Summers imeko 2011

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Progress on Measurement in Biology & Medicine: Multiscale Systems Engineering Ron Summers Dept Electronic & Electrical Engineering, Loughborough University, UK [email protected] http://www-staff.lboro.ac.uk/~lsrs1

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Transcript of Summers imeko 2011

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Progress on Measurement in

Biology & Medicine:

Multiscale Systems Engineering

Ron Summers

Dept Electronic & Electrical Engineering, Loughborough University, UK

[email protected]

http://www-staff.lboro.ac.uk/~lsrs1

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Outline

• Introduction to the Team

• Multiscale Modelling

Anatomic Level of Analysis

Cellular Level of Analysis

Protein Level of Analysis

Genome Level of Analysis

• Future Work

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International Team

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Multiscale Modelling

Context

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Engineering Dimension

“…multiscale modelling is the field of solving

physical problems which have important

features at multiple scales, particularly

multiple spatial and (or) temporal scales”.

Wikipedia, accessed 2010

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Scales of Measurement

Hunter P, Robbins P, Noble D (2002) The IUPS human physiome project. Eur J Physiol 445 1-9

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Medical Dimension

• Why is it important to better understand

congenital heart defects ?

• What is the Tetralogy of Fallot from an

anatomical standpoint ?

• Which embryological processes are

involved in the formation of the Tetralogy

of Fallot ?

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Why is it important to know more about the congenital

heart defect and particularly about the Tetralogy of Fallot ?

The prevalence of congenital heart defects,

the most common congenital anomaly

observed in newborns, has been reported to

be 5-10 per 1000 births

10% of the childhood mortality

Tetralogy of Fallot is the most common form

of cyanotic congenital heart disease.

It affects 9%-15% of all infants and children

with congenital heart disease (CHD) which

represents 55%-70% of all cyanotic

congenital malformations

We need to improve our knowledge about

this abnormality

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Multiscale Modelling

Anatomic Level

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Aorta

Pulmonary artery

Right

Ventricle

Anterior view Posterior view

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Anatomy of the Normal Human Heart

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Tetralogy of Fallot

Pulmonary Stenosis

Ventricular Septal Defect by

malalignment

Dextroposition of the Aorta

(aortic overriding)

Right ventricular hypertrophy

desaturation

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Muscular

Septum

Membranous

Septum

Nature

Normal Anatomic Development

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Multiscale Modelling

Cellular Level

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Scales of Measurement

Hunter P, Robbins P, Noble D (2002) The IUPS human physiome project. Eur J Physiol 445 1-9

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Epithelial to Mesenchymal Transition

Notch Delta

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EMT Simulations

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In vitro EMT

Wildtype Notch1 BMP2

L. Luna-zurita et al. “Integration of a Notch-dependent mesenchymal gene

program and Bmp2-driven cell invasiveness regulates murine cardiac

valve formation,” The Journal of Clinical Investigation, vol. 120, 2010.

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Multiscale Modelling

Protein Level

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Multiscale Modelling

Genome Level

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Which embryological processes are involved

in the formation of the Tetralogy of Fallot ?

Scale of tissue and cells

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Which embryological processes are involved in the

formation of the Tetralogy of Fallot ? Scale of gene regulation

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Future Work

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A lot of work remains…

• Information Issues • Scale-linking

• Biological Networks

• Methodological Issues • Multiscale Model Process

• Multiscale Model Validation

• Multiscale Visualization

• Software Issues • Multiscale Software Programming

• Patho-physiological Issues • Anatomic Definition of Tetralogy of Fallot

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Thank you for your

attention

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Optical Physiological Tomography: Concepts

Comprises biomedical photonics, microelectronics engineering, systems engineering, applied signal and image processing, and multiscale modelling/simulation

Fast Fast

digital digital

CameraCamera

USBUSB

MicroMicro--

electronicselectronics

Oxyg

en

level

O2%

Oxyg

en

level

H i g h

Low

Frequency

6 – 9 HzW

avelength

(400 –900nm

)

MultiMulti--

wavelengthwavelength

illuminatorilluminator

Electronic sub system

Photonics sub system

Biophotonics Imaging System