Structural and Computational Biophysics Training Program Program Retreat for T32-GM095440 April 24,...
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Structural and Computational Biophysics Training Program
Program Retreat for T32-GM095440April 24, 2015
Wake Forest Biotech PlaceRoom 155
External AdvisoryCommittee
LeCompte Estes
Program Administration
Co-DirectorsPoole Lyles
Executive CommitteePoole Lyles Salsbury King
TrainingFaculty
StudentTrainees
Advanced Courses in Structural and Computational Biophysics
Discipline-Specific Coursework
Program CurriculumMolecular and Cellular
Biosciences
MolecularMedicine
Biochemistry MolecularGenetics
Chemistry Physics
MCB 711Biological Systems
and Structures
PHY 607Biophysics
Center for Structural BiologySeminar Series
Structural and ComputationalBiophysics Discussion Group
Training in Responsible Conduct of Research
Training for a Diversity of Careers
• Career workshops• SCB-sponsored workshops• Shared workshops with Graduate School and other T32
training programs
• Courses• Principles and Practice of Teaching Biochemistry (BICM 717,
718)• Drug Discovery, Design, and Development - Molecules to
Medicines (CHM 740, also listed as BICM 740)
Training for a Diversity of Careers (cont.)
• Internships• Biotechnology (Targacept, Keranetics)• Pharma (GSK)• Tech Transfer (Wake Forest Innovations)• Intellectual Property (Kilpatrick Townsend & Stockton, LLP)
• Combined Degrees• Ph.D.-M.B.A.• M.D.-Ph.D.
Recruitment of Trainees
• Web-based recruiting and application
• Career Day at Wake Forest
• Campus visits
• Masters degree program• Mathematics, Computer Science, Physics, Chemistry,
Biomedical Science• Certificate Program in Structural and Computational
Biophysics
Recruitment of Members of Minority Groups Under-represented in Science
• Attendance at national meetings (NIGMS TWD, ABRCMS)
• Partnership with North Carolina A&T State University• Participation in MARC Program (T34-GM083980, Mary Smith,
PI)• Participation in BUILD grant application• Attendance at annual MORE-STEM fair• Research collaborations
• Participation in PREP Program (R25-GM064249, Debra Diz, PI)
Program Evaluation
• Student evaluations at annual committee meetings according to their Individual Development Plans
• Course evaluations by student surveys and by coordination with course directors
• Individual training program evaluations by anonymous exit interviews with the Dean of the Graduate School.
• External program reviews
Student Discussion Groups
Student GroupMacnamara 1Lawson 1Nilsson 1Mukherjee 1Godwin 1Mauney 2Wang 2Yang 2Xiao 2Dushime 2Davis 3Zahid 3Black 3Belanger 3Lucas 4Davidson 4Su 4Melvin 4
Student GroupLawson 1Mauney 1Dushime 1Belanger 1Melvin 1Macnamara 2Godwin 2Xiao 2Black 2Su 2Mukherjee 3Yang 3Zahid 3Davidson 3Nilsson 4Wang 4Davis 4Lucas 4
Session 1 Session
Recommendations of External Advisory Committee
• Inter-campus communication: course listing, transportation, internet access
• Training faculty size and composition
• Program cohesiveness and intellectual focus
• Curriculum and outcome evaluation
• Certificate Program and internships not widely understood
• Communication and interaction among students and faculty
• Value added
T32 GM095440: Structural and Computational Biophysics Training Program
Goal: To bridge the gap between biomedical sciences and more basic quantitative sciences
Interdisciplinary Research at WFU
COBCAPconsortium of biological chemistry and physics
(2002 retreat, 34 faculty across campuses)
• Translational Science Center• Center for Molecular
Communication and Signaling
applying chemical and physical theory and techniques to biological problems
• shared resources • combined seminars• cross-departmental teaching• cross-departmental research
opportunities
Dany Kim-Shapiro (Biophysics)
Interdisciplinary Research at WFU
COBCAPconsortium of biological chemistry and physics
(2002 retreat, 34 faculty across campuses)
Recruitment of Reynolds Professorin Computational Biophysics:
Jacquelyn Fetrow (Physics & CompSci)
Dany Kim-Shapiro (Biophysics)
Interdisciplinary Research at WFU
•Center for Structural Biology move to BGTC, near WFU
2003
2004
2006
20082011
2012
Bowman Gray Technical Center
Interdisciplinary Research at WFU
•Center for Structural Biology•GAANN grant application (Fetrow)•Structural and Computational Biophysics Journal Club
2003
2004
2006
20082011
2012
Interdisciplinary Research at WFU
2003
2004
2006
20082011
2012
•Center for Structural Biology•GAANN grant application (Fetrow)•Structural and Computational Biophysics Journal Club•DMS-NSF/NIGMS Mathematical Biology Initiative (Funded), 2005-2009 (redox biology/proteomics with mathematical modeling)•Certificate Program: Interdisciplinary Graduate Track in Structural and Computational Biophysics at Wake Forest University•Interdisciplinary Drug Discovery course (Hantgan)•Molecular and Cellular Biology unified curriculum for incoming Ph.D. stud•Predoctoral Training Program (T32) in Structural and Computational Biophysics (Lyles & Poole PIs, Salsbury & Fetrow, executive board)•CSB & Biochem, with Immunol/Microbiol, Phys/Pharm, Bioengineering, move to Biotechnology Place
Training Grant Award, 2011-2016
July 1, 2011, Start of Predoctoral T32 Training Grant (2 slots, then 4 slots/year)
Continued SCB Discussion Group, monthly at Foothills Brewery
August 25, 2014, External review of T32-GM095440 Juliette Lecomte, Johns HopkinsMary Estes, Baylor
April 24, 2015, SCB Retreat
May 25, 2015, Deadline to submit competitive renewal
Sept-Oct 2015, expected site visit before Nov. study section meeting
Training Grant Award, 2011-2016
2011-2012: Laura Dillon (Wang, Biochemistry, yr 5)Andrea Belanger (Kim-Shapiro, Physics, yr 2)
2012-2013: Andrea Belanger (Kim-Shapiro, Physics, yr 3)Chris Mauney (Hollis, Biochemistry, yr 2)Thomas Poole (King, Chemistry, yr 2)Amanda Smelser (Macosko, yr 2) ** NSF fellowship
2013-2014: Chris Mauney (Hollis, Biochemistry, yr 3)Thomas Poole (King, Chemistry, yr 3) ** GSK internshipJanelle Leuthaeuser (Fetrow, yr 4)Jade Mims (Furdui, yr 2)
2014-2015: Janelle Leuthaeuser (Fetrow, yr 5)Jade Mims (Furdui, yr 3)Reed Lawson (Lowther, yr 2)Ryan Godwin (Salsbury, yr 2)
Faculty in SCB Training ProgramDepartmental Affiliations
Internal MedicineSection on Molecular Medicine
Cristina Furdui
ToddLowther
DougLyles
Biochemistry
LesliePoole
FredPerrino
TomHollis
UliBierbach
BruceKing
Chemistry
DanyKim-
Shapiro
MartinGuthold
FredSalsbury
Jed Macosko
JacqueFetrow
Physics
Suzy TortiDave Horita
Yuh-Hwa Wang
Faculty in SCB Training Program
SCB Related Facilities
Cristina Furdui
ToddLowther
DougLyles
LesliePoole
FredPerrino
TomHollis
UliBierbach
BruceKing
DanyKim-
Shapiro
MartinGuthold
FredSalsbury
Jed Macosko
JacqueFetrow
Mass Spectrometry Triple Quad, Q-ToF, LTQ-Oribtrap (Velos & XE), MALDI-ToF
Xray diffractometersCSB: 1 generator,
2 detectors
Protein analysisAnalytical
Ultracentrifuge, SPR, DLS, Typhoon
scanner
SpectroscopyUV-Vis & Fluor, Stopped-flow
fluorimeter, time-resolved
fluorimeter, CD, EPR
Scanning Tunneling & Atomic Force
Microscopes, TEM, SEM, LSCM
Computational Resources
CSB Linux cluster and graphics facility, DEAC
cluster
Nanotechnology: NextGenSequencing
NMRBruker 300,
500 & 600 MHz
Interdisciplinary Research at WFU
COBCAP
Interdisciplinary Science CentersMedical Center:
Comprehensive Cancer CenterTranslational Science Institute (MMTS & MGG)
Reynolda Campus: Translational Science Center (to promote and maintain functional health in aging)Center for Molecular Communication and Signaling
•Center for Structural Biology (2003), new site at BGTC•GAANN grant application (Fall 2003)•Structural and Computational Biophysics Journal Club (Spring 2004)•DMS-NSF/NIGMS Mathematical Biology Initiative, (Fall 2004): 2005-2009 (redox biology and proteomics with mathematical modeling using computational algebra and Bayesian tools)•Curriculum changes to add advanced training in structural biology (2005), unified
basic curriculum for molecularly-oriented biomedical Ph.D. students (2006), Interdisciplinary Drug Discovery course (2008)•Certificate Program (2006): Interdisciplinary Graduate Track in Structural and Computational Biophysics at Wake Forest University•Predoctoral Training Program (T32) in Structural and Computational Biophysics (Lyles & Poole PIs, Salsbury & Fetrow, executive board)