Stereochemistry of biaryls and ansa compounds
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Transcript of Stereochemistry of biaryls and ansa compounds
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April 12, 2023 1By Mohd Anzar Sakharkar
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April 12, 2023 2By Mohd Anzar Sakharkar
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STEREOCHEMISTRY OF BIARYLS
April 12, 2023 3By Mohd Anzar Sakharkar
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April 12, 2023 4By Mohd Anzar Sakharkar
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R
R R
R COOHCOOH
April 12, 2023 5By Mohd Anzar Sakharkar
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P-3 b b
a a
b a
a b
b b
a a
90o 180o 270o 360o
Interplanar angle
b a
a b
April 12, 2023 6By Mohd Anzar Sakharkar
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April 12, 2023 7By Mohd Anzar Sakharkar
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NO2
HOOC
NO2
COOH
R
NO2
O2N
COOH
COOH
Al(CH3)3
H
H
HS
Al3(CH3)
H
H
F
April 12, 2023 8By Mohd Anzar Sakharkar
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X X
H2C CH2
(CH2)n
April 12, 2023 9By Mohd Anzar Sakharkar
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X X
H2C CH2
(CH2)n
April 12, 2023 10By Mohd Anzar Sakharkar
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R-S NOMENCLATURE:
April 12, 2023 11By Mohd Anzar Sakharkar
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O O
H2C CH2
(CH2)n
Pilot Atom 2
H3C CHIRAL PLANE
2
2
O O
H2C CH2
(CH2)n
CHIRAL PLANE
Pilot Atom
CH3
R S
O
O
H2CCH2
(CH2)n
Pilot Atom
H3C
CHIRAL PLANE
S
1 1
1
3 3
3
April 12, 2023 12By Mohd Anzar Sakharkar
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April 12, 2023 13By Mohd Anzar Sakharkar
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April 12, 2023 14By Mohd Anzar Sakharkar
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April 12, 2023 15By Mohd Anzar Sakharkar