SOCIETY FOR THE STUDY OF INGESTIVE … · Jennifer Ann Barrett, University of California--Davis,...

University of California Santa Cruz, USA

August 7-11, 2002

Program

Abstracts for this meeting have been published in Appetite Vol. 39, Issue 1, pp. 61-109, 2002.

2001-2002

OFFICERS

President .......................................................Ralph Norgren, Ph.D., M.S. Hershey Medical Center President-Elect ....................................... Joseph R. Vasselli, Ph.D., St. Luke's-Roosevelt Hospital Past-President............................. Thomas R. Scott, Ph.D., University, San Diego State University Secretary .......... Suzanne Sunday, Ph.D., North Shore University Hospital/NYU Medical College Treasurer ....................................Nori Geary, Ph.D., Weill Medical College of Cornell University

BOARD MEMBERS Karen Ackroff, Ph.D. ............................................................................................Brooklyn College Linda Bartoshuk, Ph.D............................................................ Yale University School of Medicine Patricia Sue Grigson, Ph.D. ...............................................................M.S. Hershey Medical Center Wolfgang Langhans, Ph.D................................................... Swiss Federal Institute of Technology Allen S. Levine, Ph.D. .................................................................. VA Medical Center-Minneapolis Neil Rowland, Ph.D. ........................................................................................University of Florida Gary Schwartz, Ph.D..................................................Weill Medical College of Cornell University Ken Simansky, Ph.D. ........................................................... MCP Hahnemann School of Medicine

BOARD/OFFICERS ................................................................................................................ inside front coverACKNOWLEDGMENTS / SPONSORS........................................................................................................... 2AWARDS........................................................................................................................................................... 3PROGRAM ...................................................................................................................................................4-20

Wednesday, August 7........................................................................................................................... 4Thursday, August 8 .........................................................................................................................4-10Friday, August 9............................................................................................................................11-12Saturday, August 10 ......................................................................................................................13-17Sunday, August 11 ........................................................................................................................17-20

ABSTRACTS (not published in Appetite)........................................................................................................ 21AUTHOR DIRECTORY.............................................................................................................................22-30ADVERTISEMENTS .................................................................................................................................31-33SOCIETY INFORMATION AND MEMBERSHIP ........................................................................................ 34SUMMARY PROGRAM......................................................................................................... inside back cover2002 ANNUAL MEETING ...............................................................................................................back cover

WELCOME Dear Colleagues, Welcome to the Tenth Annual Meeting of the Society for the Study of Ingestive Behavior being held at the University of California at Santa Cruz among the redwoods overlooking Monterey Bay from August 7 – 11, 2002. We not only have this stunningly beautiful campus for our annual conclave, but also the extra assurance that two of our members, M. R. C. Greenwood and John Simpson, who are respectively, Chancellor and Vice-Chancellor of UCSC, will be our hosts. This wonderful setting will be awash in first class scientific presentations highlighted by six invited symposia, five invited lectures, and our centerpiece New Investigator Presidential Symposium. A new feature this year is that two of the invited lectures cover topics of broad interest, but beyond the usual purview of SSIB. The Women's Forum is sponsoring Dr. Nancy Hopkins of MIT who will speak on “A Report on the Status of Women Faculty in Science -How MIT Responded.” And our Keynote Speaker, M.R.C. Greenwood will give her perspective on “Research in the Post 9-11 Era: Challenges and Opportunities.” We welcome your participation. Enjoy!

Ralph Norgren

SSIB President 2001-2002

MRC Greenwood, ChaJohn B. Simpson, Cam

Univer

Local Organize

Dorothy Gi

Program Commi

WolfgaDorothy

Stacy M

Local Hostsncellor, University of California, Santa Cruz pus Provost and Executive Vice Chancellor, sity of California, Santa Cruz

r, SSIB 2002 Annual Meeting

etzen, University of California, Davis

ttee, SSIB 2002 Annual Meeting

ng Langhans, Chairperson Gietzen, Local Organizer

Susan Johnson arkison, New Investigator

Randall Sakai Gary J. Schwartz Laurence Tecott Stephen Woods

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ACKNOWLEDGMENTS / SPONSORS On behalf of the entire membership of the Society for the Study of Ingestive Behavior (SSIB), The Board and the Organizing Committee of the 2002 Annual Meeting sincerely thank the following organizations for their generous support of the Society:

Ajinomoto Co., Inc., Japan

Campbell Soup

Elsevier Science, Inc.

Firmenich

Johnson & Johnson

Lindt & Sprüngli (Switzerland) AG

Mead Johnson Nutritionals

Mini Mitter

Nestec Ltd.

Proctor & Gamble

Research Diets

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of Alcohol Abuse and Alcoholism

University of California, Santa Cruz

We would also like to thank all the individual SSIB members who made personal contributions to the Society this year. We especially thank Dr. M.R.C.

Greenwood, Chancellor, for her many efforts in helping organize this year’s meeting and for donating her honorarium for our Keynote Speech to the fund for

our New Investigator Awards.

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http://www.elsevier.nl/

http://www.firmenich.com/

http://www.johnsonandjohnson.com/home.html

http://www.lindt.com/

http://www.researchdiets.com/

HONORS AND AWARDS

AWARDS

Johnson and Johnson Career Award for Research in Ingestive Behavior Lecture by J.C. SMITH: Mentors and colleagues: the evolving of science.

Alan N. Epstein Research Award Lecture by R.R. SAKAI: The good, the bad, the salty.

New Investigator Awards Listed alphabetically here and marked in the program with #.

Tanja C. M. Adam, Maastricht University, The Netherlands

Nicole M. Avena, Princeton University, USA

Anthony V. Azzara, Ph.D., WMC of Cornell University, USA

Jennifer Ann Barrett, University of California--Davis, USA

Lucy F. Hemsley-Faulconbridge, University of Pennsylvania, USA

Jennifer L. Lachey, University of Cincinnati, USA

Susanne Eva la Fleur, Ph.D., University of California--San Francisco, USA

Joo Young Lee, Ph.D., Yonsei University College of Medicine, South Korea

Manuela Lejeune, Maastricht University, The Netherlands

Yolanda Martins, Ph.D., Monell Chemical Senses Center, USA

Paula J. Regan, Queen Margaret University College, Scotland

April D. Strader, Ph.D., University of Wisconsin, USA

Nanette Stroebele, Georgia State University, USA

Andrew Thorpe, University of Minnesota, USA

Esther H. E. M. van de Wall, University of Gronigen, The Netherlands

Neeltje Vogels, Ph.D., Maastricht University, The Netherlands

Peter Ydo Wielinga, University of Gronigen, The Netherlands

Diana Leigh Williams, University of Pennsylvania, USA

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Wednesday, August 7 – Thursday, August 8

PROGRAM Special Note: The symposium “Modifying the food environment: Energy density, cost, and

portion size” (chaired by Adam Drewnowski and Barbara Rolls), scheduled for Sunday morning, has been cancelled due to an illness. The Society extends its best wishes for a speedy recovery, and hopes to reschedule this symposium next year. Poster Session 2 will now start at 9:00 a.m. instead of 10:30 a.m. in order to give members more time and flexibility prior to departure.

Presenting authors are indicated by Bold type.

Wednesday, August 7

11:00-14:00 Long Range Planning Committee – Room J102

12:00-15:00 Registration and On-Campus Housing Check-in – College Eight Cafe

14:00-16:00 Board Meeting – Room J102

16:00-18:00 Welcome Reception/Strolling Dinner -University House, home of Chancellor MRC Greenwood. Please note that the reception will take the place of dinner. There will be ample food and wine served at this function. Dinner will not be provided at the dining hall for our group on Wednesday evening.

Thursday, August 8

07:15-8:00 Breakfast - College Eight Dining Hall

08:00-11:00 Registration - Room P108

08:15-08:25 Opening – Room M110 (R. NORGREN)

08:30-10:30 Symposium 1: Metabolic consequences of chronic stress (Chairs: S.F. AKANA, M.F. DALLMAN) - Room M110

08:30-08.35 Introduction (S.F. AKANA, M.F. DALLMAN)

08:35-09:00 R.B.S. HARRIS, J. ZHOU, D.H. RYAN: Chronic changes in body weight of rats exposed to acute stress.

09:00-09:25 M.F. DALLMAN, A. BHARGAVA, L.R. SORIANO, K.L. LAUGERO, S.F. AKANA, M.E. BELL: Sucrose makes the (stressed) body better.

09:25-09:50 B.E. LEVIN, S. BROWN, C. MICHEL: Stress and the obese rat: on being fat and happy.

09:50-10:15 E.S. EPEL, B. MCEWEN, T. SEEMAN, K. MATTHEWS, J. ICKOVICS: Can chronic stress shape your body? Associations between stress-induced cortisol and abdominal fat distribution among lean and overweight pre-menopausal women.

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Thursday, August 8

10:15-10:30 General Discussion

10:30-11:00 Refreshment Break/Exhibitor’s Display - Room P108

11:00-12:30 Oral Session 1: Metabolic controls (Chair: N. GEARY) - Room M110

11:00-11:15 M.S. WESTERTERP-PLANTENGA, A.H.C. GORIS, E.P. MEIJER, K.R. WESTERTERP: Habitual meal frequency differentially related to resting and activity induced energy expenditure in younger and older men.

11:15-11:30 A.J.W. SCHEURINK, P.Y. WIELINGA, E.H.E.M. VAN DE WALL, L. BENTHEM: Coping styles and insulin resistance.

11:30-11:45 P. Y. WIELINGA#, J. LOUTER-VD HAAR, M.G. POELMAN, M. ROMEIJN, A.G. NIEUWENHUIZEN, A.J.W. SCHEURINK: The effects of (-)-hydroxycitric (HCA) and grape seed on food intake, body weight and metabolism.

11:45-12:00 M. LEONHARDT, U.L. JAMBOR DE SOUSA, W. LANGHANS: Hepatic portal vein infusion of caprylic acid decreases food intake by reducing the size and number of meals in male rats.

12:00-12:15 M.M.J.W. KAMPHUIS, M.P.G.M. LEJEUNE, M.S. WESTERTERP-PLANTENGA: CLA affects resting metabolic rates, fat free mass and appetite, but not body weight regain, fat mass or energy intake.

12:15-12:30 M.D. WORTMAN, D.J. CLEGG, S.C. WOODS, R.J. SEELEY: Central administration of the fatty acid synthase (FAS) inhibitor C75 reveals a role for central nervous system (CNS) metabolism in the regulation of energy balance.

11:00-12:30 Oral Session 2: Modulation of human food intake (Chair: H. R. KISSILEFF) - Room Second Stage

11:00-11:15 J. M. DE CASTRO, S. PLUNKETT: A general model of intake regulation.

11:15-11:30 L. KELLY, S.T. BORRA, S. ROWE, S. GOLDBERG: Beginning a new nutrition conversation with consumers: Creating messages that work.

11:30-11:45 Y. MARTINS#, P. PLINER: The impact of meal size and body size on individuals’ perceptions of males and females.

11:45-12:00 D.A. LEVITSKY, T. YUN: We eat what we’re served: Effect of portion size on food intake.

12:00-12:15 M.R. LOWE, C.A. TIMKO: Toward an understanding of differences in eating regulation between restrained dieters and restrained non-dieters.

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Thursday, August 8

12:15-12:30 B. BREHM, S.R. DANIELS, D.A. D’ALESSIO: Comparison of a very low-carbohydrate diet and a calorie-restricted low-fat diet on reported calorie intake and body weight.

12:30-14:00 Lunch - College Eight Dining Hall

14:00-16:00 New Investigator Presidential Symposium (Chair: R. NORGREN) - Room M110

14:00-14:15 A.V. AZZARA#, S. CHUA, H. B. SCHIÖTH, G.J. SCHWARTZ: Characterization of controls of feeding in db/db mice with transgenic neural specific replacement of the functional (LEPR-B) leptin receptor.

14:15-14:30 S.E. LAFLEUR#, S. MANALO, M.F. DALLMAN: Hepatic vagotomy completely attenuates the changes in food intake and hypothalamic peptide expression in streptozotocin diabetic rats fed a high-fat diet or given the choice of lard.

14:30-14:45 J.L. LACHEY#, D.A. D’ALESSIO, D.J. DRUCKER, R.J. SEELEY: Central glucagon-like peptide-1 (GLP-1) administration supports conditioned taste aversion learning in wild-type mice, but not in mice with a targeted disruption of the GLP-1 receptor.

14:45-15:00 E.H.E.M. VAN DE WALL#, E.R. POMP, D.X. GRAM, A.J.W. SCHEURINK: The role of capsaicin sensitive afferent nerves in the control of energy balance.

15:00-15:15 D.L. WILLIAMS#, J.M. KAPLAN, D.E. CUMMINGS, H.J. GRILL: Metabolic and endocrine responses to nutrient loading and food deprivation in chronic decerebrate and intact rats.

15:15-15:30 T.C.M. ADAM#, M.S. WESTERTERP-PLANTENGA: Moderate exercise stimulates GLP-1 release in healthy, normal-weight subjects.

15:30-15:45 P.J. REGAN#, H.I.M. DAVIDSON, R.A. RICHARDSON, O.J. GARDEN, W. LANGHANS: Changes in test meal size and metabolic abnormalities in response to a carbohydrate preload following liver transplantation.

15:45-16:00 N. VOGELS#, G. EGGER, K.R. WESTERTERP: Changes over time in physical activity and effect on body weight.



16:30-18:30 Symposium 2: Probing biological contributions to anorexia nervosa (Chair: E.M. BERRY) - Room M110

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Thursday, August 8

16:30-16:35 Introduction (E.M. BERRY)

16:35-16:55 J. TREASURE, F. CONNAN, S. LIGHTMAN, I. CAMPBELL: Anorexia nervosa: A neurodevelopment disorder.

16:55-17:15 R.C. CASPER: Starvation in anorexia nervosa: does the negative energy balance mobilize a biologically based survival mechanism?

17:15-17:35 J. HEBEBRAND, C. EXNER, M. KLINGENSPOR, H. REMSCHMIDT: Leptin’s role in anorexia nervosa.

17:35-17:55 Y. AVRAHAM, S. HAU, O. BONNE, E.-L. MARCUS, S. SHOHAM, E.M. BERRY: What can we learn from animal models for anorexia nervosa?

17:55-18:15 B. LASK: Toward an understanding of the neurobiological contribution to anorexia nervosa.


16:30-18:30 Oral Session 3: Extrahypothalamic mechanisms (Chairs: H.J. GRILL, K.J SIMANSKY) - Room Second Stage

16:30-16:45 J-A.M. MCQUADE, S.C. BENOIT, S.C. WOODS, R.J. SEELEY: Peripheral doses of the dopamine 3 receptor agonist, 7-OH-DPAT, differentially reduce food intake in an ad libitum versus meal feeding paradigm.

16:45-17:00 P. RADA, A. MENDIALDUA, L. HERNANDEZ, B.G. HOEBEL: Glutamate release in the lateral hypothalamus corresponds with meal initiation, and GABA with satiation.

17:00-17:15 V.P. BAKSHI, S.M. NEWMAN, L.E. WEINBERG, N.H. KALIN: Anatomical substrates and CRH receptor subtype mediation of urocortin-induced anorexia.

17:15-17:30 S. MARKISON, D. DANIELS, H.J. GRILL, J.M. KAPLAN: Feeding and c-Fos activation in response to urocortin administration in intact and chronic decerebrate rats.

17:30-17:45 J.E. TURMAN JR., S.H. CHANDLER: Molecular and physiological changes in trigeminal neurons precede the onset of chewing in rats.

17:45-18:00 K.J. SIMANSKY, D.M. NICKLOUS. Mu receptor activation in the parabrachial nucleus (PBN) increases food intake in rabbits.

18:00-18:15 B.D. HUDSON, S. RITTER: Selective immunotoxin lesion of hindbrain norepinephrine (NE) and epinephrine (E) neurons impairs the consummatory feeding response to glucose deficit.

18:15-18:30 P.J. CURRIE, M. BRAVER, M. KHAN, K. SRICHAROON: Dorsal and median raphe nuclei injections of 8-OH-DPAT differentially inhibit the anorectic action of fluoxetine in female and male rats.

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Thursday, August 8

18:30-19:45 Dinner - College Eight Dining Hall

20:00-22:00 Poster Session I, with Wine, Cheese, and Fruit – Rooms H101—posters 1-36 and P108—posters 37-50

1. L. ABDALLAH, K. NONOGAKI, L.H. TECOTT: Hyperactivity and reduced energy

cost of physical activity in obese 5-HT2c mutant mice.

2. M.D. LEE, G.A. KENNETT, C.T. DOURISH, P.G. CLIFTON: The hypophagic action of 5-HT2c agonists is attenuated in mice lacking functional 5-HT-1b receptors.

3. S.F. AKANA, D. SAN JUAN, T. HOLSCHER, M.F. DALLMAN: Provoked hyperphagia in neonates and weight at weaning presage the mid-life obese phenotype of the 5-HT2C receptor KO mouse.

4. J.-P. VOIGT, CH. MAYER, A. REX, S. JACOBS, H. FINK: 5-HT1A-receptor activation decreases brain but not peripheral glucose level.

5. D.P. DIXON, H.M. RIVERA, L.A. ECKEL: Fenfluramine-induced hypophagia is increased during estrus in female rats.

6. D.P. DIXON, L.A. ECKEL: Fenfluramine enhances activity-based anorexia in female rats.

7. B.A. BALDO, C.F. LANDRY, A.E. KELLEY: Studies on nucleus accumbens-hypothalamus interactions in the control of feeding behavior.

8. N.M. AVENA#, B.G. HOEBEL: Amphetamine cross-sensitizes to sugar, producing increased locomotor activity and subsequent sugar consumption.

9. C.S. FREET, J.D. TESCHE, D.A. TOMPERS, K.E. RIEGEL, P.S. GRIGSON: Relative to Fischer 344 rats, Lewis rats demonstrate greater successive negative contrast and reduced effect of CDP on recovery from the loss of reward and on appetite.

10. R.A. WHEELER, C. LIU, K.W. SANCHEZ, N. SUBLETTE, E. LEUENBERGER, P.S. GRIGSON: Fischer 344 rats are more sensitive to the aversive kappa-mediated effects of opioids than Lewis rats.

11. D.H. HO, P.J. WELLMAN, J.R. NATION, L. BELLINGER: Antagonism of cocaine-induced hypophagia by the α1-adrenoceptor antagonist prazosin in the rat.

12. R.I. GEDDES, P.S. GRIGSON: The effect of cocaine on consummatory and instrumental responding in rats.

13. R.C. TWINING, V. SANCHEZ, K. WARDROP, P.S. GRIGSON: Avoidance of a gustatory CS and subsequent cocaine self-administration depend upon the nature of the CS.

14. B. KWON, S.H. CHOI, J.W. JAHNG, T.A. HOUPT: Systematic MK801 increases intraoral intake of sucrose.

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Thursday, August 8

15. S. HIGGS, R. HALAMANDRES, A.J. COOPER: Effects of nicotine on the behavioural satiety sequence in outbred mice.

16. S. HIGGS, C.M. WILLIAMS, T.C. KIRKHAM: Microstructural analysis of the effect of exogenous and endogenous cannabinoids on licking for sucrose.

17. L.L. BELLINGER, P.J. WELLMAN: The effect of intermittent nicotine (NIC) administration on meal patterns in female rats.

18. Y.YIIN, L. THIBAULT: Odor-cued fasting-anticipatory satiety is influenced by gender and dietary macronutrients.

19. S.J. SYNOWSKI, Z.S. WARWICK: Meal patterning of high fat and high carbohydrate diet consumption in rats: Relevance to single meal studies.

20. Z.S. WARWICK, S.J. SYNOWSKI, K.R. BELL: Orosensory and postingestive factors in high-fat diet hyperphagia.

21. K.R. BELL, Z.S. WARWICK: The effect of taste on subsequent satiety in rats.

22. J. KAUER, P. ROZIN, M.L. PELCHAT: Adult picky eating: is there more to it?

23. J.F. BRUNSTROM, G.L. WITCOMB, S. HIGGS: Preference learning in restrained and unrestrained eaters.

24. M.L. BUTRYN, R. ANNUNZIATO, C. CRERAND, L. DIDIE, C. OCHNER, M.R. LOWE: The power of the food scale: Rationale and psychometric evaluation.

25. K. FAST, B. GREEN, L.M. BARTOSHUK: Developing a scale to measure just about anything: comparisons across groups and individuals.

26. D. J. SNYDER, V.B. DUFFY, K. FAST, B.G. GREEN, L.M. BARTHOSHUK: Standardizing adjective-labeled scales: Are all maximum intensities the same to all people?

27. V. L. MOIZE, J.M. PERI, B. SUREDA, R. MORINIGO, C. YOLDI, J. VIDAL: Restraint and disinhibition are related to psychopathology in morbidly obese patients seeking bariatric surgery.

28. J.A. ELLO-MARTIN, L.S. ROE, J.S. MEENGES, D.E. WALL, B.J. ROLLS: Increasing the portion size of a unit food increases energy intake.

29. T.V.E. KRAL, L.S. ROE, J.S. MEENGS, D.E. WALL, B.J. ROLLS: Increasing the portion size of a packaged snack increases energy intake.

30. E.S. EPEL, L.M. BARTOSHUK: Cortisol reactivity is related to taste perception among pre-menopausal women.

31. N. STROEBELE#, J.M. DE CASTRO: Food intake in the elderly.

32. B.J. TEPPER, G.L. GOLDSTEIN, N.V. ULLRICH: PROP taster status and sensory responses to sweetened and unsweetened milk mixtures.

33. M. KAMPHUIS, M.P.G.M. LEJEUNE, M.S. WESTERTERP-PLANTENGA: Relative fat and carbohydrate intake is different for PROP tasters and non-tasters.

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Thursday, August 8

34. E.M.R. KOVACS, M.P.G.M. LEJEUNE, M.S. WESTERTERP-PLANTENGA: The effects of enterostatin intake on food intake and energy expenditure.

35. J.H. GOLDBERG, S.J. KINGSTON, E.S. EPEL, K.B. HORGEN, M.A. NAPOLITANO, K.D. BROWNELL: Taste and stress-induced eating changes.

36. J.A. NASSER, S.M. EVANS, R.W. FOLTIN: The relationship between self-reported eating behavior and performance in a behavioral task assessing food reinforcement.

37. C.H. VAUGHAN, N.E. ROWLAND: Neonatal endotoxin exposure increases alcohol intake of mice in early adulthood.

38. S. EYLAM and A.C. SPECTOR: Inbred mouse strain differences in licking behavior to water and sucrose under water-restricted and non-restricted conditions.

39. R.F. LUNDY Jr., M.E. BLAIR, R. NORGREN: Dose-response of furosemide induced sodium appetite.

40. A.M. DOERFLINGER, S.E. SWITHERS: Expression of Fos protein following administration of mercaptoacetate in rat pups.

41. J.E. COX, A. RANDICH, S.T. MELLER, G.R. KELM: Suppression of food intake by intragastric ethyl oleate in normal and vagotomized rats. WITHDRAWN

42. J.Y. LEE#, S. LEE, D.G. KIM and J.-W. JAHNG: Proteomic analysis of the rat hypothalamus experienced mother-pup separation early in life.

43. D.F. JOHNSON, G. COLLIER: Price affects choice between pellets of sucrose and chow.

44. P.J. CURRIE, C.D. COIRO, R. DUENAS: Paraventricular nucleus administration of DOPI potentiates the inhibitory effect of urocortin on neuropeptide Y stimulated eating and respiratory quotient.

45. D.E. DAY, T.J. BARTNESS: NPY and AgRP increase food hoarding more than food intake in Siberian hamsters.

46. D.R. LEWIS, M.A. JOPPA, S. MARKISON, K.R. GOGAS, D.A. SCHWARZ, F. ZHU, R.A. MAKI, A.C. FOSTER: Melanin-concentrating hormone receptor antagonists decrease food intake in rodents.

47. A.J. THORPE#, C.M. KOTZ: Food restriction enhances orexin-A stimulated food intake in rats.

48. J.A. REED, D.J. CLEGG, R.J. SEELEY: Analysis of orexigenic mRNAs by RNAse protection assay.

49. K.L.K. TAMASHIRO, T. WAKAWAMA, H. AKUTSU, Y. YAMAZAKI, J.P. HERMAN, S.C. WOODS, R. YANAGIMACHI, R.R. SAKAI: Hypothalamic neuropeptide expression in obese adult cloned mice.

50. K.A. WILMER, R.J. SEELEY, M.B. JONES, R.J. SHELDON: The effect of long-term MT-II administration in dietary-induced obesity (DIO) and weight-reduced rats.

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Friday, August 9

Friday, August 9


08:00-10:00 Symposium 3: Developmental aspects of ingestion (Chair: K.L. GROVE) - Room M110

08:00-08:02 Introduction (K.L. GROVE)

08:02-08:24 S. BOURET: Development of pathways from the arcuate nucleus implicated in neural control of feeding behavior in mice.

08:24-08:46 L. RINAMAN; Postnatal development of vagal-hypothalamic pathways.

08:46-09:08 S. SWITHERS: Do metabolic signals stimulate intake in rat pups?

09:08-09:30 M.G. ROSS: In utero development of thirst and appetite: Neuronal and physiologic correlates.

09:30-09:35 Closing Remarks (K.L. GROVE)


08:00-10:00 Oral Session 4: Peripheral signaling and GI function (Chair: T.H. MORAN) - Room Second Stage

08:00-08:15 C.C. HORN, M.I. FRIEDMAN: Hepatic branch vagal afferent fibers are directly sensitive to 5-HT and contain 5-HT3 receptors.

08:15-08:30 V. BUCINSKAITE, J.P. SOKOLNICKI, G.J. SCHWARTZ: Serotonin-3 receptor (5-HR3R) mediation of gastrointestinal vagal afferent signaling in rat.

08:30-08:45 E. ROLF, R.D. REIDELBERGER: Effects of intragastric infusions of glucose,

polycose, peptone, 80% polycose/20% peptone, oleic acid, Intralipid, and corn oil on food intake and meal patterns in rats.

08:45-09:00 U. SMEDH, S. KNIPP, T.H. MORAN: Gastric emptying and intragastric pressure during and following multiple meals in rhesus monkeys.

09:00-09:15 C.-Y. CHEN, F.-Y. CHANG, S.-D. LEE: Delayed gastrointestinal transit in patients with hepatocellular carcinoma.

09:15-09:30 H.R. KISSILEFF, M. TORRES, A. GELIEBTER, F.X. PI-SUNYER: Combined effects of suprathreshold gastric distention and CCK-8 on food intake in humans – preliminary report.

09:30-09:45 T.M. ROBINSON, S.J. FRENCH, R.W. GRAY, M.R. YEOMANS: The influence of meal palatability on intestinal control of feeding and appetite.

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Friday, August 9

09:45-10:00 M. LEJEUNE#, C.J. HUKSHORN, W.H.M. SARIS, M.S. WESTERTERP-PLANTENGA: Effect of dietary restraint during and following pegylated recombinant leptin treatment (PEG-OB) of overweight men.



10:30-12:30 Symposium 4: Nutritional neuroscience of amino acids: How the brain recognizes protein quality and adjusts ingestive behavior to spare protein (Chairs: D.W. GIETZEN, K. TORII) - Room M110

10:30-10:35 Introduction (D.W. GIETZEN, K. TORII)

10:35-10:55 G.K. BEAUCHAMP, A.A. BACHMANOV: Peripheral mechanisms for detecting amino acids.

10:55-11:15 D. TOME: The role of proteins and amino acids in energy nutrients homeostasis.

11:15-11:35 J. D. FERNSTROM: Could hypothalamic catecholamines participate in the chronic control of protein ingestion?

11:35-11:55 D.W. GIETZEN, J.W. SHARP, T.J. KOEHNLE, J.A. BARRETT, B.G. TRUONG: Recognition of essential amino acid availability: the view from the anterior piriform cortex.

11:55-12:15 K. TORII, M. SMRIGA, T. KONDOH: Brain mechanism of learned preference for an essential amino acid, lysine, in rats with lysine deficiency.


10:30-12:30 Oral Session 5: Mineral and Fluid Balance / Learning and Selection (Chair: R.R. SAKAI) - Room Second Stage

10:30-10:45 L.R. LUCAS, A. HAJNALI, C.A. GRILLO, Z. CELEN, B.S. MCEWEN: Natrioirexic behavior induces dopamine release in the nucleus accumbens.

10:45-11:00 E.M. STRICKER, M.L. HOFFMANN, C.A. SMITH AND A.F. SVED: Control of water intake and neurohypophyseal hormone secretion in rats fed high-NaCI diet.

11:00-11:15 M.G. TORDOFF, A.A. BACHMANOV: Mouse strain survey of voluntary mineral consumption.

12

Friday, August 9 – Saturday, August 10

11:15-11:30 D.K. YEE, J. HINES, S.J. FLUHARTY: Investigation of the molecular mechanism of angiotensin II type 1 receptor mediated mitogen-activated protein kinase (MAPK) activation.

11:30-11:45 C. POLIDORI, L. FOSCOLO, F. LUCIANI, R. CICCOCIOPPO, N. GEARY, M. MASSI: Central injections of leptin reduce food intake, but not ethanol intake in marchigian Sardinian alcohol-preferring (msP) rats.

11:45-12:00 A.L. TRACY, T.L. DAVIDSON: Mercaptoacetate suppresses intake of a fat-associated flavor in the presence, but not in the absence, of fat calories.

12:00-12:15 P.E. SCHROY, E. LEUENBERGER, D.S. WHEELER, P.S. GRIGSON: Female rats, like male rats, exhibit individual differences in cocaine-induced avoidance of saccharin intake and greater avoidance of the tastant is associated with greater conditioned elevations in circulating corticosterone levels at test.

12:15-12:30 K. ANGERS, L. THIBAULT: Effect of melatonin in female and male rats fed two-way choices of sensorily contrasting macronutrients.


14:00-15:00 Keynote Lecture (Chair: R. NORGREN) - Room M110 M.R.C. GREENWOOD: Research in the post 9-11 era: challenges and opportunities


15:00-18:00 Exhibitor’s Display - Room P108

15:00-16:30 Women’s Forum - Room M110. N. HOPKINS: A Report on the Status of Women Faculty in Science - How MIT Responded

16:30-18:00 New Investigator Forum - Room M110

18:30-19:45 Dinner - College Eight Dining Hall

Saturday, August 10


13

Saturday, August 10

08:00-10:00 NIAAA-sponsored Symposium 5: Peptides: Their role in excess alcohol drinking and their promise as a therapeutic tool, (Chairs: M. EGLI, B.G. HOEBEL) - Room M110

08:00-08:05 Introduction (M. EGLI, B.G. HOEBEL)

08:05-08:25 T.E. THIELE, N.E. BADIA-ELDER: The relationship between neuropeptide Y (NPY) and ethanol-related behaviors in mutant mice lacking specific NPY receptor and in rats selectively bred for alcohol preference.

08:25-08:45 B.G. HOEBEL, S.F. LEIBOWITZ: Hypothalamic galanin in relation to alcohol intake and dopaminergic motivation.

08:45-09:05 D.L. CRANKSHAW, J.E. BRIGGS, C.J. BILLINGTON, A.S. LEVINE: Effects

of central administration of ethanol on behavior and cFos IR. 09:05-09:25 B. BOUTREL, V. FABRE, G. MARTIN, G.F. KOOB, L. DE LECEA: The

hypocretins in the nucleus accumbens: linking sleep with reward mechanisms.

09:25-09:45 M. MASSI, R. CICCOCIOPPO, A. FEDELI, C. POLICORI: The nociceptin-orphanin FQ/NOP receptor system as a target for treatment of alcohol abuse.


08:00-10:00 Oral Session 6: Central responses to peripheral signals (Chair: G.J. SCHWARTZ) - Room Second Stage

08:00-08:15 J.D. ROTH, L.N. WEINBERGER, J. HINES, D. DANIELS, D.K. YEE, S.J. FLUHARTY: Expression, function and regulation of insulin receptors in murine N1E-115 neuroblastoma cells.

08:15-08:30 D.J. CLEGG, C.A. RIEDY, K.A. BLAKE SMITH, S.C. BENOIT, S.C. WOODS: A comparison of the role of leptin and insulin action in the CNS to regulate energy and reproduction in male and female rats.

08:30-08:45 D.L. DRAZEN, D.J. CLEGG, M.W. SCHWARTZ, G. VAN DIJK, S.C. WOODS, R.J. SEEELEY: Adrenalectomy increases sensitivity to central leptin- and melanocortin-induced anorexia.

08:45-09:00 T.A. LUTZ, A. BLOCH-THOMSEN, M. TANG-CHRISTENSEN, A. MOLLET, D. ZÜND, T. RIEDIGER: Amylin activates hindbrain neurons in areas expressing glucagon-like peptide-1.

09:00-09:15 S. AJA, C. EWING, T.H. MORAN: Blockade of central glucagon-like-peptide-1-receptors (GLP-1R) prevents the short-term anorectic response to i.c.v. CART peptide (CARTp).

09:15-09:30 L.F.H. FAULCONBRIDGE#, D.E. CUMMINGS, J.M. KAPLAN, H.J. GRILL: Effects of brainstem ghrelin administration on meal patterning.

14

Saturday, August 10

09:30-09:45 E.E. LADENHEIM, L. BARON, L.L. HAMPTON, J.F. BATTEY, T.H. MORAN: Pair-feeding normalizes body weight in bombesin receptor subtype 3 deficient mice.

09:45-10:00 L. BEVERLY, M.G. DE VRIES, N. GUEDET, L.M. ARSENEAU: Interstitial glucose concentration in the hypothalamus of rats during hypoglycemia.


10:30-12:30 Symposium 6: Thirst and sodium appetite (Chair: J. SIMPSON) - Room M110

10:30-10:35 Introduction (J. SIMPSON)

10:35-11:00 R.S. WEISINGER, J.R. BLAIR-WEST, P. BURNS, D.A. DENTON, M. MCBURNIE, M.J. MCKINLEY, B. PURCELL, L.L. WALKER, J. RIVIER, W. VALE, K. SUNAGAWA, R. SHADE: The influence of hormones associated with stress on ingestive behavior.

11:00-11:25 R.L. THUNHORST, A.K. JOHNSON: Thirst and salt appetite responses in aging rats.

11:25-11:50 A.G. WATTS: Functional interactions between dehydration and feeding.

11:50-12:15 A. KOCHLI, Y. RAKOVER, M. LESHEM: Salt preference in patients with CAH-21-OH deficiency (congenital adrenal hyperplasia).


10:30-12:30 Oral Session 7: Illness and malaise (Chair: S.C. WOODS) - Room Second Stage

10:30-10:45 N.E. ROWLAND, J. THOMAS, D.J. GREEN, K.L. ROBERTSON: Characteristics of flavor avoidance in rats and mice compared using a non-deprivation protocol.

10:45-11:00 J.A. BARRETT#, B.G. TRUONG, D.W. GIETZEN: Injection of threonine (THR) into the anterior piriform cortex (APC) alters meal patterns within the first 4 hours of exposure to a THR imbalanced diet (IMB).

11:00-11:15 T.A. HOUPT, B.S. KWON, J.A. CASSELL, C. RICARDI, J. SMITH: Magnetic field exposure decreases ad lib drinking by increasing latency.

11:15-11:30 K.P. KINZIG, D.A. D’ALESSIO, R.J. SEELEY: The diverse role of specific GLP-1 receptors in the control of food intake and the response to visceral illness.

11:30-11:45 C. VON MEYENBURG, B.J. HRUPKA, G.J. SCHWARTZ, R. LANDMANN, W. LANGHANS: Role for CD14 and TLR2 in bacterial product-induced anorexia.

15

Saturday, August 10

11:45-12:00 J. SHEAHAN, L. ASARIAN, W. LANGHANS, N. GEARY: Sexual differentiation in the potency of bacterial lipopolysaccharide to inhibit feeding.

12:00-12:15 B.J. HRUPKA, W. LANGHANS: Prostaglandin E2 may act at the raphe nucleus to mediate the anorexia following peripheral lipopolysaccharide administration.

12:15-12:30 T.A. LENNIE: Reversal of inflammation-induced anorexia by ICV injection of SHU9119.


14:00-15:30 Oral Session 8: Hypothalamic mechanisms (Chair: L.H. TECOTT) - Room M110

14:00-14:15 C.S. PATTEN, L.N. WEINBERGER, D. DANIELS, M.A. KUHN, J.D. ROTH, J. HINES, D.K. YEE, S.J. FLUHARTY: Melanocortin receptors couple to multiple signal transduction pathways in cultured cells.

14:15-14:30 D. DANIELS, S.J. FLUHARTY: Phosphorylation of mitogen-activated protein kinase (MAPK) in the rat hypothalamus by a melanocortin receptor agonist.

14:30-14:45 S.C. BENOIT, D.J. CLEGG, E.L. AIR, A. JACKMAN, P. TSO, D.A. D’ALESSIO, S.C. WOODS, R.J. SEELEY: Increased dietary fat attenuates the anorexic effect of intracerebroventricular MTII in rats.

14:45-15:00 E.H. GOULDING, P. JUNEJA, J. WADE, L.H. TECOTT: Quantitative analysis of ingestive behavior pattern in 5-HT2c receptor, obese, and agouti mutant mice.

15:00-15:15 S. BI, E.E. LADENHEIM, T.H. MORAN: Hypothalamic corticotropin-releasing factor gene overexpression may contribute to voluntary exercise-induced anorexia of rats.

15:15-15:30 G. M. SUTTON, M.M. CORKERN, L.M. PATTERSON, H. ZHENG, H.-R. BERTHOUD: Vagal afferent input to peptidergic hypothalamic neurons involved in food intake and energy balance.

14:00-15:30 Oral Session 9: Human eating disorders (Chair: A. GELIEBTER, G.S. BIRKETVEDT) - Room Second Stage

14:00-14:15 G.S. BIRKETVEDT, R. OLSTAD, J. SUNDSFJORD, J. FLORHOLMEN: The hypothalamic pituitary adrenal axis in female subjects suffering from bulimia nervosa.

14:15-14:30 A. GELIEBTER, M.E. GLUCK, E. YAHAV: Cortisol following a stress test and dexamethasone suppression test (DST) in relation to psychopathology in the night eating syndrome.

16

Saturday, August 10 - Sunday, August 11

14:30-14:45 M.E. GLUCK, A. GELIEBTER, E. YAHAV, J. HUNG: Obese binge eaters have a greater waist-hip-ratio (WHR), related to greater cortisol stress responsivity and hunger as compared to obese non-binge eaters.

14:45-15:00 J.L. GUSS, B.T. WALSH, H.R. KISSILEFF, E. ZIMMERLI, R. SYSKO, M.J. DEVLIN: Normalization of delayed gastric emptying after treatment for bulimia nervosa.

15:00-15:15 K.A. HALMI, D.E. GRICE, W.H. KAYE, W.H. BERRETTINI: Linkage analysis for anorexia nervosa.

15:15-15:30 K. WILLIAMS, M. GARLAND, K. RIEGEL: Four years of feeding: Outcomes of an intensive behavior treatment for severe feeding problems.

15:30-16:00 Refreshment Break- Room P108

16:00-17:00 Business Meeting - Room M110

17:00-18:00 Award Lectures (Chair: J.R. VASSELLI) - Room M110

17:00-17:30 Alan N. Epstein Research Award Lecture

R.R. SAKAI: The good, the bad, the salty.

17:30-18:00 Johnson & Johnson Career Award for Research in Ingestive Behavior Lecture

J.C. SMITH: Mentors and colleagues: the evolving of science.

19:00-23:00 Banquet - Cocoanut Grove, 400 Beach Street, Santa Cruz. Transportation will be provided.

Sunday, August 11


09:00-11:00 Poster Session 2, with Coffee, juice, fruit and pastry – Rooms H101—posters 51-86 and P108—posters 87-98

51. A. WOLFE, J. SHEAHAN, M. MANGIARACINA, M. MASSI, N. GEARY: CCK-A receptor mediated control of alcohol ingestion in Sardinian alcohol-preferring rats.

52. K. ACKROFF, A. SCLAFANI: Ethanol-conditioned flavor preferences in short daily sessions.

17

Sunday, August 11

53. K.P. MYERS, A. SCLAFANI: Conditioned increase in acceptance and preference, but not palatability of sour or bitter tastes paired with intragastric glucose infusions.

54. A. SCLAFANI, K. ACKROFF: Sweet taste facilitates flavor preference conditioning by intragastric fructose.

55. C.A. CARILLO, B.G. HOEBEL: Sensitization of sugar-induced feeding: enhancement of the appetizer effect.

56. S.H. CHOI, T.A. HOUPT, B.S. KWON, D.G. KIM, J.W. JAHNG: Effect of NMDA antagonism on lithium-induced conditioned taste aversion in males rats.

57. D.J. CLEGG, M.D. WORTMANN, S.C. BENOIT, CC. MCOSKER, R.J. SEELEY: Comparison of central and peripheral administration of C75 on food intake, body weight, and conditioned taste aversion.

58. M. COVASA, R.C. RITTER: Hindbrain Fos expression and intestinal satiation depend on carbohydrate hydrolysis not glucose absorption.

59. M. COVASA, R.C. RITTER, G.A. BURNS: Attenuation of CCK satiation by NMDA ion channel blockade depends on post-oral feedback but not on increased gastric emptying.

60. H. ZHENG, S.D. SMID, L.A. BLACKSHAW, H.-R. BERTHOUD: Ghrelin and CCK’s opposing effects on short-term food intake: interaction at peripheral or central sites?

61. T. ADAGE, B. ROORDA, G.H. VISSER, S. DAAN, A.J.W. SCHEURINK: Hormonal, metabolic and behavioral consequences of high intensity workloads in rats.

62. M. CIAMPOLINI, M. VAN WEEREN, B. DE PONT, W. DE HAAN, L. BORSELLI: Are overweight adults able to predict the preprandial glycemia by subjective feelings after training as accurately as lean adults do?

63. M. ARNOLD, W. LANGHANS: Influence of different anesthesia and blood sampling procedures on plasma levels of metabolites and corticosterone in rats.

64. G.S. BIRKETVEDT, D. AVENARIUS, J. STROMER, J. SUNDSFJORD, J. FLORHOLMEN: Hypertrophia of the adrenal gland in one subject suffering from the night eating syndrome.

65. J. YIEE, V.B. DUFFY, L.M. BARTOSHUK: Mixture suppression in nontasters, medium tasters and supertasters of PROP (6-n-propylthiouracil).

66. M.R. YEOMANS, R.W. GRAY, L. WEINBERG: How do palatability and satiation interact?

67. P.J. HAVEL, J. GRAHAM, K.L. STANHOPE: Low circulating adiponectin levels and reduced adipocyte adiponectin production in obese, insulin-resistant Sprague-Dawley rats.

68. E.K. DIGITALE, O. NICOLESCU, K.L. STANHOPE, K. CIANFLONE, P.J. HAVEL: Increased energy expenditure and uncoupling protein 2 and 3 expression, with normal locomotor activity and in vitro leptin production in obesity-resistant complement 3/acylation stimulating protein knockout mice.

69. X.Q. XIAO, B. GRAYSON, P. WILLIAMSON, K.L. GROVE, M.S. SMITH: Changes in uncoupling protein (UCP)-subtype expression in response to altered metabolic status during lactation and development.

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Sunday, August 11

70. L.M. BROWN, S. THOMAS, S.O. LIEU, C.T. HANSEN, T.W. CASTONGUAY: The effects of adrenalectomy and genetic background on carcass composition and neuropeptide Y5 receptor expression in lean and obese corpulent rats.

71. A.D. STRADER#, H.P. SCHIOTH, J.D. BUNTIN: The role of the melanocortin system and the melancortin-4 receptor in ring dove (Streptopelia risoria) feeding behavior.

72. R. CICCOCIOPPO, A. FEDELI, M. MASSI: Inhibition of CRF-induced anorexia by orphanin FQ/nociception: search for the site of action.

73. C. POLIDORI, M. SIMONATO, M. MASSI: Pro-orphanin FQ/nociception mRNA and NOP receptor mRNA levels in the forebrain of food-deprived rats.

74. S. STRIBLING, R.E. CAMACHO, K.M. ROSKO, G.J. HICKEY, D.E. MACINTYRE, A.M. STRACK, L.P. SHEARMAN: Cannabinoid regulation of appetite in lean and diet-induced obese rats.

75. M.J. WILL, E. FRANZBLAU, A.E. KELLEY: Enhancement of fat intake induced by accumbens µ-opioid stimulation is dependent on activation of selected input and output structures.

76. T.A. LUTZ, T. RIEDIGER, D. ZÜND, P. WOOKEY: Amylin activates a dopaminergic pathway in the area postrema.

77. A.A. RUHF, D.A. FITTS: Brain oxytocin blockade induces drinking and salt appetite.

78. S.A. MCCAUGHEY, D.A. FITTS, MG. TORDOFF: Lesions of the subfornical organ reduce the expression of calcium appetite by calcium-deprived rats.

79. E.G. KRAUSE, K.S. CURTIS, L.M. DAVIS, R.J. CONTRERAS: Estrogen attenuation of stimulated water intake is specific to angiotension II.

80. J.N. GORSKI, G.J. HICKEY, A.M. STRACK, J. METZGER: Comparison of CNS infusion of melanocortin nonselective and –4 receptor selective agonists on energy balance in rats.

81. B. GRAYSON, S. ALLEN, M.S. SMITH, K.L. GROVE: Postnatal ontogeny of arcuate nucleus neuropeptide Y (NPY) projections to orexin and melanin-concentrating hormone (MCH) neurons in the lateral hypothalamic area (LHA).

82. H. ZHENG, H.-R. BERTHOUD: CART-expressing vagal primary afferent neurons: Quantitative assessment of gastrointestinal and medullary projections.

83. C.C. HORN, M.I. FRIEDMAN. Feature clustering as a tool for the analysis of single-unit vagal afferent activity.

84. B. J. HRUPKA, G.J. SCHWARTZ, W. LANGHANS: Subdiaphragmatic vagal deafferentation increases meal size in male Sprague-Dawley rats.

85. H. JI, M.I. FRIEDMAN: Differential hepatic energy status and food intake in genetically obese and lean rats and mice.

86. H. JI, M. STEFAN, J.L. KNEPPER, R.S. AHIMA, R.D. NICHOLLS, M.I. FRIEDMAN: Hepatic energy metabolism in a mouse model of Prader-Willi syndrome.

19

Sunday, August 11

87. P.C. BUTERA, J.J. TRIPLET: Effect of estradiol on interleukin-1- beta-induced c-Fos expression in female rats.

88. M. MANGIARACINA, N. GEARY: Estradiol inhibits real feeding, but not sham feeding, of corn oil emulsions in ovariectomized rats.

89. P. SANCHEZ, L. OVERDUIN, L. HAMPTON, J. BATTEY, R. HENDERSON, J. GIBBS: Hyperphagia of mice lacking the bombesin receptor subtype-3 is characterized by increased meal size and decreased meal number.

90. J.P. SOKOLNICKI, A.V. AZZARA, G.H. SCHARTZ: Gastrointestinal controls of feeding in a mouse model.

91. J.W. JAHNG, Y.M. KIM, K.I. PARK: Glucocorticoid receptor mediated down-regulation of nNOS in the rat PVN during food deprivation.

92. H.J. KIM, D.G.. KIM, J.W. JAHNG: Stressful experience early in life modulates gene expression of neuropeptide Y in the arcuate nucleus of rats in late age.

93. J.T. KIM, D.G. KIM, J.W. JAHNG: Dexamethasone prolongs, RU486 facilitates, the extinction of lithium-induced conditioned taste aversion in rats.

94. I. VILLANUEVA, L. QUEVEDO-CORONA, R. MARTINEZ-OLIVARES, D. RIVERA, R. RACOTTA: Adrenal medulla does not contribute to the compensation of the effects of chronic sympathectomy on feeding.

95. T.J. KOEHNLE, A. STEPHENS, D.W. GIETZEN: Alteration of the microstructure of feeding behavior during the first meal of a threonine-imbalanced diet.

96. J.W. SHARP, L.J. MAGRUM, C.M. ROSS, D.W. GIETZEN: Molecular signaling in the anterior piriform cortex in response to corrected and threonine-devoid diets.

97. L. MAKARIOS LAHHAM, S. ROSEAU, D. TOME, P. EVEN: Feeding strategy in rats offered a choice between pure proteins and a carbohydrate-lipid mix.

98. L. MAKARIOS LAHHAM, S. ROSEAU, J.-C. BOUTHEGOURD, D. TOME, P. EVEN: Adaptation to high protein diet involves both nitrogen and carbohydrate metabolism in rat.

09:00-11:00 Exhibitor’s Display

11:00 Adjourn


20

ABSTRACTS Abstracts for the 10th SSIB meeting have been published in Appetite Vol. 39, Issue 1, pp. 61-109, 2002. Abstracts not published in Appetite per the authors’ request are printed below in alphabetical order. Linkage Analysis for Anorexia Nervosa. K.A. HALMI, D.E. GRICE, W.H. BERRETTINI, W.H. KAYE, THE PRICE CONSORTIUM. Weill Cornell Medical College, 21 Bloomingdale Rd., White Plains, New York, 10605, USA. A genomewide linkage analysis of 192 families with one anorexia nervosa proband and one affected eating disorder relative produced a nonparametric linkage (NPL) score, 1.80 at marker D452367 on chromosome 4. A linkage analysis in a subset of families, 37 with reduced heterogeneity (two affected relatives with restricting anorexia nervosa) produced the highest multipoint NPL score of 3.03 at marker D153721 on chromosome 1p. Genotyping of additional markers in this region gave a peak multipoint NPL score of 3.45. This finding is suggestive evidence for the presence of an anorexia nervosa susceptibilitiy locus on chromosome 1p. Meal patterning of high fat and high carbohydrate diet consumption in rats: Relevance to single meal studies. S.J. SYNOWSKI, Z.S. WARWICK, University of Maryland Baltimore County, Baltimore MD 21250. In rats, consumption of diets high in fat typically elicits greater intake and weight gain than consumption of diets high in carbohydrate. Isocaloric (2.3 kcal/ml) high-fat (HF) and high-carbohydrate (HC) liquid diets have been utilized to investigate macronutrient effects on meal size (kcals) and satiety (Am. J. Phys. 269, R30-7, 1995). In single laboratory meals (typically elicited by a conditioned stimulus), meal size of HF was approximately 34% greater than HC. In preload-testmeal paradigms, HF produced approximately 27% less postprandial satiety than HC. However, the relationship of these findings to spontaneous feeding is not known. The present study evaluates the ecological validity of findings from single laboratory meals by recording ad libitum feeding of HF and HC across eight days in a between-subjects design. Computerized records of lick activity are being analyzed to identify discrete meals according to established criteria (Am. J Phys. 275, R1511-22, 1998). From these data, measures of meal size, meal frequency and postprandial satiety will be derived. If the relative intake of HF and HC in spontaneous meals is consistent with that observed in a single laboratory meal, this will support the use of single meal strategies to understand macronutrient effects on feeding over longer periods of time. Supported by NIH DK55367. Mouse strain survey of voluntary mineral consumption. M.G. TORDOFF, A.A. BACHMANOV. Monell Chemical Senses Center, 3500 Market St., Philadelphia, PA 19104, USA. We conducted two surveys of the preference for calcium, sodium, and other minerals by mice. In one, 10-12 male mice from 28 strains received two-bottle tests with a choice between water and 4 or 5 concentrations of NaCl, KCl, CaCl2, and NH4Cl. In the other, 10 male and 10 female mice from 40 strains received two-bottle tests with three concentrations of CaCl2, Ca.lactate, NaCl, and Na.lactate. At the end of behavioral testing, blood was collected to analyze calcium and hormones related to mineral appetite. The results show the rich diversity of responses displayed by mice. Modest, although significant, correlations were present between strain mean CaCl2 and NH4Cl preferences, which suggests the possible involvement of a common physiological substrate. Other correlations were nonsignificant, including those between calcium and sodium preferences. This demonstrates that the intake of different minerals involves independent control mechanisms. We were surprised to find that few (if any) mouse strains showed sex differences in preferences for either sodium or calcium. This contrasts with work using other species and raises questions about the importance of reproductive steroids in determining mineral intake. The results form part of the Mouse Phenome Project, so they can easily be compared with many other behaviors and physiological measures, and thus create novel hypotheses about the controls of calcium and sodium preference. They also provide reference data for recognizing mutants and other mice with aberrant phenotypes. Finally, they provide a solid foundation for the dissection of the genetic basis of calcium and sodium intake. Investigation of the molecular mechanisms of angiotensin II type 1 receptor mediated mitogen-activated protein kinase (MAPK) activation. D.K. YEE, J. HINES, S.J. .FLUHARTY. Department of Animal Biology and Institute of Neurological Sciences, University of Pennsylvania, Philadelphia, PA. 19104. Increased thirst and salt appetite, which are classically associated with the neuropeptide angiotensin II (AngII), are mediated by centrally-located AngII type 1 receptors (AT1-Rs). This subtype is known to signal through (i) inositol trisphosphate (IP3) turnover, which controls cellular calcium mobilization, and (ii) activation of the p42 and p44 MAPKs, which control gene expression and cell proliferation. Using AT1-R mutants, we investigated the molecular determinants of AngII-induced receptor activation using both signaling pathways as functional indices. Surprisingly, receptor mutants that demonstrated drastically impaired AngII-induced IP3 responses still showed full ability to activate MAPK, thereby indicating that activation of these two signaling pathways involve different structural determinants within the receptor protein and that receptor activation may involve multiple activation states. In other G-protein coupled receptors, activation of MAPKs has been reported to be mediated by both Gq. and Gi. While the AT1-R is capable of coupling to these two G-proteins, the signaling pathway(s) utilized to activate MAPKs has not been completely determined for this receptor. Accordingly, we made use of specific inhibitors to protein kinase C (blocking the Gq pathway) and to Gi in further functional characterizations of wild type and mutant receptors. Preliminary data from these experiments do not support a role for either Gq or Gi in AT1-R mediated activation of MAPKs and suggest that an alternate signaling pathway(s) may connect this receptor to MAPK activation. Supported by NIH grants HL58792 and MH43787.

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AUTHOR DIRECTORY

Dr. Luna Abdallah Psychiatry University of California San Francisco 401 Parnassus Avenue San Francisco, CA 94143-0984 USA Tel.: 1(415)476-7894 Fax: 1(415)476-7884 Email: [email protected] Dr. Karen Ackroff Psychology Brooklyn College of CUNY 2900 Bedford Avenue Brooklyn, NY 11210 USA Tel.: 718-951-5606 Fax: 718-951-4824 Email: [email protected] Ms Tanja C M Adam Human Biologie Maastricht University Universiteitssingel 50 Maastricht, The Netherlands 6200 MD The Netherlands Tel.: 0031-43-3882111 Fax: 0031-43-3670976 Email: [email protected] Dr. Susan Aja Psychiatry Johns Hopkins University School of Medicine 720 Rutland Avenue, Ross 618 Baltimore, MD 21205 U.S.A. Tel.: (410)955-2996 Fax: (410)614-0013 Email: [email protected] Dr. Susan F Akana Physiology, Box 0444 UCSF 513 Parnassus Ave San Francisco, CA 94143-0444 USA Tel.: 415 476-3861 Fax: 415 476-4929 Email: [email protected] Ms. Myrtha Arnold Institute of Animal Sciences Swiss Federal Institute of Technology (ETH) Schorenstrasse 16 8603 Schwerzenbach, ZH 8603 Switzerland Tel.: x41-1-655-7345 Fax: x41-1-655-7201 Email: [email protected] Ms. Nicole M Avena Psychology Princeton University Washington Rd. Princeton, NJ 08544 USA Tel.: (609) 258-4463 Fax: (609) 258-1113 Email: [email protected]

Dr. Anthony V Azzara Psychiatry NY Hopsital-Weill Cornell Medical College 21 Bloomingdale Road White Plains, NY 10605 USA Tel.: 914-682-9100x2488 Fax: 914-682-3793 Email: [email protected] Dr. Nancy E. Badia-Elder Psychology IUPUI 402 North Blackford Indianapolis, IN 46202 USA Tel.: 317-278-1815 Fax: 317-274-6756 Email: [email protected] Dr. Vaishali Pradip Bakshi Psychiatry University of Wisconsin at Madison 6001 Research Park Blvd. Madison, WI 53719 USA Tel.: 608-265-6062 Fax: 608-265-3050 Email: [email protected] Dr. Brian Anthony Baldo Psychiatry University of Wisconsin-Madison Medical School 6001 Research Park Blvd. Madison, WI 53719 U.S.A. Tel.: (608) 263-4019 Fax: (608) 265-3050 Email: [email protected] Mrs. Jennifer Ann Barrett Anatomy, Physiology and Cell Biology University of California, Davis School of Veterinary Medicine Davis, CA 95616 USA Tel.: 530-752-8073 Fax: 530-752-7690 Email: [email protected] Dr Gary K. Beauchamp Monell Chemical Senses Center 3500 Market Street Philadelphia, PA 19104 USA Tel.: 215 898 8878 Fax: 215 898 2084 Email: [email protected] Ms. Kimberly R. Bell Psychology University of Maryland, Baltimore County 1000 Hilltop Circle Baltimore, MD 21250 US Tel.: (410) 455-2360 Fax: (410)871-0190 Email: [email protected]

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22

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Pharmacology Psychology Yonsei University College of Medicine Barnard College, Columbia University

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Psychiatry Human Nutrition Institut National Agronomique Paris-Grignon

Neuroendocrinology University of Cincinnati University of Groningen 231 Albert Sabin Way, Box 670559 16, rue Claude Bernard Kerklaan 30 Cincinnati, OH 45267-0559 USA Paris, Paris 75231 cedex 05 FRANCE Haren, The Netherlands PO 14 9750

AA The Netherlands Tel.: 513-558-6588 Tel.: +33 1 44081718 Fax: 513-558-5783 Fax: +33 1 44087248 Tel.: ++31 50 363 2337 Email: [email protected] Email: [email protected] Fax: ++31 50 363 2331 Email:

[email protected] Dr. Beverly J. Tepper Dr. Michael G. Tordoff Dept. of Food Science Monell Chemical Senses Center Rutgers University 3500 Market St Ms. Cheryl Hope Vaughan 65 Dudley Road Philadelphia, PA 19104-3308 USA Psychology New Brunswick, NJ 08553 USA Tel.: 215-898-9680 University of Florida Tel.: 732-932-9611 x 221 Fax: 215-898-9680 PO BOX 112250 Fax: 732-932-6776 Email: [email protected] Gainesville, FL 32611-2250 USA Email: [email protected] Tel.: 352-392-0601 Dr. Kunio Torii Fax: 352-392-7985 Prof. Louise Thibault Institute of Life Science Email: [email protected] School of Dietetics and Human Nutrition Ajinomoto Co.,Inc. McGill University 1-1 Suzuki-cho, Kawasaki-ku Mr. Ivan Villanueva 21,111 Lakeshore Road Kawasaki, Kanagawa 210-8681 Japan Physiology Ste-Anne de Bellevue, Quebec H9X 3V9 Canada

Tel.: +81-44-244-7183 Escuela Nacional de Ciencias Biologicas Fax: +81-44-210-5893 Carpio y Plan de Ayala S/N

Tel.: 514-398-7848 Email: [email protected] Mexico City, Mexico, D.F. 11340 Mexico Fax: 514-398-7739

Email: [email protected] Ms. Andrea Lyn Tracy Tel.: (52)57-29-63-00 x 62348 Psychological Sciences Fax: (52) 57-29-62-06 Mr. Andy John Thorpe Purdue University Email: [email protected] Neuroscience 1364 Psychological Sciences Bldg. University of Minnesota West Lafayette, IN 47907 USA Dr Neeltje Vogels VAMC, 1 Veterans Drive, GRECC 11G, Tel.: 765-494-6224 Human Biology Minneapolis, MN 55417 USA Fax: 555-555-5555 Maastricht University Tel.: 612) 384-3377 Email: [email protected] Universiteitssingel 50 Fax: 612) 725-2084 Maastricht, Limburg 6200 MD The

Netherlands Email: [email protected] Prof. Janet Treasure Academic Psychiatry Tel.: +31 43 3882115 Dr. Robert L. Thunhorst King's College London Fax: +31 43 3670976 Psychology 5th Floor Thomas Guy House Email: [email protected] University of Iowa London, SE1 9RT England 11 Seashore Hall E Tel.: 020 7955 4247 Dr. Joerg-Peter Wolfgang Voigt Iowa City, Iowa 52242-1407 USA Fax: 020 7955 8886 Institute of Pharmacology and

Toxicology Tel.: (319)335-0509 Email: [email protected] Fax: (319)335-0191 Freie Universität Berlin, School of

Veterinary Medicine Email: [email protected] Prof. Jack Edward Turman, Jr. Biokinesiology and Physical Therapy Koserstr. 20 Dr. Todd E. Thiele University of Southern California Berlin, Berlin 14195 Germany Psychology 1540 E. Alcazar St., CHP155 Tel.: #49-30-83853513 UNC at Chapel Hill Los Angeles, CA 90089 USA Fax: #49-30-83853112 Campus Box 3270 Tel.: 323-442-2947 Email: [email protected] Chapel Hill, NC 27599-3270 USA Fax: 323-442-1515 Tel.: 919-966-1519 Email: [email protected] Dr. Zoe Sybil Warwick Fax: 919-962-2537 Psychology Email: [email protected] Mr. Robert C. Twining Univ. of Maryland Baltimore County Neuroscience and Behavioral Science 1000 Hilltop Circle

The Pennsylvania State College of Medicine

Baltimore, MD 21250 USA Tel.: 4104552360

500 University Dr. Fax: 4104551055 Hershey, PA 17033 USA Email: [email protected] Tel.: 717-531-6063 Fax: 717-531-6916 Email: [email protected]

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Dr. Alan Watts Neuroscience University of Southern California Hedco Neuroscience Building, 3641 Watt Way Los Angeles, CA 90089 USA Tel.: 213-740-1497 Fax: 213-741-0561 Email [email protected] Dr. Richard Stuart Weisinger Neurobiology Howard Florey Institute University of Melbourne Melbourne, Victoria 3010 Australia Tel.: 613-8344-7459 Fax: 613-9348-1707 Email: [email protected] Dr. Margriet S. Westerterp-Plantenga Human Biology University of Maastricht Universiteitssingel 50 Maastricht, Zuid-Limburg 6200 MD The Netherlands Tel.: + 31 43 3881617 Fax: + 31 43 3670976 Email: [email protected] Mr. Robert Allen Wheeler Behavioral Science Penn State College of Medicine 500 University Drive Hershey, PA 17033 USA Tel.: (717) 531-3758 Fax: (717) 531-6916 Email: [email protected] Mr. Peter Wielinga Neuroendocrinology University of Groningen P.O.Box 14 Haren, Groningen 9750 AA The Netherlands Tel.: +31 50 363 2333 Fax: +31 50 363 2331 Email: [email protected] Dr. Matthew James Will Psychiatry University of Wisconsin, Madison 6001 Research Park Blvd. Madison, WI 53719 USA Tel.: 608-265-4629 Fax: 608-265-3050 Email: [email protected] Ms Diana Leigh Williams Psychology University of Pennsylvania 3815 Walnut St. Philadelphia, PA 19104 USA Tel.: 215-898-8617 Fax: 215-898-5957 Email: [email protected]

Ms. Kihmberly Ann Wilmer Psychiatry University of Cincinnati 231 Albert Sabin Way Cincinnati, Ohio 45267 USA Tel.: 513 558 1152 Fax: 513 558 8990 Email: [email protected] Ms. Amy Namohai Wolfe Bourne Lab NY Presbyterian Hospital-Weill Cornell Medical College 21 Bloomingdale Road White Plains, NY 10605 U.S.A. Tel.: (914) 997-5935 Fax: (914) 682-3793 Email: [email protected] Dr. Matt D Wortman Psychiatry University of Cincinnati 231 Albert Sabin Way Cincinnati, OH 45267 USA Tel.: 513-558-5373 Fax: 513-558-8990 Email: [email protected] Dr. Xiaoqui Xiao Division of Neuroscience Oregon National Primate Research Center, 505 NW 185 th AVE Beaverton, OR 97006 USA Tel.: (503)690-5294 Fax: (503)690-5384 Email: [email protected] Dr. Daniel K. Yee Department of Animal Biology University of Pennsylvania 3800 Spruce St., Rm 261E Philadelphia, PA 19104-6046 USA Tel.: 215-898-9149 Fax: 215-898-0899 Email: [email protected] Dr Martin Richard Yeomans Experimental Psychology University of Sussex Falmer Brighton, East Sussex BN1 9QG UK Tel.: +44 1273 678617 Fax: +44 1273 678058 Email: [email protected] Ms. Jenny Yiee Otolaryngology Yale University School of Medicine P.O. Box 208041 New Haven, CT 06520-8041 USA Tel.: 203-785-2587 Fax: 203-785-3290 Email: [email protected]

Dr. Huiyuan Zheng Neurobiology of Nutrition Laboratory Pennington Biomedical Research Center 6400 Perkins Road Baton Rouge, LA 70808 USA Tel.: (225) 763 3001 Fax: (225) 763 3030 Email: [email protected]

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SOCIETY INFORMATION AND MEMBERSHIP

SSIB and how to join SSIB is a professional organization of research scientists who study eating and drinking behavior. The Society’s main goal is to advance the study of ingestive behavior by facilitating communication among its members. “Intake” is the Society’s periodic newsletter. SSIB membership information and applications are available at the meeting registration desk, at the SSIB web site (http://www.ssib.org), or by writing to the Central Office (address below). Executive Office Harry R. Kissileff, Ph.D., Executive Officer Joseph R. Vasselli, Ph.D., Associate Executive Officer Central Office Marianne Van Wagner, Executive Coordinator SSIB Central Office 8181 Tezel Road, #10269 San Antonio, TX 78250 USA Tel.: 210-682-4190 Fax: 210-682-4195 Email: [email protected]

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SUMMARY SCHEDULE

Wednesday, August 7 11:00-14:00 Long Range Planning Committee – Room J102 12:00-15:00 Registration and On-Campus Housing Check-in – College Eight Cafe 14:00-16:00 Board Meeting – Room J102 16:00-18:00 Welcome Reception/Strolling Dinner -University House Thursday, August 8 07:15-08:00 Breakfast - College Eight Dining Hall 08:00-11:00 Registration - Room P108 08:15-08:25 Opening – Room M110 08:30-10:30 Symposium 1: Metabolic consequences of chronic stress - Room M110 10:30-11:00 Refreshment Break/Exhibitor’s Display - Room P108 11:00-12:30 Oral Session 1: Metabolic controls - Room M110 Oral Session 2: Modulation of human food intake - Room Second Stage 12:30-14:00 Lunch - College Eight Dining Hall 14:00-16:00 New Investigator Presidential Symposium - Room M110 15:00-17:00 Registration - Room P108 16:00-16:30 Refreshment Break/Exhibitor’s Display - Room P108 16:30-18:30 Symposium 2: Probing biological contributaries to anorexia nervosa - Room M110 Oral Session 3: Extrahypothalamic mechanisms - Room Second Stage 18:30-19:45 Dinner - College Eight Dining Hall 20:00-22:00 Poster Session I / with Wine and Cheese – Rooms H101—posters 1-36 and P108—posters 37-50

Exhibitor’s Display Friday, August 9 07:15-08:00 Breakfast - College Eight Dining Hall 08:00-10:00 Symposium 3: Developmental aspects of ingestion - Room M110 Oral Session 4: Peripheral signaling and GI function - Room Second Stage 09:00-11:00 Registration - Room P108 10:00-10:30 Refreshment Break/Exhibitor’s Display - Room P108 10:30-12:30 Symposium 4: Nutritional neuroscience of amino acids: … - Room M110 Oral Session 5: Mineral & Fluid Balance/Learning and Selection - Room Second Stage 12:30-14:00 Lunch - College Eight Dining Hall 14:00-15:00 Keynote Lecture - Room M110 15:00-17:00 Registration - Room P108 15:00-18:00 Exhibitor’s Display- Room P108 15:00-16:30 Women’s Forum - Room M110 16:30-18:00 New Investigator Forum - Room M110 18:30-19:45 Dinner - College Eight Dining Hall Saturday, August 10 07:15-08:00 Breakfast - College Eight Dining Hall 08:00-10:00 Symposium 5: Peptides: Their role in excess alcohol drinking … - Room M110 Oral Session 6: Central responses to peripheral signals - Room Second Stage 10:00-10:30 Refreshment Break/Exhibitor’s Display - Room P108 10:30-12:30 Symposium 6: Thirst and sodium appetite - Room M110 Oral Session 7: Illness and malaise - Room Second Stage 12:30-14:00 Lunch - College Eight Dining Hall 14:00-15:30 Oral Session 8: Hypothalamic mechanisms - Room M110 Oral Session 9: Human eating disorders - Room Second Stage 15:30-16:00 Refreshment Break- Room P108 15:30-17:00 Exhibitor’s Display - Room P108 16:00-17:00 Business Meeting - Room M110 17:00-18:00 Award Lectures - Room M110 19:00-23:00 Banquet – Cocoanut Grove, 400 Beach Street, Santa Cruz Transportation will be provided. Sunday, August 11 07:15-08:00 Breakfast - College Eight Dining Hall 09:00-11:00 Poster Session 2 / with refreshment break – Rooms H101—posters 51-86 and P108—posters 87-98 Exhibitor’s Display 11:00 Adjourn 11:45-13:15 Lunch - College Eight Dining Hall

Next SSIB Meeting

July 15-19, 2003 Biological Center

University of Groningen The Netherlands

SOCIETY FOR THE STUDY OF INGESTIVE … · Jennifer Ann Barrett, University of California--Davis,...

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