Stefano Rufini [email protected] Tel. 0672594370.
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Transcript of Stefano Rufini [email protected] Tel. 0672594370.
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Langmuir's monolayers (1920)
Langmuir showed that if phospholipids are dissolved in benzene they could be dispersed as a monolayer on the surface of water in a Langmuir trough.
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Gortner & Grendel's bilayers (1925)
These researchers extracted the lipid from the plasma membrane of RBCs and applied them to a Langmuir trough. They covered twice the area of the original membrane showing that natural membranes are bilayers.
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Source Protein (%w/w) Lipid (%w/w) Carbohydrate(%w/w)
Myelin nerve sheath 18 79 3
Erythrocyte 49 43 8
Chloroplast 70 30 0
Mitochondrion (inner) 76 24 0
Davison & Danielli's sandwich (1935)
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Robertson's unit membrane
Under the electron micrograph, this model appears acceptable: 7 nm thick, with lipid in the middle (white) and protein on outside (black)
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Singer-Nicholson fluid mosaic (1972)
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