Start (or continue) going to TA sections
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Transcript of Start (or continue) going to TA sections
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Lecture 6 Slides
Go to TA sections; challenge them!
Come to R’s and/or TAs office hours2130 Pac Hall Mon 2-3
Tue 2-3
details on course web site:
http://course.ucsd.edu/rhampton/bibc102
Warburg Effect
the Warburg effect is the observation that most cancer cellspredominantly produce energy by a high rate of glycolysisfollowed by lactic acid fermentation in the cytosol
Otto HeinrichWarburg
1931 Nobel Prizein Medicine
Warburg Effect
fig 14-10
Gettingother sugarsinto theglycolyticpathway
pg 545
A second route for fructose (in liver)
Glycogen: nature’s sugar bowl
fig 14-11 more about glycogen later
Liberating glucose units from glycogen
From glycogen to glycolysis…
phosphogluco-mutase
another mutase…
fig 14-1
Now what?
fig 14-1
Now what?
fig 14-1
Now what?
Fermentation: anaerobicmetabolism of glucosewithout oxidation...
pg 547
LDH converts pyruvate to lactate, restoring the pool of NAD+
pg 547
LDH converts pyruvate to lactate, restoring the pool of NAD+
pg 547
ethanol production: another NAD+ restoration strategy
fig 14-14
Thiamine pyrophosphate (TPP): an activated carbon
fig 14-14
Thiamine pyrophosphate in ethanol production
fig 14-14
TPP as a carbanionnucleophilein pyruvate metabolism
fig 14-14
TPP as a carbanionnucleophile in pyruvate metabolism
fig 14-14
TPP as a carbanionnucleophile in pyruvate metabolism
TPP-mediated enzymatic reactions
TPP is all about carbonyl activationtable 14-1
The glycolysis energy landscape
(pyruvate set to 0)
Regulated glycolytic enzymes
hexokinse (and glucokinse)
phosphofructokinase (PFK-1)
pyruvate kinase
regulated by G6P allosterically
liver isozyme is glucokinase, different
regulated by ATP, citrate, and fatty acids
The glycolysis energy landscape
(pyruvate set to 0)
regulation of hexokinase: isozymes can differ
fig 15-12
fig 15-14
PFK-1 :a rightfancy enzyme!
fig 15-14
PFK-1: allosteric regulation by ATP, etc…
PFK-1: allosteric regulation by ADP, etc…
xxx
fig 15-14
FPK-1 has multiple allosteric regulators
fig 15-14
Our book’s notation for regulators
inhibition activation
fig 15-14
PFK-1 has multiple allosteric regulators
fig 14-21
Glucose asa source ofother stuff
Pentosephosphatepathway
oxidative reactions
fig 14-21
Pentosephosphatepathway
oxidative reactions
fig 14-21
Pentosephosphatepathway
oxidative reactions
fig 14-21
Pentosephosphatepathway
oxidative reactions
fig 14-22
Pentose phosphate pathway: non-oxidative rxns
all movementof carbonyl groupsto and fro…
fig 14-22
Pentose phosphate pathway: non-oxidative reactions
2C
2C
2C
3C2C
3C
end of lecture 6
pg 547
LDHconverts pyruvateto lactate, restoring the pool of NAD+