SUMMER SCHOOL GENOMIC MEDICINE – Bridging research...

SUMMER SCHOOL GENOMIC MEDICINE – Bridging research and the clinic REPORT 03. 05. 2016 – 07. 05. 2016

Summer school Genomic medicine – Bridging research and the clinic

IMPRINT Publisher University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia Authors Katja Goričar and Vita Dolžan Pictures Andrej Zore Date 13 June 2016 Please take note that the content of this document is property of the ISBE and CASyM consortium. If you wish to use some of its written content, make reference to: ISBE and CASyM report.

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Table of Contents 1 INTRODUCTION ................................................................................................................ 4

2 PROGRAMME .................................................................................................................... 6

3 EVENT OUTCOME ........................................................................................................... 10

3.1 General information ................................................................................................... 10

3.2 Survey statistics ......................................................................................................... 11

4 LIST OF PARTICIPANTS ................................................................................................. 13

5 ACKNOWLEDGEMENTS ................................................................................................. 16

6 APPENDIX ......................................................................... ¡Error! Marcador no definido. 6.1 Survey and questionnaire ........................................... ¡Error! Marcador no definido.

6.2 Approved ECTS accreditation ................................................................................... 17

6.3 Approved CME accreditation ..................................................................................... 18

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1 INTRODUCTION The summer school “Genomic Medicine: Bridging Research and the clinic” took place between May 3rd - 7th at the Hotel Histrion in Portorož, Slovenia. The Summer school was organized by Pharmacogenetics laboratory, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana as a collaborative action between Artemida Teaming project, CASyM, COST Action EUPancreas (BM1204), COST Action EU-ROS (BM1203) and SERBORDISinn. The Summer School received recognition from several associations and professional societies and was endorsed by Slovenian Biochemical Society, Golden Helix Institute of Biomedical Research, Genomic Medicine Alliance, ESPT, Eu-PIC and H2020 project U-PGx. The summer school covered a wide range of topics related to genomic medicine (personalized, 4P or stratified medicine), pharmacogenomics and epigenomics, systems medicine and translation of basic research into clinical practice and public health. In total 77 researchers, medical doctors, PhD students, post docs and lecturers, mostly from Europe, but also from Israel and Argentina, participated (Figure 1). Among them 4 students were accredited with ECTS (5 credits) and 12 MDs with CME credit points (25 credits). On the morning of May 3rd 2016, before the opening of the Summer school, a Satellite workshop “In vitro and in vivo models for development of novel diagnostic and therapeutic approaches” took place. Various models from spheroid systems, systems for detection of genotoxic agents and zebra fish models to skeletal muscle cell models and models of neurodegenerative diseases were described during the workshop. The Summer School opening lecture was delivered by prof. Ron van Schaik, who talked about clinical implementation of pharmacogenomics in The Netherlands. The main focus of the lecture were DNA passports that are used in pre-emptive genotyping and enable patients to receive medication adjusted on genomic profile for over 80 drugs. The afternoon session on NGS and genomic medicine and rare diseases was organised by SERBORDISinn. Lectures focused mostly on use of NGS in genetic diagnostics, but also in other fields such as orphan drug development. In the evening a welcome reception in the hotel Histrion was organized for all the participants. On Wednesday May 4th 2016, pharmacogenomics and pharmacoepigenetics were covered in the morning session. Several lectures described the potential use of miRNA and non-coding RNAs as biomarkers. Summer school participants presented their research during the poster session. The lectures on personalised medicine in the afternoon session illustrated the role of pharmacogenomics in various diseases, from type 2 diabetes and inflammatory bowel disease to psychiatry to transplantation. Clinical implementation was also discussed. On Thursday May 5th 2016, oxidative stress and gene-environment interactions were discussed in the morning. Different approaches were presented, including genome-wide association interaction studies. In the afternoon, a round table ‘The needs and directions for research and development services in pharmacy and biomedicine’ was held. The round table discussion was opened to public and presenters from University of Trieste and Faculty of Pharmacy joined the panellists. After the round table an excursion to Piran was organized followed by dinner in one of the Piran’s well-known Mediterranean restaurants. On Friday May 6th 2016, morning session started with the presentation of ‘CASyM and Systems Approaches to Tackle Multifactorial Pathologies’, by prof. Damjana Rozman. She has thoroughly explained the relevant definitions, the need for systems medicine training and the aims of the CASyM. She has explained the conceptual framework of systems medicine, and the systems (global) approaches, including mathematical modelling, on the example of multifactorial liver diseases. The morning session continued with lectures on bioinformatics and biostatistics for translational research and the emerging technologies in pharmacogenomics. Summer school participants also presented their research during the second poster session after the lunch break. The afternoon sessions focused on cancer genomics, cancer epidemiology, personalized cancer treatment and novel approaches to cancer treatment. The day extended late into the night with the gala dinner in the hotel Histrion.

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On Saturday May 7th 2016, translation to clinical practice was discussed in the morning, covering a range of topics, from biomarkers to genotype-based drug dosing and pre-emptive testing. The closing plenary lecture was delivered by Sir Munir Pirmohamed and focused on the current challenges in personalized medicine and on the opportunities brought by genomic information and novel approaches. Due to the diverse scientific topics and excellent lecturers the participants were able to broaden their knowledge on the latest achievements in translational, personalized, 4P and stratified medicine. There was plenty of time available for the discussions after each session, where MDs had the opportunity to receive further information on implementation of basic research into clinical practice. The coffee breaks and meals organized in the hotel as well as several social events encouraged the participants to establish new connections that will foster further international collaborations. Prof. Dr. Vita Dolžan Chair of the International Scientific Committee and Organizing committee Assist. Dr. Katja Goričar Co-chair of the Organizing Committee

Figure 1: Group photo, taken at Hotel Histrion.

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2 PROGRAMME Satellite Workshop: In vitro and in vivo models for development of novel diagnostic and therapeutic approaches Tuesday, 03. 05. 2016 9.00 – 12.30 PROGRAMME Chairpersons: Antonio Cuadrado, Tamara Lah Turnšek

• 8.30 – 9.00 Registration • 9.00 – 9.30 Delilah F.G. Hendriks, Karolinska Institute, Sweden – Novel in vivo like in

vitro spheroid systems for prediction of drug response, long term adverse reactions and for studies of liver disease

• 9.30 – 10.00 Metka Filipič, National Institute of Biology, Slovenia – HepG2CDKN1A–DsRed biosensor system for rapid and simple detection of genotoxic agents

• 10.00 – 10.30 Tamara Lah Turnšek, National Institute of Biology, Slovenia – Experimental oncology from in vitro to in vivo: Zebra fish model

• 10.30 – 11.00 Coffee break • 11.00 – 11.30 Sergej Pirkmajer, Faculty of Medicine, University of Ljubljana, Slovenia –

Skeletal muscle cells as a model for identification of novel targets for insulin resistance/type 2 diabetes treatment: to starve or not to starve?

• 11.30 – 12.00 Antonio Cuadrado, Autonomous University of Madrid, Spain – Models of neurodegenerative diseases

• 12.00 – 12.30 Discussion • 12.30 – 14.00 Lunch break, Registration

SUMMER SCHOOL PROGRAMME Tuesday, 03. 05. 2016 14.00 – 18.30 Opening address Opening plenary lecture

• 14.30 – 15.30 Ron van Schaik, Erasmus MC, Rotterdam, The Netherlands – Do you have your DNA passport?

• 15.30 – 16.00 Coffee break NGS in genomic medicine and rare diseases Chairpersons: Maja Stojiljkovic, Sonja Pavlovic

• 16.00 – 16.30 Maja Stojiljkovic, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia – Diagnosis of rare diseases – an NGS approach

• 16.30 – 17.00 Jernej Kovač, Center for Medical Genetics, University Children's Hospital, University Medical Centre Ljubljana, Slovenia – Introduction of NGS technology in a routine genetic diagnostics setup: Experience from Slovenian paediatric population

• 17.00 – 17.30 Natasa Tosic, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia – Genetic profiling of haematological malignancies

• 17.30 – 18.00 Borut Peterlin, Ales Maver, Clinical Institute of Medical Genetics, University Medical Center Ljubljana, Slovenia – NGS in Slovene health system improves diagnosis of rare diseases

• 18.00 – 18.30 Emilio J. A. Roldan-Prinsich, Scientific Direction, Gador SA, Buenos Aires, Argentina – NGS expediting Orphan Drug Developments: The need of fast global drug availability, accessibility and equity

19.30 Welcome reception Wednesday, 04. 05. 2016 8.30 – 12.30

• 8.30 – 9.00 Meet the speakers o Vita Dolžan, Samo Ribarič, Faculty of Medicine, University of Ljubljana, Slovenia –

Presentation of ARTEMIDA project Pharmacogenomics and pharmacoepigenomics

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Chairpersons: Kristel Van Steen, Vita Dolžan • 9.00 – 9.45 Kristel Van Steen, Université de Liège, Belgium – Reductionism and

complexity in the omics era • 9.45– 10.30 Tanja Kunej, Biotechnical Faculty, University of Ljubljana, Slovenia –

Potential of microRNAs for biomarker development • 10.30 – 11.00 Coffee break • 11.00 – 11.30 Marianna Lucafò, University of Trieste, Italy – Role of non-coding RNAs in

glucocorticoid response • 11.30 – 12.00 Nadja Kern Prezelj, VWR International gmbH – QuantaBio Innovative qRT-

PCR, qPCR and miRNA technologies (sponsor lecture) • 12.00 – 12.30 Fabian Kuck, Biotek – CytationTM Cell Imaging Multi-Mode Reader: An

Advanced Tool for Smarter Target-Based and Phenotypic Screening (Kemomed sponsor lecture)

• 12.30 – 14.00 Lunch break Wednesday, 04. 05. 2016 14.00 – 18.30

• 14.00 – 14.40 Poster session Pharmacogenetics and personalized medicine Chairpersons: Ron van Schaik, Nada Božina

• 14.40 – 15.20 Ron van Schaik, Erasmus MC, Rotterdam, The Netherlands – Pharmacogenetics in Transplantation: what can we use?

• 15.20 – 16.00 Giuliana Decorti, University of Trieste, Italy – Therapy personalization of IBD • 16.00 – 16.30 Coffee break • 16.30 – 17.00 Nada Božina, Clinical Institute of Laboratory Diagnosis, Zagreb University

School of Medicine, Croatia – Pharmacogenetic testing in psychiatry • 17.00 – 17.30 Vita Dolžan, Faculty of Medicine, University of Ljubljana, Slovenia –

Pharmacogenetics of Type 2 diabetes treatment • 17.30 – 17.50 Lana Ganoci, University of Zagreb School of Medicine, Croatia – Clinical

implementation of pharmacogenetics in Croatia • 17.50 – 18.10 Ernest Tambo, Universite des Montagnes, Cameroon – Developing and

promoting genetics and genomic medicine integration and uptake strategies in Africa • 18.10 – 18.30 Nikola Kotur, , Institute of Molecular Genetics and Genetic Engineering,

University of Belgrade, Belgrade, Serbia – Maintenance therapy of childhood ALL patients induces TPMT gene expression in VNTR dependent manner

19.30 Dinner

Thursday, 05. 05. 2016 8.30 – 12.30 • 8.30 – 9.00 Meet the speakers

o Nada Božina, Clinical Institute of Laboratory Diagnosis, Zagreb University School of Medicine, Croatia – Integrating Pharmacogenomics with Pharmacovigilance - Croatian Experience

Oxidative stress and disease, Gene-environment interactions Chairpersons: Antonio Cuadrado, Irina Milisav

• 9.00 – 9.45 Antonio Cuadrado, Autonomous University of Madrid, Spain – Redox Biology in Translational Medicine

• 9.45– 10.30 María Monsalve, Instituto de Investigaciones Biomédicas Alberto Sols, Spain – Oxidative stress induces loss of pericyte coverage and vascular instability in PGC-1alpha deficient mice

• 10.30 – 11.00 Coffee break • 11.00– 11.40 Kristel Van Steen, Université de Liège, Belgium – Living in a world of

interactions • 11.40– 12.10 Irina Milisav, Faculty of Medicine, University of Ljubljana, Slovenia –

Oxidative protein modifications in diabetes and neurodegenerative diseases • 12.10– 12.30 Alenka Franko, Clinical Institute of Occupational Medicine, University Medical

Centre, Ljubljana, Slovenia – Gene environment interactions: the case of asbestosis • 12.30 – 14.00 Lunch break

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Thursday, 05. 05. 2016 14.00 – 18.30 • 14.00 – 16.00 The needs and directions for research and development services

in pharmacy and biomedicine: round table discussion • Chairpersons: Tamara Lah Turnšek, Metka Filipič • 16.00 – 16.30 Coffee break • 16.30 Excursion to Piran • 19.30 Dinner in Piran

Friday, 06. 05. 2016 8.30 – 12.30

• 8.30 – 9.00 Meet the speakers o Damjana Rozman, Faculty of Medicine, University of Ljubljana – CASyM and

Systems Approaches to Tackle Multifactorial Pathologies Bioinformatics and biostatistics for translational research Chairpersons: Noël Malod-Dognin, Matthias Samwald

• 9.00 – 9.45 Magnus Ingelman-Sundberg, Karolinska Institute, Sweden – Rare genetic variants do play a major role for interindividual variation in drug response

• 9.45 – 10.30 Noël Malod-Dognin, Imperial College London, UK – Network Data Integration Enables Precision Medicine

• 10.30 – 11.00 Coffee break Emerging technologies in pharmacogenomics

• 10.00 – 10.30 Janez Mavri, Institute of Chemistry, Slovenia – Introduction to Multiscale Simulation of Enzyme Catalysis: Application to Monoamine Oxidase Catalyzed Decomposition of Biogenic Amines

• 11.30 – 12.00 Matthias Samwald, Medical University of Vienna, Austria – One man's *1 is another man's *13? Trouble with current nomenclatures in personalized medicine

• 12.00 – 12.30 Peter Jacobs, Thermo Fisher Scientific – Emerging technologies in pharmacogenomics (sponsor lecture)

• 12.30 – 14.00 Lunch break Friday, 06. 05. 2016 14.00 – 18.30

• 14.00 – 14.40 Poster session Cancer genomics Chairpersons: Erika Cecchin, Núria Malats

• 14.40 – 15.20 Erika Cecchin, CRO Aviano, Italy – Clinical implementation of host pharmacogenomics: focus on colorectal cancer

• 15.20 – 16.00 Núria Malats, CNIO, Madrid, Spain – Molecular epidemiology of pancreatic cancer

• 16.00 – 16.20 Coffee break New approaches to personalized cancer treatment

• 16.20 – 16.50 Gregor Serša, Institute of Oncology Ljubljana, Slovenia – Electroporation based treatments, electrochemotherapy and electrogene therapy for treatment of cancer

• 16.50 – 17.20 Maja Čemažar, Institute of Oncology Ljubljana, Slovenia – Immunogene therapy for canine cancer: a translational model for human oncology

• 17.20 – 17.50 Chris Allen, Thermo Fisher Scientific – A comprehensive view of Liquid Biopsy from ThermoFisher Scientific (sponsor lecture)

• 17.50 – 18.10 Sara Gagno, CRO Aviano, Italy – Role of pharmacogenetics in metastatic breast cancer (MBC) patients treated with exemestane as first-line hormone therapy. An Italian multicentre study

• 18.10 – 18.30 Katja Goričar, Faculty of Medicine, University of Ljubljana – Clinical-pharmacogenetic model predicting treatment outcome in malignant mesothelioma

19.30 Gala dinner Saturday, 07. 05. 2016 8.30 – 12.30

• 8.30 – 9.00 Meet the speakers o Antonio Cuadrado, Autonomous University of Madrid, Spain

Translation to clinical practice Chairpersons: Ron van Schaik, Vita Dolžan

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• 9.00 – 9.30 Magnus Ingelman-Sundberg, Karolinska Institute, Sweden – Pharmacogenomic and epigenomic biomarkers for prediction of drug response

• 9.30 – 10.00 Núria Malats, CNIO, Madrid, Spain – EUPancreas - An integrated European platform for pancreas cancer research: from basic science to clinical and public health interventions

• 10.00 – 10.30 Nada Božina, Clinical Institute of Laboratory Diagnosis, Zagreb University School of Medicine – Genotype-based dosing of oral anticoagulants in clinical practice

• 10.30 – 11.00 Coffee break • 11.00 – 11.30 Vita Dolžan, Faculty of Medicine, University of Ljubljana, Slovenia –

Preemptive testing in pharmacogenomics • 11.30 – 12.00 Matthias Samwald, Medical University of Vienna, Austria – Bridging theory

and practice: Clinical decision support systems for personalized medicine Closing plenary lecture

• 12.00 – 13.00 Professor Sir Munir Pirmohamed, MRC Centre for Drug Safety Science and Wolfson Centre for Personalised Medicine and Institute of Translational Medicine, University of Liverpool, UK – Genomics and Therapeutics: The Opportunities

13.00 Closing ceremony

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3 EVENT OUTCOME 3.1 General information Among 77 participants, 52 (67.5%) were female and 25 (32.5%) were male (Figure 2). The majority of participants were from Slovenia (45.5%), followed by Serbia (18.2%), Italy (6.5%), Spain (5.2%), United Kingdom (5.2%), Croatia (3.9%), Sweden (3.9%) and Germany (2.6%), and with individual participants from Israel, Greece, Bosnia and Herzegovina, Argentina, Austria, The Netherlands and Belgium. 28 invited speakers (Figure 2) presented the topics related to genomic medicine (personalized, 4P or stratified medicine), pharmacogenomics and epigenomics, systems medicine and translation of basic research into clinical practice and public health. 6 participants only attended the satellite workshop and among 43 summer school participants, 19 had a poster or oral presentation. Among the participants were principal investigators, PhD students, postdoctoral researchers, early career investigators, MDs, commercial employees and undergraduate students. Altogether, 12 MDs attended the summer school, several of which were also principal investigators.

Figure 2: Event participants according to gender, country, position and what they registered for (n = 77).

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3.2 Survey statistics The link to the online survey and questionnaire was sent to each participant (Appendix 6.1) and here we summarize the outcome regarding overall evaluation (Figure 3), organization (Figure 4), expectations of the course and speakers (Figure 5), and discussions (Figure 6). The number of responses is indicated for each question.

Figure 3: Workshop survey questions about overall evaluation and the distribution of answers.

Figure 4: Workshop survey questions about organization and the distribution of answers.

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Figure 5: Workshop survey questions about expectations of the course and speakers and the distribution of answers.

Figure 6: Workshop survey questions about discussions and the distribution of answers.

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4 LIST OF PARTICIPANTS First name(s) Family name(s) Institution

1 Christopher M. Allen Thermo Fisher Scientific, United Kingdom

2 Marina Andjelkovic Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Serbia

3 Sivia Barnoy Tel-Aviv University, Israel

4 Nada Božina Zagreb University Hospital Centre, Croatia

5 Barbara Breznik National Institute of Biology, Slovenia

6 Erika Cecchin Centro di Riferimento Oncologico - National Cancer Institute, Italy

7 Maja Cemazar Institute of Oncology Ljubljana, Slovenia

8 Antonio Cuadrado Autonomous University of Madrid, Spain

9 Giuliana Decorti University of Trieste, Italy

10 Mateja Delač National Institute of Biology, Slovenia

11 Allesia di Silvestre University of Trieste, Italy

12 Klemen Dolinar Faculty of Medicine, University of Ljubljana, Slovenia

13 Vita Dolžan Faculty of Medicine, University of Ljubljana, Slovenia

14 Katarina Esih Faculty of Medicine, University of Ljubljana, Slovenia

15 Jana Ferdin Faculty of Medicine, University of Ljubljana, Slovenia

16 Metka Filipic National Institute of Biology, Slovenia

17 Alenka Franko University Medical Centre Ljubljana, Slovenia

18 Sara Gagno Centro di Riferimento Oncologico - National Cancer Institute, Italy

19 Lana Ganoci Zagreb University Hospital Centre, Croatia

20 Katja Goričar Faculty of Medicine, University of Ljubljana, Slovenia

21 Milka Grk Faculty of Medicine University of Belgrade, Serbia

22 Delilah F.G. Hendriks Karolinska Institutet, Sweden

23 Klara Hercog National Institute of Biology, Slovenia

24 Marta Herreros AMADIX

25 Magnus Ingelman-Sundberg Karolinska Institutet, Sweden

26 Peter Jacobs Thermo Fisher Scientific, United Kingdom

27 Vid Jan Faculty of Medicine, University of Ljubljana, Slovenia

28 Barbara Jenko Faculty of Medicine, University of Ljubljana, Slovenia

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29 Katharina Kaumanns Federal Institute for Drugs and Medical Devices, Germany

30 Iva Klarica Domjanović Agency for Medicinal Products and Medical Devices, Croatia

31 Nikola Kotur Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Serbia

32 Jernej Kovač University Medical Centre Ljubljana, Slovenia

33 Tilen Kranjc Faculty of Pharmacy, University of Ljubljana, Slovenia

34 Fabian Kuck BioTek

35 Tanja Kunej Biotechnical Faculty, University of Ljubljana, Slovenia

36 Tamara Lah Turnšek National Institute of Biology, Slovenia

37 Eva Legaki School of Medicine, University of Athens, Greece

38 Metka Lenassi Faculty of Medicine, University of Ljubljana, Slovenia

39 Marianna Lucafò University of Trieste, Italy

40 Núria Malats CNIO, Spain

41 Noël Malod-Dognin Imperial College London, United Kingdom

42 Janja Marc Faculty of Pharmacy, University of Ljubljana, Slovenia

43 Tomaž Marš Faculty of Medicine, University of Ljubljana, Slovenia

44 Aleš Maver University Medical Centre Ljubljana, Slovenia

45 Janez Mavri National Institute of Chemistry, Slovenia

46 Irina Milisav UL, Faculty of Medicine, Inst. of Pathophysiology

47 Maria Monsalve Instituto de Investigaciones Biomédicas Alberto Sols, Spain

48 Gordana Nikčević Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Serbia

49 Jerica Novak Institute of Oncology Ljubljana, Slovenia

50 Matjaž Novak National Institute of Biology, Slovenia

51 Mirjana Novkovic Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Serbia

52 Sonja Pavlovic Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Serbia

53 Ivan Pavlović Vinca Institute of Nuclear Sciences, Serbia

54 Snezana Pejic Vinca Institute of Nuclear Sciences, Serbia

55 Miha Petrič University Medical Centre Ljubljana, Slovenia

56 Munir Pirmohamed Institute of Translational Medicine,University of Liverpool, United Kingdom

57 Irena Prodan Žitnik Faculty of Pharmacy, University of Ljubljana, Slovenia

58 Špela Puh National Institute of Biology, Slovenia

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59 Ljiljana Rakicevic Institute of Molecular Genetics and Genetic Engineering, University of Belgrade

60 Jasmin Ramic Institute for Genetic Engineering and Biotechnology, University of Sarajevo, Bosnia and Herzegovina

61 Sara Redenšek Faculty of Medicine, University of Ljubljana, Slovenia

62 Emilio Roldan-Prinsich Gador SA, Argentina

63 Damjana Rozman Faculty of Medicine, University of Ljubljana, Slovenia

64 Matthias Samwald Medical University of Vienna, Austria

65 Gregor Serša Institute of Oncology Ljubljana, Slovenia

66 Primož Sever University Medical Centre Ljubljana, Slovenia

67 Biljana Stankovic Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Serbia

68 Maja Stojiljkovic Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Serbia

69 Barbara Šenk Kraške lekarne Ilirska Bistrica, Slovenia

70 Ana Todorovic Vinca Institute of Nuclear Sciences, Serbia

71 Natasa Tosic Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Serbia

72 Ron van Schaik Erasmus MC, The Netherlands

73 Kristel Van Steen University of Liège, Belgium

74 Sabine Vorrink Karolinska Institutet, Sweden

75 Misa Vreca Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Serbia

76 Andrej Zore University Medical Centre Ljubljana, Slovenia

77 Bojana Žegura National Institute of Biology, Slovenia

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5 ACKNOWLEDGEMENTS The Summer school was organized by Pharmacogenetics laboratory, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana as a collaborative action between Artemida Teaming project, CASyM, COST Action EUPancreas (BM1204), COST Action EU-ROS (BM1203) and SERBORDISinn. The Summer School received recognition from several associations and professional societies and was endorsed by Slovenian Biochemical Society, Golden Helix Institute of Biomedical Research, Genomic Medicine Alliance, ESPT, Eu-PIC and H2020 project U-PGx. International Scientific Committee

• Vita Dolžan, chair (University of Ljubljana, Slovenia) • Henk-Jan Guchelaar (Leiden University Medical Center, The Netherlands) • Magnus Ingelman-Sundberg (Karolinska Institutet, Sweden) • Núria Malats (Spanish National Cancer Research Centre, Spain) • George Patrinos (University of Patras, Greece) • Sonja Pavlović (Institute of Molecular Genetics and Genetic Engineering University of

Belgrade, Serbia) • Ron van Schaik (Erasmus Medical Center, The Netherlands)

Organizing Committee

• Vita Dolžan, chair • Katja Goričar, co-chair • Barbara Jenko • Irina Milisav Ribarič • Peter Juvan

Golden sponsors

• Kemomed • Thermo Fisher Scientific

Sponsors

• CASyM • VWR • Quantabio • Krka • Omega • SBD • Biomedica • Genos • Sanolabor

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6.2 Approved ECTS accreditation

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6.3 Approved CME accreditation

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