Solubilizing excipients for parenteral preparations
-
Upload
saurabh-patel -
Category
Documents
-
view
605 -
download
5
Transcript of Solubilizing excipients for parenteral preparations
![Page 1: Solubilizing excipients for parenteral preparations](https://reader031.fdocuments.us/reader031/viewer/2022020116/55aaa2991a28ab733e8b4597/html5/thumbnails/1.jpg)
“Solubilizing Excipients for Parenteral Preparations”
Compiled by:Maroof AlviPulkit Khatri
Saurabh PatelSapan
![Page 2: Solubilizing excipients for parenteral preparations](https://reader031.fdocuments.us/reader031/viewer/2022020116/55aaa2991a28ab733e8b4597/html5/thumbnails/2.jpg)
SOLUBILIZATION TECHNIQUES FOR PARENTERAL FORMULATIONS
• Solubilization techniques for injectabes formulations are similar to those in oral formulations that includes,pH adjustmentmixed aqueous/organic cosolventsorganic solvent mixturescyclodextrin complexationemulsion liposomespolymeric gels
![Page 3: Solubilizing excipients for parenteral preparations](https://reader031.fdocuments.us/reader031/viewer/2022020116/55aaa2991a28ab733e8b4597/html5/thumbnails/3.jpg)
PARENTERALS
• The term Parenteral is derived from two Greek word, para & enteron, meaning “beside the intestine”.
• As defined in European Pharmacopoeia(EP) 1997 and British Pharmacopoeia(BP) 1999,“Parenteral are defined as sterile preparations intended for administration by injection,infusion or implantation into human or animal body”.
![Page 4: Solubilizing excipients for parenteral preparations](https://reader031.fdocuments.us/reader031/viewer/2022020116/55aaa2991a28ab733e8b4597/html5/thumbnails/4.jpg)
AS PERFECT AS POSSIBLE
• Since the highly efficient barrier of the skin and mucous membrane are bypassed ,the introduction of micro-organism or toxic agents can be very dangerous.
• Because of this, it is imperative that parenteral preparations be nearly as perfect as possible with respect topurity,
freedom from toxicity,&
freedom from contamination
![Page 5: Solubilizing excipients for parenteral preparations](https://reader031.fdocuments.us/reader031/viewer/2022020116/55aaa2991a28ab733e8b4597/html5/thumbnails/5.jpg)
What is the requirement of excipients in parenteral preparations?
• To make preparations Isotonic with respect to blood
• To adjust pH
• To increase solubility
• To prevent deterioration of the active substance or to provide adequate antimicrobial properties.
![Page 6: Solubilizing excipients for parenteral preparations](https://reader031.fdocuments.us/reader031/viewer/2022020116/55aaa2991a28ab733e8b4597/html5/thumbnails/6.jpg)
Excipients should not
• Adversely affect the intended medicinal action of the preparation at the concentration used
• Cause toxicity
• Undue local irritation
![Page 7: Solubilizing excipients for parenteral preparations](https://reader031.fdocuments.us/reader031/viewer/2022020116/55aaa2991a28ab733e8b4597/html5/thumbnails/7.jpg)
Routes of administrations
• These injections may be administered by one or more routes such as: Intravenous (IV) Subcutaneous (SC) Intradermal Intramuscular (IM) Intraspinal Intracisternal Intrathecal
• The nature of product will determine the particular route of administration that may be employed