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Transcript of Slide 1 June 06Download K2.4_2.0a Science Knowledge: Science 2: Life Processes and living things...
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June 06 Download K2.4_2.0a Slide 1
Science Knowledge: Science 2: Life Processes and living things
K2.4 Variation, Inheritance & Evolution
• This document can be freely copied and amended if used for educational purposes. It must not be used for commercial gain. The author(s) and web source must be acknowledged whether used as it stands or whether adapted in any way.
• Download K2.4_2.0a Authored by Liz Lakin and Keith Ross, University of Gloucestershire. accessed from http://www.ase.org.uk/scitutors/
• date created March 2006
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June 06 Download K2.4_2.0a Slide 2
Variation, Inheritance & Evolution Learning Objectives
• To explore the science behind the headlines
• To establish a timeline of events leading to our current scientific understanding
• To identify the ‘big ideas’ in this field of biology and recognise how they are interlinked
• To discuss modern applications & their associated issues
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June 06 Download K2.4_2.0a Slide 3
http://www.ncseweb.org/evc/EvsC-cover_400.jpg
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June 06 Download K2.4_2.0a Slide 4
http://users.hol.gr/~dilos/prehis/Darwcar.jpg
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June 06 Download K2.4_2.0a Slide 5
http://www.healthcastle.com/images/vegetables.jpg &
: www.picture-newsletter.com/ vegetables/index.htm
Variation
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June 06 Download K2.4_2.0a Slide 6
www.nmm.ac.uk/.../ outputRegister/lowhtml
Charles Darwin recognised the significance of variation in a range of organisms
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June 06 Download K2.4_2.0a Slide 7
The Story of the Peppered Moth
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June 06 Download K2.4_2.0a Slide 8
Human Evolution
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June 06 Download K2.4_2.0a Slide 9
Selection?
• What we are is determined by our genes and our environment
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June 06 Download K2.4_2.0a Slide 10
Father of Modern Genetics
• Gregor Mendel• Austrian Monk
(1850s)• Identified the patterns
of inheritance• Laws of Inheritance
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June 06 Download K2.4_2.0a Slide 11
Multiple choice questions
The questions in the slides that follow are taken from a set of over 100 available from
www.escalate.ac.uk/1141 Percentages quoted in the slides are for a group of 100
trainee primary teachers on entry to ITE, having obtained a ‘C’ or better at GCSE, usually two or three years previously.
This gives secondary trainees an insight into the misconceptions that survive a GCSE course, and all trainees some comfort that they are not alone with their own misconceptions about how genetics and evolution works.
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Recessive GenesIf you and your partner both carry the disease for cystic fibrosis (but are not
sufferers), what would be the probability that your children will then inherit
the actual disease?
a. 25% (1 in 4) 5%
b. 33.3% (1 in 3) 19%
c. 50% (1 in 2) 35%
d. 100% (1 in 1 - certainty) 39%(% are for a survey of post GCSE students – see notes)
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June 06 Download K2.4_2.0a Slide 13
Mendelian Cross
Both parents carry the recessive gene for cystic fibrosis (c) they also carry the ordinary gene (C). The cross can be summarised as follows:
Father
Mother
C
C CC CcCF carrier
c CcCF carrier
ccCF
sufferer
CC
c
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June 06 Download K2.4_2.0a Slide 14
Eye Colour
In eye colour the allele for brown eyes is dominant (B) and the allele for blue eyes is recessive (b). Try some different crosses with homozygous parents (BB or bb) and heterozygous parents (Bb):
Father
Mother
B b
b Bb bb
b Bb bb
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June 06 Download K2.4_2.0a Slide 15
So what are Genetics?
• Look at the person next to you and identify as many external similarities between the two of you, as you can.
• Now identify as many differences as possible.
Our common inheritance as humans
The tiny amount of variation in our genesWe share half our genes with bananas and 99% with the chimpanzee
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June 06 Download K2.4_2.0a Slide 16
One fertilised cell to an organism!
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June 06 Download K2.4_2.0a Slide 17
Development of an egg
What will happen to the weight of a fertilised bird's egg from time of laying to just before the chick hatches?
• It gets lighter 6%• It gets heavier 54%• It stays much the same 35%(% are for a survey of post GCSE students – see notes)
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June 06 Download K2.4_2.0a Slide 18
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June 06 Download K2.4_2.0a Slide 19
Genes
• What are your genes?
• Do bacteria have genes?
• Is the genetic information in the sex cells the same as in other cells?
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June 06 Download K2.4_2.0a Slide 20
Let’s look at cells …
• Several types • 75 billion in a human
being• Capable of carrying
out many different functions e.g. …– Protection– Movement– Excretion
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June 06 Download K2.4_2.0a Slide 21
Importance of Proteins
Click on the one statement you most agree with about why proteins are so important to living things.
a. They are a nutritious food 8% b. They are the enzymes in our bodies which enable our cells
to work. 37% c. When combined with oxygen, lots of energy is given off
6% d. Protein provides the structural material in all living things
45% (% are for a survey of post GCSE students – see notes)
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June 06 Download K2.4_2.0a Slide 22
Material of Inheritance …
• What are the requirements of hereditary material?
– Store information
– Permanence
– Ability to change (mutate)
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June 06 Download K2.4_2.0a Slide 23
Unique function of DNA
• Stores information for protein synthesis
• Makes copies of itself ~ self replication
• Able to change/vary/mutate
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June 06 Download K2.4_2.0a Slide 24
DNA• Deoxyribonucleic Acid• Molecular language ~ 4 different
letters• Codon – three letter word – most
code for an amino acid• GENE ~ sentence of many words
(amino acids) which enables it to build PROTEINS
• Proteins are enzymes that enable reactions to take place in cells
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June 06 Download K2.4_2.0a Slide 25
… base, nucleotide, gene, chromosome
The following terms all relate to the DNA molecule. List them in relation to their size, starting with the smallest
a gene b nucleotide c chromosome d bases (4% of the BEd Students got it right)
http://en.wikipedia.org/wiki/Nucleotide
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DNAClick on the four sentences about human DNA that are true.
a. It carries the code to make proteins. 50%
b. It can pass from one generation to the next. 83%
c. It can make copies of itself. 68%
d. It is a single stranded molecule. 26%
e. It is made of protein. 51%
f. It is identical in almost every cell of our body. 66% (% are for a survey of post GCSE students – see notes)
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June 06 Download K2.4_2.0a Slide 27
Protein Synthesis
• A simulation …
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June 06 Download K2.4_2.0a Slide 28
Link to HOME Quiz
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June 06 Download K2.4_2.0a Slide 29
Variation from mutation
Which two of the following processes leads to 'variation' in the offspring:
a. Cell cloning. 4%
b. Gamete formation. 34%
c. Mitosis (normal cell division). 51%
d. Meiosis (sex cell formation) 55% (% are for a survey of post GCSE students – see notes)
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June 06 Download K2.4_2.0a Slide 30
Tracing your ancestry
A mutation of which of the following could be inherited from both your parents?
a. Messenger RNA 20
b. Nuclear DNA 29
c. Ribosomal RNA 13
d. Mitochondrial DNA 35 (% are for a survey of post GCSE students – see notes)
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June 06 Download K2.4_2.0a Slide 31
Artificial Selection
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June 06 Download K2.4_2.0a Slide 32
Manipulation of genes …
• Genotype
• Phenotype & selective breeding
• Manipulation of genes
• Biotechnology
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June 06 Download K2.4_2.0a Slide 33
How genes work …
• Inheritance
• Mutations
• Stem cells
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June 06 Download K2.4_2.0a Slide 34
Genetic Engineering
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June 06 Download K2.4_2.0a Slide 35
What do we need to do to genetically engineer something?
• Location of genes
• Isolation of genes
• Removal of genes
• Transfer of genes
• Cultivation of genes
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June 06 Download K2.4_2.0a Slide 36
Where do we go from here …?
• Dolly ~ cloned from a mature cell by nuclear transfer
• Polly ~ cloned from an embryo cell, but contains a human gene which produces the human protein in the sheep’s milk
• Why are they scientifically significant?
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June 06 Download K2.4_2.0a Slide 37
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June 06 Download K2.4_2.0a Slide 38
What are the issues … ?
• Monsanto monopoly
• 1998 Government moratorium on the growth of GM crops
• Media hype and scare mongering
• Human cloning & designer babies
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June 06 Download K2.4_2.0a Slide 39
So what do you think?
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June 06 Download K2.4_2.0a Slide 40
So what do you really think?
• Should scientist be allowed to alter animal genes:– For medical
reasons?– For healthier or
more efficient food production?
– For commercial reasons?
• Should scientists be allowed to alter Human genes:– For medical
reasons?– For commercial
reasons?
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June 06 Download K2.4_2.0a Slide 41
Recap …
• What do genes do?
• Where do we find genes?
• What makes DNA so good as hereditary material?
• What information does DNA store?
• How does it store it?
• What happens next …
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June 06 Download K2.4_2.0a Slide 42
Protein (enzyme) Synthesis• Key points:
– Copy DNA– Messenger RNA copy to site of synthesis– Collect (Transfer RNA) selection of amino
acids and arrange amino acids in correct sequence
– Builds a polypeptide chain (= protein)– Several produced at one time– Allows chemical reactions to take place in cell.
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June 06 Download K2.4_2.0a Slide 43
Gene Expression
• Switching genes on and off …
• Stem cells and mature differentiated cells
• Growth = cell division and cell differentiation
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June 06 Download K2.4_2.0a Slide 44
Gene Therapy
• Treatment of diseases by the introduction of powders containing working copies of the defective gene ~ saturation approach
• Cystic Fibrosis• Problems:
– Disease is rare in the population– Expensive to treat– Research pressure into common ailments
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June 06 Download K2.4_2.0a Slide 45
Genetic Engineering
• Transfer of genes from one species to another.
• How is it done?
• Gene Splicing
• Limitations ~ can only add genes
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June 06 Download K2.4_2.0a Slide 46
• http://www.food.gov.uk/gmdebate/aboutgm/?view=GM%20Microsite
Countries which are already growing some GM crops
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June 06 Download K2.4_2.0a Slide 47
Concept map
• Compare building a house and cell?
• DNA, genes and enzymes
• Mitosis (cell division) and meiosis (sex)
• Phenotype and genotype – recessive genes
• Growth = cell division & differentiation
• Mutation - natural and artificial
• GM debate and other issues
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June 06 Download K2.4_2.0a Slide 48
Learning log
• Look at the questions – where were your conceptual misunderstandings?