(S,S)-2,3-Dihydroxy-2,3-dihydrobenzoic Acid: Microbial Access with Engineered Cells of Escherichia...

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2003 Carboxylic acids Carboxylic acids Q 0420 (S,S)-2,3-Dihydroxy-2,3-dihydrobenzoic Acid: Microbial Access with Engineered Cells of Escherichia coli and Application as Starting Material in Natural-Product Synthesis. — An efficient microbial synthesis of the title acid (II) is reported using methods of deregulating the metabolic flux in E. coli strains. (II) can easily be trans- formed into the enantiomer(V) of the plant-growth inhibitor streptol. — (FRANKE, D.; LORBACH, V.; ESSER, S.; DOSE, C.; SPRENGER, G. A.; HALFAR, M.; THOEMMES, J.; MUELLER, R.; TAKORS, R.; MUELLER*, M.; Chem. Eur. J. 9 (2003) 17, 4188-4196; Inst. Biotechnol., Forschungszent. Juelich GmbH, D-52425 Juelich, Germany; Eng.) — Jannicke 51- 093

Transcript of (S,S)-2,3-Dihydroxy-2,3-dihydrobenzoic Acid: Microbial Access with Engineered Cells of Escherichia...

2003 Carboxylic acids

Carboxylic acidsQ 0420 (S,S)-2,3-Dihydroxy-2,3-dihydrobenzoic Acid: Microbial Access with Engineered

Cells of Escherichia coli and Application as Starting Material in Natural-Product Synthesis. — An efficient microbial synthesis of the title acid (II) is reported using methods of deregulating the metabolic flux in E. coli strains. (II) can easily be trans-formed into the enantiomer(V) of the plant-growth inhibitor streptol. — (FRANKE, D.; LORBACH, V.; ESSER, S.; DOSE, C.; SPRENGER, G. A.; HALFAR, M.; THOEMMES, J.; MUELLER, R.; TAKORS, R.; MUELLER*, M.; Chem. Eur. J. 9 (2003) 17, 4188-4196; Inst. Biotechnol., Forschungszent. Juelich GmbH, D-52425 Juelich, Germany; Eng.) — Jannicke

51- 093