Study flow diagram BB=blockers; HTN=hypertension; RCT=randomized controlled trial Bangalore S. et...
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Transcript of Study flow diagram BB=blockers; HTN=hypertension; RCT=randomized controlled trial Bangalore S. et...
![Page 1: Study flow diagram BB=blockers; HTN=hypertension; RCT=randomized controlled trial Bangalore S. et al. Am J Cardiol. 2007;100:1254-62.](https://reader035.fdocuments.us/reader035/viewer/2022062516/56649e535503460f94b48ef8/html5/thumbnails/1.jpg)
Study flow diagramBB=blockers; HTN=hypertension; RCT=randomized controlled trial
Bangalore S. et al. Am J Cardiol. 2007;100:1254-62
![Page 2: Study flow diagram BB=blockers; HTN=hypertension; RCT=randomized controlled trial Bangalore S. et al. Am J Cardiol. 2007;100:1254-62.](https://reader035.fdocuments.us/reader035/viewer/2022062516/56649e535503460f94b48ef8/html5/thumbnails/2.jpg)
Clinical trials comparing ß-blockers with placebo or diuretics
Bangalore S. et al. Am J Cardiol. 2007;100:1254-62
![Page 3: Study flow diagram BB=blockers; HTN=hypertension; RCT=randomized controlled trial Bangalore S. et al. Am J Cardiol. 2007;100:1254-62.](https://reader035.fdocuments.us/reader035/viewer/2022062516/56649e535503460f94b48ef8/html5/thumbnails/3.jpg)
Bangalore S. et al. Am J Cardiol. 2007;100:1254-62
Blood pressure response: ß-blockers versus placebo or diuretics
![Page 4: Study flow diagram BB=blockers; HTN=hypertension; RCT=randomized controlled trial Bangalore S. et al. Am J Cardiol. 2007;100:1254-62.](https://reader035.fdocuments.us/reader035/viewer/2022062516/56649e535503460f94b48ef8/html5/thumbnails/4.jpg)
Bangalore S. et al. Am J Cardiol. 2007;100:1254-62
Clinical trials comparing ß-blockers with nondiuretic antihypertensive agents
![Page 5: Study flow diagram BB=blockers; HTN=hypertension; RCT=randomized controlled trial Bangalore S. et al. Am J Cardiol. 2007;100:1254-62.](https://reader035.fdocuments.us/reader035/viewer/2022062516/56649e535503460f94b48ef8/html5/thumbnails/5.jpg)
Bangalore S. et al. Am J Cardiol. 2007;100:1254-62
Blood pressure response: ß-blockers versus nondiuretic antihypertensive agents
![Page 6: Study flow diagram BB=blockers; HTN=hypertension; RCT=randomized controlled trial Bangalore S. et al. Am J Cardiol. 2007;100:1254-62.](https://reader035.fdocuments.us/reader035/viewer/2022062516/56649e535503460f94b48ef8/html5/thumbnails/6.jpg)
Bangalore S. et al. Am J Cardiol. 2007;100:1254-62
Effect of ß-blockers on the risk for new-onset DM when compared to nondiuretic antihypertensive agents (CCBs, ACE inhibitors [ACEi], and ARBs)
![Page 7: Study flow diagram BB=blockers; HTN=hypertension; RCT=randomized controlled trial Bangalore S. et al. Am J Cardiol. 2007;100:1254-62.](https://reader035.fdocuments.us/reader035/viewer/2022062516/56649e535503460f94b48ef8/html5/thumbnails/7.jpg)
Bangalore S. et al. Am J Cardiol. 2007;100:1254-62
Effect of different ß-blocker types on the risk for new-onset DM compared with other agents
![Page 8: Study flow diagram BB=blockers; HTN=hypertension; RCT=randomized controlled trial Bangalore S. et al. Am J Cardiol. 2007;100:1254-62.](https://reader035.fdocuments.us/reader035/viewer/2022062516/56649e535503460f94b48ef8/html5/thumbnails/8.jpg)
Bangalore S. et al. Am J Cardiol. 2007;100:1254-62
Meta-regression analysis
![Page 9: Study flow diagram BB=blockers; HTN=hypertension; RCT=randomized controlled trial Bangalore S. et al. Am J Cardiol. 2007;100:1254-62.](https://reader035.fdocuments.us/reader035/viewer/2022062516/56649e535503460f94b48ef8/html5/thumbnails/9.jpg)
Bangalore S. et al. Am J Cardiol. 2007;100:1254-62
RR for new-onset DM (NODM) as a function of systolic blood pressure (SBP) difference between
ß-blockers and nondiuretic antihypertensive agents
![Page 10: Study flow diagram BB=blockers; HTN=hypertension; RCT=randomized controlled trial Bangalore S. et al. Am J Cardiol. 2007;100:1254-62.](https://reader035.fdocuments.us/reader035/viewer/2022062516/56649e535503460f94b48ef8/html5/thumbnails/10.jpg)
Bangalore S. et al. Am J Cardiol. 2007;100:1254-62
RR for new-onset DM as a function of baseline fasting blood glucose levels
![Page 11: Study flow diagram BB=blockers; HTN=hypertension; RCT=randomized controlled trial Bangalore S. et al. Am J Cardiol. 2007;100:1254-62.](https://reader035.fdocuments.us/reader035/viewer/2022062516/56649e535503460f94b48ef8/html5/thumbnails/11.jpg)
Bangalore S. et al. Am J Cardiol. 2007;100:1254-62
RR for new-onset DM as a function of baseline BMI
![Page 12: Study flow diagram BB=blockers; HTN=hypertension; RCT=randomized controlled trial Bangalore S. et al. Am J Cardiol. 2007;100:1254-62.](https://reader035.fdocuments.us/reader035/viewer/2022062516/56649e535503460f94b48ef8/html5/thumbnails/12.jpg)
Bangalore S. et al. Am J Cardiol. 2007;100:1254-62
RR for new-onset DM as a function of length of follow-up
![Page 13: Study flow diagram BB=blockers; HTN=hypertension; RCT=randomized controlled trial Bangalore S. et al. Am J Cardiol. 2007;100:1254-62.](https://reader035.fdocuments.us/reader035/viewer/2022062516/56649e535503460f94b48ef8/html5/thumbnails/13.jpg)
Bangalore S. et al. Am J Cardiol. 2007;100:1254-62
ß-blockers for primary hypertension: pathogenesis for increased risk. BP=blood pressure SM=smooth muscle