Therapeutic perspective of chronic hepatitis B and C in HIV-coinfected patients:

from recent advances in immunopathogenesis to the patient

March 31st - April 1st 2006Caravella Pinta HallSan Raffaele Congress CenterVia Olgettina, 58Milan

PresentationOn the threshold of the third decade of HIV infec-tion, the improved survival of patients due to the use of HAART in industrialised countries has led to greater weight being placed on some causes of co-morbidity. On of these is decompensated hepatopathy, which represents the second cause of death after AIDS.

Alhough the clinical management of HCV and HBV co-infections is becoming increasingly relevant in the treatment of HIV-positive subjects, there are still many barriers to hepatitic therapy due to both poor virologi-cal responses and possible interactions with antiretro-viral drugs. The results could be improved by strategies aimed at increasing the tolerability of pharmacological combinations as well as the effi cacy, defi ne of current therapies.

The need to come to terms with highly differed thera-peutic questions has encouraged us to organise a meeting of clinicians and researchers with the aim of defi ning clinical pathways that will improve the treat-ment of HIV-positive patients.

Based on the most recent immunopathogenetic and pharmacological fi ndings, the scientifi c programme will consider how the immunopathogenesis of viral hepa-titis and HIV infection affects the natural history of co-infections, how retroviral therapy affects HCV and HBV therapy, and how to defi ne the timing and treatment of the two infections in such a way as to ensure a better outcome by avoiding pharmacological interactions and viral drug resistance.

In addition to lectures by experts, the meeting will provide an opportunity for practical and interactive dis-cussions of clinical cases and most frequent problems encountered in clinical practice. The aim of this critical review of clinical behaviour is to identify shared thera-peutic pathways on the basis of the most recent thera-peutic and pathogenetic fi ndings.

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General InformationScientifi c SecretariatAdriano Lazzarin and Caterina Uberti-FoppaVita Salute San Raffaele University, Clinic of Infectious Diseases, Milan, ItalyVia Stamira d’Ancona, 20 · 20127 Milan · ItalyTel. +39 02 26437939Fax +39 02 26437030E-mail: adriano.lazzarin@hsr.it

caterina.uberti@hsr.it

Organizing SecretariatNadirex International SrlVia Riviera, 39 · 27100 PaviaTel. +39 0382 525735-14 Fax +39 0382 525736E-mail: ombretta.bollati@nadirex.comHttp: www.nadirex.com

Under the aegis ofVita Salute San Raffaele University, Milan

Congress VenueCaravella Pinta HallSan Raffaele Congress CenterVia Olgettina, 58 · Milan

AccreditationThis program has been CME accredited by the Ministry of Health

With support from

By public transport: Underground line 2, Cascina Gobba stop, then Underground railway for San Raffaele (or Bus for Milano 2 for those directed to Dimer).

From highways: Tangenziale Est - Cascina Gobba exit.Follow road signs. From Linate Airport: Given the short distance, taxi is the fastest trans-port.

Taxi: A taxi parking is in front of the hospital.

Taxi coordination of the Commune of Milano: free number 147 - 814781 Parking of Piazza Udine: tel. 022154972 Parking of Milano 2: tel. 022153924 Radio taxi: 02 5353 · 02 8383 · 02 8585

Underground Railway for San RaffaeleThe special ticket valid for the S.A.T. Cascina Gobba-San Raffaele Hospital.Connection costs 1,00 € and can be used for 2 runs within 24 hours. It is on sale in:

Station bar MM2 Cascina Gobba Allocation machines Station MM2 Cascina Gobba and station S.A.T. Cascina Gobba

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How to reach San Raffaele

Faculty March 31st, 2006

Welcome and Introduction A. Lazzarin (Milan)

SESSION I: HBV infection immunopathogenesis and treatment

Chairmen: V. Barnaba (Rome) - M. Levrero (Rome)

h 13,00 Immunopathogenesis of viral hepatitis B L. Guidotti (Milan) h 13,30 Immunopathogenesis of HIV G. Pantaleo (Lausanne) h. 14,00 Discussion

h. 14,15 Coffee Break

h 14,30 HBV coinfection in HIV seropositives: guidelines for clinical care Y. Benhamou (Paris)

h 15,00 Interactive discussion Case study 1 R. Bruno (Pavia)

h 15,30 Treatment options in chronic hepatitis B P. Lampertico (Milan)

h 16,00 Interactive discussion Case study 2 M. Viganò (Milan)

April 1st, 2006

Session II: HCV infection treatment

Chairmen: M. Mondelli (Pavia) - A. Craxi (Palermo) - A. Cargnel (Milan)

h 09,00 Immunopathogenesis of viral hepatitis C C. Ferrari (Parma)

h 09,30 Discussion

h 09,45 Treatment options in chronic hepatitis C (with particular attention to therapeutic options for diffi cult-to-treat patients)

M. Colombo (Milan)

h 10,15 Interactive discussion Case study 3 A. Aghemo (Milan)

h 10,45 Treatment algorithm for HCV in HIV coinfected patients V. Soriano (Madrid)

h 11,15 Coffee Break

h 11,30 Interactive discussion Case study 4 C. Uberti-Foppa (Milan)

h 12,00 Tolerance and management of adverse events M. Nuñez (Madrid)

h 12,30 Interactive discussion Case study 5 E. Angeli (Milan)

h 13,00 Closing remarks

Therapeutic perspective of chronic hepatitis B and C in HIV-coinfected patients:

from recent advances in immunopathogenesis to the patientto the patientMarch 31st - April 1st 2006

Caravella Pinta HallSan Raffaele Congress CenterVia Olgettina, 58Milan

To be sent by March 20th, 2006:Nadirex International Srl

Via Riviera, 39 · 27100 Pavia Tel. 0382 525735-14 · Fax 0382 525736E-mail: ombretta.bollati@nadirex.com

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Date Signature

Alessio AghemoDepartment of Gastroenterology and Endocrinology, IRCCS Maggiore Hospital, Policlinico Foundation, Mangiagalli, Regina Elena and University of Milan, Milan, Italy

Elena AngeliII Department Infectious Diseases, Luigi Sacco Hospital · Milan, Italy

Vincenzo BarnabaAndrea Cesalpino Foundation, Department of Internal Medicine, La Sapienza University of Rome, Italy

Yves BenhamouPitie´-Salpetrie`re Hospital, Service of Hepatology and Gastroenterology, Paris, France

Raffaele BrunoDivision of Infectious and Tropical Diseases, IRCCS San Matteo Hospital, University of Pavia, Pavia, Italy

Antonietta CargnelII Department Infectious Diseases, Luigi Sacco Hospital · Milan, Italy

Massimo ColomboDepartment of Gastroenterology and Endocrinology, Division of Hepatology, IRCCS Maggiore Hospital, University of Milan · Milan, Italy

Antonio CraxìUniversity of Palermo, Gastroenterology and Hepatology Unit, Palermo, Italy

Carlo FerrariDivision of Infectious Diseases and Hepatology, A. O. P., Parma, Italy

Luca GuidottiImmunopathogenesis of Liver Infectious Unit, DIBIT-San Raffaele Scientifi c Institute Milan, Italy

Pietro LamperticoDept. of Gastroenterology and Endocrinology IRCCS Maggiore Hospital, Fondazione Policlinico, Mangiagalli, Regina Elena, University of Milan · Milan, Italy

Adriano LazzarinVita Salute San Raffaele University, Clinic of Infectious Diseases, Milan, Italy

Massimo LevreroLaboratory of Gene Expression, Andrea Cesalpino Foundation, La Sapienza, University of Rome, Rome Italy

Mario MondelliInfectious Diseases Area, IRCCS Policlinico San Matteo - University of Pavia, Pavia, Italy

Marina NuñezDepartment of Infectious Diseases, Carlos II Hospital, Madrid, Spain

Giuseppe PantaleoDivision of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

Vicente SorianoDepartment of Infectious Diseases, Carlos II Hospital, Madrid, Spain

Caterina Uberti-FoppaVita Salute San Raffaele University, Clinic of Infectious Diseases, Milan, Italy

Mauro ViganòDept. of Gastroenterology and Endocrinology, IRCCS Maggiore Hospital, Policlinico Foundation, Mangiagalli, Regina Elena and University of Milan, Milan, Italy