Strange responses of the Hodgkin-Huxley model to highly fluctuating inputs

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Sakai, Yamada & Yoshizawa Sakai, Yamada & Yoshizawa Strange responses of Strange responses of the Hodgkin-Huxley model the Hodgkin-Huxley model to highly fluctuating to highly fluctuating inputs inputs taka Sakai (Saitama Univ., Japa sahiro Yamada (Univ. Tokyo, Japan) uji Yoshizawa (Saitama Univ., Japan)

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Strange responses of the Hodgkin-Huxley model to highly fluctuating inputs. Yutaka Sakai ( Saitama Univ., Japan ) Masahiro Yamada ( Univ. Tokyo, Japan ) Shuji Yoshizawa ( Saitama Univ., Japan ). class II. HH (Hopf bifurcation). frequency. frequency. - PowerPoint PPT Presentation

Transcript of Strange responses of the Hodgkin-Huxley model to highly fluctuating inputs

JNNSSakai, Yamada & Yoshizawa
Neuron: excitable system
silent → periodic firing
frequency
μ
Discontinuous
Leaky integrate-and-fire(LIF) Model
transient, inactivating
In naïve consideration,
… receives fluctuate inputs
Sakai, Yamada & Yoshizawa
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Sakai, Yamada & Yoshizawa
LIF: monotone increasing
HH: monotone decreasing
Sakai, Yamada & Yoshizawa
+ A-current
“monotone decreasing variability”
Typical behavior before bifurcation
2. Second firing for a single perturbation
3. Refractory
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Before Saddle-node bifurcation
Before Hopf bifurcation
Sakai, Yamada & Yoshizawa
Typical before Hopf bifurcation
dV
dt
=I
syn
+ref
0
1
2
3
σ
CV
HH
LIF
)
(
CdVdt=Isyn(t)+gL(VL¡V);ifV>Vµ;thenV!V0CdVdt=Isyn(t)+gL(VL¡V)+gNam3h(VNa¡V)+gKn4(VK¡V)dxdt=®x(V)(1¡x)¡¯x(V)x;(x=m;h;n)C
dV
dt
=I
syn
A
I