating Officer, Blood Operations Executive Director, The Blood & Tissue Center Foundation South Texas Blood & Tissue Center San Antonio, TX USA Pampee Young,, MD, PhD Chief Medical Officer American Red Cross Nashville, TN USA

1615-1630 Break 1630 SESSION 4 Moderators:

Ernest Moore, MD Editor, Journal of Trauma Professor, Vice Chair of the Department of Surgery University of Colorado Health Sciences Center Denver, Colorado USA

Victor Convertino, PhD

US Army Institute of Surgical Research San Antonio, TX USA

1630-1700 Importance Of Oxygen Delivery And How It Can Be Improved

Kevin Ward, MD Professor, Department of Emergency Medicine University of Michigan Director, Michigan Center for Integrative Research in Critical Care Ann Arbor, Michigan USA

1700-1720 Non-Hemostatic Effects Of Plasma Jakob Stensballe, MD, PhD Consultant Anaesthetist Rigshospitalet, Denmark

1720-1805 Permissive Hypotension Debate Moderator:

COL (Ret) Brian Eastridge, MD, FACS Professor, Department of Surgery UT Health Science Center San Antonio, TX, USA

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PANELISTS: Herbert Schochl, MD Associate Professor of Anaesthesiology Senior Anaesthesiologist and Intensivist, AUVA Trauma Hospital Salzburg, Austria

Col Thomas Woolley, MD, FRCA, RAMC Defence Professor of Anaesthesia and Critical Care UK Geir Strandenes, MD Senior Anesthetist Dept of War Surgery and Emergency Medicine Norwegian Armed Forces Medical Services Bergen, Norway Patrick Thompson Medic UK / S. Africa

1805-1900 Industry Showcase 1900 Dinner

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Tuesday, June 19 0830 SESSION 5 Moderators:

Kevin Ward, MD Professor, Department of Emergency Medicine University of Michigan Director, Michigan Center for Integrative Research in Critical Care Ann Arbor, Michigan USA Daniel Spaite, MD, FACEP Professor Virginia Piper Distinguished Chair of Emergency Medicine Director, EMS Research Collaboration, The University of Arizona USA

0830-0900 Blood Failure Phenotypes And Clinical Relevance Mitchell Jay Cohen, MD FACS Director of Surgery, Denver Health Medical Center Professor and Vice Chair, Department of Surgery University of Colorado Denver, CO, USA

0900-0930 Blood Failure Pathophysiology Controversies And Clinical Relevance Barbara A. Gaines, MD Clinical Director, Pediatric General and Thoracic Surgery Director, Trauma and Injury Prevention Professor of Surgery and Clinical and Translational Science University of Pittsburgh School of Medicine Pittsburgh, PA, USA

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0930-1015 Case Presentation Moderator: Daniel Spaite, MD, FACEP Professor Virginia Piper Distinguished Chair of Emergency Medicine Director, EMS Research Collaboration, The University of Arizona USA Panelists: Geoffrey Ling, MD, PhD Professor of Neurology Johns Hopkins Medical Institutions Baltimore, Maryland USA Andrew N. Beckett CD MD FRCS(C) FACS Mcgill University Canadian Army Canada Mitchell Jay Cohen, MD FACS Director of Surgery, Denver Health Medical Center Professor and Vice Chair, Department of Surgery University of Colorado Denver, CO, USA

1015-1030 Break 1030 SESSION 6 Moderators: Michael Dubick, PhD, FCCM US Army Institute of Surgical Research San Antonio, TX USA

Heidi Doughty, MD Civilian Defence Consultant Adviser Transfusion Medicine Headquarters Surgeon General United Kingdom

1030-1100 Traumatic Brain Injury Patient Resuscitation

Daniel Spaite, MD, FACEP Professor Virginia Piper Distinguished Chair of Emergency Medicine Director, EMS Research Collaboration, The University of Arizona USA

1100-1130 Coagulopathy Associated With Traumatic Brain Injury Jing-fei Dong, MD, PhD Member, BloodWorks NW Research Institute Professor of Medicine, Hematology Division, Department of Medicine University of Washington Seattle, WA, USA

1130-1200 Fibrinogen concentrates and Reconstituted Whole Blood Studies

Herbert Schochl, MD Associate Professor of Anaesthesiology Senior Anaesthesiologist and Intensivist, AUVA Trauma Hospital Salzburg, Austria

1200-1400 Lunch

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1400 SESSION 7 Moderators:

COL Andrew P Cap, MD PhD Medical Corps, US Army Chief, Blood Research, US Army Institute of Surgical Research Associate Professor of Medicine, Uniformed Services University Program Director, Clinical Research Fellowship | Staff Hematologist-Oncologist San Antonio Military Medical Center Texas USA

Mark H. Yazer, MD Professor of Pathology, University of Pittsburgh Medical Director of the RBC Serology Laboratory at the Centralized Transfusion Service (a division of the Institute for Transfusion Medicine) Pittsburgh, PA, USA

1400-1430 Cold Platelet Norway Trial Data (With Review Of Cold Platelet In Vitro/In Vivo Data) Torunn Apelseth, MD, PhD | Department of Immunology and Transfusion Medicine Haukeland University Hospital Bergen, Norway Geir Strandenes, MD Senior Anesthetist Dept of War Surgery and Emergency Medicine Norwegian Armed Forces Medical Services Bergen, Norway

1430-1500 Cold Stored Platelet Effect In Subjects On Dual Antiplatelet Agents Stephen M. Cohn, MD FACS Professor of Surgery Hofstra Northwell School of Medicine New York, New York USA

1500-1530 Future Of Platelet Formulations (Frozen/Dried/ Nanoparticle) And Storage Solutions

Jose A. Cancelas Perez, MD, PhD Director, Research Division and Medical Director for Cell Therapies, Hoxworth Blood Center Deputy Director, Hoxworth Blood Center Professor, UC Department of Pediatrics Cincinnati Children’s Hospital Cinicnnati, OH, USA

1530-1630 Recent Pre-Hospital Plasma And TXA Study Results Jason L. Sperry, MD, MPH Assistant Professor of Surgery and Critical Care Department of Surgery, Division of Trauma and General Surgery Department of Critical Care Medicine and the Clinical and Translational Science University of Pittsburgh Pittsburgh, PA, USA Philip C. Spinella, MD FCCM Professor, Pediatrics Director, Translational Research Program Division of Critical Care, Department Pediatrics Washington University in St Louis, St Louis, MO USA Ernest Moore, MD Editor, Journal of Trauma Professor, Vice Chair of the Department of Surgery University of Colorado Health Sciences Center Denver, Colorado USA

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Hunter Moore, MD PhD PGY7 University of Colorado Department of Surgery Denver, Colorado USA

1630-1645 Discussion of Prehospital Plasma and TXA trials 1645-1705 Break 1705 SESSION 8 Moderator: Kevin Ward, MD

Professor, Department of Emergency Medicine University of Michigan Director, Michigan Center for Integrative Research in Critical Care Ann Arbor, Michigan USA

1705-1745 Debate: Plasma As Volume Expander

Donald Jenkins, MD Vice Chair for Quality, Department of Surgery University of Texas Health Science Center at San Antonio San Antonio, TX USA Simon Stanworth, MA, FRCP (Paeds, UK), PhD, FRCPath Consultant Haematologist NHS Blood and Transplant and Oxford Radcliffe Hospitals NHS Trust UK

1745-1830 Industry Showcase 1830 Dinner

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Wednesday, June 20 0830 SESSION 9 Moderators:

Mary Homer, PhD Biomedical Advanced Research and Development Authority (BARDA) Office of the Assistant Secretary for Preparedness and Response U.S. Department of Health and Human Services USA Ashley Cecere, PhD Biomedical Advanced Research and Development Authority (BARDA) Office of the Assistant Secretary for Preparedness and Response U.S. Department of Health and Human Services USA

0830-0900 US DoD Comprehensive CBRN/Trauma Treatment Program COL Andrew P Cap, MD PhD Medical Corps, US Army Chief, Blood Research, US Army Institute of Surgical Research Associate Professor of Medicine, Uniformed Services University Program Director, Clinical Research Fellowship | Staff Hematologist-Oncologist San Antonio Military Medical Center Texas USA

0900-0920 DCR For Patients With Burn Injuries

COL Jennifer M. Gurney, MD, FACS Assistant Professor of Surgery, United States Uniformed Services University US Army Joint Trauma System USA

0920-0940 Disaster Preparedness, Models Of Possible Scenarios And Blood Inventory James Stubbs, MD (Con) Medical Director, Division of Transfusion Medicine Mayo Clinic Rochester, Minnesota USA

0940-1010 Blood As Counter Measure For Radiation Injury Arik Eisenkraft MD MHA Director of Homeland Defense Projects, Pluristem Israel

1010-1040 Game Of Drones – Unmanned Patient Transport And Blood Delivery

Geoffrey Ling, MD, PhD Professor of Neurology Johns Hopkins Medical Institutions Baltimore, Maryland USA

1040-1100 Break 1100 SESSION 10 Moderators: Marc Depasquale

Medic USA Patrick Thompson Medic South Africa / UK

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1100-1120 Blood Donor Management Issues Barbara Jean Bryant, MD, FCAP, FASCP Interim Director, Hematopathology Division, Department of Pathology; Medical Director, Transfusion Medicine, Specialist in Blood Bank Technology Program, Department of Pathology Associate Director, Blood Bank Division, Department of Pathology; Galveston, TX, USA

1120-1140 Donor Performance After Whole Blood Donation Håkon S. Eliassen Medic Norway

1140-1200 French Fresh Whole Blood Trial in Traumatic Massive Hemorrhage Christophe Martinaud MD PhD French Military Blood Institute Clamart, France

1200-1215 THOR-AABB Working Group Update Mark H. Yazer, MD Professor of Pathology, University of Pittsburgh Medical Director of the RBC Serology Laboratory at the Centralized Transfusion Service (a division of the Institute for Transfusion Medicine) Pittsburgh, PA, USA

1215-1315 Lunch 1315 SESSION 11

Moderators: Geir Strandenes, MD Senior Anesthetist Dept of War Surgery and Emergency Medicine Norwegian Armed Forces Medical Services Bergen, Norway Philip C. Spinella, MD FCCM Professor, Pediatrics Director, Translational Research Program Division of Critical Care, Department Pediatrics Washington University in St Louis, St Louis, MO USA

1315-1400 Prolonged Field Care

MAJ Doug Powell, MD Medical Director, Intensive Care Unit, Womack Army Medical Center Fort Bragg, North Carolina

1400-1430 ALM Fluid Therapy: Targeting Non-Compressible Hemorrhage and TBI

Geoffrey P. Dobson M.Sc. Ph.D. FAHA Professor, Personal Chair Heart, Trauma & Sepsis Research Laboratory College of Medicine and Dentistry James Cook University, Townsville, Queensland, Australia

1430-1445 Wrap Up/Feedback Session

Geir Strandenes, MD Philip C. Spinella, MD FCCM