(Souvenir) CHASCON 2020 · 2020. 12. 19. · CHASCON 2020 1 (Souvenir) CHASCON 2020 “Science and...
Transcript of (Souvenir) CHASCON 2020 · 2020. 12. 19. · CHASCON 2020 1 (Souvenir) CHASCON 2020 “Science and...
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(Souvenir)
CHASCON 2020 “Science and Technology Innovations”
USHERING IN THE ERA OF MAKE IN INDIA
14th CHANDIGARH SCIENCE CONGRESS (ONLINE MODE)
17-19 DECEMBER, 2020
ORGANISED BY
PANJAB UNIVERSITY, CHANDIGARH
In Association with
CHANDIGARH REGION INNOVATION AND KNOWLEDGE CLUSTER
(CRIKC)
chascon.puchd.ac.in [email protected]
mailto:[email protected]
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TEAM CHASCON WELCOMES
YOU TO E-SOUVENIR OF
CHASCON-2020
Patron:
Prof. Raj Kumar
Vice Chancellor
Panjab University, Chandigarh
Website: chascon.puchd.ac.in
Email: [email protected]
Coordinator
Prof. Desh Deepak Singh
Professor, Department of
Biotechnology
Panjab University
Sector-25, Chandigarh-160014
Email: [email protected]
Co-Coordinator
Prof. Sandeep Sahijpal,
Professor, Department of
Physics, Panjab University
Sector-14, Chandigarh-160014
Email: [email protected]
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CONTENTS
TITLE PAGE NUMBER
About CHASCON 4
About Panjab university 4
About CRIKC 5
Organizing committee 6
Team Chascon 2020 7
Messages 8
Speakers (Abstract of Talks) 17
Scientific Sessions
38
o Pharmaceutical Sciences 44
o Physical Sciences 72
o Mathematical Sciences 105
o Engineering and Management Sciences 123
o Life Sciences 141
o Earth and Environmental Sciences 170
o Basic Medical Sciences and Dental Sciences 196
o Chemical Sciences 238
Sessions: Panel Discussion 262
Acknowledgements 263
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ABOUT CHASCON 2020
Panjab University, Chandigarh in association with Chandigarh Region Innovation and Knowledge
Cluster (CRIKC) is organizing Chandigarh Science Congress (CHASCON-2020)- ONLINE MODE
from December 17th to 19th 2020 on the theme “Science and Technology Innovations: Ushering in
the era of Make in India” realizing that science and technology are the key elements in the
economic growth of Modern India.
Panjab University along with the CRIKC institutions has been organizing CHASCON every year
since 2007. The Congress has come a long way and continues to encourage the young and
innovative minds by providing them with a suitable platform for interaction with researchers,
academicians and industry leaders from all over the country. Several eminent scientists and experts
from various fields are expected participate and deliberate on the theme. The technical sessions will
comprise of plenary lectures, oral and poster presentations.
The 14th Chandigarh Science Congress would be an event to rejoice science and technology and
would showcase for what is being done and can be done in Chandigarh region to define the future
India.
ABOUT PANJAB UNIVERSITY
Panjab University (PU), established in 1882 at Lahore (Now in Pakistan) was shifted to
independent India in 1947. It is one of the four universities established in India before partition by
the then Federal Government. In 1956, PU shifted to Chandigarh and in 1966, after re-organization
of Punjab and was made as an Inter State Body Corporate under the Act of Parliament. PU is
imparting education to over 2.5 lakh students through its 78 teaching and research departments
located on the twin campus at Chandigarh and through 195 affiliated/constituent colleges spread
over Punjab and Chandigarh besides 4 Regional centers at Mukatsar, Ludhiana, Hoshiarpur and
Kauni.
PU has a long tradition of pursuing excellence in teaching and research in Science & Technology,
humanities, social sciences, performing arts and sports. By virtue of its history, experience,
achievements, and philosophy, PU has a national character and it enjoys an international stature
drawing both the faculty and students from all over the country and different parts of the globe. PU
faculty includes some of the most distinguished scientists and academicians. Over the years, the
reputation of the PU has grown to emerge as an institution at the pinnacle in innovative teaching,
research and community outreach. Its alumni include two former Prime Ministers and several past
and present cabinet ministers of the country, two Noble Laureates, a large number of Fellows of
various Academies, both in Science and Social Science, Theatre Artists, Actors. There is hardly any
sphere where the university has not made its mark. The university is ranked amongst the top
Universities in India and Internationally by various agencies/bodies.
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ABOUT CHANDIGARH REGION INNOVATION AND KNOWLEDGE
CLUSTER (CRICK)
Initiated by PU, the institutions in Chandigarh region called for the creation of Knowledge Cluster
in 2012, named as Chandigarh Region Innovation and Knowledge Cluster (crikc.puchd.ac.in) with
a view to expand technological innovations by close collaboration of academia and the private and
government sectors using accumulated knowledge. The ecosystem is expected to expand its
technological innovations in Chandigarh region on a global level. At present CRIKC has thirty
institutions from the region that are collaborating in various areas of National and Global priority.
The Govt. of India has recently recognized CRIKC model and is planning to create similar
knowledge
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ORGANIZING COMMITTEE
Chief Patron
▪ Prof. Raj Kumar
Vice Chancellor, Panjab University, Chandigarh
Advisory Committee
▪ Professor R K Singla, Dean University Instructions, Panjab
University (PU)
▪ Professor VR Sinha, Dean Research, PU
▪ Professor Prince Sharma, Dean Faculty of Science, PU
Organizing committee
▪ Professor Bhupinder Singh Bhoop, UIPS, PU
▪ Professor SK Tomar, Mathematics Department, PU
▪ Professor Rajat Sandhir, Biochemistry Department, PU
▪ Professor Archana Bhatnagar, Biochemistry Department, PU
▪ Dr. Ganga Ram Chaudhary, Chemistry Department, PU
▪ Professor Daizy Batish, Botany Department, PU
▪ Dr. Rohit Sharma, Microbial Biotechnology, PU
▪ Professor Desh Deepak Singh, Biotechnology Department, PU (Coordinator)
▪ Professor Sandeep Sahijpal, Physics Department, (Co-coordinator)
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Team CHASCON 2020
COMMITTEES NAMES
STUDENT
COORDINATOR
Manmehar Kaur
REGISTRATION COMMITTEE
1.
2.
3.
4.
5.
6.
Divyanshu Bansal
Maitri
Riya Sharma
Vasudha Sharma
Drishti Moudgil
Harshita
SOUVENIR
1.
2.
3.
4.
5.
6.
Riya Rani
Janvi
Pallavi
Eshita Jain
Harshita
Gurleen Kaur
CERTIFICATE COMMITTEE
1.
2.
3.
4.
5.
6.
7.
Pulkit Sharma
Magnolia
Akanksha Nayyar
Varinda
Prabhnoor
Gautam Pandey
Brinder
ORATION COORDINATORS
1.
2.
3.
4.
5.
6.
7.
8.
Lovepreet Singh
Manmeher Kaur
Pooja Aggarwal
Mahima Arora
Harshita
Amandeep Singh
Nimisha Raina
Richika Arora
SESSION COORDINATORS
1.
2.
3.
4.
5.
6.
7.
Gurleen Kaur (Basic Medical Science and Dental Science)
Nimisha Raina (Life Sciences)
Maitri (Pharmaceutical Sciences and Earth and Environment
Sciences)
Pooja Aggarwal (Chemical Sciences)
Aman Murari (Physical Sciences)
Akanksha Nayyar (Mathematical Sciences)
Hrishika Raj (Engineering and Management Sciences)
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MESSAGES
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MESSAGE
Dear Colleagues
It is with great pleasure that I greet you on behalf of the Chandigarh Science Congress on
December 17-19, 2020 at Panjab University, Chandigarh in collaboration with Chandigarh Region
Innovation and Knowledge cluster (CRIKC). This year we came up with the theme: ““Science and
Technology Innovations: Ushering in the era of Make in India”.
Following its tradition, this year the congress again offers a wide range of highly interactive
sessions on the role of start-ups and New Education Policy (NEP) in creating environment for
innovations and further to discuss the related issues. This congress is a wonderful opportunity to not
only educate students and young researchers but also deepen understanding of changing ideas and
innovative methods of problem solving. We also expect to provide technical demonstrations, and
numerous opportunities for informal networking.
I am convinced that this is an excellent event for professionals that will allow you to learn many
new things as well as share your experience. See you at Chandigarh Science Congress!!!
Professor Ravinder Kumar Singla
Prof. Ravinder Kumar Singla
Dean University Instructions
Panjab University, Chandigarh
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MESSAGE
It is a matter of immense pleasure and pride that Panjab University (PU) in association with
Chandigarh Region Innovation and Knowledge Cluster (CRIKC) is hosting the Fourteenth
Chandigarh Science Congress from December 17-19, 2020 through online mode on the topic:
“Science and Technology Innovations: Ushering in the era of Make in India”. Several eminent scientists and experts from various fields will participate and deliberate on the
theme. Such Conferences provides jovial environment for the academicians and research scholars to
present their work and exchange their views and ideas with the fellow researchers. I am sure that
this conference will also ignite the young minds for innovation and motivate them to work towards
making country self sufficient and self reliant.
I take this opportunity to congrats the organizing team of CHASCON and CRIKC institutions for
making this Fourteenth Chandigarh Science Congress possible, despite this unprecedented situation
due to COVID-19.
I extend my best wishes for the success of the conference.
Professor V R Sinha
Professor V R Sinha
Dean Research
Panjab University
https://en.wikipedia.org/wiki/Panjab_Universityhttps://creativecommons.org/licenses/by-sa/3.0/
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MESSAGE
CHASCON (Chandigarh Science Congress) unequivocally has become the face of Panjab
University’s scientific academia. Since its inception, CHASCON has grown from strength to
strength and has blossomed from regional to national to international event hosting academic
luminaries from across the globe. CHASCON-2020, an three days event from Dec.17-19, has been
aptly titled in line with the Honorable Prime Minister’s wishes to make India an “Atamnirbhar”
country through science and technology innovations and is believed to encompass academic
sessions for all walks of science, including “Start-Up and Entrepreneurs” and “COVID-19
Vaccines” and “New Education Policy”. This year’s CHASCON is being organized online, one of
the positive fallouts of Covid-19 pandemic, and is being endeavored as a “NO PENNY SPENT”
event.
I wish CHASCON-2020 a great success.
Prof. Prince Sharma
Prof. Prince Sharma Dean Faculty of Science Panjab University
https://en.wikipedia.org/wiki/Panjab_Universityhttps://creativecommons.org/licenses/by-sa/3.0/
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Prof. S.K. Mehta
Coordinator, CRIKC
Professor, Chemistry
Department, Panjab University
MESSAGE
On behalf of Chandigarh Region Innovation and Knowledge Cluster (CRIKC), It gives us immense
pleasure to extend our warm greetings to you all for hosting the 14th Chandigarh Science Congress
(CHASCON-2020) being held at Panjab University during 17-19th December, 2020. Ever since its
inception in 2013, CRIKC has been closely associated in taking the CHASCON agenda forward. It
needs to be mentioned that CHASCON aims and objectives are very much in sync with the CRIKC
objectives. Briefly the essential motto of CRICK is to foster and sustain close academic alliances
between institutions of higher education and research in the Chandigarh region, to facilitate
innovation and knowledge creation. Broadly speaking this is also the underlying objective of
holding CHASCON by Panjab University every year since 2007.
We are happy to note that CHASCON is an important event to promote the exchange of
knowledge, innovations and experiences for future developments of technologies in industrial
applications that address societal needs. The intensive deliberations during CHASCON would be
quite helpful in providing the researchers with the concepts and methods to plan, conduct, and
organize research activities. This will also an opportunity for young researchers to interact with the
renowned experts on a one to one basis, to clarify their doubts and questions leading to a healthy
interactive sessions. It also provides a very good opportunity to large number of researchers to
showcase their research activities, besides promoting interactions amongst the scholars from
different institutions of the region.
The 14th Chandigarh Science Congress entitled,’ Science and Technology Innovations:
Ushering in the era of Make in India’ is very much in accordance with our national priorities.
We are sure that the congress would bring large number of researchers from CRIKC
institutions on a common platform to take innovations in science and technology for the
benefit of our country. On the occasion, we would like to extend our best wishes to the organizers
as well as all the participants of CHASCON for grand success of the event.
Prof. S.K. Mehta and Prof. M.M. Gupta
Coordinators, CRIKC
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SPEAKERS
(ABSTRACT OF TALKS)
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Indian Planetary Missions
Abstract
The planetary exploration program in India started with the Chandrayaan-1 orbiter mission to the
Moon in 2008. This was followed by a mission to Mars, the Mars Orbiter Mission (MOM),
launched in November 2013 and arrival on Mars in September 2014. The second India mission to
Moon is the ongoing Chandrayaan-2 mission. India also has a planned mission to study Sun from
the L1 vantage-point called the Aditya-L1, as well as future planetary missions. This talk will
briefly discuss the Indian planetary missions, related challenges, and highlight the science derived
from them.
Dr. Anil Bhardwaj
FNA, FASc, FNASc
J. C. Bose National Fellow
Director, Physical Research
Laboratory, Ahmedabad
Email: [email protected]
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Professor Amulya K Panda a leading expert in field of vaccine development in the country will talk
on challenges in vaccine development and way forward.
Professor Amulya K Panda
Director, National Institute of
Immunology, New Delhi
Email: [email protected]
Challenges in Development of Vaccines
mailto:[email protected]
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ADVANCES IN CHEMICALTECHNOLOGY and CHEMICAL
ENGINEERING
Abstract
Chemical Industry is highly science based and has always been evolving. Catalytic Transformations
have brought out dramatic changes, starting with the synthesis of ammonia and have fetched many
Nobel Prizes. Some examples are ethylene to ethylene oxide, propylene to propylene oxide with
hydrogen peroxide, n-butane to maleic-anhydride, cat-cracking, platforming, etc. More recent
examples are metathesis, asymmetric synthesis, etc. Separation Technology has witnessed major
advances with the advent of Pressure Swing Adsorption, Chiral Engineering, Membrane
separations, including nano-filtration, Reactive Distillation/Extraction, Divided Wall Columns, etc.
Bio-transformations will make a major impact, particularly through Directed Evolution, and a
reference can be made for many intermediates for APIs and even vanillin, substitute for sandal
wood oil, etc. New Technologies will emerge to exploit renewable raw materials, including lignin
and renewable energy, etc. The future of the essential Chemical Industry is very bright and
celebrates science behind these ventures
Professor MM Sharma, FRS
Emeritus Professor of Eminence
Institute of Chemical Technology,
Mumbai
Email: [email protected]
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Impact of Carbohydrate Science in Innovation Niches
Abstract
The important chemical, biological and materials properties inherent in carbohydrates provide
immense wealth to value additions arising from these naturally-occurring biomolecules. Many
frozen technological advancements of carbohydrates rely on their structural properties and energy
storage capacities, glaring examples of which are the cellulose fibres and food starches,
respectively. Atomic view of these chemical entities will also reveal their fine constitutions and
these fine constitutions are rich source to unravel multitude of biological roles that sugars are
involved with in the maintenance and sustenance of life. Innovation niches are thus clear
possibilities arising from varied roles and properties of carbohydrates. Innovation niches pertaining
to healthcare, energy production and evolution of new materials are abound when utilizing
carbohydrates in general. Water-resistant cellulosic fibre and a paper resulting from thereof,
vaccine development and drug repositioning are some of the illustrative innovation niches. Many
innovative niches are in offing at scientific and technological frontiers. The lecture will endeavour
into bringing out some of the innovative niches arising from the science of carbohydrates.
Professor N. Jayaraman
Department of Organic Chemistry
Indian Institute of Science,
Bangalore 560 012
Email: [email protected]
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Immunogen design for a COVID-19 vaccine
Abstract
An affordable, efficacious vaccine against SARS-CoV-2, the causative agent of the ongoing
COVID-19 pandemic is essential to curb infections and minimize disease spread. Neutralizing
antibodies that prevent viral entry into host cells are currently the clearest correlate of protection
and are largely directed against the Receptor Binding Domain of the viral Spike protein. Most
current vaccines in clinical testing require low temperature storage, a major impediment to
widespread deployment. We describe a highly expressed, thermotolerant Receptor Binding Protein
derivative that induces titers of neutralizing antibodies well above those required for protection in
animal challenge studies, and higher than several vaccine candidates currently in clinical trials.
Such a subunit vaccine formulation holds great potential to combat COVID-19.
Professor Raghavan Varadarajan,
Molecular Biophysics Unit
Indian Institute of Science Bangalore
Email: [email protected]
mailto:[email protected]
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Sustainability and Drug Discovery and Development: Bridging the Gap
Abstract
Chemistry holds the centre stage of the drug discovery and development program.1 It is inherently
implied that the development of modern chemistry needs to be well integrated to the various facets
of drug discovery and development. In the context of modern development of chemistry addressing
sustainability is the key indicator leading to the cultural change under the slogan of green
chemistry. To keep pace with the modern developments in chemicals research and cope up with the
necessity of sustainable development2it is pertinent to continue to enrich medicinal chemists’
synthetic tool box.3The inadequate implementation of the modern developments of synthetic
methodologies in practicing medicinal chemistry4has been of concern and much talked about topic
due to its otherwise negative impact on new drug discovery narrowing down the chemical space
and hencelimitingthe IP (Intellectual Property) space as well. These indicate the necessity to bridge
the gap of modern chemistry development and the practices in new drug discovery for sustainable
medicinal chemistry research.5Towards this endeavour the present would showcase a few case
studies of sustainable approaches integrating the recent development of synthetic methodologies6 to
generate7and optimize8new therapeutic leads as well as new processes9of therapeutic agents.
References: 1. M. MacCoss, T. A. Baillie, Science, 2004, 303, 1810.
2. P. Tundo, P. Anastas, D. S. Black, J. Breen, T. Collins, S. Memoli, J. Miyamoto, M. Polyakoff, W.
Tumas, Pure Appl. Chem. 2000, 72, 1207.
3. S. D. Roughley, A. M. Jordan, J. Med. Chem. 2011, 54, 3451.
4. D. G. Brown, J. Boström, J. Med. Chem. 2016, 59, 4443.
5. M. C. Bryan, B. Dillon, L. G. Hamann, G. J. Hughes, M. E. Kopach,E. A. Peterson, M.Pourashraf, I.
Raheem, P. Richardson, D. Richter, H. F. Sneddon, J. Med. Chem. 2013, 56, 6007.
6. S. V. Chankeshwara, A. K. Chakraborti, Org. Lett. 2006, 8, 3259. G. L. Khatik, R. Kumar, A. K.
Chakraborti, Org. Lett. 2006, 8, 2433.A. K. Chakraborti, S. Rudrawar, K. B. Jadhav, G. Kaur, S. V.
Professor Asit K. Chakraborti
Department of Chemistry,
S. S. Bhatnagar Block, Main Campus,
Indian Institute of Technology-Ropar,
Rupnagar, Punjab 140001, India
Email: [email protected],
mailto:[email protected]
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Chankeshwara, Green Chem. 2007, 9, 1335. N. Parikh, D. Kumar, S. Raha Roy, A. K. Chakraborti,
Chem. Commun. 2011, 47, 1797.
7. K. Seth, S. K. Garg, R. Kumar, P. Purohit, V. S. Meena, R. Goyal, U. C. Banerjee, A. K.
Chakraborti,ACS Med. Chem. Lett. 2014, 5, 512.P. Shah, T. M. Dhameliya, R. Bansal, M. Nautiyal, D.
N. Kommi, P. S. Jadhavar, J. Padma Sridevi, P. Yogeeswari, D. Sriram, A. K. Chakraborti, Med. Chem.
Commun. 2014, 5, 1489.S. Pancholia, T. M. Dhameliya, P. Shah, P. S. Jadhavar, J. Padma Sridevi, P.
Yogeshwari, D. Sriram, A. K. Chakraborti, Eur. J. Med. Chem. 2016, 116, 187. T. M. Dhameliya, R.
Tiwari, A. Banerjee, S. Pancholia, D. Sriram, D. Panda, A. K. Chakraborti, Eur. J. Med. Chem. 2018,
155, 364.
8. K. Seth, P. Purohit, A. K. Chakraborti, Org. Lett.2014, 16, 2334; P. Purohit, K. Seth, A. Kumar, A. K.
Chakraborti, ACS Catal. 2017, 5, 2452.B. V. Pipaliya, A. K. Chakraborti, J. Org. Chem.2017, 82, 3767.
9. D. N. Kommi, D. Kumar, K. Seth, A. K. Chakraborti, Org. Lett.2013, 15, 1158. D. N. Kommi, D.
Kumar, A. K. Chakraborti, Green Chem. 2013, 15, 767.K. Seth, S. Raha Roy, B. V. Pipaliya, A. K.
Chakraborti, Chem. Commun. 2013, 49, 5886
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NMR approach to investigate glycan structure and function
Yoshiki Yamaguchi
Yoshiki Yamaguchi, Ph.D.
Laboratory of Pharmaceutical Physical Chemistry
Tohoku Medical and Pharmaceutical University
Address: 4-4-1 Komatsushima, Aoba-ku, Sendai,
Miyagi 981-8558, Japan
Email: [email protected]
Abstract
Glycans are highly diverse and the structural complexity has a great potential to work as signalling
molecule or functional modulator in biomolecular network system. To figure out the functional role
of each glycan, we believe structural glycobiology approach will play a significant role. Especially,
solution NMR spectroscopy is the only method to provide structure and dynamics of biomolecules
in solution at atomic level. We have developed an NMR method to analyse the structure and
dynamics of immunoglobulin G as a model glycoprotein (1) and the study is now expanded to
analyse glycan-lectin interaction (2) and glycolipid (3). I will present some of our activities working
on glycan structure and function by solution NMR.
(References)
1. Kato K, Yamaguchi Y, Arata Y. Stable-isotope-assisted NMR approaches to glycoproteins using
immunoglobulin G as a model system. Prog. NMR Spect. 56, 346-59 (2010)
2. Nagae M, Yamaguchi Y. Sugar recognition and protein-protein interaction of mammalian lectins
conferring diverse functions. Curr. Opin. Struct. Biol. 34, 108-15 (2015)
3. Kanie and Yamaguchi et al. Structural analysis of a novel lipooligosaccharide (LOS) from
Rhodobacterazotoformans. Carbohydr. Res. 473, 104-114 (2019)
mailto:[email protected]
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Opportunities in Nanotechnology
Abstract
Since the invention of the semiconductor transistor in 1947, the phenomenal progress in electronics
systems is enabled by the transistor scaling in the micro to nano regime coupled with very large
scale to giga scale integration, driven by storage and compute applications. It is contemplated that
nanotechnology and heterogeneous integration must drive the Moore's law in future. In addition,
with the advancement in Nanotechnology, the stage is now set for future Nanosystems to be
equipped with massive sensory functions, specifically with biological and chemical sensors, going
beyond conventional compute and storage paradigm. I will also present two case studies from our
research:
(i) Biosensor systems for point of care diagnostics: the story of managing the sensing of multiple
analytes in blood and urine with an eventual goal to realize "Lab on Palm"
(ii) Gas sensor systems for environmental monitoring, breath analysis and hazardous gas leakage
detection, with an eventual goal to realize the "Electronic Nose"
With this backdrop, I will end my talk with some thoughts on future challenges in achieving highly
complex Nano enabled Systems.
Professor Navakanta Bhat
Centre for Nano Science and
Engineering (CeNSE), Indian
Institute of science Bangalore
Email: [email protected]
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Ups and Downs in the Himalaya - using the ancient sedimentary record to
constrain Himalayan uplift and erosion
Abstract
The present-day bedrock geology of the Himalaya reflects the sum of its geological history of rock
formation and erosion, but an historical view of the evolution of the Himalaya requires us to infer
the previous history of rocks once deposited in the Himalaya but since eroded. This is challenging,
but is best addressed by looking at intervals of geological time that are widely represented both
across the orogen and laterally within it. The Neoproterozoic and Cambrian offers one such
interval, and is also represented in the Indian foreland basin and in outcrop on the cartoon itself.
This talk will present current understanding of the record of the northern India margin during that
interval and then consider when these rocks were uplifted and eroded, and how that might have
impacted global geochemical signatures many millions of years after these deposits themselves
formed.
Nigel Hughes
Dept. of Earth and Planetary Sciences
University of California, USA
Email: [email protected]
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Structural biology of coronaviruses
Abstract
The first report on a novel virus infecting the upper respiratory track and causing common cold like
symptoms in humans appeared in 1965. Two years later, electron micrographs of the virus revealed
that the virus particles resembled distorted spheroids of 70-80 nm diameter. It was named
coronavirus based on the appearance of the spike proteins protruding from the virus particles. The
protein capsid of coronaviruses is constructed from four proteins, the spike protein, the envelop
protein, the membrane protein and the nucleic acid associated protein. The capsids are also
surrounded by a bilayer lipid membrane. The size of coronavirus is large compared to common
human viruses such as polio virus, the particles of which possess icosahedral symmetry and have
diameters of ~ 30 nm. Infection by a novel strain of coronavirus was recognized in 2003 in the
Guangdong province of China which caused severe infection of the human respiratory track. The
virus strain was named Severe Acute Respiratory Syndrome coronavirus (SARS-coronavirus). This
initiated intense work towards determining the three-dimensional structures of coronavirus genome
encoded proteins. Another strain of corona virus was found to cause widespread infection in Saudi
Arabia (Middle Eastern Respiratory Syndrome MERS-coronavirus) and many other Arabian
countries. The 2019 pandemic of SARS coronavirus, Covid-19, is unprecedented in its impact. This
has resulted in an unbelievable volume of research on coronavirus encoded proteins in a short span
of time. The work on the structural biology of coronaviruses will be briefly discussed in this
presentation.
M.R.N. Murthy; [email protected]; [email protected]
Professor MRN Murthy
Distinguished Professor and
Astra Zeneca Chair,
Institute of Bioinformatics
and Applied Biotechnology
Biotech Park, Electronic
City Phase I,
Bengaluru 560100,
Email: [email protected]
mailto:[email protected]:[email protected]:[email protected]
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Clinical management of COVID and the way forward for innovation
Abstract
Covid pandemic struck the mankind as a bolt from blue. There was no preparedness in terms of
infrastructure, manpower, materials and human readiness to tackle this deadly disease. There were
not SOPs in the literature. The treatment and prevention guidelines changed almost on daily basis.
There was lot of panic amongst public as well as the health care workers.
As the first case of Covid positive with mild symptoms arrived in our hospital on 18th March, the
patient was treated in a private room. The SOPs were prepared by making a COVID care group so
that the patient is treated optimally as well as the disease is not spread to the relatives of the patients
as well as health care workers.
The protocols included round the clock monitoring of the patient in an isolation room, symptomatic
medicinal care, provision of proper diet, proper disposal of biomedical waste (BMW), sanitations of
the area at frequent intervals, provision of proper patient protective equipment (PPE) to health care
workers, education of the health care workers regularly, liaising with the administration regarding
reporting of the cases, contact tracing and quarantine of the family. The other tasks included setting
up and sprucing up the isolated ICU, starting of the testing lab, setting up of special operation
theatres, optimal management of air circulation/ air conditioning, running of the screening OPD,
restricting the entry points of the hospital so that patients with covid like symptoms can be traced,
Prof Ravi Gupta MS, FRCS, FACS, FAMS
(Medical Supdt);
Jyoti Kathwal PhD (Principal College of
Nursing),
Sonali Shamdasani DNB (Deputy Medical
Supdt)
Department of Hospital Administration,
GMCH Chandigarh
Email: [email protected]
mailto:[email protected]
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procurement of PPEs, sanitizers, drugs etc, provision of diet and refreshments to the HCWs
working tirelessly.
Due to curfew/ lockdown many health care workers were not able to commute from their homes to
hospital. So, provision of transport with special curfew passes as well as provision of in-house
accommodation for HCWs by converting one private room wing of the hospital into temporary
accommodation area was done. Also, three floors of one hospital block were ear marked for covid
patients to avoid mixing of COVID-19 and non-COVID-19 patients.
Every day the meeting of COVID-19 care group was held from 10 am to 12 noon to review the
SOPs on the basis of experience of team members as well as on the basis of ever-changing
guidelines from the literature and the government.
In addition to the COVID-19 care, the routine emergency care was also provided to emergency
patients who could be potential source of spread of virus. Hence all precautions of Covid
prevention were incorporated into the routine non covid care of patients as well. As the number of
cases increased and more sick patients started coming in, a special 100 bedded covid hospital (for
critically ill patients) was established in south campus sector 48 where in the provision of ICU beds
and oxygen was made in a record time due to the active efforts of all team members of the hospital
as well as the engineering department.
With further increase in the spike of the disease, another 155 beds were created in GMCH for
critically ill patients (total 255 including south campus). During all this time, there was a great
whole hearted support from Chandigarh Administration as well as Government of India for
providing all kinds of logistic, material and financial support like provision of 55 ventilators, PPE
kits etc. The situation of covid care of the tricity was monitored on daily basis by Chandigarh
Administration through video conferencing.
Till now, in GMCH we tested a total number of RTPCR 21885, out of which 3481 were positive
and --- total number of RAT 8488 and 537 positives.
Total patients screened in screening OPD were 11690.
Total number of admissions in GMCH main campus were 3969, out of which 1892 were positive.
No. of COVID positive patients admitted in GMCH South Campus were 330, in Sood Dharmshala
(CCC) were 1650 and in Dhanwantry Hospital were 820.
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Production of various microbial metabolites and use of enzymes and whole
cells for the process development
Production of various microbial metabolites and use of enzymes and whole cells
for the process development Uttam Chand Banerjee
Department of Pharmaceutical Technology, National Institute of Pharmaceutical Education &
Research
Sector – 67, SAS Nagar – 160062, Punjab, India.
The fermentative product, rifamycin B is biologically inactive and needs
chemical/biochemical transformation. One of the soil isolates, Curvularia lunata, was found
to have rifamycin oxidase activity. The growth and production of enzyme was fully
optimized in shake flask as well as in Fermenter with the determination of various kinetic
parameters of biotransformation. We had optimized the growth and streptokinase production
by Streptococcus equisimilis in 150 L bioreactor having 100 L working volume in controlled
pH and temperature. A highly activity phytase has been isolated, bioprocess was optimized
and technology was transferred to industry. One of the soil isolates, Pseudomonas putida
was found to produce ADI with higher specific activity. Process parameters were completely
optimized for the growth and production of ADI by P. putida. The cell disruption processes
by various methods were optimized and ultimately ADI was purified. Growth and production
of mycophenolic acid by Penicillium brevicompactum, growth and production of Shikimic
acid by Bacillus megaterium, Tachrolimus by Pseudomonas sp. and interferon beta by
Professor UC Banerjee
Professor & Head,
Pharmaceutical Technology
In-charge Biotechnology, NIPER,
SAS Nagar
Email: [email protected]
mailto:[email protected]
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recombinant E. coli were optimized in 10 L laboratory scale reactor. It is known that
chirality plays an important role in the efficacy of many drugs and agrochemicals. Among
different enzymes used for biocatalytic reactions, lipases, nitrilase, nitrile hydratase, epoxide
hydrolase and oxidoreductases have found to have tremendous applications. Pseudomonas
aeruginosa lipase mediated kinetic resolution of (RS)-1-chloro-3-(3,4-difluoro phenoxy)-2-
propanol to enantiomerically pure (S)-alcohol for the synthesis of a drug, lubeluzole was
achieved in our laboratory. Nitrilases from Alcaligens faecalis was used for the
biotransformation of racemic mandelonitrile. Further the A. faecalis nitrilase has been cloned
into a vector pJOE2775 and transformed into E. coli JM109 cells. Nitrilases produced in the
recombinant E. coli JM109 has been purified and formed into cross-linked enzyme
aggregates (CLEAs). Enantiopure α-hydroxy acids especially (R)-(-)-mandelic acid is a key
intermediate for the synthesis of several pharmaceuticals. A number of carbonyl reductase
producing microorganisms were isolated and screened from the soil using acclimatization
technique. The (S)-selective microorganisms were tried for the bioreduction of complex
heteroaryl ketone. Candida viswanathii MTCC 5158 has been found to be capable of
carrying out enantioselective reduction of a number of prochiral aryl ketones like
acetophenone, acetonaphthone, acetyl pyridine, acetyl thiophene and N, N-dimethyl-3-keto-
3- (2-thienyl)-1-propanamine (DKTP). Among all the strains, Metschnikowia koreensis
(MTCC 5520), Candida viswanathii MTCC 5158, Geotrichum candidum, Candida
parapsilopsis, and Candida melibiosa were selected on the basis of their ability to carry out
the (S)-selective reduction of ketones.
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Engineering Nanoelectronic Devices beyond the speed of conventional
Rectifiers
Abstract
Most efforts on graphene electronic devices have been made on graphene transistors. This is a very
challenging task and often requires generating a suitable bandgap in order to achieve a reasonable
on/off ratio while preserving the carrier mobility. In contrast to transistors, the functionality of
some types of diodes does not necessarily require a large bandgap. In particular, a nano-rectifier
known as the ballistic rectifier can greatly benefit from the extremely long carrier mean-free-path in
graphene while being not sensitive to the size of bandgap. Ballistic rectifier structures can be
fabricated by creating an asymmetric cross-junction in a single-layer graphene. A high mobility of
graphene ensures a mean-free-path well beyond that required for the device to operate in the
ballistic regime. This enables a very high intrinsic responsivity at room temperature. Taking
advantage of the four terminal device architecture in which the output channels are orthogonal to
the input channels, it is shown that the device noise is hardly influenced by the input and is mainly
limited by thermal noise, and this enables an exceptional noise-equivalent power in the order of
pW/Hz1/2 . High-frequency characterization and imaging experiments at hundreds of GHz have
also been carried out.
References
1. A. K. Singh, G. Auton, E. Hill, A. Song, Graphene based ballistic rectifiers, Carbon 84, 124,
2015.
2. G. Auton, J. Zhang, R. Kumar, H. Wang, X. Zhang, E. Hill and A. Song, Nature
Communications, 7, 11670, 2016
3. A. Garg, N. Jain, S. Kumar, S. R. Kasjoo, and A. K. Singh, Nanoscale Advances, 1(10), 4119,
2019.
4. A. K. Singh, S. R. Kasjoo, and A. M. Song, IEEE Trans. Nanotechnol., 13(3),527, 2014. 5. A.
Garg, N. Jain, and A. K. Singh, J. Comput. Electron., 17 (2), 562, 201
Dr. Arun Kumar Singh Dept. of
Electronics and Communication
Engineering, Punjab
Engineering College (Deemed to
be University, Chandigarh
(India)
Email: [email protected]
mailto:[email protected]
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Glycoimmunology: sugars on the fuss for improved
immunotherapies?
Abstract
The more we understand the immune responses, the more we ally it to specific glycan alterations,
and this has motivated the development of targeted immunotherapies. Our group has been
particularly interested in understanding how glycans expressed at the cell surface can interfere with
immunity. One of our interests has been the sialylated antigens, as sialyl Tn (STn) and sialyl Lewis
X. These are aberrantly expressed in several cancers and associated with aggressiveness and
immune tolerance. We developed novel antibodies which show high specificity against STn and its
derivatives, reacting with higher intensity to cancer tissue but not healthy tissues. These antibodies
are currently being explored for diagnostic purposes and have potential therapeutic applications.
Recently, it was found that SARS-CoV-2 infections also lead to aberrant expression of sialylated
glycans. These findings open an opportunity for re-purposing anti-tumour associated glycan based
therapies to fight viral infections.
In another perspective, we have inquiry patients/families with congenital disorder of glycosylation
for alteration in their immune responses. Our recent findings suggest that relevant immune
disfunction exist and relate to the disease aggressiveness.
In this talk, I will present an overview of the current ongoing project and latest results.
Paula Videira
Glycoimmunology Group @
UCIBIO
Departamento Ciências da Vida
Faculdade de Ciências e Tecnologia
Universidade Nova de Lisboa
2829-516 Caparica, Portugal
Email: [email protected]
http://sites.fct.unl.pt/glycoimmunology/homemailto:[email protected]
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Impact of Laser assistance on the accuracy of micro holes generated on
carbon reinforced composite using electrochemical discharge machining
Abstract
Electrochemical discharge machining (ECDM) is a prominent hybrid process for machining of
difficult to cut materials. In recent years, various research investigations have been attempted to
enhance the process capability of ECDM using further hybridization with ultrasonic, magnetic,
rotary assistance etc. In present work, an attempt has been made to enhance the process capability
of ECDM process by LASER assistance. The proposed technique explore the effect of LASER
assisted electrochemical discharge machining (LA-ECDM) on output quality characteristics such as
overcut and taper of hole. The purpose of low power LASER is assist the machining process by
localized heating of electrolyte. A comparative study has been performed between LA-ECDM and
ECDM process. Carbon fiber reinforced polymer composite was machined with four input process
parameters as tool diameter, tool travel rate, tool rotation and duty cycle. The investigation reveals
that overcut and taper of hole decreases approximately by 10–12 % with assistance of LASER. The
micro-hole machined by LA-ECDM exhibits superior machining quality in terms of circularity of
hole, dimensional accuracy and surface damages. SEM micrographs shows uniform distribution of
carbon fibers all along the machined surface. This improvement is attributed to formation of stable
and thinner gas film during machining. The behaviour of gas film and spark phenomenon during
ECDM and LA-ECDM has been investigated using high shutter speed camera.
Dr. Sarabjit Singh
Department of Mechanical
Engineering, Panjab Engineering
College, Chandigarh
Email: [email protected]
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Translation of Knowledge into Innovation
Abstract
Innovation is the main driver of modern economy. India ranks 48 in world ranking of global
innovation index. India is third amongst low middle-income group and is preceded by Vietnam (42)
and Ukraine (45). There is disparity in our ranking in Knowledge and creative output. India ranks
very high in terms of quality of scientific publications (21st globally) and the quality of its
universities (22nd) but ranks low in creative output (64). In creative output Vietnam is ranked at 38
and Ukraine at 44. From this it is obvious that having knowledge alone is not adequate. As a nation
we need to gear up in better translation of knowledge to innovation (Creative output). To translate
knowledge into innovation, there is a need for creative thinking and hard work. The process of
translating knowledge to innovation is not always successful. The failure rate is very high in
pharmaceutical innovation. In a talk fundamental of translating knowledge in to Innovation
successfully will be discussed. The journey of translating knowledge in to Innovative products will
be illustrated by three success stories in which author were involved:
1) K-M media for whole eye ball preservation: This allows preservation of whole eyeball using simple techniques and product. This was based on simple observation made by a
technician which led to knowledge creation and ultimately Innovation
2) Risorine for tuberculosis: This is based on a well-documented Ayurveda principal of enhancement of efficacy by TRIKTU. Further research using modern methods led to
piperine as a world’s first bio enhancer which when added to Rifampicin led to decreased
amount of rifampicin with improved safety profile and sustained bioavailability of
Rifampicin.
3) Sepsivac for gram negative sepsis and COVID-19 (Treatment and Prophylaxis): Sepsivac is an immunomodulator of Indian origin. Simple observation during its clinical development
led to exploration of its unique properties leading to its approval as an adjunct to gram
negative sepsis to reduce mortality. Looking at similarities between gram negative sepsis
and COVID-19 , it is being repurposed for COVID-19. Data suggest, Sepsivac is able to
a) provide prophylaxis against COVID-19 b) improve outcome in critically ill patients with covid-19. c) Modulated Platforms for Drug Delivery
Dr. Bakulesh Khamar
Executive Director,
Cadila Pharma, Ahmedabad
Email: [email protected]
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Modulated Platforms for Drug Delivery
Professor VR Sinha
Professor, UIPS, PU
Dean Research, Panjab University
Abstract
The delivery of drugs is a crucial factor in formulation development for the affective therapy. Most
of the formulations are for the immediate release of the drug. These formulations achieve quick
onset of action leading to rapid increase in the blood drug levels but having short duration of action.
This necessitates the multiple administrations to the drug resulting poor compliance in case of
chronic therapy. To overcome these limitations sustained release formulations were developed.
These systems provided multiple benefits viz. lower frequency of drug administration, extended
duration of action, lower side effects, improved patient convenience and compliance. First sustained
release formulation came in the market in year 1952. Further research was focused not only to
achieve extended release but also to control the release rate of the drug from the formulations.
Further targeting and site-specific delivery of the drug can reduce both the drug dose as well as
associated side effects. The modified release systems is utilized for delivery of drugs through
transdermal, buccal/sublingual, oral, parenteral, implantation, ocular, nasal pulmonary,
rectal/vaginal routes. Each route has its own advantages and limitations necessitating specific
design appropriate for delivery of the drug through the intended route of administration. Several
novel delivery systems which are in the market have been developed using several innovative
design, concept and modulation techniques for drug release. These modulated systems can
maximize therapeutic benefits.
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SCIENTIFIC SESSIONS
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S.
No.
Section Departments/Centres/Institutes Section coordinator
1 Basic Medical
Sciences and Dental
sciences
o Biochemistry o Biophysics o Biotechnology o Microbiology o Microbial Biotechnology o Dental Science (HSJIDS) o Stem Cell & Tissue
Engineering
o Human Genome o Systems Biology &
Bioinformatics
o Nuclear Medicine o Public Health
• Professor Jagat Bhushan (Dental Science)
• Professor AS Naura (Biochemistry)
• Professor Gurparkash Singh Chahal (Dental Science)
2 Life Sciences o Botany o Zoology o Anthropology o Forensic Science
• Professor DaizyBatish (Botany)
• Professor Harpreet Kaur (Zoology)
3 Pharmaceutical
Sciences
o UIPS • Professor Alka Bali
• Dr. Neelima Dhingra 4 Chemical Sciences o Chemistry • Professor Gurjaspreet Singh
• Professor Rohit Kumar Sharma
(Chemistry)
5 Physical Sciences o Physics o Nanoscience &
Nanotechnology
o Medical Physics
• ProfessorVipin Bhatnagar
• Dr. Lokesh Kumar (Physics)
6 Mathematic sciences o Mathematics o Statistics o Computer Sciences
• Professor Dinesh Khurana (Mathematics)
7 Engineering and
Management Sciences
o Engineering & Technology (UIET)
o Chemical Engineering and Technology (UICET)
o Sophisticated Analytical Instrumentation Facility
o University Institute of Applied Management Sciences
o University Business School o University Institute of Hotel &
Tourism Management
o Fashion Technology and Vocational Development
• Professor Savita Gupta
• Dr. Madhu Khatri (UIET)
• Professor Sanjeev Sharma (UIAMS)
8 Earth and
Environmental
Sciences
o Geology o Geography o Environmental Sciences
• Professor Rajeev Patnaik (Geology)
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Program for CHASCON-2020 (ONLINE MODE)
Day Program Title of Talk Time
17th December,
2020
(Thursday)
Inaugural function Prof. DD Singh,
Prof. Prince Sharma,
Prof. RK Singla, DUI, PU
Prof. Raj Kumar, Vice
Chancellor, PU
Chief Guest Lecture Prof.
Anil Bhardwaj, Director,
Physical Research Lab.
Ahmedabad
Program introduction
Lecture
Indian Planetary
missions
10-11.00 AM
Lecture
Prof. Amulya K Panda (Director, NII, New Delhi)
Challenges in
Development of
Vaccines'
11.00-11.45AM
Session
(Pandemics Covid-19)
Prof. MRN Murthy (Astra Zeneca Chair, IBAB,
Bangalore)
Prof. R Vardarajan (Molecular Biophysics Unit,
IISc, Bangalore)
Lunch
Prof. Ravi Gupta (Medical Superintendent,
Govt Medical College &
Hospital -32, Chandigarh)
Dr. Paula Videira Glycoimmunology Group @
UCIBIO, Departamento
Ciências da Vida, Faculdade
de Ciências e Tecnologia,
Universidade Nova de
Structural biology of
corona viruses
Immunogen design for
COVID vaccine
Clinical management of
COVID and the way
forward for innovation
Glycoimmunology:
sugars on the fuss for
improved
immunotherapies?
11.45-12.15PM
12.15-1.00PM
1.00-1.15 PM
1.15-2.00PM
2.00-2.45 PM
http://sites.fct.unl.pt/glycoimmunology/home
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Lisboa, 2829-516
Caparica, Portugal
Session (Chemistry
and drug discovery)
Prof. Yoshiki
Yamaguchi (Tohoku Medical and
Pharmaceutical University,
Japan)
Prof. AK Chakraborti (Department of Chemistry,
Indian Institute of
Technology-Ropar)
Prof. N Jayaraman
(Organic Chemistry,
IISc, Bangalore
NMR approach to
investigate glycan
structure and function
Sustainability and Drug
Discovery and
Development: Bridging
the Gap
Impact of Carbohydrate
Science in Innovation
Niches)
2.45-3.30PM
3.30-4.15PM
4.15-5.00PM
Lecture
Professor M. M.
Sharma, (Emeritus Professor of
Eminence
Institute of Chemical
Technology, Mumbai)
Advances in Chemical
Technology and
Chemical Enginnering
5.00PM-5.45PM
Panel Discussion
Start ups (Coordinator
Dr. Rohit Sharma,
Panjab University,
Chandigarh)
Panel members: Dr.Rohit Sharma, Project Leader,
BioNEST, Panjab University,
Chandigarh
Dr.Ashutosh Pastor, Manager
Incubation, FITT, IIT, New
Delhi
Dr. Malay Dixit, CEO, Piscium
Health Sciences,Pvt.
Ltd.,Mumbai.
Dr.Anasuya Roy, Founder
CEO,Nanosafe Solutions Pvt.
Ltd., New Delhi
Ms. Pragati Aggarwal, i-TTO,FITT,
IIT, New Delhi
5.45 PM-6.45PM
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Lecture
Prof. Nigel Hughes
(Dept. of Earth and
Planetary Sciences
University of California
Riverside)
Ups and Downs in the
Himalaya - using the
ancient sedimentary
record to constrain
Himalayan uplift and
erosion"
6.45 PM-7.30 PM
18th December,
2020 (Friday)
Scientific section
activities
E-posters, oral
presentations of selected
abstracts, subject specific
lectures
Full day activity
19th December,
2020(Saturday)
Session (Engineering
and Nano Science)
Prof. Navakant Bhatt (Centre for NanoScience and
Engineering (CeNSE), IISc,
Bangalore)
Prof. UC Banerjee (Department of
Pharmaceutical Technology,
NIPER, SAS Nagar, Panjab)
Dr. Arun Singh
(Deptt of Electroincs
and Instrumentation,
Panjab Engineering
College, Chandigarh)
Dr. Sarabjit Singh
(Department of
Mechanical
Engineering, Panjab
Engineering College,
Chandigarh)
Prof. VR Sinha
(Dean Research, Panjab
University)
Prof. SK Mehta, Prof.
MM Gupta, Panjab
Opportunities in
Nanotechnology
Production of various
microbial metabolites
and use of enzymes and
whole cells for the
process development
Engineering Nano
electronic devices beyond
the speed of conventional
rectifiers
Impact of Laser
assistance on the
accuracy of micro holes
generated on carbon
reinforced composite
using electrochemical
discharge machining
Modulated Platforms for
Drug Delivery
10.00AM-10.45AM
10.45-11.30AM
11.30AM-12.00PM
12.00 PM-12.30PM
12.30-1.00PM
1.00-1.30 PM
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University, Chandigarh CRIKC activities
Lunch 1.30-2.00PM
Panel Discussion
NEP2020;Gearing
Science education for
Self Reliant India
(Coordinator Prof.
Latika Sharma, Panjab
University, Chandigarh)
Panelists:
Prof. Sarit Das Director
IIT Ropar
Prof. Ashok Srivastav
Dean/ Advisor SVSU
Prof. Vanana Patravale
ICT Mumbai
Prof. Prakash Babu
University Of Hyderabad
2.00PM-3.00PM
Valedictory function
Prof. VR Sinha, Dean
Research, Panjab
University
Dr. Bakulesh Khamar,
Executive Director,
Cadila Pharma,
Ahmedbad
Compilation of
proceedings
Overview
Translation of
Knowledge in to
Innovation
3.00-3.15 PM
3.15-4.00 PM
4.00-5.30PM
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Pharmaceutical sciences
section
•University Institute of Pharmaceutical
Sciences
COORDINATORS:
Prof Alka Bali
Dr Neelima Dhingra
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REGISTRANTS
Sr. No.
Name Affiliation
1. Harinder Kaur UIPS
2. Monica UIPS
3. Sruthi Laakshmi m SRM college of pharmacy, SRM institute of science and technology
4. SubhajitMandal SRM college of pharmacy, SRM institute of science and technology
5. Khushboo University Institute of Pharmaceutical Sciences, Panjab University
6. Dr. Poonam Arora chitkara college of pharmacy
7. Vivek p Chavda L. M college of pharmacy
8. Shamandeep Kaur National Institute of Pharmaceutical Education and Research, Mohali
9. Alisha Sachdeva UIPS, panjab university, Chandigarh
10. Abhay Uiet, Panjab University
11. Arpan Sharma Uiet, Panjab University
12. Laxmi Gharti UIPS, PU-CHd
13. Neelima Dhingra UIPS, PU-Chd
14. Dr Ashok KumarYadav University Institute of Pharmaceutical Sciences, Panjab University
15. Dr Sangeeta PilkhwalSah UIPS, PU-CHd
16. AmitaSarwal UIPS, Panjab University
17. Gurpreet Singh UIPS, Panjab University
18. VanditaKakkar UIPS, Panjab University
19. Parina Kumari University Institute of Pharmaceutical Sciences, Panjab University
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ABSTRACT PARTICIPATION
Sr. No.
Name Institute Title
1. Sakshi UIPS Personalized Medicine: the new era
2. MansiPrashar UIPS Preparation and Characterization of
Norfloxacin Cocrystal
3. Harnoor Kaur UIPS 17a-aza-D-Homosteroids as 5alpha reductase inhibitors: synthesis and
characterization
4. Alka Kumari UIPS MAO inhibitors in contemporary treatment
of depression: current and future perspectives
5. Teenu UIPS QbD-enabled development of SLNs for Co-
delivery of sorafenib and crysin for improved biopharmaceutical performance
6. Nikhil Gupta LPU Jalandhar/Sunpharma Formation of sustained release mups
tablets of S (-) metoprolol succinate using wurster process
7. Preeti Shivalik college of pharmacy, Ropar
Nanoparticle drug delivery
8. B. Sivakumar UIPS Insilco docking studies of phytochemicals from adhatoda species against covid-19
target proteins
9. Ayush Jain Dr. H.S.J.I.D.S, Sec25, P.U,
Chandigarh Towards Building Indian Pharmaceutical
Empire
10. Shalini k Department of
pharmaceutical chemistry, SRM college of pharmacy
Antioxidant activity of Novel Polyherbal formulation for the Management of
Polycystic Ovarian Disease
11. Parul Sood
Department of Pharmaceutical Sciences
and Drug Research, Punjabi University, Patiala
Acute oral toxicity study of methanol extract of Morus alba L. (Moraceae) fruit
12. Mohit Kumar
Department of pharmaceutical sciences
and technology, MRSPTU, Bathinda
Transdermal patch formulation with combination of herbal and synthetic
compound for treatment of type-2 DM
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13. Kalyani Kumari PGGCG- Sec-11 Chandigarh Effect of Oxytocin on the health of cattle.
14. Sheetal
Department of pharmaceutical sciences
and technology, MRSPTU, Bathinda
Quality by design-based formulation of simvastatin loaded hydrogel sheet for
wound healing
15. ChakshuWalia DoPST, MRSPTU, Bathinda Bilayered nail lacquer of Itraconazole for
treatment of onchomycosis
16. DeekshaKumari DoPST, MRSPTU, Bathinda The Effect OfFABA Bean And Mung Bean
Starch On Tablet Properties: A Comparative Study Against Corn Starch
17. Sanjay Kant Dept of pharmaceutical
sciences technology, MRSPTU, Bathinda
Simultaneous estimation of Glipizide and ethanolic extract of MomordicaCharantia
with the help of simple HPLC method
18. Vinod Kumar Jaiswal
University Institute of Pharmaceutical Sciences,
Panjab University, Chandigarh
Characterization of stress degradation products of azelastine hydrochloride by
employing LC-MS technique
19. Ranjot Kaur
University Institute of Pharmaceutical Sciences,
Panjab University, Chandigarh
Nebulized Surface-Active Lipid Particles of Ceftazidime Embedded into Microdroplets
for Site-Specific Delivery to Lungs
20. Pooja Singh UIPS, PU-Chd Development of validated stability
indicating methods (HPLC) of Ibrutinib
21. RipandeepKaur
University Institute of Pharmaceutical Sciences,
Panjab University, Chandigarh
Development, characterization and in vivo evaluation of choline analogue-based drug
delivery system of antimalarial drug
22. Deep Shikha Sharma Lovely Professional
University, Phagwara
Formulation of 5-Flurouracil loaded nanostructured lipid carriers for the management of diabetes retnopat
23. AkshitaJindal UIPS, Panjab University
Cocrystal of an antiulcer agent famotidine: a step towards modulation and
optimization of its biopharmaceutical properties
24. Prachi UIPS, Panjab University Cocrystal of mesalamine for enhancement
of its biopharmaceutical properties, utilizing supramolecular chemistry approach
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E-POSTER PARTICIPATION
25. KabyaPratap royal UIAMS Panjab University Traditional plants and their
phytoconstituents for prevents and disease management; Influenza and COVID19.
26. Dr. Harpreet Kaur UIPS, Panjab University
Improving The Physicochemical &Biopharmaceutical Parameters Of 5-Flurouracil Using Crystal Engineering
Approach
27. Abhishek
SinghRathor UIPS, Panjab University
Designing, Preparation And Evaluation Of Cocrystals Of "Imatinib"
28. Manju University Institute
OfPharmaceutical Sciences, Panjab University
Diacerein: A Boon For Critically Ill Covid-19 Treatment Therapy
Sr.No. Name Affiliation Title
1. Radhika Yadav UIPS Injecting innovation into Indian pharma
2. Sangeeta Sharma UIPS TLRF agonist as an effective influenza vaccine
adjuvant
3. Priya Badyal UIPS The Dangers of Self Medication
4. Sumant Saini UIPS
QbD-Steered Development and validation of an RP-HPLC Method for Quantification of
Ferulic Acid: Rational application of Chemometric tools
5. PratishthaLambodra UIPS INDIA: the world's innovative pharmacy
6. Pooja Sharma DPSDR, Panjabi university,
Patiala Plants And Plant Metabolites Possessing
Anticancer Activity
7. Aanchal Devi UIPS National innovation and startups
8. Nisha Raina UIPS Role of HER in healthcare
9. Garima Khanna UIPS A Gene Bases Crispr/Cas9 Innovative Delivery
Approach For Cancer And Immunotherapy
10. Sanjeevni Dhamija UIPS A Gene Bases Crispr/Cas9 Innovative Delivery
Approach For Cancer And Immunotherapy
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11. Rupam Sharma Shivalik college of pharmacy, Ropar
Science And Technology Innovations: Ushering In The Era Of Make In India &
Science And Tech In COVID-19
12. Mei nee chiu UIPS A gene-based CRISPR/Cas9 Innovative
Delivery Approach for Cancer and Immunotherapy
13. Somi Priya University Institute of
Pharmaceutical Sciences, Panjab University
Characterisation of Stress Degradation Products of Ibrutinib by Hyphenated Mass
Spectroscopic Techniques
14. Jastarn Toor UIPS, Panjab University,
Chandigarh
Current scenario of pharmaceutical nanotechnology products: challenges and
opportunities
15. Kapil Sharma
UIPS, Panjab University, Chandigarh
Current scenario of pharmaceutical nanotechnology products: challenges and
opportunities
16. Lalit Saraswat
UIPS, Panjab University, Chandigarh
Current scenario of pharmaceutical nanotechnology products: challenges and
opportunities
17. SinaTajeri
UIPS, Panjab University, Chandigarh
Current scenario of pharmaceutical nanotechnology products: challenges and
opportunities
18. Ishita Atwal UIPS, Panjab University Ayushkwath for enhancing immunity against
COVID-19
19. Kalyani Kumari PGGCG- Sec-11 Chandigarh Effect of Oxytocin on the health of cattle.
20. Shivani
Department of pharmaceutical sciences
and technology, MRSPTU, Bathinda
Simvastatin loaded foam based topical formulation for effective wound healing
21. Vinod Kumar Jaiswal UIPS, PU-Chd Characterization of stress degradation
products of azelastine hydrochloride by employing LC-MS technique
22. Pooja Singh UIPS, PU-Chd Development of validated stability indicating
methods (HPLC) of Ibrutinib
23. KabyaPratap royal UIAMS Panjab University Traditional plants and their
phytoconstituents for prevents and disease management; Influenza and COVID19.
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24. Khushboo Pathania UIPS, PU-Chd Lignin nanoparticles - A novel tool for drug
delivery
25. Lakshita Dogra University Institute of
Pharmaceutical Sciences, Panjab University
Analytical Quality-by-Design enabled HPLC method development and validation of
Voriconazole
26. Akanksha Sharma
University Institute of Pharmaceutical Sciences,
Panjab University, Chandigarh
Nanostructured Lipidic Carriers (NLCs) with Enhanced and Extended Dissolution Profiles:
Exploring Drug Release Kinetics using Mathematical Modeling
27. RozyKumari University Institute of
Pharmaceutical Sciences
Development and Validation of Analytical Method for Simultaneous Quantification of Artemether and Lumefantrine Using HPTLC
Method
28. Pallvitempta UIPS, PU-CHd Curcumin nano formulation for cancer
therapy: recent advancement
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Personalised medicine: the new era of treatment Sakshi
UIPS, Panjab University
With this abstract I will give an overview of personalized medicine and why it’s so imperative and how we
can pave our way towards it.
What’s personalized medicine?
Personalized medicine is the tailoring of medical treatment to the individual characteristics of each patient
(1). Producing the medicine uniquely made for unique you. It is a multi-faceted approach to patient care that
not only improves our ability to diagnose and treat disease but offers the potential to detect disease at an
earlier stage when it is easier to treat effectively (1).
Why do we need personalized medicine?
The drugs we give our chemical molecules which interact with receptors and enzymes to cause their action.
These receptors and enzyme are made up of protein, which in turn are produced from RNA molecules which
are produced from DNA. So the precursor of everything is DNA and this biomolecule expresses itself
differently in everyone. We have genes which are translated differently to produce a protein which makes us
all unique phenotypically and genetically. This is the variability observed at a molecular level, the level
where drugs work. This is the reason we observe so poor response rates of drugs treating Alzheimer (30%),
diabetes (57%), migraine (50%), and oncology (25%) (4). Investment and development in making new drugs
are burgeoning, billion dollars are spent in producing new drugs, and still, we are getting low efficacy rates.
From the pool of information, we need to extract the precise one. Here is when personalized medicine comes
to rescue. Equipped with more precise tools, physicians can select a therapy or treatment protocol based on a
patient’s molecular profile that may not only minimize harmful side effects and ensure a more successful
outcome but can also help contain costs compared with a “trial-and-error “approach to disease treatment. (1)
Because the study we do while producing the drug is population-based, and we are targeting on an individual
level. From the genetic information of the patient, we can predict the best drug for them. So with the
example of diabetes, breast cancer and cardiovascular diseases, I will explain how personalized medicine
revolutionized the diagnosis and treatment (3). The best-known example is the CYP 450 enzyme and its
application to Coumadin/warfarin therapy. The correct personalized dosing of warfarin could prevent 17,000
strokes in the United States and avoid 43,000 emergency room visits. The Mayo Clinic and Medco2 tested
this prediction in 3,600 patients and found hospitalizations were reduced by 30 %.( 4).
How personalized medicine work?
Personalized medicine work at six strata:
“Risk Assessment: In which we study the genome of the individual. With Genetic testing and family history,
we can evaluate the risk for the disease.
Prevention: Behavior/Lifestyle/ Treatment intervention to prevent disease
Detection: Early detection of disease at the molecular level. With the advancement in technology, we can
detect diseases at a molecular level.
Diagnosis: Accurate disease diagnosis enabling individualized treatment strategy
Treatment: Improved outcomes through targeted treatments and reduced side effects
Management: Active monitoring of treatment response and disease progression” (1)
For the diseases having genetic variability and behavioral influence, we need personalized medicine more
than ever. Using electronic records and with biostatics, we can organize and analyze data eas
References:
1.http://www.personalizedmedicinecoalition.org/Userfiles/PMC
Corporate/file/pmc_age_of_pmc_factsheet.pdf
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957753/
mailto:[email protected]
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3. Case studies in personalized medicines: Coursera
4.https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(01)01986-
4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1471491401019864%3
Fshowall%3Dtrue
Preparation and characterization of norfloxacin cocrystals
Mansi Prashar1, Vikas2, Renu Chadha1 and Neelima Dhingra1*
1University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India
Keywords: Norfloxacin- nicotinamide (NF- NIC); norfloxacin- cinnamic acid (NF- CN); intrinsic
dissolution; solubility.
ABSTRACT:
The pharmaceutical industries are observing a developing crisis in the procedure of drug development due to
the failure of some successful drug candidates exhibiting poor aqueous solubility. The solid phase
modification (i.e. formation of cocrystals) improves the physicochemical properties of active pharmaceutical
ingredients (APIs) such as bioavailability, solubility, intrinsic dissolution, melting point, stability.
Cocrystals are crystalline structure composed of at least two components (one is API and other is coformer),
where the components may be atoms, molecules or ionic compounds generally in a stoichiometric ratio
which are neither solvates nor simple salts. The components interact via non-covalent interaction such as
hydrogen bonding, van der Waals interaction. Norfloxacin is a broadspectrum antibiotic belonging to the
second generation of the fluoroquinolone’s. It has low permeability and belongs to the class IV of the
biopharmaceutics classification system, BCS because of its poor solubility. Present works report the
preparation and structural characterization of its two cocrystals norfloxacin– nicotinamide and norfloxacin–
cinnamic acid.
*Corresponding author:
Dr. Neelima Dhingra Assistant Professor
University Institute of Pharmaceutical Sciences Panjab
University,
Chandigarh-160014, India Phone number:
9876573312 Email:
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17a-Aza-D-Homo Steroids as 5α- Reductase Inhibitors: Synthesis and Characterization
Harnoor Kaur1, Priyanka Rana2, Neelima Dhingra1* 1University Institute of Pharmaceutical Sciences, Panjab University, Chandigar
Keywords: Benign Prostatic Hyperplasia; 5α- Reductase inhibitors; 17a-Aza-D-Homo Steroids.
Abstract:Benign Prostatic Hyperplasia (BPH) is one of the common and intricate oncologic problem associated with lower urinary tract symptoms (LUTS). It is an age‐related problem with a prevalence of
approximately 10% for men in their thirties, 20% for men in their forties, 50–60% for men in their sixties,
and a staggering 80–90% for men 70 years and above. Advancement in this field of research leads to
formation of the less invasive techniques and therapeutic treatment to provide relief from the LUTS. 5α-
Reductase is the key enzyme responsible for dihydrotestosterone (DHT) biosynthesis and has been
considered as an important target for designing inhibitors as potent therapeutic agents. Present work is
focused on the synthesis and characterization of 17a-Aza-D-Homo Steroid Esters, using various analytical
techniques such as Thin layer chromatography (TLC), Infra-red spectroscopy (IR), Proton nuclear magnetic
resonance spectroscopy (HNMR).
*Corresponding author:
Dr. Neelima Dhingra
Assistant Professor
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh
Tel:+919876573312
E-mail: [email protected]
MAO Inhibitors in Contemporary Treatment of Depression: Current and Future
Perspectives
Alka Kumari1, Neelima Dhingra1*
1University Institute of Pharmaceutical Sciences, Panjab University Chandigarh
Keywords: Depression, MAO inhibitors, current and future perspectives.
ABSTRACT:
Depression is a mood disorder characterized by a sense of inadequacy, despondency, decreased activity
pessimism, anhedonia, sadness and adversely affect the person’s life. It is a common and recurrent disorder
accounting for significant morbidity and mortality worldwide. According to WHO, the total number of
people living with depression in the world is 322 million. Globally 11.3% of adults,8.7% of women and
5.3% of men have depression. It has been observed that COVID-19 lockdown and pandemic has increased
the depression symptoms by three times.Most of the antidepressants currently available act by enhancing the
activity of monoamine neurotransmitters, either by reuptake inhibition, enzyme inhibition or activity at pre-
about:blankmailto:[email protected]
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or postsynaptic receptors. Monoamine oxidases (MAOs) are involved in the oxidative deamination of
different amines and neurotransmitters. This pointed them as potential targets for several disorders and along
the last 70 years a wide variety of MAO inhibitors have been developed as successful drugs for the treatment
of complex diseases, being the first drugs approved for depression in the late 1950s. MAOIs can be a
powerful therapeutic intervention for patients with depression, panic disorder, who have failed first-line
treatments.
*For Correspondence
Dr. Neelima D Passi
Assistant Professor
University Institute of Pharmaceutical Sciences
Department of Pharmaceutical Chemistry
Panjab University
Chandigarh- 160014
Tel: +91-9876573312
E.mail: [email protected]
Formulation of sustained release mups tablets of s (-) metoprolol succinate
using wurster process
G. Nikhil1, G. Aman3, M. Paramjot1, G. Vikram2, W. Sheetu1
Department of Pharmaceutical Science,
Lovely Professional University, Phagwara Jalandhar, Punjab, India
1. Department of Pharmaceutical Science, Lovely Professional University Jalandhar, India
2. Associate Director, Emcure R&D, Bhosari, Pune, India
3. School of Pharmaceutical Sciences, Rajiv Gandhi ProdyogikiVishwavidhyalaya, Bhopal, India
ABSTRACT
The idea behind this research work was to develop pellets of S (-) Metoprolol succinate using platform
technology to get sustained drug release through the oral route. Wurster process was used to develop
sustained release MUPS tablets of MS by using few cushioning agents and different polymers such as
mailto:[email protected]
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Ethylcellulose (5cps and 10 cps), Eudragit, Methocel K100, and MethocelK4M to investigate the effect of
polymer coating on drug release pattern. Obtained tablets characterized by flow property, Assay,
Dissolution, SEM imaging, friability, etc. Prepared tablets were characterized by different methods and
found bulk density and tapped density of blend was 0.83±0.03g/ml and 0.90±0.02g/ml, surface morphology
was carried out by SEM analysis and drug encapsulation efficiency was 99.46 % also drug dissolution was
95.77% in up to 20 hrs. It was found that using a fixed combination of Methocel K4M and Methocel K100
will be a good option to get the desired sustained release pattern. MCC PH 102 is used for the sustained
release coating. This type of approach will be a better option to formulate a controlled delivery system for
highly soluble drugs (class-1 drugs).
Keywords: Wurster Process, Metoprolol Succinate, Oral controlled delivery, Pellets, MUPS table
Nanoparticle drug delievery system in oncology
Preeti
Shivalik college of pharmacy, Ropar
House no: 77/G Nangal Town Ship, Distt. Ropar
Cancer is the life threatening disease. Acc to NCI mortality rate in worldwide is 9.5 million. The main
demerit of anticancer drug is that they can occur apoptosis in cancerous cell as well as host cell.
Nanotechnology is smart approach which is target specific because of Folate receptor and
Asialoglycoprotein are able to make them directly bind by cancerous cell. In 2005 FDA approved a drug
ABRAXANE which is solvent free Albumin bound Paclitaxel used for Metastasis breast cancer. Major
Advantages of nanotechnology is that it must improved Therapeutic Index and increase the bioavailability by
increasing solubility due to increase surface area. They must Active targeted into cells without triggering P
Glycoprotein pump. PGA-Taxol, HPMA-DOX (For lung cancer) are the example of Polymeric nanoparticle
in the anticancer drug delivery. The SHELTH technique is the part of nanotechnology in which nanoparticles
are prevented from attacking by Immune system in EPR effect by covering them with PEG. Chemo-Gd-
Neutron capture therapy is the new discovery for breast cancer treatment and for gastric carcinoma or
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ovarian cancer treatment Cisplatin is encapsulated with ICG (Indo cyanine green).Various nanocatalyst such
as ZnO, CuFe2O4, Fe2O3 are used in synthesis of Anticancer drugs. Overall our study revealed that
Nanotechnology has the greatest scope in the research of oncology.
In silico docking studies of phytochemicals from adhatoda species against covid-
19 target proteins
B. Siva kumar and K. Ilango
Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and
Technology, Kattankulathur – 603203, Chengalpattu (Dt), Tamil Nadu, India. CORRESPONDING
AUTHOR email id: [email protected]
Abstract
A novel coronavirus (COVID-19) was identified as one of the severe acute respiratory syndrome coronavirus
(SARS CoV-2) and emerged as a pandemic disease in 2020.
The World Health Organization [WHO] has declared the current outbreak of a global public health crisis.
There is no drug or no suitablevaccines available against viral proteins till today. Hence, there is an urgent
need to develop inhibitor against the viral proteins for the coronavirus is a promising idea to develop
structure-based drugs from phytochemicals. Here, the novel drug was identified and well studied against the
viral receptors by using the molecular docking technique. Phytocompounds from Adhatoda like
Vascinolone, Vasicol, Adhatodine were selected for the present study. The analysis of drug-likeness is
predicted through these 5 parameters namely Lipinski rule, Ghose, Egan, Vebers&Muegge rules. As
molecular docking is routinely used for understanding drug-receptor interaction, the above-plant derived
compounds were subjected to molecular docking studies. Highest binding affinity ranging from -4.34 to -
8.02KJ/mol were obtained with 5R80, 5R81, 5R83, 6LU7, 6XA4, 7AD1 viral protein targets. Our study
reveals that Vasicinolone, Vasicol, Ahatodine could act as a promising molecule of choice to treat COVID
19.
KEYWORDS: SARS–Cov-2; COVID-19; vasicinolone, vasicol, adhatodine, coronavirus
mailto:[email protected]
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Antioxidant activity of Novel Polyherbal formulation for the
Management of Polycystic Ovarian Disease
Shalini K*1, Ilango K2
Department of Pharmacognosy*1, Department of Pharmaceutical Chemistry2,
SRM College of Pharmacy, SRM Institute of Science and Technology,
Kattankulathur-603 203, Chengalpattu (Dist), Tamilnadu, India.
Corresponding author mail id: [email protected]
Abstract
Polycystic ovarian syndrome (PCOS) is a multifactorial endocrine disorder predominantly affecting
between 5% - 10% of reproductive – aged women. PCOS women commonly have classical clinical
features of oligo- or anovulation, obesity, and hyperandrogenism. Moreover, PCOS can occur with
hyperinsulinemia, gluose intolerance, hperlipidemia, type 2 diabetes mellitus, hypertension, coronary
atherosclerosis, and endometrial cancer. Antioxidants are a class of molecules that can reduce the destructive
effects of free radicals. They are of two types: either enzymatic like superoxide dismutase, catalase,
glutathione peroxidase (GPx), and glutathione redutase (GR), or non-enzymatic such as glutathione (GSH),
ɑ-tocopherol (vitamin E), ascorbate (vitamin C), and ß-carotene. These antioxidants have been reported to
have an important role in the female reproductive system and in the pathogenesis of female infertility.
Oxidative stress has been associated with PCOS. Studies have suggested that oxidative stress seems to be
involved in PCOS by causing altered steroidogenesis in the ovaries, which subsequently contributes to
increasing androgen levels, distributing follicular development, and infertility. Moreover, factors such as
obesity, insulin resistance, and cardiovascular risks have shown to be linked to oxidative stress in PCOS
women. The study was designed as in vitro antioxidant potential of polyherbal formulation.
Polyherbal formulation was prepared using hydroalcoholic extract powder of the selected plants viz.
Asparagus racemosus, Caesalpiniabonducella, Saracaasoka, and Symplococusracemosus. Polyherbal
formulation were tested for scavenging activity against DPPH radical, total reducing power assay, and
hydrogen peroxide scavenging activity even when compared to ascorbic acid. The results showed that the
combination extract has best antioxidant effect at a dose of 200µg/ml when it was compared with ascorbic
acid as the reference standard.
Key words: Steroidogenesis, ɑ-tocopherol, Infertility, Oxidative stress.
mailto:[email protected]
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Acute oral toxicity study of methanol extract ofmorusalbal. (moraceae) fruit
Parul Sood1*, Pankaj Bhatia1, Karishma1, Diksha1, Richa Shri1
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala,
(147002), Punjab, India
*Corresponding Author: ParulSood, Department of Pharmaceutical Sciences and Drug Research, Punjabi
University, Patiala (147002), Punjab, India. Email id: [email protected]; 7018429747, 8427187366
ABSTRACT
Introduction: Different parts ofMorusalbaL. (Moraceae) are valued in traditional systems of medicine. The
fru