SRI KRISHNA PHARMACEUTICALS LIMITED - Welcome to...

PRE-FEASIBILITY REPORT

FOR TERMS OF REFERENCES

October, 2016

SRI KRISHNA PHARMACEUTICALS LIMITED PLOT NO. F-1,

MIDC CHINCHOLI,

TALUKA- MOHOL,

SOLAPUR DISTRICT

MAHARASTRA

Studies & Documentation By M/S Pridhvi Enviro Tech pvt. Ltd

Submitted by (MoE&F O.M – S.NO: 122, rev 46,

dated 5.10.2016) Sri Krishna pharmaceuticals Ltd, 184/C, Lawn House Plot No. F-1 Vengal Rao Nagar

MIDC, Chincholi Hyderabad-500038

Taluka Mohol Ph: 040-40179770

Solapur (D) Fax: 040-66730926

Maharastra E-Mail: [email protected]

SUBMITTED TO MINISTRY OF ENVIRONMENT & FORESTS, GOI

PARYAVARAN BHAWAN, CGO COMPLEX,

LODHI ROAD, NEW DELHI-110003

CONTENTS

S.No. Description Page No.

1 Introduction 1

2 Introduction of the project 2

Introduction of the company and the

proponent

3

3 Project Description 4

3.1 Production Capacity 4

3.2 Manufacturing Process 5

3.3 Raw materials 5

3.4 Water Requirement 5

3.5 Waste generation and control systems 6

3.5.1 Liquid effluents 6

3.5.2 Solid waste management 9

4 Site Analysis 10

4.1 Plant location 10

5 Planning in Brief 16

6 Resource requirement 16

6.1 Power requirement and Supply/ Source 16

6.2 Production facilities , Utilities and

effluent handling facilities

16

6.3 Land requirement 17

7 Air pollution 18

8 Bulk chemical storage 18

9 Base line data studies 19

10 Project financial 19

LIST OF TABLES

LIST OF FIGURES

LIST OF ANNEXURES

Table No. Description Page No.

1.0 Salient Features of the Project 2

2.0 List of Proposed Products 4

3.0 Water Balance Proposed 5

4.0 Solid Waste and Disposal 9

5.0 Utilities /ETP-Proposed 16

6.0 Land Statement 17

7.0 Emission Source Proposed 18

8.0 Storage facilities of bulk chemicals 18

Fig No Description Page No.

1.1 Schematic treatment scheme of high

TDS effluents

7

1.2 Low TDS Effluent Treatment System 8

1.3 Topo Map of the Study Area 12

1.4 Base Map of the Study Area 13

1.5 Photographs of current condition of the

site

14

1.6 Site layout plan 15

Annexure Description

I Typical Technical details of proposed products

II List of Raw materials

Pre-Feasibility Report Sri krishna Pharmaceuticals Limited, Plot No. F-1

1

1. Introduction

Sri Krishna Pharmaceuticals Ltd., engaged in manufacturing of Active

Pharmaceutical Ingredients, and Intermediates was established in the year

1975. Research and Development forms the backbone of the organization with

state of the art instrumentation facilities. They have Five manufacturing sites in

India four in Telangana manufacturing bulk drugs & formulations and one in

Maharastra manufacturing Drug intermediates .

Sri Krishna Pharmaceuticals limited proposed to establish a new unit at

Plot. No. F-1, MIDC, Chincholi, Taluka-Mohol, Sholapur District,

Maharastra state.

The unit obtained TOR for the proposed unit from SEAC, Maharastra and

submitted draft EIA Report based on Model TOR’s on April 5th 2014. The

proposed unit is located in Notified industrial Area, MIDC, Chincholi, As

the unit is within 5 KM from the proposed eco sensitive zone of the Nanaj

Sanctuary Great Indian Bustard sanctuary.

In the year 2014, Hon. Supreme Court had given directions to all State

Govts. to finalize the ESZs for all the PAs coming under them. Further,

directions were given by Hon. Supreme Court that in absence of finalized

ESZ or for a period till the ESZ gets finalized, a distance of 10 Km from

the boundary of PA would be treated as ESZ.

Under such circumstances, as per the provisions in MoEF notification

dated 14.09.2006, any project in Cat. B coming in ESZ of a Protected

Area would be treated as Cat. A and hence the State Level EIA Authority

rejected the case and advised the company to approach MOEF in Delhi for

the clearance


2

Hence this application is made for obtaining fresh TOR. As the unit is

located in IE, Chincholi which is notified industrial area established prior

to 2006 notification, Public hearing may be exempted for this unit.

In order to meet the market demand it is now proposed to manufacture 6

API’s with a production capacity of 2545 TPM.

2. Introduction of the Project

The proposed unit is to manufacture Bulk Drugs (APIs) to a tune of 1250

TPA. The salient features of the project are described in the table given

below

TABLE 1.0

Salient Features of the Project

Location F-1, MIDC Chincholi (V), Mohol (Taluk), Solapur (district), Maharashtra

Longitude and Latitude 17o46’20.9’’ N 75o 48’13.0’’ E 17o46’35.3’’ N 75o 48’12.9’’ E 17o46’35.2’’ N 75o 48’05.3’’ E

17o46’20.6’’ N 75o 48’05.5’’ E

Product Category 5(F) Bulk Drugs & Intermediates

Project Category as per EIA notification

Category A (located within 5 Km distance from the proposed ESZ of GIB Nanaj Sanctuary)

Proposed Activity Drugs & Drug intermediates- 2545 TPM

Total investment on the plant Rs. 125 Crores

Total Investment on

Environmental Infrastructure

Rs. 8 Crores

Total area of the plant 25.0 Acres

Total area of green belt 9.3 Acres

Water requirement Total water requirement for project will be 1430 KLD. Fresh water requirement- 973 KLD Recycled water- 457 KLD

Source of water MIDC, Chincholi.

Nearest habitation and distance from the site

Chincholi Village-0.97 Km from the site (S)

Nearest surface water bodies Nanaj Odha is at a distance of 0.83 km from the site

Nearest reserve forest There are no reserve forests in 10 km radius from the site

Environmentally sensitive None


3

areas within 10 km radius

Any national parks, wild life sanctuaries within 10 km

radius

GIB Nanaj Sanctuary is at a distance of 7.68 Kms from the site.

Proposed ESZ of GIB Nanaj Sanctuary- 1.84 Kms

Nearest air port and distance Solapur Airport- 21.3 km

Nearest railway station and distance

Pakni Railway Station-5.76 km

National Highway NH 9 is at a distance of 3.1 Km from the site

i) Introduction of the company and proponent

Sri Krishna Pharmaceuticals Ltd., engaged in manufacture, custom

manufacturing of Active Pharmaceutical Ingredients, and Intermediates was

established in the year 1975. Research and Development forms the backbone of

the organization with state of the art instrumentation facilities. They have four

manufacturing sites in India with a cumulative monthly production capacity of

200 TPM of chemical entities (APIs and APIs formulations about 710 TPM). Sri

Krishna have handled a wide spectrum of chemical unit processes significantly

being plant scale column chromatography, carbohydrate chemistry, natural

product extraction and other complex synthetic chemical reactions for high

purity compounds.

The company recognized the vital role of R & D for becoming successful in the

generic market. The proposed project under consideration would be located at

Plot No. F-1, MIDC, Chincholi, Taluka -Mohol, Dist. Solapur, State –Maharashtra.

state.

The company has Headquarter in Hyderabad, India, and is catering to the ever

growing demand of Active Pharmaceutical Ingredients (API’s) from single State-

of-the-art manufacturing facility. Already established unit in Chincholi MIDC

(Maharashtra) and has built up a reputation for excellence on the foundations of

consistent high quality, a constantly expanding product portfolio and timely

launches of new API’s.

The in-house QC Laboratories are equipped with sophisticated instruments to

assure the quality of the raw materials, intermediates and API’s. The company

believes in quality by design and continuous improvement in all aspects of its

operations. By this endeavor, Sri Krishna Pharma necessitates to recognize in

the global market of Pharmaceuticals as an important partner for API’s.


4

About Proponent

The management at Sri Krishna Pharmaceuticals Limited consists of highly

qualified and richly experienced persons who have given the company the edge

in terms of quality, consistency, timely delivery and ability.

The Group is headed by a technocrat with academic excellence. Dr. V.V. Subba

Reddy, Founder Chairman is a Post Graduate in Technology, Doctorate in

Science and a Post-Doctoral fellow from National Cancer Institute, NIH,

Maryland, USA. He also serves various trade associations, Government bodies

and Institutions as a representative of the pharmaceutical industry in India.

Quality Management: Strict quality control measures, Good Manufacturing

Practices (GMP) are integrated throughout the manufacturing process to ensure

strict adherence to the quality parameters for both in-process and finished

products.

3. Project Description

3.1 Production Capacity SKPL intends to manufacture 2545 TPM of API (Bulk Drug & Intermediates)

products. Product wise capacity is given below:

TABLE 2.0

PROPOSED PRODUCTS & CAPACITY

S.No Name of the Products Quantity in TPM

Remarks

1A Paracetamol- 4 stages 400

Starting from PNCB -4 Stages

1B Paracetamol – 2 stages 1100

Starting from Penultimate stage-2 Stages

2 Ibuprofen 500

3 Metformin 500

4 Domperidone 15

5 Dextromethorphan Hydrobromide

20

6 Omega -3 10

Total 2545

By Product

1 Acetic Acid 1788 Generates in the process and sold to consumers

2 Soap 40.0


5

3.2 Manufacturing Process

Brief process description and process flow charts are given at Annexure I

3.3 Raw Materials List of raw material product wise is given at Annexure II

3.4 Water Requirement The water requirement for process, domestic, gardening, boiler feed & for

cooling water make up is about 1430.0 KLD. The source of water is already

available from existing water works of MIDC and the same is adequate and

satisfactory. The water balance for daily consumption is presented below.

TABLE 3.0 Water Balance–Proposed

S.

No

Stream Water

requirement in KLD

Waste

Water discharge in

KLD

Proposed Method

of Treatment and Disposal

1 Process 566.0 649.0 Stripper, MEE and ATFD (Condensate to RO) Stripper, MEE and ATFD (Condensate to RO)

2 Washings 10.0 10.0

3 Laboratory

washings

1.0 1.0

4 Scrubbers 50.0 50.0

5 Boiler 201.0 20.0 ETP followed by RO ( RO Reject to MEE)

6 DM/Softener 3.0 3.0

7 Cooling & Regeneration

510.0

51.0

8 Domestic 50.0 40.0 Sewage Treatment Plant & reused for

gardening & flushing’s

9 Gardening 39.0 -

Total 1430.0 824.0


6

3.5 Wastes generation and control systems

3.5.1 Liquid Effluents

As detailed in Table 3.0 waste water generation due to process, domestic,

scrubbers, boilers and other activities would be 824.0 KLD. The quantity of

process effluent from the proposed activity will be segregated as high TDS and

low TDS streams.

High TDS and High COD stream would be treated in stripper followed by

MEE and ATFD. The resultant sludge would be disposed to TSDF,

Hyderabad. The Low TDS stream would be treated along with MEE/ATFD

condensates in biological ETP followed by RO. The RO rejects would be fed

back to MEE. The Permeate from RO would be used for cooling tower

make up. Domestic effluents are treated in sewage treatment plant. Thus

the treatment system proposed is based on “Zero Liquid Discharge” (ZLD)

Concept.

The schematic diagrams of ETP proposed are given in Figure 1.1 and

Figure 1.2 below

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9

3.5.2 Solid wastes management

Hazardous and non - hazardous wastes generated from the proposed

project are detailed below. Mode of disposal are also identified and listed.

Adequate storage of hazardous waste is ensured at the site

TABLE 4.0

Solid Wastes and Disposal

S.No

Type of waste Schedule No.

Quantity in TPM

Disposal

Hazardous waste

1 ETP Sludge 34.3 30.0 CHWTSDF

2 MEE salts / ATFD salts and

inorganic residue

34.3 2511.0

CHWTSDF

3 Spent carbon 28.2 47.5 CHWTSDF

4

Distillation bottom Residue/process

sludge

20.3 412.4 Authorized cement Industries/ CHWTSDF

5 Spent solvents 28.5 52.0 CHWTSDF

6 Iron sludge 28.1 580.0 Authorized cement Industries

7 Waste oil 5.1 0.2 Authorized recyclers/

CHWTSDF

8 oil from process 5.1 10.0 Authorized recyclers/

CHWTSDF

9 E- Waste - 0.240 Send to E- waste Recycler

10 Used Lead acid

batteries - 2 Nos.

Return to supplier for

replacement in exchange

Biodegradable waste

1 ETP Bio sludge - 12.9 Composting and used as manure for

gardening


10

Non Biodegradable waste

1 Waste paper - 100.0

Kgs/month Sale

2 Corrugated boxes

- 500.0

Kgs/month Sale

3 Broken glass - 100.0

Kgs/month Sale

4 Decontaminated

used drums -

100.0

Kgs/month Sale

5 Decontaminated HDPE Bags

- 100.0

Kgs/month Sale

6 Coal ash - 280.0 Sale

CHWTSDF facility at Ranjangaon which is at a distance of 200 Km from

the site has agreed to cater the solid waste from the proposed site.

Transport of Hazardous wastes to TSDF is done by the CHWTSDF. In case

other hazardous wastes, authorized recyclers will transport the wastes.

4. Site Analysis

4.1 Plant Location

M/S Sri Krishna Pharmaceuticals Limited, F-1, MIDC, Chincholi(V), Mohol

(T), Solapur(D), Maharastra state. The site is situated at the following

Latitudes and longitudes

17o46’20.9’’ N 75o 48’13.0’’ E

17o46’35.3’’ N 75o 48’12.9’’ E 17o46’35.2’’ N 75o 48’05.3’’ E

17o46’20.6’’ N 75o 48’05.5’’ E

The land area of the plant is 25.0 acres. The nearest habitation from the

site is Chincholi (V) at a distance of 0.97 km. The nearest railway station

located at Pakni 5.76 KM from the Plant. GIB Nanaj Sanctaury which is

ecologically sensitive area is at a distance of 7.68 Km from the site and

the proposed Eco sensitive zone of GIB Sanctuary is at a distance 1.84

Km from the site. There are no reserve forests in 10 Km radius


11

Following are the surroundings of the site

North – MIDC Road and Tara Hydro laboratories

South –MIDC Road

East – Road followed by LR indust–ries

West - Open land and Challa Chlorides

Topo graphic features of the site and 10 KM study area and base map are

given at Fig 1.3 & 1.4.

Plant & Green Belt Photographs are given at Fig. 1.5

Site lay out map is given at Fig 1.6

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16

5.0 Planning in Brief

The project is envisaged to be completed by November 2017, and the

production shall be initiated thereon. Consultants are identified for

preparing the detailed project report.

6. Resource requirements 6.1 Power Requirement and Supply/Source

The total power requirement for this proposed project will be 6000 HP.

The required power connection is available from MSEDCL.

In case of emergency, backup of three nos. of DG sets of capacity 1000

KVA each are proposed with acoustic enclosure.

6.2 Production facilities, Utilities and effluent handling facilities

SKPL it is proposed to arrange the production facilities, utilities and

effluents treatment infrastructure with an investment of Rs.125.0 Crores.

The details are outlined in the below table

TABLE 7.0

Production facilities/Utilities/ETP –Proposed

S.NO Details Capacity/

No Proposed

Production facilities

1 Production Blocks Nos 5

2 Clean rooms Nos 1

3 Boiler (coal Fired) TPH 2 x15 & 1x10*

4 DG sets KVA 2 X 1000

5 Cooling tower TR 5000

6 Softener/DM plant M3/hour 2.5

7 Fresh water RO Plant M3/hour 2.5

Effluent handling & treatment facilities

8 Collection tanks-

Storage

KL 400

9 Neutralization tanks KL 10

10 Stripper, MEE, ATFD KLD 2 X 400

11 RO & Biological

treatment

KLD 600

12 Sewage treatment plant KL 40

* 1 X 10 TPH Boiler is stand by boiler


17

6.3 Land Requirement

The unit is proposed to build the plant in 25 Acres of land and out of which

6.0 acres will be built up area and 9.3 acres of green belt will be

developed. Below table provides the land statement. Detailed site lay out

plan outlining proposed activities is given at Figure 1.6

Table 8.0 Land Statement

S.No Purpose Units Extent

1 Built up area Acres 6.0

2 Green belt Acres 9.3

3 Open area Acres 9.7

Total Acres 25.0

7.0 Air Pollution

The Proposed sources of air emissions from the plant are 15 TPH coal

fired Boilers two in number and 10 TPH boiler and 3 X 1000 KVA DG sets.

The process emissions containing Acetic acid & HCl are scrubbed with

caustic and scrubbed waste send to MEE. Below Table gives proposed

emission sources from the plant

Table 9.0 Emission Source Proposed

S.No Proposed Capacity Fuel Anticipated emissions

Control system

1 Process --- -- Acetic acid fumes, HCl

Scrubber

2 Boiler

Stack

15 TPH

(2 nos)

Coal

SPM,SO2 &NOx

Stack Ht 47

meters, cyclone &

Dust collector

3 Boiler

Stack

10 TPH Coal SPM,SO2

&NOx

Stack Ht

41.5 m

cyclone & Dust collector

4 DG sets 3 X 1000

KVA

HSD SPM,SO2

&NOx

Stack height

of 6.3 meters & acoustic

enclosure


18

8.0 Bulk Chemical Storages:

Following bulk chemical storage facilities are proposed

Table No 10.0

Storage facilities of bulk chemicals

S.No Name of the Solvent MOC No Of

Tanks

Storage

Quantity

1 Isopropyl alcohol MS 1 20KL

2 Isobutyl Benzene MS 1 20KL

3 Isobutyl Acetophenone MS 1 20KL

4 Isopropyl Chloro

acetate

MS 1 20KL

5 Acetone MS 1 20KL

6 O-Xylene MS 1 20KL

7 Toluene MS 2 40KL

8 Methanol MS 1 20KL

9 MIBK MS 1 20KL

10 Caustic Lye (48%) MS 2 50KL

11 Sulphuric Acid MS 1 25KL

12 Acetic anhydride Aluminum 4 100KL

13 HCl PP-FRP 2 50KL

14 Liquor ammonia 25% MS 1 25KL

15 Acetic acid SS 4 100KL

16 Ammonia-LIQ cylinders 1 25KL

9. Baseline data studies

We have a unit at B-14/2 in MIDC Chincholi which is in the same MIDC

of the proposed site for which baseline data has been collected during the


19

period of April 2016 to June 2016 so we request you to kindly allow us to

consider the same data for current study.

10. Project Financial

The estimated cost of the proposed project is approximately 125 Crores.

Out of this Rs. 8.0 Crores will be for effluents treatment facilities and rest

for other process equipment and safety equipment

Project cost

Rs. In

Crores

Plant& machinery 50.0

Civil & Structural 20.0

Total 70.0

Pipe lines & insulation

20% on plant &

machinery 14.0

Electricals & instrumentation 10% on plant & machinery 7.0

Erection & commissioning &

painting

8% on plant & machinery and

structures 5.6

Safety & Environment 10.0

Furniture, fixtures, computers, lighting etc 0.5

Total 107.10

Contingencies & pre-operative expenses 17.5

Project cost say 125 Crores

Annexure I

Typical technical details of the proposed products

PARACETAMOL

Process description and flow sheets

Brief manufacturing process of Paracetamol

Stage-1 (Hydrolysis)

Para Nitro Chloro Benzene is treated with aqueous sodium hydoexide at a temperature of 135-

140oC in an autoclave and neutralized with sulphuric acid to get Para Nito Phenol.

Stage- 2 (Reduction)

Para Nitro Phenol is reduced in boiling water under mild acidic condition with iron poweder

and acetic acid to get Para Amino Phenol,

Stage -3 (Acetylation)

Para Amino Phenol is condensed with Acetic Anhydride in aqueous medium to get

paracetamol and acetic acid.

Stage-4 (Purification)

Paracetamol technical is dissolved in hot water, treated with carbon, crystallized to get

Paracetamol with is dred, milled and packed in LDPE lined HDPE bags.

CHEMICAL PATHWAY OF PARACETAMOL SYSNTHESIS

Stage I -P-Nitro Phenol:

Cl

+ 2NaOH + NaCl + H2O

ONa

NO2

161

NO2

PNCB

157.5

Step 2.

ONa

NO2

161

+ 0.5 H2SO4

OH

NO2

+ 0.5 Na2SO4

0.5 x 142

139

Step 1.

2 x 40 58.5 18

Para Nitro Phenol

(PNP)

OH

NO2

+ 18 Fe + 7H2O+ 9FeO + 3Fe3O4+ xCH3COONa + xH2O

82

7 x 139

18x55.84 7x18xCH3COOH + xNaOH

OH

NH2

7 x 109

60 40 6Fe3O3.5(Av)

6 x 223.52

7

Stage -II - P-Amino phenol:

PNP Para Amino Phenol

(PAP)

18

O

O

S T A G E I II - P a ra c e ta m o l T e c h n ic a l

O H

N H 2

+C H 3 C

O

CC H 3

O H

N H C O C H 3

+ C H 3C O O H

6 0

1 5 11 0 21 0 9

P A P A c e tic A n h yd r id e P a ra c e ta m o l

S ta g e - IV - P a ra c e ta m o l P h a rm a

O H

N H C O C H 3

O H

N H C O C H 3

+ S pen t ca rbonA ctiv e C a rbon

Ph a rm a M L

PARACETAMOL

PROCESS FLOW DIAGRAM

4-Nitrochlorobenzene

Caustic soda Lye

Water

Stage I

Sulphuric acid

Aq layer

PNP

PAP ML / Water

Dilute Acetic acid

Iron powder

Caustic soda Lye

Stage II

Iron sludge

Hydros

SMBS Aq layer

PAP PAP ML

Pharma ML

Acetic anhydride

Soda ash

EDTA

Hydros

SMBS

Stage III

Hydrolysis

Conversion of PNCB to Nitrophenol

(PNP)

Neutralisation

Reduction

Conversion of PNP to

Aminophenol (PAP)

Filtration

candle filter

Cooling and Filtration

Pusher Centrifuge

Acetylation

Conversion of 4-Aminophenol

(PAP) to Paracetamol technical

Filtration

Pusher Centrifuge

Process water/Pharma ML

Soda ash

Activated carbon

Hydros

SMBS

Stage IV

Hydros Pharma ML

DM Water

Acetaminophen (Paracetamol) pharma (wet)

Carbon treatment

Filtration through Leaf

filter and Polishing filter

Recrystallisation

(cooling)

Filtration through

Agitated Nutsche Filter

Acetaminophen Technical

Annexure II

List of Raw Materials

List of Raw Materials of Paracetamol (Starting

from PNCB)

S.No Name of raw material

Qty

(Kgs/day)

1 PNCB 16062.7

2 Caustic Lye (48%) 8486.6

3 Sulphuric Acid 5998.5

4 Iron Powder 14476.4

5 Acetic Acid (20%) 6731.7

6 Acetic anhydride 10184.1

7 EDTA 13.3

8 Hydros 26.7

9 SMBS 13.3

10 Activated Corbon 120.0

11 Sodium Hydro Sulphite(Hydros)

13.3

12 Sodium Meta Bisulphite(SMBS) 13.3

13 Caustic flakes 93.3

List of Raw Materials of Paracetamol

(Starting from PAP)


Qty

(Kgs/day)

1 PAP (1% ) moisture) 29218.0

2 Acetic anhydride 28008.2

3 EDTA 36.7

4 Hydros 73.3

5 SMBS 36.7

6 Activated Corbon 329.9

7

Sodium Hydro

Sulphite(Hydros) 36.7

8

Sodium Meta

Bisulphite(SMBS) 36.7

9 Caustic flakes 256.6

List of Raw Materials of Metformin HCl


Qty

(Kgs/day)

1 Dicyanodiamide 8866.7

2 Dimethylamino hydrochloride 9566.7

3 Dimethyl formamide 11700.0

4 Toluene 6200.0

5 Methanol 2833.3

6 Activated carbon 533.3

7 Methanol 22700.0

List of Raw Materials of Domperidone

S.No Name of raw material Qty (Kgs/day)

1 Orthophenylene di amine(OPDA) 279.0

2 Methyl Aceto acetate(MAA) 299.5

3 Xylene 1196.0

4 Caustic lye 48 % 247.5

5 Carbon 18.5

6 Conc. HCl 30 % 368.5

7 1- bromo-3-chloro-propane 335.0

8 Toluene 1195.0

9 Potassium carbonate 315.0

10 Conc. HCl 30 % 320.0


12 N- Methyl Piperidone 360.0

13 Ethyl chloro formate 480.0

14 CS Flakes 290.0

15 Toluene 1295.0

16 Methanol 505.0

17 Raney Nickel 10.0

18 Ammonia gas 75.0

19 Hydrogen 5.0

20 DCNB 515.0

21 K2 CO3 300.0

22 Toluene 860.0

23 Potassium carbonate 150.0

24 Potssium chloride 160.0

25 Toluene 1435.0

26 Methanol 860.0

27 Raney Nickel 35.0

28 Hydrogen 15.0

29 Urea 255.0


31 Ammonium chloride 575.0

32 Carbon 5.0

33 Conc. HCl 30 % 210.0

34 Ammonia 30% 430.0

35 Soda ash 185.0

36 MIBK 1785.0

37 Methanol 4765.0

38 Carbon 20.0

39 Acetic acid 175.0

40 Ammonia 50.0

List of Raw Materials of Ibuprofen


Qty

(Kgs/day)

1 Mono Chloro acetic acid 11431.8

2 Iso propyl alcohol 8381.8

3 Sulphuric acid 4170.0

4 Sodium bi carbonate 822.2

5 Sodium carbonate 205.6

6 Isobutyl benzene 12884.5

7 Acetyl chloride 8530.3

8 Aluminum chloride 14641.5

9 Conc. Hcl 30% 1273.2

10 Liq Ammonia 25 % 1273.2

11 Sodium metal 3163.8

12 Isopropyl alcohol 41793.8

13 CS Lye 48% 14681.1

14 Sodium dichromate dehydrate 8796.5

15 Sulphuric acid 16204.0

16 Acetone 40741.5

17 N- Hexane 22685.6

List of Raw Materials of Dextromethorphan

Hydrobromide


Qty

(Kgs/day)

1 2-[1-Cyclohexyl) ethylamine 784.0

2 4- Methoxy phenyl acetic acid 862.7

3 O-xylene 3136.0

4 Phosphorous oxy chloride 1027.3

5 Sodium borohydride 192.7

6 C S lye 48 % 470.7

7 Toluene 1960.0

8 (-) Mandelic acid 687.3

9 Acetone 1764.0

10 Toluene 2085.3

11 Acetone 1254.0

12 C S lye 177.3

13 Toluene 957.3

14 Caustic 210.0

15 Methyl formate 462.7

16 Methanol 509.3

17 Toluene 816.7

18 Phosphoric acid 1474.0

19 Potassium hydroxide 400.0

20 Toluene 1936.7

21 Formaldehyde (40%) 62.7

22 Formic acid 78.7

23 Toluene 752.7

24 40% Hydroboric acid 431.3

25 Activated carbon 3.3

26 Toluene 880.0

27 Conc. HCl 441.3

List of Raw Materials of Omega-3


Qty

(Kgs/day)

1 Sea water 15984.0

2 Dextrose 8658.0

3 Toluene 3330.0

4 Crude oil 1332.0

5 Alkali Solution 666.0

SRI KRISHNA PHARMACEUTICALS LIMITED - Welcome to...

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