Slide discussion Dr Neena-edit 4 - IAPM Kerala discussion Dr Neena...Typhifast Positive Widal...
Transcript of Slide discussion Dr Neena-edit 4 - IAPM Kerala discussion Dr Neena...Typhifast Positive Widal...
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Case discussion Case discussion Dr. Neena Mampilly, MD
Senior Consultant
Baby Memorial Hospital
Kozhikode
IAPM Kerala Chapter June 2020
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Case 1
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• 45 yr male
• H/O swelling left upper cervical level IIb
• No fever, pain, dysphagia
• Treated case of Koch’s adenitis 6 months back• Treated case of Koch’s adenitis 6 months back
• General examination and systems: WNL
• Routine blood investigations : WNL
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Cervical lymph node biopsy
• Lymph node 4x3x3cm
• Cut section fleshy
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Case 2
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Clinical history
• 19 yr male
• C/O left submandibular swelling of 6 months duration, increased in size since 1 month
• No H/O fever/ weight loss• No H/O fever/ weight loss
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Clinical examination
• General condition fair
• No pallor/ edema/ icterus
• Swelling left submandibular region 3.5 cm
• No other lymph nodes palpable• No other lymph nodes palpable
• No organomegaly
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Investigations
• Complete Blood Count
• Hb 15.4g%
• Total count 8700/cmm; N 50%, L 40%, E 7%, M 3%
• Platelets 2.5 L/cmm
• Blood urea 21mg/dl• Blood urea 21mg/dl
• S. Creatinine 0.9 mg/dl
• S. uric acid 7.3 mg/dl
• LFT WNL
• LDH 156
• Peripheral smear WNL
• HIV/ HBsAg Negative
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• Left submandibular lymph node biopsy
• Grossly , lymph node mg 3cm/3cm/3cm. Cut section uniform fleshy whitesection uniform fleshy white
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Case 3
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• 11 yr male
• C/O fever 1 month
• Swelling in back and thigh 1 week
• No h/o significant illness in the past• No h/o significant illness in the past
• O/E, 2.5x2.5cm swelling (R) infrascapular region, 1.5x1.5cm swelling (R) preauricular region, 1x1cm swelling anterolateral region of (R) thigh
• Systemic examination : WNL
• Blood investigations: WNL
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• Trucut biopsy from chest wall lesion and thigh lesionlesion
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Case 4
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Clinical history
• 28 yr lady
• C/O high grade fever 1 week
• Toothache and generalised tiredness
• O/E cervical lymph nodes• O/E cervical lymph nodes
• Splenomegaly
• CVS, CNS, RS , WNL
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Investigations
• Hb 12, TC 6.6(N60,L38,E2)
• Plt 110K
• ESR 28
• S.Creat 0.6• S.Creat 0.6
• Na 135,K 4.3
• Urine RE : wnl
• CXR : normal
• TB 0.9, SGPT 274, SGOT 296
• ALP 444,TP 7.2(3.5/3.7)
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Investigations…
• Hb 10/TC 2.6K/Plt 47K
• ESR 36
• S creat 0.5
• SGPT 151(274)• SGPT 151(274)
• Cultures Sterile
• Rpt CXR no patch
• S Ferritin 1300/ TG 267
• ANA : Neg.
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Peripheral smear
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• Dengue Ab : Neg.
• Leptospira Ab : Neg.
• Rickettsial Ab : Neg.
• Malaria Card : Neg.
• Rpted Thick smear• Rpted Thick smear
for MP : Neg.
Hepatitis markers : Neg.
Typhi fast Positive
Widal Negative
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Clinical differentials
• Dental abscess
• Viral syndrome
• Enteric fever
• Malaria• Malaria
• Rickettsial fever
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USG Abdomen
• Liver mildly enlarged
• Acute hepatic parenchymal disease
• Splenomegaly
• Upper abdominal lymphnodes• Upper abdominal lymphnodes
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• Fever persisting
• Tachycardia
• Rpt Cultures negative
• 2D Echo to R/O IE• 2D Echo to R/O IE
• S ferritin 3966(1361)
• TG 389(267)
• Bicytopenia
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• Bone marrow showing histiocytosis with hemophagocytosis
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Clinical diagnosis
• Hemophagocytic Lymphohistiocytosis(HLH)
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• Cervical lymph node biopsy
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