Subject index
Transcript of Subject index
A Al hnRNP protein: nucleic acid
renaturation 181 A5 protein: adhesive domain 40 acetylated low-density lipoprotein
receptors 237 aconitase: iron-sulphur dependent
dehydrations 298 actomyosin molecular motors:
nanomanipulation 319 acute intermittent porphyria (BR)
355 acylation: transducin (l) 164 adhesive domain: MAM 40 I)-adrenergic receptor kinase
coiled-coil domain 315 PH domain 343
affinity binding: immunoglobulin binding protein, BiP 3
aldehyde dehydrogenases: lens constituent 303
alkaline protease: l3-superhelix motif 313
allosteric signal transduction: haemoglobin 385
Alzheimer's disease 480 amino acids: titration curves 69 aminopeptidases
action mechanism 167 methionyl: evolution 403
Amplify program (CC) 448 amyloid plaques: Alzheimer's disease
480 amyloid precursor protein 480 annexins: molecular phylogeny 462 antigens
HPC-l 124 human leucocyte, class II 140
antisense RNA, gene silencing 419
apo-a-Iactalbumin: molten globule state 1
apoptosis mammalian cells 307 neurons 157
ARF proteins: ER-Golgi transport role 3
arginino-succinate lyase: lens constituent 302
association rates: macromolecular 181
AlP hydrolysis 116 AlP-dependent organic anion transporter
(l) 164 autoimmune diseases 140 autophosphorylation: receptor tyrosine
kinases 273 azurin 115
~UBJECT INDEX
Compiled by Diane Albin
B bacteria
cell-surface proteins 136 enzyme sequence similarities 466 genetics (BB) 193 Gram-negative: protein secretion 7 L-serine dehydratases 297 toxins: membrane-insertion domain
391 transmembrane solute transporters
13 bacteriophage plaques: lambda library
contamination (CC) 484 baculovirus expression vectors (BR)
110 l3-barrels: triose phosphate isomerase
313,372 base-pairing: tautomerism 160 bcl-2 gene: apoptosis inhibition 308 bestatin: aminopeptidase inhibition
168 13'1 complexes 292, 315 BIK1, S_ cerevisiae 82 biomolecular processes: computer
288 405
62,354 189
modelling (BR) 311 biochemical equations: K' biochemical organization biochemistry, general (BR) bioenergetics, general (BR) biogenesis (BR) 230 BioGopher servers (CC) 485 bionet (CC) 446 BIOSCI newsgroups (CC) 310 BiP: high-affinity binding 3 botulinum neurotoxin 324 bovine lens leucine aminopeptidase
167 brain-derived neurotrophic factor 49 Brefeldin A 214 bulletin boards (CC) 145
C C-type lectins, animals 224 calcium flux regulation: inositol
phosphates 53 calcium-independent protein kinase Cs
207 calmodulin
a-helices 116 nitric oxide synthases regulation
35 cAMP-dependent protein kinase
I)-adrenergic receptor phosphorylation 276
crystal structure 84, 120 targeting subunits 175
Candida boidinii: PMP47 protein 427 capillary electrophoresis 409
carboxy-terminal domain: RNA polymerase II 117
carnitine palmitoyltransferase I: role in ketogenesis 28
catechols 437 cationic detergents: nucleic acid
renaturation 181 cdc2 gene 195 cdc25: ell00 similarity 377 cell adhesion proteins
MAM: adhesive domain 40 cell cycle
cyclin-dependent kinases 195 differentiation: Ras activation by
receptor tyrosine kinases 273 elongation: lens formation 303 neurons 157 P-domain peptide role 239 proliferation: hypusine role 475 RCel 96
cell death see also apoptosis mammalian cells 307 neurons 157
cell regulation factors 125 cell signalling: inositol phosphate
53 cell-surface proteins: bacteria 136 cereal lectins 223 chaperon ins 81 chloroplast genome introns, E. gracilis
467 chloroplast ribosomal proteins:
molecular genetics 177 chloroplasts: thylakoid membranes
415 chromatin
assembly 90 RCel interaction 99
chromophores: spectroscopy 74 chromophytes: thylakoid membranes
418 chromosome
condensation regulator (RCC1) 96 structure maintenance, lrp 260
chronic granulomatous disease 43 cis-acting elements: tRNA splicing, yeast
33 citrovorum factor: one-carbon
metabolism role 102 CLlDa gene, human 377 class II human leucocyte antigens
140 clinical conditions: human diseases
(BR) 62 Clostridium: neurotoxins 324 co-translational transport
mitochondrial proteins 366 secretory proteins 456
493
coiled-coil domains a-keratin 360 G proteins 315
Cold Spring Harbor (BR) 269 colicin: membrane-insertion domain
391 collision theory: macromolecules 181 complementarity: rRNA-mRNA 406 complex polysaccharides: assembly in
plants 210 computer modelling: biomolecular
processes (BR) 311 computer networks
BIOSCI newsgroups (CC) 310 Internet (CC) 107, (BR)231,
(CC)297, (CC)398, (CC)446, (CC)448, (CC)485
computers for molecular biologists (CC) 57
control analysis 26 cooperativity: haemoglobin 385 creatinase: evolution 403 Crohn's disease 242 crystallins: eye lens 301 cyanobacteria: thylakoid membranes
418 cyclic amplification and selection of
targets 77 cyclin-dependent protein kinases
cell cycle 195 targeting subunits 175
cyclins 195 cyclosporin A: action mechanism 334 cytochromes: flavocytochrome b 44 cytoplasmatic linker protein-170 82 cytoskeleton-associated proteins 82 cytosolic polysomes: mitochondrial
protein import 367
o degenerative diseases: nervous system
157 dehydratases: L-serine/threonine 297 dehydrogenases
flavoprotein 44 lens constituents 301
developmental mechanisms: evolutionary conservation (BR) 401
diazotrophs (BR) 109 dictionary
NMR concepts (BB) 192 science and technology (BR) 190
Dictyostelium discoideum antisense RNA: gene regulation
421 inositol pyrophosphates 55
differential scanning calorimetry: protein folding energetics 2
dihedral angles 317, (l) 464 diphtheria toxin: membrane-insertion
domain 391 DNA
analysis: capillary electrophoresis 412
binding sites: CASTing 77 damage checkpoint mechanism
433 oxidative damage (BR) 486 packaging 202 replication 202
DNA Strider (CC) 187 DNA-activated protein kinase 433
494
DNA-binding proteins low sequence specificity, multimeric
complexes 202 TFlIIA 226
DNASTAR (CC) 187 Drosophila melanogaster: cytoskeleton
associated protein 82 drug-resistance proteins 13 dynein-associated prote..ir'l .. 82
E electrogenic ion pumps (BR) 63 electrokinetic processes (BR) 64 electron light microscopy (BR) 450 electron transport chain: NADPH oxidase
43 electronic mail (CC) 267, (CC) 398 electrophoresis (BB) 64
capillary 409 elongation factor Tu 155 encounter-limited reactions: rate
constants 181 endocytosis: eukaryotic cells 355 endonuclease
iron-sulphur clusters 153 yeast tRNA splicing 31
endoplasmic reticulum membrane transport 453, 456 protein retention 3
energy-selective optical spectroscopy: proteins 71
energy transduction: haemoglobin 385 engrailed homeodomain proteins:
molecular phylogeny 461 enzymes
as a mechanical device 115, 197 catalytic function diversity 372 evolution 403 immunoassay: genetically prepared
conjugates 279 nomenclature 113, (BR) 192
epidermal growth factor receptors 273
epimorphin 124 equilibrium constant: K' 288 ERD-2 gene, yeast 3 Erwinia chrysanthemi: pectate lyase C
313 Euglena gracilis: chloroplast genome
introns 467 eukaryotes
antisense RNA 419 membrane traffic 395 mRNA transcripts: spliceosomal
system 31 secretory pathway 3
eukaryotic initiation factors 429, 475 even-skipped homeodomain proteins:
molecular phylogeny 460 evolution
bacterial cell-surface proteins 136 chloroplast ribosomes 177 enzymes 372, 403 major facilitator superfamily proteins
13 metazoan 459
exocytosis: control 5 exopolyphosphatase 247 exotoxin 393 eye lens crystallins: gene recruitment
301
F farnesyltransferase
inhibitors 349 sequence repeats 426
fatty acid-binding domain: NMDA receptor 41
fibroblast growth factor receptors 273 fidelity-enhancement: mRNA splicing
381 FITSIM program (CC) 58 FK506: action mechanism 334 flavocytochrome b: electron transport in
NADPH oxidase 44 flavoprotein dehydrogenase 44 fluorescence line narrowing
spectroscopy 74 FMR1 gene: fragile X syndrome 331 folinic acid: one-carbon metabolism role
102 Fourier-transform infrared spectroscopy
198 fragile X syndrome: FMR1 gene 331
G G proteins see GTP-binding and
heterotrimeric G proteins GALl/GALlO genes, S. cerevisiae 90 j3-galactosidase: radiation target size
237 Gcl, G. candidum 20 gene expression
antisense-regulated 419 lens cells 304 translational control 429 translational introns 294
gene fusion: preparation of enzyme conjugates 279
gene recruitment: eye lens Crystallins 301
gene transcription see transcription general regulatory factors 91 genetics, molecular (BR) 451 Geneworks (CC) 188 Geotrichum candidum: Gcl 20 glucocorticoids
apoptosis stimulation 308 nucleosome disruption 90
glued gene product, D. melanogaster 82
glycolytic enzymes: Type I aldolase 36 glycoproteins
plants 210 radiation target size 237
Golgi apparatus KDEl receptor 3 KDEl sequ~nce 395 plants 210 retrieval and retention mechanisms
395 SNAPs 453 SNAREs 453 TGN38 4,397 trans-Golgi network 395
Gopher system (CC) 107, (eC) 485 Gram-negative bacteria: protein
secretion 7 grana stacks, plant chloroplasts 415 growth factors and receptors
apoptosis inhibition 308 nerve growth factor 48 platelet-derived growth factor 49,
273
SH2 domains 273, (L) 464 transforming growth factor fj2 49
GS-X pump (L) 164 GTP-binding proteins 3
ARF 3 rab 3,4 rac 43 rap 46 Ras 43,250,273,349
see a/so p21ras
guanosine penta phosphate phosphatase 247
H H+ symporter proteins 13 haemoglobin
binding energy transduction 385 oxygen affinity 53
Harrington, William Fields (0) 364 HDEL receptor, yeast 3 heat shock proteins 125 helper T lymphocytes 140 heterotrimeric G proteins 275, 315
a-subunit 4, (L) 164, 292 fj-y subunits/complexes 292, 315
HIV1 see human immunodeficiency virus HMG-CoA pathway: ketogenesis role
28 HOM/HOX homeodomain proteins:
molecular phylogeny 460 homeodomain proteins: molecular
phylogeny 459 hormone-sensitive lipase 466 HPC-1 antigen: epimorphin sequence
similarity 124 human
eL1Da gene 377 haemoglobin: binding energy
transduction 385 hormone-sensitive lipase 466 leucocyte antigens, Class II 140 neurotrophins 50 pancreatic lipase (hPL) 20 protein data (SR) 190 WRSgene 263
human diseases autoimmune 140 clinical condition (SR) 62 immunodeficiency virus (HIV-1) 255,
307 human immunodeficiency virus (HIV-1)
apoptotic cell death 307 regulatory proteins 255
hydrogen exchange rates: proteins 359
hydrolysis aminopeptidases 167 ATP 116
hydro peroxides 437 hydrophobicity curvature (L) 81 hyperphosphorylation: carboxy-terminal
domain 117 hypusine: eukaryotic cell proliferation
role 475
immediate-early genes: activation by interferons 338
immune response autoimmune diseases 140 src family tyrosine kinases regulation
215
immunoglobulin heavy chain binding protein: SiP 3
immunosuppressive drugs: action mechanism 334
import: mitochondrial proteins 66 infrared difference spectroscopy:
reaction-induced 197 inositol polyphosphate 5-phosphatase
378 inositol phosphates 53, (SR) 271 insecticidal 8-endotoxin: membrane
insertion domain 391 integral membrane protein localization:
eukaryotic cells 395 interfacial activation: triacylglyceride
lipases 20 interferons
signalling 338 tryptophanyl-tRNA synthetase
induction 263 intermediate compartment: ER-Golgi 3 intermediate filaments: a-keratin
structure 360 Internet (GG)107, (SR)231, (CC)267,
(CC)398, (CC)446, (CC)448, (CC)485 intramolecular chaperones: protein
folding role 442 intronic snRNA (L) 330 introns
E. graCilis chloroplast genes 467 translational 294
ion channels: NMDA receptor 41 iron metabolism: eukaryotes 432 iron-responsive element binding protein
298 iron-sulphur clusters 153
bacterial L-serine dehydratases 297 isoenzymes: nomenclature 114
Johnson, William Arthur (0) 61
K K', equilibrium constant 288 KDEL
receptor 3 retention mechanisms 395
a-keratin: structure 360 ,B-ketoadipate pathway: evolution 373 ketogenesis: top-down control analysis
28 kinases see a/so specific kinase entries
cAMP dependent 84 hinge motions 116 phosphoglycerate: folding
intermediates 2 kinetic mechanisms: computer
evaluation (CC) 58 kinetic proofreading 381 KINSIM program: reaction mechanism
evaluation (CC) 58 Krebs cycle 61
intermediates 13 Kunitz-type protease inhibitor
superfamily 208, (L) 424, (L) 425
L lac system, E. coli 472 lactate dehydrogenase S: lens
constituent 301 laminin: molecular phylogeny 462 lateral proton conduction: lipid-water
interfaces 243 lectin-like interactions: P-domain
peptides 239 lectins 221 legume lectins 221 lens crystallins: gene recruitment 301 leucine-responsive regulatory protein
(Lrp) 260 leucocytes
antigens, class II human 140 cell-surface receptor-mediated signal
transduction 215 leucovorin: one-carbon metabolism role
102 ligase: yeast tRNA splicing 32 ligation reaction, ultrasonic (CC) 446 limonene: farnesyltransferase inhibition
357 linoleic acid: transducin acylation
precursor (L) 164 lipases
hormone-sensitive 466 triacylglyceride: molecular structure
20 lipid modification, proteins (SR) 400 lipocalins (L) 206 lipoprotein
analysis (SR) 192 low-density: radiation target size
237 Lowe's oculocerebrorenal syndrome
378 lymphocyte
activation: src family tyrosine kinases 215
helper T 140 NADPH oxidase 43
lysozyme: motion 116
M MacDNAsis Pro (GG) 187 macromolecular association: rate 181 MacVector (GG) 187 major facilitator superfamily 13,
(L) 248 MAM: adhesive domain 40 mandelate pathway: evolution 372,
403 Mantoniella: thylakoid membranes
417 manumycin: farnesyltransferase
inhibition 350 MAP kinases
cascade 128 phosphatase: Cll00 377
membrane fusion (L) 81, 453 insertion: bacterial toxins 391 lateral cornrnunlcation 243 surface curvature (L) 81 transport 395, 453, 456
membrane proteins PMP47 427 targeted membrane fusion 324,
327,453 meprin: adhesive domain 40 messenger RNA
antisense: gene silencing 419 splicing: fidelity-enhancement 381 splicing: snRNAs 131 transcripts, eukaryotes: spliceosomal
system 31
495
translation initiation 406, 429 metabolism
control analysis 26 leucovorin role 102
metalloproteases: molecular phylogeny 461
metazoan phylogeny 459 methionyl aminopeptidase: evolution
403 microfibrils: a-keratin structure 360 mimicry, molecular: bacteria cell-surface
proteins 136 mitochondria
ketogenesis: rat liver 28 peptidases: nomenclature (l) 249 protein import and synthesis 366
mitochondrial solute carrier proteins 427
mitogen-activated protein kinases see MAP kinases
molecular biology computers (CC) 57, (6R) 311
molecular genetics (BR) 451 motor proteins: actomyosin 319 mouse
nerve growth factor 48 neurodegenerative disorders 157
mRNA see messenger-RNA msh homeodomain proteins: molecular
phylogeny 461 mucins: P-domain 239 muconate lactonizing enzyme 373,
403 Multalin 4.0 (CC) 106 multimeric complex DNA-binding proteins
202, (l) 424 mutagenesis: tautomerism role 160 myoglobin: folding energetics 1
N N-linked glycans: assembly role of Golgi
apparatus 211 NAD see nicotinamide adenine
dinucleotide NADP see nicotinamide adenine
dinucleotide phosphate nano-manipulation in vitro: actomyosin
molecular motors 319 NEM-sensitive fusion protein: membrane
fusion role 453 nerve growth factor 48 neurofibrillary tangles: Alzheimer's
disease 480 neurodegeneration 157 neuropeptides: molecular phylogeny
461 neurotoxins, clostridial 324 neurotransm itters
blockage by clostridial neurotoxins 325
release inhibition: tetanus toxin 327
neurotrophins 49 neutral lipases: molecular structure
20 Nicotiana
genomic lambda library: contamination (CC) 484
Golgi apparatus 210 nicotinamide adenine dinucleotide
278 nicotinamide adenine dinucleotide
496
phosphate 278 NADPH oxidase 43
nitric oxide synthases 35 nitrogen fixation (BR) 109 nitrogenase iron protein: iron-sulphur
clusters 153 nitrogenase molybdenum-iron protein:
iron-sulphur clusters 153 NK homeodomain proteins: molecular
phylogeny 461 NMDA receptor 41 NMR, dictionary (B6) 192 NOGGIN 208, (l) 424, (l) 425 nomenclature 113
enzymes (66) 192 mitochondrial peptidases (l) 249
nuclear pre-mRNA introns 467 nucleic acid: renaturation 181 nucleolar RNA 131 nucleosomes: transcription regulation
function 90 nucleotides: tautomerism 160
o O-linked glycans: assembly role of Golgi
apparatus 212 oligomeric proteins 65 oncogenes see also proto-oncogenes
acquisition by retroviruses 233 bcl-2, apoptosis inhibition 308
oncogenesis 157 one-carbon metabolism: leucovorin role
102 organic phosphate esters: anti porters
13 organization, biochemical 405 oxidases: NADPH 43 oxidative damage
DNA (BR) 486 proteins and ageing 437
p P-clusters 153 P-domain peptides 239 P-glycoproteins (l) 164 p21 rap protein 46 p21ras protein
activation 273 effector interactions 250
PAC-l gene, human 378 pancreatic lipase (hPl) 20 pathogens: killing and digestion: NADPH
role 43 PCR see polymerase chain reaction pectate lyase C 313 Pep12p: epimorphin sequence similarity
124 peptidases: nomenclature 114 peptide analysis: capillary
electrophoresis 411 peptide bonds: dihedral angles 317 Peptostreptococcus asaccharolyticus:
L-serine dehydratases 297 periplasm: protein secretion, Gram
negative bacteria 8 peroxisomal membranes: PMP47 protein
427 phagocytes: NADPH oxidase 43 phase III detoxification reaction (l)
164 phosphatases
Cll00 377
E. coli 247 targeting subunits 172 VHl 6
phosphates inositol 53, (BR) 271
phosphatidylinositol 3-kinase 378 phosphoglycerate kinase
folding intermediates 2 hinge motions 116
phospholipases A2 activating protein 292 C 53,403
phosphorylation abnormal: tau protein 480 carboxy-terminal domain 117 DNA-activated protein kinase 433 MAP cascades 128 reversible, proteins 172 rhodopsin 275 tyrosine, leucocyte signal
transduction role 215 phosphotransferase: yeast tRNA splicing
32 photoreceptors: protein kinase C 275 photosystems: thylakoid membrane role
415 phycobilisomes, cyanobacteria 418 phylogeny: metazoan 459 plastic gene transcripts: splicing system
31 platelet-derived growth factors
receptors 273 structure 49
pleckstrin homology: PH domain 343 PlP-dependent L-threonine dehydratases
297 PMP47 protein 427 polyamines: cell growth 477 polygalacturonic
acidjrhamnogalacturonan-I 213 polymerase chain reaction
Amplify program (CC) 448 CASTing 77 contamination (CC) 447
polymeric domains: macromolecular association 181
polymerization: proofreading mechanism 381
post-translational import: mitochondrial proteins 366
poxvirus DNA-dependent ATPases 291 pre-mRNA: splicing 117 pre-tRNA: splicing 31 prenylation: proteins 349 primary biliary cirrhosis 141 programmed cell death see apoptosis prolidases: evolution 405 proofreading, kinetic 381 propeptides: protein folding role 442 protein analysis
capillary electrophoresis 411 e-mail servers (CC) 267 Geneworks (CC) 188
protein data Data Sank 65 human (BR) 190
protein folding SiP-binding role 3 chaperonin 81 energetics 1 pectate lyase C 313 propeptide role 442
slow-exchange core 359 protein kinase Cs
calcium-independent 207 PH domain 343 rhodopsin desensitization 275
protein kinases cAMP-dependent 84, 120 mitogen-activated (MAPK) 128 molecular phylogeny 461 targeting subunits 172
protein phosphatase-l: targeting subunits 172
protein sequence motifs calcium-independent protein kinase
Cs 207 chaperonin 81 eLlOO gene 377 cytoskeleton-associated proteins
82 epimorphin 124 farnesyltransferase 426 FMRl gene 331 hormone-sensitive lipase 466 lipocalins (L) 206 MAM 40 NMDA receptor 41 NOGGIN 208, (L) 424, (L) 425 PMP47 ~27 polyphosphates 247 polyphospholipase A2 activating
protein 292 related GAP domains 378 SNF2 family 291
protein sequences alignment: Multalin 4.0 (CC) 106 Human Protein Data (BR) 190
protein structure (BR) 270 dihedral angles 317, (L) 464 evolution 372 ,6-roll motif 313 secondary structure 120 size, shape and function 65
protein synthesis 155 tRNA function (BR) 356
protein tyrosine kinases see tyrosine kinases
protein-protein interaction (BR) 450 Kunitz domain 208 P-domain peptides 239 p21ras protein 250 PH domain 343 transcription factor 77 tyrosine phosphorylation role 219
proteins bacteria cell-surface 136 chloroplast ribosomal 177 disorder 71 homologous: evolution 403 interaction (BR) 450 iron-sulphur clusters 153 lipid modification (BR) 400 major facilitator superfamily (L) 248 mitochondrial, import and synthesis
366 molecular phylogeny 461 multimeric complex dsDNA binding
202 nomenclature 113 prenylation 349, 426 radical-damaged: accumulation
437 reaction-induced infrared difference
spectroscopy 197 retention in endoplasmic reticulum
3 reversible phosphorylation 172 size, shape and function 65 solute transporters 13 secretion: Gram-negative bacteria 7 targeting (BR) 191 toxins: membrane-insertion domain
391 translocation across ER membrane
456 protonic networks: membranes 243 proto-oncogenes 233 see also
oncogenes trkA 51
pseudomonads exotoxin 393 mandelate pathway evolution 372 Pul protein homologues 9
Pul proteins 8 Purkinje cell, death 157 pyrophosphates: inositol 55
R Rab proteins
ER-Goigi transport role 3 S. pombe 4
rac proteins 43 racemases, mandelate 372, 403 radiation target analysis 236 radical-damaged proteins, accumulation
437 Ran: RCCl interaction 99 rap proteins 46 rapamycin: action mechanism 334 Ras proteins 43, 250 see also p21ras
activation by protein tyrosine kinases 273
farnesyltransferase 349 RCCl protein 96 reaction-induced infrared difference
spectroscopy 197 reaction mechanisms: computer
programs (CC) 58 RecA protein, E. coli (L) 424 receptor kinases
(3-adrenergic 315 receptor protein tyrosine phosphatase
",,: adhesive domain 40 receptors
comn:lOn adhesive domain 40 NMDA 41 protein tyrosine kinase 215, 273
regulatory factors, transcriptional 90 replication, DNA: multimeric complex
binding proteins role 202 restin 82 restriction enzyme mapping, DNA Strider
(CC) 187 retinol G proteins: transducin (L) 164 retroviruses 233 Rev proteins 255 reversible associations: quantitative
characterization 284 reversible transcription: retroviruses
233 Rhizomucor miehei: RmL 20 rhodopsin: desensitization 275 ribonucleoprotein Al 421 ribosomal proteins, chloroplast
177
ribosomal RNA protein synthesis 155 transcription processing, snoRNA
131 translation initiation role 406
RmL, R. meihei 20 RNA see also messenger, pre-,
ribosomal and transfer RNA antisense: gene silencing 419
binding: TFlIlA 227 metabolism: FMRl gene 331 processing: carboxy-terminal domain
role 117 recognition: HIV-l regulatory proteins
255 RNA helicases 125 RNA polymerase II 90
carboxy-terminal domain 117 rRNA see ribosomal RNA (3-roll motif. 313
S Saccharomyces cerevisiae
cytoskeleton-associated proteins 82
GALl/GALlO genes 90 immunosuppressive drugs 334 MAP kinase cascade homologues
129 SH2 domain (L) 464 snRNAs 131 tRNA splicing pathway 31 yeast VHl (YVH1) 6
a-sarcin loop, translocation 155 Schiff base-forming Lys 37 Schizosaccharomyces pombe
cdc2 gene 195 cdc25 protein 6 MAP kinase cascade homologues
129 membrane traffic model 4
science and technology, dictionary (BR) 190
secretory pathway eukaryotic cells 3, 395 proteins: Gram-negative bacteria 7
secretory proteins P-domain peptides 239
sedimentation equilibrium measurement and analysis 284
self-splicing RNA systems 31 sequence alignment: Multalin 4.0 (CC)
106 sequence analysis
bye-mail (CC) 267 computer programs (CC) 187
sequence homology calcium-independent protein kinase
Cs 207 cytoskeleton-associated proteins
82 epimorphin 124
serine dehydratases 297 SH2 domain, yeast (L) 464 signal transduction pathways
endoplasmic reticulum membrane translocation 456
effector-protein activation 292 haemoglobin 385 inositol phosphates 53 interferons 338 leucocytes, cell-surface receptor
497
mediated 215 MAP kinase cascade 128 p21ras 250 phototransduction 275 Ras activation by receptor tyrosine
kinases 273 RCCl 100 T cell receptor 334 tools for elucidating 334
slow-exchange core: protein folding 359
small nuclear RNA (snRNA) 131, (l) 330
SNAPs 453 SNAREs 453 SNF2 family proteins 291 snoRNA see nucleolar snRNA snRNA see small nuclear RNA soluble proteins 65, 453 solute transporter proteins 13 Southern blots (CC) 484 spectrin: molecular phylogeny 462 spectroscopy
energy-selective 71 Fourier transform 198 reaction-induced infrared 197
spliceosomal snRNA 131 spliceosomal system: eukaryotic mRNA
transcripts 31 splicing
introns: E. gracilis chloroplast genes 467
pre-mRNA 117 RNA 31 snRNAs 131
splicing factors 117 src family tyrosine kinases 215 Staphylococcus: cell-surface proteins
136 statistical thermodynamics: protein
folding energetics 1 Streptococcus: cell-surface proteins
136 Strider, DNA (CC) 187 subtilisin: intramolecular chaperones
443 sugar-facilitator proteins 13 ~-superhelix motif 313 surface curvature: membranes (l) 81 synapsin I 327 synaptobrevin 325, 329, 453 syntaxins 124, 329, 453 synthetase, tRNA 362
T T cell
blockage by immunosuppressive drugs 334
src family tyrosine kinases 215 T lymphocytes 140 targeting, proteins (BR) 191 targeting membrane fusion: membrane
proteins 453 targeting subunits: protein
phosphorylation regulation 172 Tat proteins 255 tau protein: Alzheimer's disease marker
480
498
tautomerism, nucleotides 160 tear-specific prealbumin (l) 206 technology and science, dictionary
(BR) 190 tetanus neurotoxin 324, 327 TFIlIA 226 TGN see trans-Golgi network TGN38 4, 397 thanatogenesis 157 thermodynamics, statistical: protein
folding energetics 1 threonine dehydratases 297 thylakoid membranes, plants 415 thymocytes: apoptosis 307 titration curves: amino acids 69 top-down control analySis 26 toxins: membrane-insertion domain
391 trans-acting factor: yeast tRNA splicing
31 trans-activation see transcription trans-Golgi network (TGN) 210
eukaryotic cells 395 vesicle budding 4
transcription artificial regulatory systems 471 initiation 90, 117 multimeric complex dsDNA binding
proteins 202 TFlIIA 226
transcriptional regulatory factors 90, 459
transducin 275, 293 acylation (l) 164
transfer RNA protein synthesis (BR) 356 splicing 31 tertiary structure 362
transforming growth factor ~2: structure 49
transglutaminase: activation by tetanus toxin 327
transition mutation 160 transition state theory 181 translation
bypassing in mRNA 294 initiation, rRNA-mRNA
complementarity 406 initiation regulation 429
translational introns: gene expression regulation 294
translocation a-sarcin loop role 155 Gram-negative bacteria 7 protein 456
transport ER-Golgi 3 G proteins role 4 major facilitator superfamily proteins
13 transversion mutations 160 trefoil motif proteins 239 triacylglyceride ester hydrolases:
molecular structure 20 triose phosphate isomerase 313, 372 trkA gene 51 tRNA see transfer RNA tryptophanyl-tRNA synthetase 263
tumour necrosis factor: apoptotic cell death 308
twintrons: E. gracilis chloroplast genes 467
type I fructose biphosphate aldolase 36
tyrosine kinases
U
activation of Ras 273 src family 215
UhpC 13 ultracentrifugation: biomolecular
associations 284 ultrasonic DNA ligation (eC) 446 unstructured polymeric domains 181 Usenet (CC) 398
V vaccinia virus
NTPl protein 291 VHl phosphatase 6 WHl 377
vesicle-associated membrane proteins 453 cleavage by neurotoxins 324 cleavage by tetanus toxins 327
vesicular transport G proteins role 4 proteins (l) 248, 453 Rab6 protein 4
vibrational energy: proteins 71 viruses: fusion mechanisms (BR)
355 visual transduction: protein kinase C
role 275 Von Ebner's gland protein (l) 206
W wheat germ agglutinin 223 wobble base pairing 160 WRS gene, human 263
X Xenopus
MAP kinase cascade 128 NOGGIN gene 208, (l) 424,
(l) 425 TFIIIA 226
xyloglucan 213
y yeast
ERD-2gene 3 HDEl receptor 3 Pep12p protein 124 PMP47 protein 427 SH2 domain (l) 464 tRNA splicing 31
Yersinia enterocolitica: Yop proteins 10
Yop proteins, Y. enterocolitica 10 Ypt proteins, S. pombe 4
Z zinc endopeptidases
clostridial neurotoxins 324 tetanus toxins 327