Stress Physiology. Adrenocorticotropic Hormone Corticotropin Releasing Hormone Glucocorticoid =...
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Transcript of Stress Physiology. Adrenocorticotropic Hormone Corticotropin Releasing Hormone Glucocorticoid =...
Adrenocorticotropic Hormone
Corticotropin Releasing Hormone
Glucocorticoid = Stress Hormone
Hypothalamic-Pituitary-Adrenal AXIS
Adrenocorticotropic Hormone
Corticotropin Releasing Hormone
Glucocortoid
Increase Energy Available
Reduce InflammationReduce HistaminesReduce immunity
STRESS
Sympathetic ANS
Increase Serum Glucose
Liver LiverGlycogen Glucose
Increase plasma fatty acids
available for energy
Endorphin Release Decreased PAIN
Acute Stress Response
Increase Energy Available
Endorphin Release
Decreased PAIN
FLIGHT or FIGHT (seconds)
Glucocorticoid Response = Minutes-Hours
Chronic Stress(ors) = long term, persistent
Physical, Emotional, Sexual Abuse Demanding Job
Poverty, Malnourishment Depression, Anxiety
Chronic Stress Response
General Adaptation Syndrome (Seyle)
Body’s Initial Response(Cortisol, Epi/Norepi, Endophins)
Increase Energy Available, Increase CO, MAPSuppress Immune System, Reduce Pain
CHRONICSTRESSOR
Chronic Stress Response
General Adaptation Syndrome (Seyle)
Body’s Initial Response(Cortisol, Epi/Norepi, Endophins)
Increase Energy Available, Increase CO, MAPSuppress Immune System, Reduce Pain
Continuation of
Body is moving to a new ‘setpoint’ that is OPTIMAL for stressful conditions
ALLOSTASIS
CHRONICSTRESSOR
Chronic Stress Response
General Adaptation Syndrome (Seyle)
Body’s Initial Response(Cortisol, Epi/Norepi, Endophins)
Increase Energy Available, Increase CO, MAPSuppress Immune System, Reduce Pain
Continuation of
Body is moving to a new ‘setpoint’ that is OPTIMAL for stressful conditions
ALLOSTASIS
Exhaustion
Energy Stores depletedMyocardium fatiguedBlood vessels damagedInfection prevalentWounds don’t heal
CHRONICSTRESSOR