Subs%tución+Electro1lica+ Aromáca ( SEAr)depa.fquim.unam.mx/amyd/archivero/SEA_30683.pdf · 3H2...
Transcript of Subs%tución+Electro1lica+ Aromáca ( SEAr)depa.fquim.unam.mx/amyd/archivero/SEA_30683.pdf · 3H2...
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Subs%tución Electro1lica Aromá%ca (SEAr)
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What Is Coal?
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Nomenclature of Benzene Deriva%ves
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Polysubs%tuted Deriva%ves of Benzene
1. Iden%fy and name the parent. 2. Iden%fy and name the subs%tuents. 3. Assign a locant to each subs%tuent. 4. Arrange the subs%tuents alphabe%cally.
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Structure of Benzene
A. Kekulé (1866)
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Stability of Benzene
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The Criteria for Aroma%city
1. The compound must contain a ring comprised of con%nuously overlapping p orbitals. 2. The number of π electrons in the ring must be a Hückel number.
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Aroma%c Heterocycles
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Reac%ons at the Benzylic Posi%on
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Electrophilic Aroma%c Subs%tu%on
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Mecanismo general
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Halogena%on
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Sulfona%on
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Nitra%on
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Friedel-‐CraZs Alkyla%on
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Friedel-‐CraZs Acyla%on
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Clemmensen reduc%on