STENT DEGRADATION OF NOVEL FULLY BIOABSORBABLE SALICYLATE-BASED SIROLIMUS-ELUTING STENT EVALUATED BY...
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i2 SUMMIT A217.E2058 JACC March 9, 2010 Volume 55, issue 10A STENT DEGRADATION OF NOVEL FULLY BIOABSORBABLE SALICYLATE-BASED SIROLIMUS-ELUTING STENT EVALUATED BY OCT IN PIG CORONARY ARTERY i2 Poster Contributions Georgia World Congress Center, Hall B5 Monday, March 16, 2009, 9:30 a.m.-10:30 a.m. Session Title: Endovascular and New Technologies Abstract Category: New Technologies/Innovations Presentation Number: 2505-521 Authors: Daisuke Matsumoto, Toshiro Shinke, Sarah Geva, Nicolas Chronos, Refat Jabara, Saint Joseph’s Translational Research Institute, Atlanta, GA Background: Fully biodegradable stent is an attractive alternative strategy for current permanent metallic stents. We evaluated a novel, fully bioabsorbable sirolimus-eluting stent (8.3μg sirolimus/mm stent) synthesized entirely from salicylic-acid polymer in a animal model. Methods: Bioabsorbable balloon-expandable stents (n=33) were implanted in pig coronaries using QCA to optimize stent apposition. Animals underwent restudy and terminated at 1M, 3M, 6M, 9M and 12M. Thickness and area of each strut (implantation: 1273 struts, 1M: 640 struts, 3M: 585 struts, 6M: 625 struts, 9M: 530 struts, 12M: 319struts) were measured. And Intensity of each strut was also measured. Results: Average strut thickness and area at 1M was similar to post implantation (implant: 0.25mm, 0.14mm2, 1M: 0.26mm, 0.12mm2). Strut Thickness and area gradually decreased over time (3M: 0.23mm and 0.09mm2; 6M: 0.186mm and 0.07mm2, 9M: 0.179mm and 0.066mm2, 12M: 0.158mm and 0.055mm2, respectively, P<0.0001) On the other hands, once OCT signal intensity gradually become lower from 1M to 3M (1M: 6.06W, 3M; 5.92W, P<0.001), then gradually become higher from 3M to 6 M and again (6M: 6.16W, P<0.001). But there are no significantly difference between 6M, 9M and 12M (P=0.51, P=0.31) Conclusions: Degradation of a novel fully bioabsorbable salicylate-based stent was demonstrated by OCT. The size of this stent was remarkably decreased from 1M to 3M, 6M, 9M and 12M. But remarkable change about intensity was not observed from 6M to 9M and 12M.
Transcript of STENT DEGRADATION OF NOVEL FULLY BIOABSORBABLE SALICYLATE-BASED SIROLIMUS-ELUTING STENT EVALUATED BY...
i2 SUMMIT
A217.E2058
JACC March 9, 2010
Volume 55, issue 10A
STENT DEGRADATION OF NOVEL FULLY BIOABSORBABLE SALICYLATE-BASED SIROLIMUS-ELUTING
STENT EVALUATED BY OCT IN PIG CORONARY ARTERY
i2 Poster ContributionsGeorgia World Congress Center, Hall B5
Monday, March 16, 2009, 9:30 a.m.-10:30 a.m.
Session Title: Endovascular and New TechnologiesAbstract Category: New Technologies/Innovations
Presentation Number: 2505-521
Authors: Daisuke Matsumoto, Toshiro Shinke, Sarah Geva, Nicolas Chronos, Refat Jabara, Saint Joseph’s Translational Research Institute, Atlanta, GA
Background: Fully biodegradable stent is an attractive alternative strategy for current permanent metallic stents. We evaluated a novel, fully
bioabsorbable sirolimus-eluting stent (8.3μg sirolimus/mm stent) synthesized entirely from salicylic-acid polymer in a animal model.
Methods: Bioabsorbable balloon-expandable stents (n=33) were implanted in pig coronaries using QCA to optimize stent apposition. Animals
underwent restudy and terminated at 1M, 3M, 6M, 9M and 12M. Thickness and area of each strut (implantation: 1273 struts, 1M: 640 struts, 3M:
585 struts, 6M: 625 struts, 9M: 530 struts, 12M: 319struts) were measured. And Intensity of each strut was also measured.
Results: Average strut thickness and area at 1M was similar to post implantation (implant: 0.25mm, 0.14mm2, 1M: 0.26mm, 0.12mm2). Strut
Thickness and area gradually decreased over time (3M: 0.23mm and 0.09mm2; 6M: 0.186mm and 0.07mm2, 9M: 0.179mm and 0.066mm2,
12M: 0.158mm and 0.055mm2, respectively, P<0.0001) On the other hands, once OCT signal intensity gradually become lower from 1M to 3M
(1M: 6.06W, 3M; 5.92W, P<0.001), then gradually become higher from 3M to 6 M and again (6M: 6.16W, P<0.001). But there are no significantly
difference between 6M, 9M and 12M (P=0.51, P=0.31)
Conclusions: Degradation of a novel fully bioabsorbable salicylate-based stent was demonstrated by OCT. The size of this stent was remarkably
decreased from 1M to 3M, 6M, 9M and 12M. But remarkable change about intensity was not observed from 6M to 9M and 12M.
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