Structure of Amino Acids. Amino Acids Amino acids are the structural building blocks (monomers) of...

13
Structure of Amino Acids

Transcript of Structure of Amino Acids. Amino Acids Amino acids are the structural building blocks (monomers) of...

Page 1: Structure of Amino Acids. Amino Acids Amino acids are the structural building blocks (monomers) of proteins. There are twenty different kinds of amino.

Structure of Amino Acids

Structure of Amino Acids

Page 2: Structure of Amino Acids. Amino Acids Amino acids are the structural building blocks (monomers) of proteins. There are twenty different kinds of amino.

Amino Acids

• Amino acids are the structural building blocks (monomers) of proteins.

• There are twenty different kinds of amino acids used in proteins.

• Proteins are referred to as heteropolymers due the variety of amino acids involved in their structure.

Page 3: Structure of Amino Acids. Amino Acids Amino acids are the structural building blocks (monomers) of proteins. There are twenty different kinds of amino.

-carbon

Page 4: Structure of Amino Acids. Amino Acids Amino acids are the structural building blocks (monomers) of proteins. There are twenty different kinds of amino.

Amino Acids (cont’d.)• Amino acids, like carbohydrates, show

isomerism. Proteins are only made up of amino acids which are L-isomers.

L-isomerD-isomer

Page 5: Structure of Amino Acids. Amino Acids Amino acids are the structural building blocks (monomers) of proteins. There are twenty different kinds of amino.

Amino Acids (cont’d.)

• At neutral pH’s amino acids exist in an ionised form and have both acidic and basic properties. This is because the carboxylic group donates hydrogen ions to the solution (acidic) whereas the amino group (NH2) attracts hydrogen

ions from the solution.

Page 6: Structure of Amino Acids. Amino Acids Amino acids are the structural building blocks (monomers) of proteins. There are twenty different kinds of amino.

Amino Acids (cont’d.)

• The repeating sequence of atoms along a proteins is referred to as the polypeptide backbone. Attached to this repetitive chain are the different amino acid side chains (R-groups) which are not involved in the peptide bond but which give each amino acid its unique property.

Page 7: Structure of Amino Acids. Amino Acids Amino acids are the structural building blocks (monomers) of proteins. There are twenty different kinds of amino.

Amino Acids (cont’d.)

• Amino acids are grouped according to whether their side chains are:-

•acidic•basic•uncharged polar•non polar

Page 8: Structure of Amino Acids. Amino Acids Amino acids are the structural building blocks (monomers) of proteins. There are twenty different kinds of amino.

Aspartic

Acid

asp

 D

                                   

AcidicPolar 

AsparticAcid asp  Acidic

Polar 

GlutamicAcid glu Acidic

Polar

Page 9: Structure of Amino Acids. Amino Acids Amino acids are the structural building blocks (monomers) of proteins. There are twenty different kinds of amino.

Lysine lys  Basic

Polar

 Arginine arg  Basic

Polar

Page 10: Structure of Amino Acids. Amino Acids Amino acids are the structural building blocks (monomers) of proteins. There are twenty different kinds of amino.

Glutamine gln NeutralPolar

Tyrosine  tyr   Neutral Polar

Page 11: Structure of Amino Acids. Amino Acids Amino acids are the structural building blocks (monomers) of proteins. There are twenty different kinds of amino.

Isoleucine  ileNeutralNon-polar

Methionine  met  Neutral

Non-polar

Page 12: Structure of Amino Acids. Amino Acids Amino acids are the structural building blocks (monomers) of proteins. There are twenty different kinds of amino.

Amino Acids (cont’d.)• The type of side chain is very important

as it affects the solubility of the amino acid.

• Hydrophobic features include long non-polar (uncharged) chains or complex aromatic rings.

• Hydrophilic features include additional carboxyl groups or amino groups not involved in peptide bonding which are ionised in solution.

Page 13: Structure of Amino Acids. Amino Acids Amino acids are the structural building blocks (monomers) of proteins. There are twenty different kinds of amino.

Amino Acids (cont’d.)• Amino acids link together by covalent

peptide bonds. This involves a condensation /dehydration reaction. These bonds are very strong. When this takes place the charged amino and carboxylic groups disappear.