Course Code ACH 502

Course Title Electrical Engineering for Power Systems

Semester Spring

ECTS Credit 5

Hours / Week 3

Prerequisites -

Contents Complex numbers, impedance, AC/DC power, apparent power, idle power; reactive power, effective power, three-phase current: three-phase A.C. current, three-phase induction machine, voltage drop calculations, three-phase A.C. current transmission (ferranti-effekt), components of electrical power supply networks (Generators, Transformators, Kabel, etc.), emergency power systems; emergency power stations basics and selected applications of power electronics

Course Code ACH 504

Course Title Medical Imaging

Semester Spring

ECTS Credit 5

Hours / Week 3

Prerequisites -

Contents Medical image acquisition systems, image digitisation, statistical evaluation, gray-level operation, image subtraction, averaging, filtering (in spatial domain), frequency domain and image-restoration, image compression, three-dimensional-visualization, practical training courses: quick guide to optima, practical training courses

Course Code ACH 506

Course Title Material Science

Semester Spring

ECTS Credit 5

Hours / Week 3

Prerequisites -

Contents Basics of metal and polymer physics, production and properties of steel, metallurgy, non-iron metals, polymers

Course Code ACH 508

Course Title Medical Measurement Technology

Semester Spring

ECTS Credit 5

Hours / Week 3

Prerequisites -

Contents Basics of bioelectricity, origin of action potentials, transmission of action potentials, bioelectrical voltages on the organ level, measurement technology of bioelectrical signals, amplifiers, signal deduction, electrodes, applications, elektro caridogram (ECG), electroencephalogram (EEG), electromyogram (EMG), filters, system theory and applications, from Fourier series to Fast Fourier Transformations, the sampling theorem, signal improvement of ECG-signals, system theory of the blood pressure measurement system

Course Code ACH 510

Course Title Fundamentals of Chemical Sensors and Biosensors

Semester Spring

ECTS Credit 5

Hours / Week 3

Prerequisites -

Contents Introduction to sensors, signal transduction and biological-chemical signals, biomolecules: enzymes, antibodies and antigens, DNA, immobilisation technologies, biomolecule substrate interaction, electrochemical sensors: Potentiometrics, amperometrics, konduktometrics, reference electrodes, ion selective electrods, ISFET, Field effect sensors, pH- und Ion measurements, enzyme sensors (glucose, lactate, penicillin), biosensors in integrated systems, immuno- and DANN-Sensoren, electrical sensors, surface- and volume conductivity, gas, optical, thermal (calorimetrics), magnetic sensors, mass sensitive devices (Piezo-, SAW-Effect), production technologies

Course Code ACH 512

Course Title Dynamic Systems

Semester Spring

ECTS Credit 5

Hours / Week 3

Prerequisites -

Contents Mathematical modelling of medical and biological issues and computer simulation, dynamic systems, classification und desciption of sytem elements, experimental evaluation of dynamic systems, theoretical desciption of dynamic systems and mathematical modelling, control and stability of dynamic systems, optimization of dynamic systems

Course Code ACH 514

Course Title Laser Technology

Semester Spring

ECTS Credit 5

Hours / Week 3

Prerequisites -

Contents Laser saftey , atoms and molecules, light matter interactions, 3- und 4-Niveau-Lasers, ruby laser, laser resonators, helium-Neon-Lasers, laser measurment technology: Interferometry, Triangulation, surface modifications with CO2-Lasers and Nd-YAG-Laser, applications of Eximer lasers, laser applications in medicine

Course Code ACH 516

Course Title Cell Culture Technology

Semester Spring

ECTS Credit 5

Hours / Week 3

Prerequisites -

Contents Basics of eucariotic cell culture technology, production techn ologies of pharma proteins based on cell cultures (Vaccines, monoclonal Antibodies, rekombinant pharma proteins), application of cells and tissues for therapeutical purposes, cell lines: estabishing, characterizations, cultivation, methods of cell culturing, culture media, safety issues , flow cytometry, cell culture reactors and scale up technologies, cell sampling, production of pharmaceutical proteins (Factor VIII, t-PA, EPO, GM-CSF), glycosylation of proteins (Structure, Impact), monoclonal antibodies: Structure, production, diagnostic applications of Antibodies (ELISA, Immunohistochemistry, tumor imaging), therapeutical applications of antibodies, use of antibodies to purify proteins, stem and progenitor cells, hematopoetic stem cells, T-cells, dendric cells, embryonic and adult stem cells, gene therapy

Course Code BIO 610

Course Title Biochemistry of Extracellular Matrix

Semester Spring

ECTS Credit 6

Hours / Week 2

Prerequisites -

Contents Introduction, collagen, problem solving; a pathology related with collagen, non-collagenoues matrix proteins, adhesive glycoproteins, elastin, proplem solving; a pathology related with elastin, matrix proteoglycans, regulation of gene expression by ECM, ECM and cell surface reseptors, extracellular matrix proteolysis, wound healing and ECM, the role of the ECM in tumor invasion and metastasis

Course Code BIO 614

Course Title Selected Chapters in Biochemistry

Semester Spring

ECTS Credit 6

Hours / Week 2

Prerequisites -

Contents Biomembranes-I (structure and organization), Biomembranes-II (transport from membranes), muscle-I (structure, muscle proteins), muscle-II (biochemistry of contraction), muscle-III (energy metabolism of muscle), biochemistry of vision-I (molecular structure of the eye), biochemistry of vision-II (molecular basis of vision), red blood cells-I (structure and organization), red blood cells-II (metabolism), neurochemistry-I (structure and organization), neurochemistry-II (metabolism), extracellular matrix-I (structure and organization), extracellular matrix-II (proteins and proteoglycans), bone (structure and organization)

Course Code BIO 616

Course Title Biochemical Endocrinology

Semester Spring

ECTS Credit 6

Hours / Week 2

Prerequisites -

Contents Introduction (classification, circulation, secretion and inactivation, regulation and function), hormone action-I (hormone receptors, nuclear, thyroid and steroid receptors), hormone action-II (hormone receptors-cell surface receptors, G protein family, protein kinases), hormones of the hypothalamus and pituitary-I (hypothalamus and posterior pituitary), hormones of the hypothalamus and pituitary-II (anterior pituitary), hormones of the thyroid, hormones of the adrenal cortex, hormones of the adrenal medulla, hormones of the gonads-I (male sex hormones), hormones of the gonads-II (female sex hormones), hormones of the pancreas and gastrointestinal tract-I (insulin), hormones of the pancreas and gastrointestinal tract-II (glucagon and GI hormones), hormones that regulate calcium metabolism (PTH, vitamin D, calcitonin)

Course Code BIO 632

Course Title Metabolism I

Semester Spring

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents Nutritional biochemistry, overview of metabolism, bioenergetics, oxydative phosphorylation, digestion of carbohydrates, absorption of carbohydrates, pathways leading to glycolysis, glycolysis and TCA cycle, glycogenesis and glycogenolysis, regulation of blood glucose, pentose phosphate and glucuronate pathyways, digestion, absorption and transport of lipids, oxydation of fatty acids, synthesis of fatty acids, synthesis and degradation of phosphoglycerides and sphingolipids, synthesis and utilization of cholesterol, bile acids and other isoprenoid molecules, biosynthesis of ketone bodies, biosynthesis of lipoproteins, integration of metabolism, hormonal regulation

Course Code BIP 601

Course Title Biophysics and Systems Theory

Semester Fall

ECTS Credit 6

Hours / Week 2

Prerequisites -

Contents Introduction, biological systems theories, circulation, and respiratory system, smooth muscles, central nervous system, evolution

Course Code BIP 602

Course Title Systems Theory of The Brain II

Semester Spring

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents Wavelet decomposition, amplitude frequency characteristics, new methods, whole brain theory

Course Code BIP 603

Course Title Biophysics

Semester Fall

ECTS Credit 6

Hours / Week 2

Prerequisites -

Contents Introduction, biophysical measurement basics, transducers, bioenergytics

Course Code MBI 604

Course Title Bioelectricity II

Semester Spring

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents Electroretinography, electrocohleography, brain stem potentials, event related potentials, event related oscillations

Course Code BIP 605

Course Title Bioelectricity I

Semester Fall

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents Membrane potentials, bioelectrical fields, spikes of muscle activity, MEG, EEG, histograms of cellular activity

Course Code BIP 606

Course Title Radiation Biophysics

Semester Spirng

ECTS Credit 6

Hours / Week 3

Prerequisites -

Contents Radioactivity, synthigraphy, dual photon densimetry, irradiation, applications of nucleeer medicine

Course Code BIP 607

Course Title Systems Theory of the Brain I

Semester Fall

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents Introduction, fourier analysis, macro systems, micro systems

Course Code BIP 608

Course Title Imaging Technics

Semester Spring

ECTS Credit 6

Hours / Week 3

Prerequisites -

Contents Basic principles, X ray, MRI, ultrasonography-doppler, fMRI, PET, SPECT, 3D imaging, new technics

Course Code BIP 609

Course Title Analysis Methods I

Semester Fall

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents Acquisition, recording, analysis, sampling, brain data analysis, other analysis methods

Course Code BIP 610

Course Title Stereotaxic Preparations

Semester Spring

ECTS Credit 6

Hours / Week 3

Prerequisites -

Contents Introduction, stereotaxic basics, application methods

Course Code BIP 611

Course Title Dynamic Systems

Semester Fall

ECTS Credit 6

Hours / Week 1

Prerequisites -

Contents Introduction, respiration dynamics, circulation dynamics, brain dynamics, other approaches

Course Code BIP 613

Course Title Neuropsychological Tests

Semester Fall

ECTS Credit 6

Hours / Week 3

Prerequisites -

Contents Neuropsychology, neuropsychological tests and application, stroop test, Wisconsin test, wechsler memory test, sequentional learning, auditory, verbal, visual tests

Course Code BIP 616

Course Title Biophysical Basics of Polygraphic Technics

Semester Spring

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents Polygraphy, applications, methodology, multiple connections

Course Code BIP 618

Course Title Neurobiology and Cognition

Semester Spring

ECTS Credit 6

Hours / Week 3

Prerequisites -

Contents Neurobiology of conciousness, cognitive experiments, necker cube paradigms, new applications

Course Code BIP 620

Course Title Analysis Methods II

Semester Spring

ECTS Credit 6

Hours / Week 5

Prerequisites -

Contents Data transfer, data conversion, MATLAB applications, experimental applications

Course Code BIP 622

Course Title Article Publication Technics

Semester Spring

ECTS Credit 6

Hours / Week 2

Prerequisites -

Contents Scientific articles, refereeship,SCI, digital media

Course Code BIP 624

Course Title Nonlinear Systems

Semester Spring

ECTS Credit 6

Hours / Week 3

Prerequisites -

Contents Walvelet analysis, entropy, caos, new methods, macro and micro approaches

Course Code BIP 628

Course Title Bioelectricity and Behaviour

Semester Spring

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents Biophysical approach in psychiatry, schizoprenia, other clinical examples, abnormal changes in the EEG rhythm, biochemical functions in the brain, neurophysiological approaches, Alzheimer, demansia

Course Code CSE 220

Course Title Data Structures

Semester Spring

ECTS Credit 8.75

Hours / Week 4

Prerequisites -

Contents Introduction, analysis of algorithms (Q-notation, Ω-notation, O-notation), stacks and recurrence (stack as an abstract data type (ADT), implementing a stack, bounded stack, linked implementation of a stack recursion, recursion as a programming technique, inner working of recursion, simulation of recursion), queues (Queue as an ADT, implementing a queue, bounded queue, linked implementation of a queue), general lists and linked implementation (list as an ADT, list types, iteration over a list, list as a generalization of linear data structures, restricted lists, stack as a restricted list, queue as a restricted list, other well known restricted lists), trees (introduction, weaknesses of linear data structures, hierarchical data structures, terminology on trees, binary trees, binary search trees, balanced trees, AVL trees, red-black trees, B-trees), sorting (introduction, objective of sorting, criteria for evaluating a sorting algorithm, classification of sorting algorithms, exchange sorts, bubble sort, quicksort, distribution counting sort, straight radix sort, radix exchange sort, selection sorts, straight selection sort, binary tree sort, heapsort, insertion sorts, simple insertion sort, shell sort, address calculation sort, merge sort), searching (introduction, basic search techniques, review of tree based searching algorithms, hashing), graphs (graph as an ADT, implementing a graph, adjacency matrix representation, adjacency structure representation, some common graph problems, graph as a generalization of hierarchical data structures)

Course Code CSE 306

Course Title Database Management Systems

Semester Spring

ECTS Credit 10

Hours / Week 5

Prerequisites -

Contents Players in the systems game, information system building blocks, information systems development, systems analysis, requirements discovery, data modeling and analysis, process modeling, feasibility analysis and the system proposal, systems design methods, object-oriented analysis and modeling, case study

Course Code CSE 403

Course Title Computer Networks

Semester Fall

ECTS Credit 7.5

Hours / Week 3

Prerequisites -

Contents Introduction to computer networks, packet transmission, LAN Technologies and network topology, LAN Active devices, long distance digital communication technologies, WAN Technologies and routing, protocols and layering, internetworking,midterm Exam-I, IP Datagrams, encapsulation fragmentation, network applications, network security and network management, network planning, routing basics, midterm exam-II

Course Code CSE 504

Course Title Knowledge-Based Systems

Semester Spring

ECTS Credit 7.5

Hours / Week 3

Prerequisites -

Contents Main notions and definitions of knowledge-based systems, expert systems, advantages of expert systems, general concepts of expert systems, expert systems in medicine, problems definitions, search space, search strategies.,decomposition of the problems, decision trees, search strategies on AND/OR graphs, knowledge representation, production rules, semantic nets frames, constraint nets, inference engines, forward and backward inference combined inference, constraint satisfaction reasoning, symbolic reasoning under uncertainty, non-monotonic reasoning default reasoning, problem based reasoning, inexact reasoning, certainty factors, approximate reasoning, natural language understanding, level of language analysis, semantic interpretation, technology of expert systems design, programming languages and environments

Course Code CSE 524

Course Title Web Design and Web Programming

Semester Spring

ECTS Credit 7.5

Hours / Week 3

Prerequisites -

Contents Introduction, introduction to HTML, intermediate HTML, web design tools, animations and other objects on the web, HTML Forms and javascript, javascript-II, styling with CSS (Cascading Style Sheets), dynamic web sites, introduction to ASPX, programming with ASPX, programming with ASPX-II, infrastructure of dynamic web sites, database programming with ASP, case study

Course Code CSE 566

Course Title Multimedia Information Retrieval

Semester Spring

ECTS Credit 7.5

Hours / Week 3

Prerequisites -

Contents Textual information retrieval, introduction to MIR, indexing structures for MIR, color-based retrieval, shape-based retrieval, texture-based retrieval, video retrieval, applications of content-based image retrieval

Course Code CSE 583

Course Title Analysis of Algorithms

Semester Fall

ECTS Credit 7.5

Hours / Week 3

Prerequisites -

Contents Basic strategies used in the design of algorithms, divide and conquer, recursion, search and traversal, backtracking, and branch and bound techniques, techniques and tools for algorithm analysis. Np completeness

Course Code EEE 401

Course Title Fundamentals of Biomedical Engineering

Semester Fall

ECTS Credit 7.5

Hours / Week 3

Prerequisites -

Contents Introduction to biomedical engineering, human physiology, bioelectricity, nervous system and EEG, cardiovascular system and ECG, biomedical signal processing, medical imaging systems, effects of EM fields on human health, minimally invasive techniques / virtual reality, PACS / telemedicine / medical informatics

Course Code EEE 514

Course Title Electronic Instrumentation

Semester Spring

ECTS Credit 7.5

Hours / Week 3

Prerequisites -

Contents Basic concept of measurement: Error anaysis and noise, instrumentation system, transducers, displacement, strain, vibration pressure, flow, temparature, force and torque T, instrumentation amplifiers, signal generation and processing, filtering and signal analysis, data acquisition and conversion, digital signal transmission, input-output devices and displays, electronic test equipments

Course Code EEE 529

Course Title Artifical Neural Networks

Semester Fall

ECTS Credit 7.5

Hours / Week 3

Prerequisites -

Contents Historical perspectives, pattern recognition, classification techniques, the multilayer perceptron, kohonen self organising networks, hopfield networks, adaptive resonance theory, associative memory and applications

Course Code EEE 531

Course Title Advanced Computer Networks

Semester Fall

ECTS Credit 7.5

Hours / Week 3

Prerequisites -

Contents Sophisticated theoretical treatment for wide area networks such as multilevel approach, layered protocols, network topology, transmission, multiplexing, sliding window protocols, piggy blacking and pipelining and delecting codes, data link layer, advanced data link protocols

Course Code EEE 533

Course Title Digital Image Processing

Semester Fall

ECTS Credit 7.5

Hours / Week 3

Prerequisites -

Contents Introduction to digital image processing, digital image representation, image transforms, image enhancement, color image processing, image segmentation, mid-term examination, representation and description, morphology, some basic morphological algorithms

Course Code EEE 534

Course Title Computer Vision

Semester Spring

ECTS Credit 7.5

Hours / Week 3

Prerequisites -

Contents Geometric model for imaging, estimation of image motion and optical flow, geometric transformations and image registration, morphological image processing, pattern classification and recognition, hough transform, optical character recognition

Course Code EEE 545

Course Title Microprocessor Applications

Semester Fall

ECTS Credit 7.5

Hours / Week 3

Prerequisites -

Contents Microprocessor based communications, direct memory access, interrupt and bus arbitration techniques, magnetic recording techniques, disk interfaces, CRT controllers, sofware development techniques, survey of 8 and 16 bit microprocessors and applications

Course Code EEE 547

Course Title Microcontroller Architecture and Applications

Semester Fall

ECTS Credit 7.5

Hours / Week 3

Prerequisites -

Contents The importance of microcontrollers in the design of a control system, overview of internal architectures of different microcontrollers, memory and I/O expansion techniques, application specific hardwares, programming frame work and software developing tools, application ideas

Course Code EEE 575

Course Title Information Theory and Coding

Semester Fall

ECTS Credit 7.5

Hours / Week 3

Prerequisites -

Contents The concept of amount of information, sources, source models and source encoding, shannons channel coding theorem, linear block codes syndromes and standard array decoding, convolutional codes and encoder implementation, decoding of convolutional codes and viterbi algorithm, cylic codes and galois fields, BCH and RS codes, turbo codes, code structures and interleaver design, turbo decoding and performance of turbo codes

Course Code EEE 576

Course Title Biomedical Signal Processing

Semester Spring

ECTS Credit 7.5

Hours / Week 3

Prerequisites -

Contents Introduction to process control, process modelling, analytical and numerical methods for process control, sensors and transducers for process control, data acquisition, analog and digital process controllers, case studies

Course Code EEE 580

Course Title Biomedical Signal and Instrumentation

Semester Spring

ECTS Credit 7.5

Hours / Week 3

Prerequisites -

Contents Acquisition and processing of electrical signals that emanate from human body, origin and classification of biomedical signals, basic human physiology, bioelectricity, brain function and EEG, cardiovascular system and ECG, electrodes and sensors, biopotential amplifiers, computers in medicine, imaging systems, medical equipment maintenance

Course Code HSI 503

Course Title Medical Ethics

Semester Fall

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents What is medical ethics, different approaches about ethics, human rights and ethics, patient rights, children rights, women rights, patient-Physician relationships, malpractice, privacy, informed consent, genetics and ethics, health technology and ethics, pharmaceuticals and ethics, research ethics, publication ethics, ethics comittees

Course Code HSI 509

Course Title The Cell

Semester Fall

ECTS Credit 6

Hours / Week 5

Prerequisites -

Contents The course is designed in blocks. The contents of the blocks are introduction to biomolecules-water, the flow of genetic information, cell structure and function, cell regulation, discussion. The scenarios used in problem based learning sessions:

In vitro fertilization,

Phenylketonuria,

Sckle cell anemia,

Cystic fibrosis,

Anorexia nervosa,

Carbon monoxide poisoning,

Obesity

Teaching and Learning Methods : This multidisciplinary course will be taught in interactive lectures and problem based on oriented learning sessions.

Course Code HSI 511

Course Title Structure and Function of The Human Body

Semester Fall

ECTS Credit 6

Hours / Week 2

Prerequisites -

Contents Terminology, cells, tissues, support and movement, skeletal system, joints of the skeletal system, muscular system, transport, blood, cardiovascular system, lymphatic system and immunity, absorbtion and excretion, respiratory system, digestive system, nutrition and metabolism, urinary system, water, electrolyte and acid-base balance, integration and coordination, basic structure and function, divisions of the nervous system, somatic and special senses, endocrine system, human life cycle, reproductive system, human growth and development genetics

Course Code HSI 513

Course Title Introduction to Medical Sciences and Terminology

Semester Fall

ECTS Credit 6

Hours / Week 2

Prerequisites -

Contents History of medicine, classification of medical sciences, their contents and their practice area, history of the language of medical sciences, some important concepts used for the grammar, basic rules of declinations, adjectives, numbers, anatomic nomenclature, particles in anatomic terminology, positions, axis, directions and planes used in anatomy, main words determining location in nomenclature, terms on movement, important anatomic abbreviations, explanation of frequently used anatomic terms by alphabetical order, basic concept of clinical terminology, names of clinical departments, special concepts (For organ and systems), origin of basic concepts and their counterpart, other languages, the medical terminology which originates from other languages, the mythological definitions which are used in todays medical science, the eponyms in anatomy

Course Code HSI 515

Course Title Basic Separation and Assay Methods of Biomolecules

Semester Fall

ECTS Credit 6

Hours / Week 6

Prerequisites -

Contents 1-) General laboratory procedures: introduction to laboratory (safety in laboratory, laboratory equipment, preparation and storage of solutions, dilutions), pH, buffers (preparation of buffer solutions, measurement of pH, centrifugation, basic principles of centrifugation, centrifuge types), spectrophotometry and spectrofluorometry (basic principles, types), 2-) Separation methods: based on charge (ion exchange chromatography, electrophoresis, isoelectric focusing), based on polarity (paper chromatography, reverse-phase chromatography, hydrophobic interaction chromatography), based on size (dialysis and ultrafiltration, gel electrophoresis, gel filtration chromatography, ultracentrifugation), based on specificity (affinity chromatography), 3-) Basic immunochemical techniques: antigen-antibody (definition, structure, theory of interaction, epitopes and paratopes, affinity and avidity, cross reactions), agglutination based techniques (passive agglutination, hemagglutination, latex agglutination), complement agglutination tests (Immunotoxicity tests), enzyme immuno assay (EIA), immunofluorescence antibody techniques (IFAT), indirect fluorescence antibody techniques, direct fluorescence antibody techniques, ELISPOT assay, 4-) Basic molecular techniques: DNA extraction methods, polymerase chain reaction, blotting techniques (Western, Southern, Northern blotting), cell culture techniques

Teaching and Learning Methods : Basic topics will be taught as lectures and interactive presentations. Also the oretical knowledge will be supported will practicals

Course Code HSI 517

Course Title Research Methods and Analysis Techniques in Health

Semester Fall

ECTS Credit 6

Hours / Week 5

Prerequisites -

Contents Scientific approach (Historical and contemporary), causality (Cause, effect, confounding), types of research (prospective, retrospective, cross-sectional), validity and reliability (Sensitivity, specificity, predictivity, consistency, log likelihood, power), ratio and rate (morbidity, fatality, mortality, RR, OR, incidence rate), planning the research (variables emphasized), population and sampling (mean, standard deviation and error), data and data collection (questionnaire, processing), distributions (Binomial, Poisson, Gausian), statistical inference (p, significance, one-two way analysis), analysis of data (parametric and nonparametric), comparison of group means (t, Wilcoxon, ANOVA), analysis of frequencies (chi-square, McNemar, Mantel Haenszel), multivariate analysis (multiple and logistic regression), correlation and regression (Pearson, Spearman, Kendall), writing the research report (thesis, article, poster)

Course Code HSI 607

Course Title Planning, Applying and Evaluating Experimental Research

Semester Fall

ECTS Credit 6

Hours / Week 4

Prerequisites The students should take this course in the third semester

Contents Reading and understanding articles in scientific literature, understanding and interpreting the data given in an article

, finding a connection between the research data and the information obtained from literature, preparing a research project, understanding experimental methodologies and recording the experimental results, preparing a poster, making an oral presentation, writing an article

Teaching and Learning Methods : Basic topics will be discussed with integrated scenarios that compromise several of the learning targets. Those learning targets that can not be attained with scenarios will be supported through oral presentations, small group studies.

Course Code IND 506

Course Title Operations Management

Semester Spring

ECTS Credit 7.5

Hours / Week 3

Prerequisites -

Contents Quantitative modules A, forecasting-Chapter 4,

quantitative modules D, project management-Chapter 16, design of goods and services-Chapter 5, process strategies-Chapter 7-up to capacity, operations technologies, the internet and ERP-Chapter 7 supplement, test1, human resource and job design-Chapter 10, computer application-meet at the computer lab., materials requirements planning-Chapter 14, short term scheduling-Chapter 15, inventory management and just in time systems-Chapter 12 and its supplement, tests, review

Course Code IND 510

Course Title Design of Working Environment

Semester Spring

ECTS Credit 7.5

Hours / Week 3

Prerequisites -

Contents Applied anthropometry and work space, physical space and arrangement, design W.r.t. illumination and colour, design W.r.t. noise and vibration, design W.r.t. atmospheric conditions, design W.r.t. toxicology, evaluation and grading of working environments, the history of work design and modern approaches, procedures of work methods improvement, resistance to change and overcoming resistance to chang, fundamentels of work methods and measurements, some further applications of engineering, psycological and physiological principles to the analysis and design of human work systems, advanced concepts in work methods and measurement systems and their application, constructing standart data systems, and methodology for developing standart data systems

Course Code IND 519

Course Title Management Information Systems

Semester Fall

ECTS Credit 7.5

Hours / Week 3

Prerequisites -

Contents Principles and methodologies of industrial and systems engineering, general systems theory, management theory, study of the operational and managerial information needs of an organization, the concepts and practices of systems theory applied to the management of technical and scientific organizations, integrating and executing marketing production, finance and engineering policies and strategies for the benefit of an enterprise, analysis.

Course Code MAT 501

Course Title Applied Mathematics

Semester Fall

ECTS Credit 7.5

Hours / Week 3

Prerequisites -

Contents Linear spaces and transformations (Definition of linear spaces and linear transformations, matrix representation of linear operators eigen values of an operator, function spaces, orthogonal functions. Integral transformations)

Boundary value problems (partial differential equations of mathematical physics, the definition of boundary and initial value problems, solution of boundary value problems by integral transformations, solutions of the wave, heat and laplace equations)

Course Code MBI 509

Course Title Genetics

Semester Fall

ECTS Credit 6

Hours / Week 3

Prerequisites -

Contents Introduction to genetics; mitosis and meiosis, mendelian genetics I (Mendel's first three postulates and analytical approach), mendelian genetics II (Mendel's forth postulate and correlation of postulates with the behavior of chromosomes), laws of probability (the product and the sum law; conditional probability; the binomial theorem); pedigree analysis, approaches to solve genetic problems, extensions to mendelian genetics; modifications of mendelian ratios, quantitative genetics, linkage, crossing over, and mapping in eukaryotes, genetic recombination and mapping in bacteria and bacteriophages, extrachromosomal inheritance, sex determination and sex chromosomes, chromosome mutations: variations in chromosome number and arrangement, DNA structure and analysis, fine structure of eukaryotic chromosomes

Course Code MBI 513

Course Title Specified Research Project I

Semester Fall

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents

Course Code MBI 514

Course Title Molecular Genetics

Semester Spring

ECTS Credit 6

Hours / Week 3

Prerequisites -

Contents Introduction and fundamentals of molecular genetics, biophysical and structural aspects of DNA, genetic information and its expression, types and synthesis of RNA, RNA processing and editing, protein structure and synthesis, functions and post translational modifications of proteins, MID TERM EXAM, genetic regulation in prokaryotic cell, genetic regulation in eukaryotic cell, cell cycle and regulation, mutations and genetic recombination in bacteria and viruses, cellular differentiation in eukaryotes, immunoglobulin gene rearrangement

Course Code MBI 516

Course Title Molecular Basis of Cancer

Semester Spring

ECTS Credit 6

Hours / Week 2

Prerequisites -

Contents Introduction to cancer and terminology, in vitro characteristics of cancer cell, general features of cancer cell, carcinogenic factors and their role in carcinogenesis, oncogenes, predisposition to cancer and tumor suppressor genes, multistep carcinogenesis and clonal expansion, MID TERM EXAM, some biochemical aspects of cancer cell, signaling mechanisms its regulation and importance in cancer, cell cycle changes in cancer, programmed cell death (apoptosis) in cancer, tumor invasion and metastasis, cancer cytogenetics and molecular genetics

Course Code MBI 518

Course Title Specified Research Project II

Semester Spring

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents

Course Code MBI 520

Course Title Special Subjects in Molecular Biology

Semester Spring

ECTS Credit 6

Hours / Week 3

Prerequisites -

Contents Chromatin remodeling and its role in transcriptional control, histon modifications and its role in transcriptional control, cell cycle check points and relation to diseases, DNA repair mechanisms, DNA repair defects and diseases, apoptosis and its regulation, apoptotic defects related to some diseases, molecular effects of hipoxia, intracellular signaling mechanisms, signaling defects and cancer, homeobox genes and their role in devolopment, protein degradation and its control, gene therapy

Course Code MBI 522

Course Title Cytogenetics

Semester Spring

ECTS Credit 6

Hours / Week 6

Prerequisites -

Contents Introduction and basic genetic concepts : genes, chromosomes, and the cell cycle, human chromosomes and methods for karyotypic analysis, mechanisms of chromosomal abnormalities, peripheral blood cell culture and harvest; long term cell cultures, amniotic fluid culture and harvest; chorionic villus culture and harvest, banding procedures and special stains; microscopy and imaging systems, bone marrow cytogenetics and hematological malignancies, cytogenetic aberrations in solid tumors, clinical correlates of cytogenetic anomalies, cytogenetic nomenclature, the chromosome instability test and fragile-x, an introduction to molecular cytogenetics, applications of molecular cytogenetic techniques, gene rearrangements in molecular diagnostics

Course Code MBI 601

Course Title Advanced Molecular Genetics

Semester Fall

ECTS Credit 6

Hours / Week 3

Prerequisites Ph.D. students who has taken MBI 514 Molecular genetics course is accepted only

Contents Introduction to molecular genetics and eukaryote genome organization, structural features of eukaryote genome, cell nucleus and chromatin structures, histon modifications and transcriptional control, telomere and centromere structures and functions, DNA defects, endogenic and exogenic effectors, DNA repair mechanisms, midterm exam, transposable elements and retroviruses, recombination, cellular differentiation, stem cell: features and perspectives, DNA methylation and other gene silencing mechanisms, gene mapping strategies

Course Code MBI 602

Course Title Cancer Molecular Biology and Genetics

Semester Spring

ECTS Credit 6

Hours / Week 3

Prerequisites Ph.D. students who has taken MBI 601 Advanced molecular genetics course is accepted only

Contents Role of molecular biology in cancer, multistep carcinogenesis, cancer related genes and changes in gene functions: A) Growth factors and cell surface receptors, B) Intracellular signaling, C) Cell cycle regulation, D) Regulation of apoptosis, E) DNA repair and genomic instability, F) Chromatin remodeling and histone modifications, G) Adhesion molecules, MMPs, TIMPs-Angiogenesis, H) Regulation of protein construction/degradation, detection methods for suspected genes in cancer, multi drug resistance mechanisms in cancer, tumor immunology, gene therapy in cancer

Course Code MBI 606

Course Title Echology Evolution

Semester Spring

ECTS Credit 6

Hours / Week 3

Prerequisites -

Contents The ecosystem, energy in ecological systems, Darwin, the arguments and the evidence, the beginning, the earth, molecules and the origin of life, proteins and the genetic code, from metabolism to cells, genetic constancy and variability, systematics and classification, molecular phylogenies, evolution plants and fungi, from protozoa to metazoa, evolution among intervertebrates, origin of vertebrates, from water to air: Amphibians, reptiles and birds, evolution of mammals, primate evolution and human origins, culture and the control of human evolution

Course Code MBI 607

Course Title Cell Culture Techniques and Its Applications

Semester Fall

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents An introduction of programme, biology of cell, biology of cultured cells, design and layout of cell culture laboratory, equipment, culture vessels, media, safety, preparation and sterilization, aseptic technique, primary culture, cell lines, cloning and selection, cell separation, characterization, differantiation, contamination, cryopreservation, transformation, molecular techniques

Course Code MBI 609

Course Title Proteins and Cellular Regulation

Semester Fall

ECTS Credit 6

Hours / Week 2

Prerequisites -

Contents General features of proteins, DNA binding proteins; structural and functional characteristics, regulation of transcriptional activation, post-transcriptional regulation of gene function, regulation of enzyme activity, protein degradation and its regulation, intracellular signaling pathways and their regulation, mid term exam, extra cellular signaling molecules, functions of secondary messengers, structures and functions of protein kinases and phosphatases, tyrosine kinase receptors and related domains, signaling and the ras proteins, homeostatic roles of allosteric molecules

Course Code MBI 611

Course Title Specified Research Project I

Semester Fall

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents

Course Code MBI 614

Course Title Specified Research Project II

Semester Spring

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents

Course Code MBI 616

Course Title Molecular Cytogenetics and Its Applications

Semester Spring

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents Introduction, microscopy techniques, basic cytogenetic concepts and in situ suppression hybridization. Introduction to image analysis systems. Methods to recognize and analyze human chromosomes acquisition of digital FISH ımages and image editing. Acquired and constitutional chromosome aberrations I, culture of a carcinoma cell line. Acquired and consitutional chromosome aberrations II. Preparation of metaphase spreads from cell line. Nomenclature of cytogenetics and molecular cytogenetics (an overview). Dual color painting probe hybridization. Organization of the eukaryotic genome, post-hybridization wash and detection. Reassociation kinetics, hybridization of centromeric probe to detect aneuploidy. CGH, M-FISH, SKY-FFISH, RX-FISH techniques. Isolation of genomic DNA from cell line. Labeling of genomic DNA with flourochrome conjugated dUTP. Microdeletion syndromes and detection with FISH. Hybridization of labeled cell line DNA to normal methaphase spreads. Post-hybridization wash and detection of reverse painting study, special applications of FISH

Course Code MBI 622

Course Title Basic Medical Genetics

Semester Spring

ECTS Credit 6

Hours / Week 2

Prerequisites -

Contents An introduction of programme, the cell (cell cycle, mitosis, meiosis, spermatogenesis, oogenesis), formal genetics, population genetics, developmental genetics, mendelian inheritance, non-mendelian inheritance, chromosome abnormalities, single gene disorders I, single gene disorders II, genetic factors in common diseases, canser genetics, prenatal diagnosis, genetic counseling and ethics

Course Code MBI 624

Course Title Molecular Biological Methods

Semester Spring

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents Introduction to the course, nucleic acid isolation and analysis techniques, PCR and its applications, introduction of molecular cloning; principles behind cloning, enzymes used in molecular cloning, cloning with plasmid, bacteriophage and phagemid vectors, cloning with cosmid vectors, BAC’s and YAC’s, preparation of probes, southern and northern blotting, mutagenesis (heteroduplex analysis, site directed mutagenesis), sequencing, preparation of cDNA libraries and gene identification, expression of cloned genes in bacteria and cultured mammalian cells, introduction to protein interaction techniques, two hybrid and other two-compotent systems, phage display, western with GST fusion protein, co-immunoprecipitation, GFP, interaction trap and related technologies, review of the course and feedback

Course Code MIC 510

Course Title Basic Immunology

Semester Spring

ECTS Credit 6

Hours / Week 3

Prerequisites -

Contents Introduction to immunology, historical progress, host defense mechanisms, cells and systems involved in immune response, antigens, major histocompatibility complex antigens, antibodies, cellular interaction mediators, complement system, antigen receptor molecules, antigen recognition, hypersensitivity reactions, autoimmunity, immune tolerance and immune unresponsiveness, basics of tumor and transplantation immunology, immunization, vaccines and serum

Course Code MIC 605

Course Title Advanced Virology

Semester Spring

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents Viral replication and genetics: overview, replication models according to Baltimore classification, genomic organization and evolution, serotypical and genotypical classification in enterovirus model, genomic variation in HIV and HCV model.

Viral pathogenesis: viral transmission and spread in HAV, HBV, HIV, lyssavirus and arbovirus models, mechanisms of cellular destruction, latent viral infections and molecular mechanisms in herpesvirus model, viral oncogenesis in EBV and HPV model.

Treatment and prevention of viral infections: attenuation and conditional lethal mutations, recombinant vaccines , inactive vaccines , immunization strategies in HBV and polio virus models. New targets in the improvement of antiviral agents in HIV model.

DNA viruses: Adenoviruses, herpesviruses, papovaviruses, poxviruses, parvoviruses, HBV and other viral hepatitis viruses.

RNA viruses: Orthomyxoviruses, paramyxoviruses, picornaviruses, rhabdoviruses, arboviruses, viruses causing diarrhoea , retroviruses.

Laboratory diagnosis of viral infections: Choice of diagnostic tests in CMV model, diagnostic approach in HIV model.

Course Code MIC 607Course Title Advanced ImmunologySemester SpringECTS Credit 6Hours / Week 5Prerequisites Ph.D. students who has taken MIC 510 Basic immunology course is

accepted onlyContents Introduction to the immune system: adaptive and innate immunity,

humoral and cellular immunity, properties and stages of immune response.Cells involved in the immune response: lymphoid cells (lymphocytes types, their maturation and activation), mononuclear cells (monocyte and macrophage maturation, structure, function and their activation), granulocytic cells (neutrophils, eosinophil and basophils), endothelial cells and HEV, surface molecules used for typing the cells of the immune system.Tissues and organs of immune system: primary lymphoid organs (structure and function of thymus and bone marrow), secondary lymphoid organs (lymph nodes, spleen, MALT), lymphocyte traffic and adhesion molecules. Antigen and antibody: antigen, immunogen, epitope, hapten, structural properties of antigens, structural basis of antigen binding, thymus dependent and independent antigens, lectins ans superantigens.Antibody: molecular structure of antibodies (heavy and light chains, constant and variable regions, isotype, allotype and idiotypic determinants), effector functions of antibodies (opsonization, complement activation, ADCC), antibody-antigen interactions (afinity, avidity, cross reaction, optimal zone, pre and postzone).Immunochemical techniques: qualitative immunochemical techniques (immunoelectrophoresis, cross immunoelectrophoresis, counter immunoelectrophoresis, agglutination), quantitative immunochemical techniques (radial immunodiffusion, turbidometric and nephelometric tests, particle counting immunoassay (PACIA), RIA, EMIT, FPIA, IRMA, ELA).Structures binding to antigen I: T and B cell antigen recognition receptors, structure and function of TCR-CD3 complex, ITAM , pre T cell receptor and its importance, structure of B cell receptor, Immunoglobulins, antigen recognition repertoire and mechanism of diversity, N region diversity, somatic hypermutation.Structures binding to antigen II: major histocampatibility complex and its invention, general structure and functions of MHC molecules, localization of MHC genes and their organization, MHC halotypes and hereditary paterns, the relation between MHC and diseases, MHC like molecules and functions, endogenous and exogenous antigen presentation. T cell maturation, activation and effector functions, the control steps in T cell maturation, T cell activation, signal transduction after T cell activation, other important cellular molecules in activation (CD 40/40L, CD 28/B7, CD45), T cell subgroups and their functions (helper and cytotoxic T lymphocytes), Th 1-2-3 lymphocytes, B cell maturation and activation, B cell maturation in bone marrow and control steps in this process, signal transduction in B cells, other important cellular molecules in activation (CD40, B7, CD45, FcR, ITIM motives), antibody production by B lymphocytes ( cellular interactions in antibody production, primary and secondary response), general properties of humoral and cellular immune response.

Cytokines: Cytokines and general properties of receptors, their structure and function, lymphocyte activation by cytokines, inflammatory response and its role in haemopoezis, JAK/STAT activation system.Complement system: complement activation in alterantive, classical and lectin pathways, control of complement system, complement receptors, biological events after complement activation, complement deficiencies.Inflammation: inflammation, cellular adhesion molecules, neutrophil leucocytes and their function, acute and chronic inflammatory response

Course Code MIC 624

Course Title Medical Mycology

Semester Spring

ECTS Credit 6

Hours / Week 5

Prerequisites -

Contents General properties of fungi, metabolism, reproduction of fungi, culture media and their properties, classification of fungi, fungal immunity, fungi that cause superficial infections (their properties and infections), dermatophytes (their properties and infections), fungi that cause subcutaneous infections (their properties and infections), fungi that cause systemic infections (their properties and infections), fungi that cause opportunistic infections (their properties and infections) (others) dematiaceous fungi (their properties and infections), yeasts (their properties and infections), Candida species (their properties and infections), antifungal agents and mechanisms of their activity, antifungal resistance, antifungal susceptibility tests

Course Code MIF 501Course Title Basic Information TechnologiesSemester FallECTS Credit 7.5Hours / Week 3Prerequisites -

Contents Computer, internet and network basics (information system basic, people, software, hardware, data, computer basics, internet basics, web basics, e-mail basics)Application software (software applications, browsers, word processors, spreadsheets, database management systems, computer graphics, software suites, integrated peckages)System software (operating siystems, utilities, device drivers, language translators)The system unit ( electronic data and instructions, system board, microprocessor, memory, system clock, expansion slots and cards, bus lines, ports and cables)Input and output (pointing devices, scanning devices, image capturing devices, digitizing devices, audio-input devices, monitors, printers, audio-output devices, combination input and output devices)Secondary storage (floppy disks, hard disks, optical disks, other type of secondary storage)Connectivity and communication (connectivity, communication channels, connection devices, data transmission, network architecture, network types)Styling with CSS (Cascading Style Sheets) (Floppy disks, hard disks, optical disks, other type of secondary storage)Privacy, security, ergonomics (privacy, security, ergonomics, environment)Databases (data files, database, DBMS organization, types of databases)Information systems (organizational information flow, computer-based information systems, transaction processing systems, management information systems, decision support systems, executive support systems)Systems analysis and design (preliminary investigation, analysis, design, development, implementation, maintenance, prototyping and RAD)Programming and languages (generations of prograaming languages, usage areas of prograaming languages)Programming and languages (programs and programming, program specification, program design, program code, program test, program documentation, program maintenance)

Course Code MIF 503

Course Title Introduction to Programming and Algorithms

Semester Fall

ECTS Credit 10

Hours / Week 5

Prerequisites -

Contents Introduction, programming concepts, selection statements, loop statements I, loop statements II, procedures and functions, arrays I, arrays II, file operations, records, string operations, sparse matrices, recursive programming, case study

Course Code MIF 505

Course Title Introduction to Database Design

Semester Fall

ECTS Credit 10

Hours / Week 5

Prerequisites -

Contents Overview of database systems, introduction to database design, the relational model, relational algebra and calculus, SQL: queries, constraints, triggers, database application development, internet applications, midterm, database design (Normalization I: 1NF, 2NF, 3NF, BCNF, Normalization I: Higher normal forms), overview of transaction management (concurrency control, crash recovery), overview of storage and indexing (storing data: disks and files, tree-structured indexing, hash-based indexing), overview of query evaluation (external sorting, evaluating relational operators, typical relational query optimizers), additional topics, introduction (overwiev of database systems, definition, history, introduction to database design, DML, DLL), the relational model (E/R data model), relational algebra, SQL: Queries, database application development, internet applications, midterm exam, database design (Normalization: 1NF, 2NF, 3NF, BCNF), overview of tarsaction management (concurrency control, crash recovery), overview of storage and indexing, security (privacy, ethical issues, future of DBMS

Course Code MIF 581

Course Title Term Project

Semester Fall

ECTS Credit 30

Hours / Week 18

Prerequisites -

Contents This semester work is an independent study period leading to a term project. A distinctive achievement of post graduate study is the independent work which each student undertakes. The production of a dissertation offers students the oppurtunity to experience research, study, reflection, and critical evaluation in a focused area of interest. Each student works with two advisors, one from medicine and one from engineering. The student is expencted to meet with the advisors at least once perweek. The student is expected to work at least 20-30 hours/week under the diredtion of two faculty advisors to gain experience in posing scientific hypothesis, conducting experiments, building information systems, and measuring impact. The project is not considered complete until the student has finished a formal paper on the topic, one that the research preceptor believes as suitable for submission to a peer-reviewed journal included in the expanded SCI index

Course Code MIF 588

Course Title Basic Presentations/Practicals II

Semester Spring

ECTS Credit 7.5

Hours / Week 4

Prerequisites -

Contents The main objective of the “basic lectures” which constitute an educational component of project-based-learning during the second and third semesters is the transmission of “critical” information necessary for the realizalion of the students project, which cannot be easily found in books and other learning resources. These basic lectures will be planned between the facilitators and the students as a “learning contract”, following the decision on the project tittle. These basic presentations programmed on a two hour/week basis will be supplemented by basic practicals on related subjects, also on a two hour/week basis

Course Code MIF 589

Course Title Basic Presentations/Practicals I

Semester Fall

ECTS Credit 7.5

Hours / Week 4

Prerequisites -

Contents The main objective of the “basic lectures” which constitute an educational component of project-based-learning during the second and third semesters is the transmission of “critical” information necessary for the realizalion of the students project, which cannot be easily found in books and other learning resources. These basic lectures will be planned between the facilitators and the students as a “learning contract”, following the decision on the project tittle. These basic presentations programmed on a two hour/week basis will be supplemented by basic practicals on related subjects, also on a two hour/week basis

Course Code MIF 590

Course Title Field Study II

Semester Spring

ECTS Credit 2.5

Hours / Week 2

Prerequisites -

Contents The Medical Informatics students perform field studies during the second and third semesters (project-based-learning period) with the objective of exposure to the operation, management, and assessment of informatics systems in the medical setting. This “on-site” educational activity is programmed to meet the objectives and learning issues generated during the project-based-learning sessons

Course Code MIF 591

Course Title Field Study I

Semester Fall

ECTS Credit 2.5

Hours / Week 2

Prerequisites -

Contents The Medical Informatics students perform field studies during the second and third semesters (project-based-learning period) with the objective of exposure to the operation, management, and assessment of informatics systems in the medical setting. This “on-site” educational activity is programmed to meet the objectives and learning issues generated during the project-based-learning sessons

Course Code MIF 592

Course Title Seminar II

Semester Spring

ECTS Credit 2.5

Hours / Week 2

Prerequisites -

Contents In the second and third semesters, students must attend the weekly student seminar. Students will also give a presentation, generally once per semester, in the student seminar. The aim of this educational activity is to stimulate the acquisition, processing, synthesis, and presentation of literature data on a specific focused subject

Course Code MIF 593

Course Title Seminar I

Semester Fall

ECTS Credit 2.5

Hours / Week 2

Prerequisites -

Contents In the second and third semesters, students must attend the weekly student seminar. Students will also give a presentation, generally once per semester, in the student seminar. The aim of this educational activity is to stimulate the acquisition, processing, synthesis, and presentation of literature data on a specific focused subject

Course Code MIF 594

Course Title Project-Based-Learning Sessions II

Semester Spring

ECTS Credit 7.5

Hours / Week 3

Prerequisites -

Contents The curriculum in the second and third semesters is based on a specific, focused project proposed by the students and supervised by two faculty advisors, one from medicine and one from engineering. The number of students per project is planned to be maximum five. Projects are utilized as “tools” for the students to achieve their learning issues. At the same time, projects are a means of integrating many disciplins forming the basic subjects of the semester. “Project-based-learning sessions” are organized at least once a week for three hours, for the selection of the project title at the beginning, and for the monitoring of the progression, evaluation, and discussions. Students are expected to investigate, search, understand, and be able to discuss the generated learning issues at the next Project-based-session. Basic lectures, field studies, practicals, and other educalional activities only have a “facilitationg” effect for the “independent learning” process of the educational system

Course Code MIF 595

Course Title Project-Based-Learning Sessions I

Semester Fall

ECTS Credit 7.5

Hours / Week 3

Prerequisites -

Contents The curriculum in the second and third semesters is based on a specific, focused project proposed by the students and supervised by two faculty advisors, one from medicine and one from engineering. The number of students per project is planned to be maximum five. Projects are utilized as “tools” for the students to achieve their learning issues. At the same time, projects are a means of integrating many disciplins forming the basic subjects of the semester. “Project-based-learning sessions” are organized at least once a week for three hours, for the selection of the project title at the beginning, and for the monitoring of the progression, evaluation, and discussions. Students are expected to investigate, search, understand, and be able to discuss the generated learning issues at the next Project-based-session. Basic lectures, field studies, practicals, and other educalional activities only have a “facilitationg” effect for the “independent learning” process of the educational system

Course Code MIF 589

Course Title Basic Presentations/Practicals II

Semester Fall

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents The main objective of the “basic lectures” which constitute an educational component of project-based-learning during the second and third semesters is the transmission of “critical” information necessary for the realizalion of the students project, which cannot be easily found in books and other learning resources. These basic lectures will be planned between the facilitators and the students as a “learning contract”, following the decision on the project tittle. These basic presentations programmed on a two hour/week basis will be supplemented by basic practicals on related subjects, also on a two hour/week basis

Course Code PAR 613

Course Title Medical Protozoology

Semester Fall

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents Introduction to protozoology, protozoa: structure, classification, growth and development, amebas and amebic dysentery, non pathogenic amebas, free-living amebas, Giardia intestinalis and giardiasis, Trichomonas vaginalis and trichomoniasis, opportunictic intestinal protozoa, hemoflagellates; Trypanosoma sp., Plasmodium species and malaria, Leishmania species and leishmaniasis, Toxoplasma gondii and toxoplasmosis, Pneumocystis carinii

Course Code PHAR 505

Course Title Introduction to Autonomic Nervous System

Semester Fall

ECTS Credit 6

Hours / Week 2

Prerequisites -

Contents Autonom nervous system parts, neurotransmitters of autonomic nervous system, secretion mechanism of parasymphatic system’s neurotransmitter, secretion mechanism of symphatetic system’s neurotransmitter, non-adrenergic and non-cholinergic system’s neurotransmitters, parasymphatic system’s receptors, symphatetic system’s receptors, autoreceptors and their types, innervation of symphatetic system, innervation of parasymphatic system, effect mechanisms of parasymphatic and symphatetic system neurotransmitters, post synaptic regulation of sympathic system, post synaptic regulation of parasymphatic system, describtion of parasymphatic and symphatetic systems

Course Code PHYS 621

Course Title Peripheral Nervous System

Semester Fall

ECTS Credit 6

Hours / Week 2

Prerequisites -

Contents Introduction: Organisation of the nervous system, structural and functional properties of neurons and glial cells, nerve fiber types and function, neurotrophins, nerve degenexration and regeneration, transport across cell membranes, forces producing movement of substances across cell membranes, intercellular connections and signalling, ion channels, ion transport and membrane potential, receptors and local potentials, action potential, synaptic transmission I, neurotransmitters, synaptic transmission II

Course Code PHYS 623

Course Title Muscular System

Semester Fall

ECTS Credit 6

Hours / Week 2

Prerequisites -

Contents Introduction: the structure of skeletal muscles, neuromuscular junction, molecular mechanisms of the muscle contraction, excitation-contraction coupling, relation between force and load, mechanical properties of skeletal muscles, examination, contraction types of skeletal muscles, fiber types of skeletal muscles, energy metabolism of skeletal muscles, excitation and contraction of smooth muscles, control of smooth muscle contraction, examination

Course Code PTM 512

Course Title Rehabilitation in Amputes

Semester Spring

ECTS Credit 6

Hours / Week 3

Prerequisites -

Contents History of amputation and prosthesis, salvation of extremity and decision for amputation level, planning for optimal function, prosthetic technology, upper extremity amputations, upper extremity prostheses, upper extremity prosthetic rehabilitation in adult amputee, lower extremity amputations, lower extremity prostheses, lower extremity prosthetic rehabilitation in adult amputee, child amputees, owerview of the amputation rehabilitation, principles of amputee rehabilitation, prosthetic training

Course Code PTM 526

Course Title Foot Rehabilitation

Semester Spring

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents Development of the foot, biomechanics of the foot, shock absorbing features of the foot, assessment, the shoe, arches of the foot, pathomechanics of the congenital deficiency and rehabilitation, ankle and foot deficiency in neurologic diseases and their rehab., foot problems in systemic diseases and their rehabilitation, traumatic foot problems and their rehabilitation, rehabilitation of the reconstructed ankle and foot, diabetic foot and its rehabilitation, hallux valgus, hallux rgitus and morton toe, nail and skin problems of the foot

Course Code PTN 503

Course Title Neural Control Mechanisms of Human Body

Semester Fall

ECTS Credit 6

Hours / Week 3

Prerequisites -

Contents Properties of cell membrane, transport across cell membranes, membrane potentials, nerve cells, excitation and conduction, measurement of electrical events, nerve fiber types, degeneration and regeneration properties of nerves, growth factors related to nerves, synaptic transmission, inhibition and facilitation at synapses, synaptic plasticity and learning, neuromuscular transmission and pathologies, reflexes, strech reflex, denervation sensitivity, spinal shock, control of posture and movement, sensory and motor integration, physiology and pathophysiology of basal ganglia, cerebellum and vestibular system, limbic functions, higher functions of the nervous system, discussion

Course Code PTN 506

Course Title Intracranial Lesions and Rehabilitation

Semester Spring

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents Brain tumours, AVM anomalies and subarachnoid hemorraghe, head injuries, hydrocephaly, increasing intracranial pressure syndrome, surgical interventions, in intracranial lesions, postoperative care and physiotherapy, long-term physiotherapy and rehabilitation, spasticity and rehabilitation, rigidity and rehabilitation, occupational therapy and vocational rehabilitation, orthoses, selection and training of self care instruments, mobility aids, training of recreational and sportive activities, literature search and discussion

Course Code PTN 507

Course Title Neuroscience and Clinical Practice in Neurological Rehabilitation

Semester Fall

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents Clinical practice in neuromuscular rehabilitation department, clinical practice in neurologic rehabilitation department, discussion

Course Code PTN 508

Course Title Physiopathology and Treatment of Pain

Semester Spring

ECTS Credit 6

Hours / Week 3

Prerequisites -

Contents Sensory receptors and sensory neurons in the central nervous system, receptor potentials, differences between somatic and visceral sensory mechanisms, pain types : fast and slow pain, dual transmitter systems of pain, subcortical perception of pain, thalamic syndrome, hyperalgesia, visceral pain, hypothetical mechanisms of referred pain, central inhibition of pain, action of morphine like substance, gating in the dorsal horn, headache, migraine and other pathologies that couse pain, objective-subjective assessment, cold application-heat application, electrophysical agents, massage, exercise modalities, orthoses, surgical interventions

Course Code PTN 509

Course Title Neurological Rehabilitation I

Semester Fall

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents Principles of assessment senory system, joint, muscle, functional evaluation, evaluation of respiratory function, speech, electrophysical diagnostic tests, questionnaires, principles of treatment sensory re-education, movement disorders, fascilation methods, treatment methods, electrotherapic modalities, problems related with hypertonus and its treatment, functional activities, respiratory problems and therapy methods, pain, general therapy principles in inpatient rehabilitation, cerebro-vascular accident (CVA), hemiplegia and sensory-perception-motor integration, physiotherapy approachments in hemiplegia rehabilitation, Johnstone, Todd-Davies, Brunnstrom, conductive education, motor learning, home care of hemiplegia patients, motor neuron disease, symptoms, assessment, therapie principles, polyneuropathie pathology, medical treatment, physiotherapy, vestibular system disorders and its rehabilitation, discussion

Course Code PTN 510

Course Title Neurological Rehabilitation II

Semester Spring

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents Multiple sclerosis, parkinson, perifral nerve lesions, vestibular system disorders, headache, cerebral palsy, spina bifida and hydrocephalus, muscular dystrophy, literature search, update and discussion

Course Code PTR 505

Course Title Neural Control Mechanisms of Human Body

Semester Fall

ECTS Credit 6

Hours / Week 3

Prerequisites -

Contents Properties of cell membrane, transport across cell membranes, membrane potentials, nerve cells, excitation and conduction, measurment of electrical events, nerve fiber types, degeneration and regeneration properties of nerves. Growth factors related to nerves, synaptic transmission, inhibition and facilitation at synapses, synaptic plasticity and learning, neuromuscular transmission and pathologies, reflexes, strech reflex, denervation sensitivity, spinal shock, control of posture and movement, sensory and motor integration, physiology and pathophysiology of bazal ganglia, cerebellum and vestibular system, limbic functions, higher functions of the nervous system, discussion

Course Code PTR 512

Course Title Neurosurgical Rehabilitation

Semester Spring

ECTS Credit 6

Hours / Week 2

Prerequisites -

Contents Introduction into neurosurgery, neurosurgical anatomy, increasing intracranial pressure syndrome, head injury, brain tumours, spinal, lumbal disc herniations, cervical disc herniations, subarachnoid hemorrage, brain abscess, spinal traumas, congenital malformations, indications and contraindications for neurophysiotherapy, literature search and update

Course Code PTR 605

Course Title Pulmonary Rehabilitation

Semester Spring

ECTS Credit 6

Hours / Week 2

Prerequisites -

Contents Respiratory siystem anatomy, physiology, pathophysiology, general review of pulmonary diseases, pulmonary physiotherapy, philosophy and place of the clinic team, training, cost-effectivity, practice of national and international, pulmonary physiotherapy approaches, instrumental approaches, nen-instrumental approaches, usage of pulmonary physiotherapy in restirictive lung diseases, usage of pulmonary physiotherapy in obstructive lung diseases, usage of pulmonary physiotherapy in complex lung diseases, usage of pulmonary physiotherapy in pediatric lung disease, usage of pulmonary physiotherapy in other patholoqies, evidence-based physiotherapy, behaviorial modifications risc factors and the control, current cousensus reports in lung disease area, literature review

Course Code PTR 607

Course Title Cardiac Rehabilitation

Semester Fall

ECTS Credit 6

Hours / Week 3

Prerequisites -

Contents History of cardiac rehabilitation in Turkey and world, its standards heart-circulation system, hemodynamics, cardiac risc factors, modification of cardiac risc factors, assessment procedures at inpatient-outpatient cardiac rehabilitation, early mobilization and rehabilitation program after myocardial infarction, outpatient cardiac rehabilitation after myocardial infarction, profilactic programs and occupational therapy with cardiac patient, pre and postoperative physiotherapy and rehabilitation after cardiovascular surgery, physical fitness testing and programs in cardiac rehabilitation, alternative approaches in cardiac rehabilitation, cardiac rehabilitation in other pathologies accompanied to cardiovascular diseases, literature review, case reports and discussion

Course Code PTR 618

Course Title Intensive Care and Physiotherapy

Semester Spring

ECTS Credit 6

Hours / Week 4

Prerequisites -

Contents Intensive care description and the team, functional anatomy of the cardiopulmonary system, intensive care units, mechanical ventilatories and the purposes of the usage, conditions of to be intensive care patient, physiotherapy assessments of the patient in ICU, physiotherapy in ICU (to whom, why, when and how), instrumental approaches, purposes and the physiological effects, maturation of the cardiorespiratory system and improvement, pediatric intensive care and conditions of to be ICU patient, pediatric evaluation of the pulmonary diseases and other medical conditions, physiotherapy approaches, evaluation of the examples of the national and international applications, researches of the ICU in physiotherapy area

Course Code PTR 620

Course Title Physiotherapy in Transplantations

Semester Spring

ECTS Credit 6

Hours / Week 3

Prerequisites -

Contents Introduction to the transplantation surgery, history, transplantation process, donors, pre-operative preparation, postoperative clinical period and surviving, operative procedures, heart transplantation, lung transplantation, heart / lung transplantation, kidney transplantation, liver transplantation, bonemorrow Tx, other, postoperative care, rejection after Tx, acut rejection chronic rejection, immunosupression, infections, special considerations for physiotherapists, physiotherapy, evaluative approaches, preoperative rehabilitation, postoperative rehabilitation, early rehabilitation, out-patient rehabilitation, contraindications of the posttransplant physiotherapy, special conditions for more attention, physical training after Tx, returning to the work after Tx, literature review

Course Code STA 521

Course Title Statistical Software in Data Analysis

Semester Fall

ECTS Credit 7.5

Hours / Week 3

Prerequisites -

Contents Overview of MINITAB, one view, display and summaries, plotting data, tables, statistical distributions, simulation, one-sample confidence intervals and tests for population means, comparing two means, confidence intervals and tests

Course Code STA 522

Course Title Applied Statistics in Scientific Research

Semester Spring

ECTS Credit 7.5

Hours / Week 4

Prerequisites -

Contents Analysis of variance, correlation and regression, chi-square tests and contingency tables, nonparametric statistics