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Curriculum Vitae

Stephen P. Pereira BSc PhD FRCP

Academic Address NHS Post

Reader in Hepatology & Gastroenterology Department of Gastroenterology

Head, Liver and Pancreatic Cancer Research Group University College Hospital

The UCL Institute of Hepatology Ground Floor West Wing

9th Floor Royal Free Hospital 250 Euston Road, London NW1 2PG

London NW3 2QG Tel: 020 7935 4849 Fax: 020 7935 6826

E-mail: stephen.pereira@ucl.ac.uk

Qualifications

BSc (Med) (Distinction) (UNSW) Feb 1987

MB BS (Hons) (UNSW) Feb 1989

Diploma in Geriatric Medicine (UK) July 1991

MRCP (UK) Oct 1991

European Diploma of Gastroenterology Jun 1999

CCST Gastroenterology & General Medicine Jan 2000

PhD (University of London) Apr 2002

FRCP (UK) May 2003

Professional Associations

Royal College of Physicians 1991

British Association for the Study of the Liver 1996

British Society of Gastroenterology 1998

American Gastroenterological Association 1998

American Association for the Study of Liver Diseases 1998

International Association of Pancreatology 2000

American Pancreatic Association 2000

American Society of Gastrointestinal Endoscopy 2000

European Society of Gastrointestinal Endoscopy 2000

Pancreatic Society of Great Britain & Ireland 2000

British Association for Cancer Research 2006

European Association for Cancer Research 2008

Committee Membership

National Committee of British Society of Gastroenterology Pancreatic Section 2002-5

National Committee of Pancreatic Society of GB & Ireland 2002-5

National Committee of National Cancer Research Institute Upper GI Clinical Studies Group 2002-7

National Committee of UK & Ireland Endoscopic Ultrasound Users Group 2002-

NE Thames Gastroenterology Teaching Sub-Committee (Chairman 2007-) 2003-

Vice-Chair of The Joint UCL/UCLH Committees on the Ethics of Human Research 2003-5

National Inst. Health & Clinical Excellence, Specialist Adviser Interventional Procedures 2004-

National Committee of British Society of Gastroenterology Liver Section 2005-

Oncology Clinical Trials Facilitation Committee, University College Hospital 2005-

University College Hospitals NHS Foundation Trust Research Lead, Upper GI Tumour Board 2005-7

Member, Editorial Board of Gut 2005-9

National Topic Lead for Pancreas and Biliary Tree, National electronic Library for Health 2006-

National Inst. Health & Clinical Excellence Topic Selection Consideration Panel – Cancer 2006-

Academic Advisor, Gastroenterology Specialty Training Committee, London 2007-

President, Pancreatic Society of GB & Ireland 2006-7

National Inst. Health & Clin. Excellence Guideline Development Group – Alcohol-Use Disorders

In Adults and Young People: Clinical Management 2008-

Gastroenterology & Hepatology Faculty Advisory Board, Faculty 1000 Medicine 2008-

ESGE Education Committee, European Society of Gastrointestinal Endoscopy 2009-

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MRC EME College of Experts 2009-

Biliary Tract Cancer Section Head, International Faculty 1000 Medicine 2010-

BSG Council (Pancreatic Society GB&I representative) 2010-

Pancreatic Cancer UK Study for Survival, Board Member 2010-

Previous positions

Research Registrar in Gastroenterology, Guy's Hospital, London, Apr 1992-Dec 1994

Liver Transplant Registrar, Institute of Liver Studies, King's College Hospital, London, Jan 1995-Jan 1997

Senior Registrar in Gastroenterology / General Medicine, Guy's Hospital, London, Oct 1997-Jan 2000

Consultant Gastroenterologist & Honorary Senior Lecturer, UCL Hospitals NHS Trust, Jan 2000 – Oct 2003

Honorary Consultant in Paediatric PancreaticoBiliary Medicine, GOS Hospital for Children NHS Trust, 2003-

CLINICAL AND RESEARCH INTERESTS

I became a Reader in Hepatology & Gastroenterology at UCL in October 2010, having been a Senior

Lecturer since 2003 and a Consultant Gastroenterologist in PancreaticoBiliary Medicine at UCLH from

2000. I completed undergraduate studies in science (theoretical physics) and medicine at University of

NSW, Sydney, with postgraduate training mainly at Guy’s and King’s College Hospital and advanced

endoscopy training in Paris, Amsterdam and Indianapolis.

The research interests of the UCL Liver and Pancreatic Cancer Research Group, established at the

time of my appointment to The Institute of Hepatology, UCL, in October 2003, centre on the

pathogenesis, diagnosis and treatment of hepatocellular carcinoma, biliary tract and pancreatic cancer, as

well as the benign conditions primary sclerosing cholangitis and autoimmune pancreatitis. These

conditions represent a significant number of patients referred for specialist opinion to UCLH and the

Royal Free Hospitals, and the activity of the research group is linked closely with the clinical HPB

service at the two sites.

Publications 2003-

Before 2003, 22 original papers, nine review articles, eight book chapters, two editorials and four Letters to the

Editor published. Publications since 2003 are listed below:

ORIGINAL PAPERS

Pereira SP, Shearer MJ, Williams R, Mieli-Vergani G. Intestinal absorption of mixed-micellar phylloquinone (vitamin K1) is

unreliable in infants with conjugated hyperbilirubinaemia: implications for oral prophylaxis of vitamin K deficiency

bleeding. Arch Dis Child. Fetal Neonatal Ed 2003; 88: F113-F118.

Pereira SP, Bain IM, Kumar D, Dowling RH. Bile composition in inflammatory bowel disease: ileal disease and colectomy,

but not colitis, induce lithogenic bile. Aliment Pharmacol Therap 2003; 17: 923-33.

Pereira SP, O’Donohue J, Moniz C, Phillips MG, Abraha H, Buxton-Thomas M, Williams R. A controlled trial of

transdermal hormone replacement therapy in primary biliary cirrhosis. Aliment Pharmacol Therap 2004; 19: 563-70.

Bennett DL, Webster GJ, Molyneux P, Descamps MJ, Plant GT, Pereira SP, Reilly MM. Seeing the world through tinted

glasses. Lancet 2004; 24: 388-9.

Pereira SP, Rowbotham D, Fitt S, Shearer MJ, Wendon J, Williams R. Pharmacokinetics and efficacy of oral versus

intravenous mixed-micellar phylloquinone (vitamin K1) in severe acute liver disease. J Hepatol 2005; 42: 365-70.

O’Donohue J, Pereira SP, Ashdown AC, Haigh CG, Wilkinson JR, Williams R. A controlled trial of ondansetron in the

pruritis of cholestasis. Aliment Pharmacol Therap 2005; 21: 1041-5.

Wittmann J, Kocjan G, Sgouros SN, Deheragoda M, Pereira SP. Endoscopic ultrasound-guided tissue sampling by combined

fine needle aspiration and trucut needle biopsy; a prospective study. Cytopathology 2006; 17: 27-33.

Ayaru L, Wittmann J, MacRobert A, Novelli M, Bown SG, Pereira SP. Photodynamic therapy using verteporfin

photosensitisation in the pancreas and surrounding tissues in the Syrian golden hamster. Pancreatology 2007; 7: 20-7.

Pereira SP, Gillams A, Sgouros SN, Webster GJM, Hatfield ARW. Prospective comparison of secretin-stimulated MRCP

with manometry in the diagnosis of sphincter of Oddi dysfunction types II and III. Gut 2007; 56: 809-13.

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Pereira SP, Ayaru L, Rogowska A, Mosse A, Hatfield AR, Bown SG. Photodynamic therapy of malignant biliary strictures

using meso-tetrahydroxyphenylchlorin (mTHPC). Eur J Gastroenterol Hepatol 2007; 19: 479-85.

Ayaru L, Pereira SP, Alisa A, Pathan A, Williams R, Davidson B, Burroughs A, Meyer T, Behboudi S. Induction of tumour

necrosis unmasks alpha-fetoprotein-specific CD4+ T cell responses in patients with hepatocellular carcinoma. J Immunol

2007; 178: 1914-22.

Aithal GP, Anagnostopoulos GK, Tam W, Dean J, Zaitoun A, Kocjan G, K. Ragunath K, Pereira SP. Combining endoscopic

ultrasound-guided tissue sampling by fine needle aspiration (FNA) and trucut biopsy (TCB): Comparison of ‘dual

sampling’ (FNA and TCB) versus ‘sequential sampling’ (TCB and as needed FNA). Endoscopy 2007; 39: 725-30.

Deheragoda MG, Church NI, Rodriguez-Justo M, Munson P, Sandanayake N, Seward EW, Miller K, Novelli M, Hatfield AR,

Pereira SP, Webster GJ. The use of immunoglobulin g4 immunostaining in diagnosing pancreatic and extrapancreatic

involvement in autoimmune pancreatitis. Clin Gastroenterol Hepatol 2007; 5: 1229-34.

Church NI, Pereira SP, Deheregoda MG, Sandanayake N, Amin Z, Lees WR, Gillams A, Rodriguez-Justo M, Novelli M,

Seward EW, Hatfield AR, Webster GJ. Autoimmune pancreatitis: clinical and radiological features and objective

response to steroid therapy in a UK series. Am J Gastroenterol 2007; 102: 2417-25.

Gillams A, Pereira SP, Webster GJM, Lees WR. Correlation of MRCP quantification (MRCPQ) with conventional non-

invasive pancreatic exocrine function tests. Abdom Imag 2008; 33: 469-73.

Ayaru L, Kurzawinski TR, Webster GJM, Hatfield ARW, Pereira SP. Complications and diagnostic difficulties arising from

biliary self-expanding metal insertion before definitive histological diagnosis. J Gastroenterol Hepatol 2008; 23: 315-20.

Ayaru L, Stoeber K, Webster GJM, Hatfield ARW, Wollenschlaeger A, Okoturo O, Rashid M, Williams G, Pereira SP.

Diagnosis of pancreatiobiliary malignancy by detection of minichromosome maintenance protein 5 in bile aspirates. Br J

Cancer 2008; 98: 1548-54.

Matull WR, Andreola F, Loh A, Adiguzel Z, Deheragoda M, Qureshi U, Batra SK, Swallow DM, Pereira SP. MUC4 and

MUC5AC are highly specific tumour-associated mucins in biliary tract cancer. Br J Cancer 2008; 98: 1675-81.

Ng W, Loh AX, Teixara A, Pereira SP, Swallow DM. Genetic regulation of MUC1 alternative splicing in human tissues. Br J

Cancer 2008; 99: 978-985.

Sandanayake NS, Church NI, Chapman MH, Johnson GJ, Dhar DK, Amin Z, Deheragoda MG, Novelli M, Winstanley A,

Rodriguez-Justo M, Hatfield ARW, Pereira SP, Webster GJM. Presentation and management of post-treatment relapse

in autoimmune pancreatitis/IgG4-associated cholangitis. Clin Gastroenterol Hepatol 2009; 7: 1089-96.

Samkoe KS, Chen AA, Rizvi I, O'Hara JA, Hoopes PJ, Pereira SP, Hasan T, Pogue PW. Imaging tumor variation in response

to photodynamic therapy in pancreatic cancer xenograft models. Internat J Rad Onc Biol Phys 2010; 1: 251-9.

Valle J, Wasan H, Palmer DH, Cunningham D, Anthoney A, Maraveyas A, Madhusudan S, Iveson T, Hughes S, Pereira SP,

Roughton M, Bridgewater J; ABC-02 Trial Investigators. Cisplatin plus gemcitabine versus gemcitabine for biliary tract

cancer. N Engl J Med 2010; 362: 1273-81.

Pereira SP, Ayaru L, Ackroyd R, Mitton D, Fullarton G, Zammit M, Butruk E, Grzebieniak Z, Messmann H, Ortner MA,

Gao L, Sayyarpour F, Trinh M, Spénard J. Pharmacokinetics of porfimer sodium after repeated administrations 30 to 45

days apart to patients undergoing photodynamic therapy. Aliment Pharmacol Therap 2010; 32: 821-7.

Navani N, Kocjan G, Falzon M, Capitanio A, Pereira SP, Janes SM. The learning curve for EBUS-TBNA. Thorax 2010 Nov

20 [Epub ahead of print].

Matull WR, Dhar DK, Ayaru L, Sandanayake NS, Chapman MH, Dias A, Bridgewater J, Webster GJM, Bong JJ, Davidson

BR, Pereira SP. R0 but not R1/R2 resection is associated with better survival than palliative photodynamic therapy in biliary tract

cancer. Liv Internat 2011; 31: 99-107.

Sugumar A, Levy MJ, Kamisawa T, Webster GJM, Kim M-H, Enders F, Amin Z, Baron TH, Chapman MJ, Church NI, Clain JE, Egawa N,

Johnson GJ, Okazaki K, Pearson RK, Pereira SP, Petersen BT, Read S, Sah RP, Sandanayake NS, Takahashi N, Topazian MD,

Uchida K, Vege SS, Chari ST. Endoscopic retrograde pancreatography criteria to diagnose autoimmune pancreatitis: an international

multicentre study. Gut 2010 Dec 3 [Epub ahead of print].

Skipworth JRA, Morkane C, West NJ, Raptis DA, Deheragoda M, Imber C, Oldedamink S, Pereira SP, Malago M, Phillips RKS, Clark

SK, Shankar A. Pancreaticoduodenectomy for advanced duodenal and ampullary adenomatosis in familial adenomatous polyposis.

HPB 2011 (in press).

Friend E, Yadegarfar G, Byrne C, Johnson CD, Sezer O, Pucciarelli S, Pereira SP, Chie W-C, Banfield A, Ramage J, on

behalf of the EORTC Quality of Life Group. Development of a questionnaire (EORTC module) to measure quality of life

in patients with cholangiocarcinoma and gallbladder cancer, the EORTC QLQ-BIL21. Br J Ca 2011 (in press).

Boswell S, Sharif S, Alisa A, Pereira SP, Williams R, Behboudi S. Induction of LAP (TGF-β) expression on CD4+ T cells

reduces TLR4 ligand-induced TNF-α production in a TGF- β dependent manner. Immunology 2011 (in press).

Horsfall L, Rait G, Walters K, Swallow DM, Pereira SP, Petersen I. Association between bilirubin and oxidative stress

mediated diseases in a large UK primary care cohort. JAMA 2011 (in press).

EDITORIALS

Pereira SP, Bridgewater J. Photodynamic therapy - light at the end of the bile duct? PhotoDiag PhotoDynam Therap 2004;

1: 90-2.

Chapman MH, Pereira SP. Cholangiocarcinoma – improving biliary drainage with PDT. PhotoDiag Photodynam Therap

2009; 6: 82-3.

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LETTERS TO THE EDITOR

Matull WR, Khan SA, Pereira SP. Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on the incidence

of intra- and extrahepatic cholangiocarcinoma in the United States. J Nat Canc Inst 2007; 99: 407.

Webster GJM, Pereira SP. Mesh-metal stents for hilar cholangiocarcinoma. Gastrointest Endosc 2009; 6: 82-3.

Vasiliadis KV, Pereira SP. Diagnosis and management of GI stromal tumors by EUS-FNA. Gastrointest Endosc 2010; 71:

1102.

REVIEW ARTICLES

Dewar D, Pereira SP, Ciclitira P. Pathogenesis of coeliac disease. Internat J Biochem Cell Biol 2004; 36: 17-24.

Ayaru L, Bown SG, Pereira SP. Photodynamic therapy for pancreatic carcinoma: experimental and clinical studies.

Photodiag Photodynam Therap 2004; 1: 145-55.

Ayaru L, Bown SG, Pereira SP. Photodynamic therapy of pancreatic and biliary tract cancer. Internat J Gastrointest Cancer

2005; 35: 1-14.

Matull R, Pereira SP, O’Donohue J. Biochemical markers of acute pancreatitis. J Clin Path 2006; 59: 340-4.

Sgouros SN, Pereira SP. Systematic review: Sphincter of Oddi dysfunction — non-invasive diagnostic methods and long-

term outcome after endoscopic sphincterotomy. Aliment Pharmacol Therap 2006; 24: 237-46.

Prasad P, Wittmann J, Pereira SP. Endoscopic ultrasound of the upper gastrointestinal tract and mediastinum: diagnosis and

therapy. Cardiovasc Intervent Radiol 2006; 29: 947-57.

Siva S, Pereira SP. Acute pancreatitis. Medicine 2006; 35: 171-7.

Church NI, Pereira SP, Churchill D, Cairns S, Hatfield ARW, Webster GJM. Chronic pancreatitis: diagnosis and

management of complications. Gut 2007; 56: 1189-90

Skipworth J, Pereira SP. Acute pancreatitis. Curr Opin Crit Care 2008; 14: 172-8.

Hargunani R, Maclachlan J, Kaniyur S, Power N, Pereira SP, Malhotra A. Cross-sectional imaging of gastric neoplasia.

Clinical Radiol 2009; 64: 420-9.

Webster GJM, Pereira SP, Chapman RW. Autoimmune pancreatitis/IgG4-associated cholangitis and primary sclerosing

cholangitis – overlapping or separate diseases. J Hepatol 2009; 51: 398-402.

Sgouros SN, Vasiliadis KV, Pereira SP. Non-invasive assessment of portal haemodynamics and risk of variceal bleeding.

Aliment Pharmacol Ther 2009; 30: 965-76.

Behboudi S, Pereira SP. Alpha-fetoprotein specific CD4 and CD8 T cell responses in patients with hepatocellular carcinoma.

World J Hepatol 2010; 27: 256-60.

Huggett MT, Ghaneh P, Pereira SP. Drainage and bypass procedures for palliation of malignant diseases of the upper

gastrointestinal tract. Clin Onc 2010; 22: 755-63.

Skipworth J, Shankar A, Pereira SP. Managing acute and chronic pancreatitis. Practitioner 2010; 254: 23-7.

Baddeley RN, Skipworth JR, Pereira SP. Acute pancreatitis. Medicine 2011 (in press)

Baddeley R, Huggett M, Lovat L, Pereira SP. Light scattering spectroscopy for the detection of malignancy in the gastrointestinal tract. World J Gastroenterology 2011 (in press).

BOOK CHAPTERS

Pereira SP. Pancreatic and biliary tract carcinoma: any role for photodynamic therapy? In: Tytgat GNJ, Penninckx F. New

developments in diagnosis and management of early and advanced GI malignancy. John Libbey Eurotext, Paris, 2003,

pp 79-92.

Webster GJM, Pereira SP. Chapter 122: Diagnostic & Interventional ERCP. In: Weinstein WM, Hawkey, CJ, Bosch J.

Gastroenterology and Hepatology: the Modern Clinician’s Guide. Elsevier Science, London, 2005, 905-914.

Siva S, Johnson CD, Pereira SP. Endoscopic versus surgical drainage for chronic pancreatitis. In: Johnson CD. Pancreatic

diseases: the challenges. Springer Publishing, New York, 2010 (in press).

Bridgewater J, Pereira SP. Cancers of the gastrointestinal tract. In: Warrell DA, Cox TM, Firth JD, Benz EJ, eds. Oxford

Textbook of Medicine (5th

Edition). Oxford University Press, Oxford, 2010 (http://otm.oxfordmedicine.com).

Webster GJM, Pereira SP. Diagnostic & Interventional ERCP. In: Weinstein WM, Hawkey, CJ, Bosch J. Gastroenterology

and Hepatology: the Modern Clinician’s Guide. Elsevier Science, London, 2011 (in press).

BOOKS

Popat R, Adebayo D. One Stop Doc: Gastroenterology and Renal Medicine. Edward Arnold (Publishers) Ltd, Oxford, 2007,

240 pages. Pereira SP Editorial Advisor.

CLINICAL GUIDELINES

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Khan SA, Davidson BR, Goldin R, Pereira SP, et al. Guidelines for the diagnosis and treatment of cholangiocarcinoma:

consensus document. Gut 2002; 51 (Suppl VI): vi1-vi9.

Member Guideline Development Group. NICE Clinical Guidance 100. Alcohol-use disorders. Diagnosis and clinical

management of alcohol-related physical complications National Institute for Health and Clinical Excellence, June 2010

(268 pages).

PROCEEDINGS

Pereira, S. P., "Photodynamic therapy for pancreatic and biliary tract carcinoma" in Optical Methods for Tumor Treatment

and Detection: Mechanisms and Techniques in Photodynamic Therapy XVIII, edited by David H. Kessel, Proceedings of

SPIE Vol. 7164 (SPIE, Bellingham, WA 2009) 71640J.

Andreola, F., Cerec, V., Pereira, S. P., "Effect of verteporfin-PDT on epithelial growth factor receptor (EGFR) signaling

pathway in cholangiocarcinoma cell lines" in Photodynamic Therapy: Back to the Future, edited by David H. Kessel,

Proceedings of SPIE Vol. 7380 (SPIE, Bellingham, WA 2009) 73806P.

Cerec, V., Andreola, F., Pereira, S. P., "Effect of verteporfin-PDT on the Notch signaling pathway in cholangiocarcinoma

(CCA) cell lines" in Photodynamic Therapy: Back to the Future, edited by David H. Kessel, Proceedings of SPIE Vol.

7380 (SPIE, Bellingham, WA 2009) 73806J.

Pereira, S. P., Matull, W. R., Dhar, D. K., Ayaru, L., Sandanayake, N. S., Chapman, M. H., "Palliative photodynamic therapy

for biliary tract carcinoma may improve survival and has a similar outcome to attempted curative surgery with positive

resection margins" in Photodynamic Therapy: Back to the Future, edited by David H. Kessel, Proceedings of SPIE Vol.

7380 (SPIE, Bellingham, WA 2009) 73800V.

Sandanayake, N. S., Huggett, M. T., Bown, S. G., Pogue, B. W., Hasan, T., Pereira, S. P., "Photodynamic therapy for locally

advanced pancreatic cancer: early clinical results" in Optical Methods for Tumor Treatment and Detection: Mechanisms

and Techniques in Photodynamic Therapy XIX, edited by David H. Kessel, Proceedings of SPIE Vol. 7551 (SPIE,

Bellingham, WA 2010) 75510L.

Isabelle, M., O'Hara, J. A., Samkoe, K. S., Hoopes, P. J., Mosse, S., Pereira, S.P, Hasan, T., Pogue, B. W., "In vivo sampling

of Verteporfin uptake in pancreas cancer xenograft models: comparison of surface, oral, and interstitial measurements" in

Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX,

edited by David H. Kessel, Proceedings of SPIE Vol. 7551 (SPIE, Bellingham, WA 2010) 755116.

Zheng LZ, Spring BQ, Rai PR, Mai Z, Pereira SP, Pogue BW, Hasan T. PDT simultaneously with inhibition of EGFR and c-

Met pathways enhances treatment outcomes in experimental pancreatic cancer. In, Optical Methods for Tumor Treatment

and Detection: Mechanisms and Techniques in Photodynamic Therapy XX (David H Kessel, Ed). SPIE Proceedings Vol

7886.

Huggett MT, Baddeley RNB, Sandanayake NS, Webster GJM, Bown SG, Lovat LB, Gillams A, Pogue BW, Hasan T,

Pereira SP. Photodynamic therapy of pancreatic cancer and elastic scattering spectroscopy of the duodenal mucosa for

the detection of pancreaticobiliary malignancy (Proceedings Paper San Francisco, CA, Jan 2011). In, Optical Methods for

Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX (David H Kessel, Ed). SPIE

Proceedings Vol 7886.

January 2011