Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?
-
Upload
breastcancerupdatecongress -
Category
Health & Medicine
-
view
157 -
download
6
description
Transcript of Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?
![Page 1: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/1.jpg)
Breast MRI in neoadjuvant chemotherapy : A Predictive
response marker ?
Sophie Taïeb, Luc Ceugnart – Centre Oscar Lambret – Lille
Fabienne Thibault - Institut Curie - Paris
![Page 2: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/2.jpg)
MRI : Evaluation of response to neoadjuvant chemotherapy
Ø Neoadjuvant Chemotherapy : When ?
ü Prior to surgical treatment to reducing the size of tumour to avoid radical surgery (28-89%)
ü Inoperable breast tumors at initial diagnosis (Secondary curative surgery in 50-80%)
ü Assessment in vivo efficacy of chemotherapy
![Page 3: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/3.jpg)
MRI provides :
Ø Morphological informations
Ø Functional informations ü Microvascularisation ü Cellularity ü Metabolism
![Page 4: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/4.jpg)
Lumpectomy
Mastectomy
Concentric response
Split up response
For the surgeon Local-regional assessment
![Page 5: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/5.jpg)
Courtesy Pr K.Kinkel - Genève
![Page 6: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/6.jpg)
32-year-old, IDC, HR –, 3cm p 8mm
28-year-old, IDC, HR –, 2cm p 2cm
![Page 7: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/7.jpg)
For the medical oncologist Multiple-level information potentially useful
Ø In vivo assesst of NAC efficacy, adjuvant Trt guidance
Ø Predicting the final response after only 1 or 2 cycles stop or switch therap. agent in non-responders ?
Ø Gaining prognostic information ü Prediction of complete path. response (pCR) ? ü Prediction of rec. free and overall survival ?
![Page 8: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/8.jpg)
DCE imaging
Assessment of NAC efficacy Extent of residual disease : standard practice
![Page 9: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/9.jpg)
Ø 19 studies : 958 patients
Ø Mean differences in tumour size : ü MRI / DM (6 studies) Overestimation MRI 0.1 cm < DM 0.4cm
ü MRI / US (2 studies) Overestimation ≈ for MRI & US : 0.1cm
![Page 10: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/10.jpg)
ü MRI / Clin exam (4 studies)
![Page 11: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/11.jpg)
Causes for FN cases
Ø Tumor fragmentation, scattered residual tumour cells Ø Initial nonmasslike lesion Ø Low-intensity enhancing residium (uncertainty about
positive enhanct threshold criteria) Ø Taxane-containing NAC regimen Ø HER 2 negative tumors treated with bevacizumab
Authors reporting under-estimation and FN cases
Rieber 1997, 2002 Balu-Maestro 2002 Wasser 2003 Denis 2004
Thibault 2004 Bhattacharyya 2008 Chen JH 2008 Straver 2010
Chen JH 2011 Chen JH 2014
![Page 12: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/12.jpg)
Impact of Factors Affecting the Residual Tumor Size Diagnosed by MRI Following Neoadjuvant Chemotherapy in Comparison to Pathology
98 pts Ø 1.5T imager : 51 pts, 3T imager : 47 pts Ø 74 mass type lesions, 24 non-mass-like enhancement
Ø 85 IDC, 10 ILC, 3 mixed IDC-ILC Ø 37 high grade, 60 low or medium grade
Ø Her2 + n = 40 Ø Triple - n = 16 Ø Her2- ER+ n = 41
Ø 63 : AC + Taxane, 35 Taxane without AC
Chen JH et al, Journal of Surgical Oncology 2014
![Page 13: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/13.jpg)
Impact of Factors Affecting the Residual Tumor Size Diagnosed by MRI Following Neoadjuvant Chemotherapy in Comparison to Pathology
Ø MRI diagnosis of residual invasive C. Se 70.4% Sp 88.6% Acc 78.6%
Ø MRI / p residual tumor size : 1 + 2 cm [0-14cm]
Chen JH et al, Journal of Surgical Oncology 2014
![Page 14: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/14.jpg)
Impact of Factors Affecting the Residual Tumor Size Diagnosed by MRI Following Neoadjuvant Chemotherapy in Comparison to Pathology
Ø MRI diagnosis of residual invasive C. Se 70.4% Sp 88.6% Acc 78.6%
Ø MRI / p residual tumor size : 1 + 2 cm [0-14cm]
Chen JH et al, Journal of Surgical Oncology 2014
Contrast media ?
![Page 15: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/15.jpg)
![Page 16: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/16.jpg)
PRE-Chimio
• 37-year-old • IDC • Mass • High grade • Triple – • AC + Taxanes
pRC
IRM CR
![Page 17: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/17.jpg)
• 31-year-old • IDC + DCIS • Non mass • High grade • HR+ , Her2- • NAC ?
• post NAC MRI : 3cm • post NAC path : scattered cancer cells = 10cm
Chen JH et al, Journal of Surgical Oncology 2014
![Page 18: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/18.jpg)
Diffusion imaging
Assessment of NAC efficacy Extent of residual disease : Standard practice
![Page 19: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/19.jpg)
DWI-MRI
Ø Rational ü Measure of the movement of water molecules within
tissues ü Quantified using Apparent Diffusion Coefficient (ADC) ü In general, cancer tend to a restricted diffusion because
of high cellular densities and abundance of intra and inter cellular membranes
Ø Assessing NAC efficacy Studies have shown that successful treatment of many
tumor types can be detected using DWI as an early increase in the ADC values
![Page 20: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/20.jpg)
Extent of residual disease after NAC
Can diffusion-weighted MR imaging and contrast-enhanced MR imaging precisely evaluate and predict pathological response to neoadjuvant chemotherapy in patients with breast cancer ?
Ø 2000-2012 : 34 / 542 studies – 1932 pts Ø 6 DWI-MRI studies, 30 DCE-MRI studies
Wu LM et al, Breast Cancer Research 2012
Se Sp LR+ LR-‐ DOR DWI-‐MRI 93%
[82-‐97] 82% [70-‐90]
5,09 [3,09-‐8,38]
0,09 [0,04-‐0,22]
55,59 [21,8-‐141,8]
DCE-‐MRI 68% [57-‐77]
91% [87-‐94]
7,48 [5,3-‐10,57]
0,36 [0,27-‐0,48]
20,98 [13,24-‐33,24]
![Page 21: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/21.jpg)
Ø Higher performance with DCE-MRI + DWI
Kuroki Y, Breast Cancer 2008
Se (%) Sp (%) Accuracy(%) PPV(%) NPV (%) DCE MRI 50 88 44 64 81 DCE MRI + DWI ↑ 86 88 76 75 ↑ 94
Extent of residual disease after NAC
![Page 22: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/22.jpg)
pRC
![Page 23: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/23.jpg)
Courtesy Dr C.Balleyguier - IGR
Artifact !!!
![Page 24: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/24.jpg)
DCE functional and DWI
Assessment of NAC efficacy 1. Early prediction of response 2. Pre-treatment prediction of residual disease after NAC
![Page 25: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/25.jpg)
1. Arterial enhancement
2. Capillary enhancement
3. Intersticium enhancement
4. Veinous enhancement
Intensité
de sig
nal
Temps C.de Bazelaire – St Louis - Paris
![Page 26: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/26.jpg)
Artere Q
artere 1
Capillaire Q
cap 2
Kep
Ve
Interstitium Q
inter 3 Ktrans
Blood flow
k(0,2)
flux F
veine artère
Volume V de tissus
![Page 27: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/27.jpg)
à 02/2011 Ø 13 studies : 9 prospective, 6 retrospective – 605 pts – 1.5T
Ø Early response therapy monitoring DCE-MRI after 1-2 cycles of AC + Taxane compared to pre-NAC baseline
Ø Parameters : ü Tumour diameter, volume ü Ktrans, Kep, Ve, ECU (early contraste uptake),
Ø Response : pCR, near-pCR and residual tumour
Prediction of pCR : Tumour volume & ECU Prediction of near-pCR : Tumour volume & Ktrans Se : [83-100] ; Sp : [7-100] ; AUC : [28-100]
![Page 28: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/28.jpg)
à 01/2012 Ø 15 studies : 9 prospective, 6 retrospective – 644 pts – 1.5T
Ø 4 : pre-treatment differences between responders and non-responders
Ø 6 : early response therapy monitoring Ø 5 : both Ø DCE-MRI (14), DWI-MRI (3), MRS (1), BOLD (1) à 31 parameters
![Page 29: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/29.jpg)
Ø 15 studies, 31 parameters Ø Tumour diameter, volume
Ø Ktrans, Kep, Ve, ECU (early contraste uptake), SIR (signal intensity ratio), signal intensity time curves, ADC, MTT (mean transit time), relative blood volume and blood flow, tCho peak, T2* relaxivity ….
![Page 30: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/30.jpg)
Ø No Pre-treatment differences between responders and non-responders : Tumour diameter, volume, kinetic parameters.
§ Nor ADC (Woodhams R et al, Radiology 2010) – 398 pts § ADC useful (Li X et al. Med Oncol 2012) – 32 pts Before NAC Mean
ADC of responders lower than in non-resp. p<0,001
Ø Early response : ü Tumor diameter AUC [0.73-0.9] ü Kinetic parameters : Ktrans AUC [0.63-0.93] ü ADC : Useful but ADC cut off depends : B[800-1000],
multiB, 1.5 or 3 T.
![Page 31: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/31.jpg)
ü Objective: to identify biomarkers of early response to therapy associated
with better survival
ü Imaging component
ü MRI results correlated with molecular markers
Phase II prospective clinical trial design in the neoadjuvant setting for women with LABC Academic investigators, National Cancer Institute, FDA, Pharmaceutical and biotechnology industries, ACRIN participation (American College of Radiology Imaging Network)
Hylton N et al. Radiology 2012
![Page 32: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/32.jpg)
Ø 216 pts : Prediction pCR & Residual tumor ?
Ø Tumor volume after first cycle (209 pts) : AUC 0,70 Ø TV + Longest diameter +SER (signal enhanct ratio) + CE : AUC 0,73
Hylton N et al. Radiology 2012
![Page 33: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/33.jpg)
Need further studies !!!
Ø Standardising ü DCE-MRI parameters ü MRI thresholds ü pCR definition
Ø Reporting changes in NAC based on MRI results
![Page 34: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/34.jpg)
Ø 2000-2011 Ø 15 studies / 234 – 745pts
Ø Baseline (15), 1 (8 studies), 2 (7 studies), before surgery (15)
Ø Histologic tumor response : > ou < 50% Ø Se : 85.2% [32 – 100]; Sp : 82.6% [17 – 97] Ø ≈ after 1 or 2 cycles CT
![Page 35: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/35.jpg)
Ø 63 consecutive pts. 6/2005 – 12/2007. Ø Non-metastatic, non-inflammatory. Ø NAC : 3FEC100 – 3 Docetaxel Ø PET : BL and before 2nd cycle
Sataloff classification for T ü TA : pCR ü TB : > 50 % ü TC : < 50% ü TD : 0
![Page 36: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/36.jpg)
57 evaluable pts :
Ø Decrease SUV < 15% after 1st cycle = failure of NAC
![Page 37: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/37.jpg)
New developments
1H-MR Spectroscopy (MRS)
![Page 38: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/38.jpg)
1H-MR Spectroscopy
ü Malignant breast tissues show elevated choline-containing compounds (total choline: tCho) and water-to-fat ratios
Tozaki M et al, MR Med Science 2011
![Page 39: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/39.jpg)
MRS : metabolic response to chemotherapy
Ø Effect of therapy on tissue metabolism manifests as changes in these levels Ø Sequential MRS studies have shown significantly reduced tCho levels during
the course of therapy in patients who were responders
Bolan PJ et al Breast Cancer Res. 2005
![Page 40: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/40.jpg)
MRS, predicting response
Ø Few studies, 1.5T (Meisamy 2004, 4T) Ø Small series
4 studies 10-16 pts, 2 studies 30 and 35 pts
Ø tCho peak Not demonstrated in all of the pts (Jagannathan 2001, in 10/14 pts only)
Ø Response prediction ü Change in [tCho] after Tp2, and Tp1 (Meisamy 2004, after 24H) ü More sensitive than Tumour Size and Volume (Tozaki 2010, Sah 2010) ü NS difference between pCR and non-pCR groups (Baek 2009)
Advantages of 3 Tesla / 7 Tesla fields : on going studies
![Page 41: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/41.jpg)
DWI and MRS Clinical cases 3T
![Page 42: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/42.jpg)
• 27 y-‐old w. Pregnancy, 8 weeks of amenorrhea
• Mass in the upper outer leM quadrant : IDC Grade 3 ER-‐ PR-‐
DWI
T1 WI
ADC Map
DCE MRI
Case 1
![Page 43: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/43.jpg)
Right Breast ?
SubtracGon 3 NaGve 3
DWI b 1000
ADC Map
![Page 44: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/44.jpg)
Diffusion images and ADC map : characterizaXon
FLORID ADENOSIS High ADC: 1,26.10-‐ 3 But reliability ?
Right breast
Left breast
Low ADC: 0,83.10-‐3
![Page 45: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/45.jpg)
Ø During Trt
• muscle ADC : 2,03 x 10-‐3mm2/s • lesion ADC : 1,04 (raXo 51%)
Monitoring response ADC and MRS
tCho peak
DWI
ADC Map
MRS
![Page 46: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/46.jpg)
Ø Mid trt
• muscle ADC : 1,63 x 10-‐3mm2/s • Increase in lesion ADC : 1,42 (raXo 87%)
Decrease in tCho peak
Responder But, some invasive residual foci at
lumpectomy Pb of the sensiXvity of DWI and
MRS for small lesions
DWI
ADC Map
MRS
![Page 47: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/47.jpg)
Case 2
Ø 34 ans Ø LeM breast inflammatory cancer : RE-‐ RP-‐ Her-‐ Ki67 : 95%
Ø MRI 1 pre Trt Ø MRI 2 aMer 3 cycles of FEC 100 – Bevasizumab
![Page 48: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/48.jpg)
• 3 mn post contrast • Right breast: Fibroadenoma at biopsy
MIP image Subtraction image
![Page 49: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/49.jpg)
• Time Intensity curve : persistent, atypical enhct
![Page 50: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/50.jpg)
• DWI at b1000 • Cancer, hyper Intense on DWI, but ADC not reduced : T2 effect
due to edema
After 3 FEC 100-Avastin
Before Trt
DW images ADC Map
FA : not visible
![Page 51: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/51.jpg)
• Time Intensity curve : no change aMre Trt
Before Tt AMer Trt
![Page 52: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/52.jpg)
• MRS before and aMer Trt : ↑ in the choline peak, suggest no response aMer 3 FEC 100
Before Tt AMer Trt
![Page 53: Sophie Taieb : Breast MRI in neoadjuvant chemotherapy : A predictive response marker ?](https://reader033.fdocuments.us/reader033/viewer/2022051608/545593ddaf795998788b4945/html5/thumbnails/53.jpg)
Breast MRI in neoadjuvant chemotherapy: A Predictive response marker ?
Ø Local breast status assessment after primary medical Trt Reliability of DCE MRI and DWI, but underestimation response in
3T, Taxane only, ILC, HER- HR+ tumours. Ø Efficacy of systemic Trts
ü Imaging tools : functional, earlier information ü Technical challenges, standardized methods needed ü For practice and research objectives : integration of other
(molecular, biological) decisional parameters in the individual Trt decision process
Ø Who really changes treatment basis on earlier MRI results ??