World’s first health promoting applications based on standard mobile phone technology:

1. SLEEP DISORDER DIAGNOSTICS : SleepStick®

2. SMART ALARM CLOCK : HappyWakeUp®

More details:www.happywakeup.com

Patents pending 2006-2008©SmartValley Software Oy, Finland

SMART VALLEY SOFTWARE Ltd

RECORDING OF MOVEMENTS DURING SLEEP

Smart Valley Software Ltd

• Spin-off company (2006) from• Helsinki University and University Hospital• Tampere Technical University

• Strength: biosignal analysis, sleep disorders, computer software development

Smart Valley sleep monitoring technology is based on medical sleep research of > 20 years - full papers 1986-2008

• 15. Salmi T and Leinonen L. Automatic analysis of static charce sensitive bed records. Electroenceph Clin Neurophysiol, 1986:64:84‑87.

• 16. Salmi T, Partinen M, Kronholm E , Hyyppä M. Automatic analysis of static charge sensitive bed (SCSB) recordings in sleep related apneas. Acta Neurol Scand, 1986:74:360‑364.

• 17. Telakivi T, Partinen M, Salmi T, Leinonen L, Härkönen T. Nocturnal periodic breathing in adults with Down's syndrome. Journal of Mental Defiency Research, 1987:31;31‑39.

• 18. Erkinjuntti T, Partinen M, Sulkava R, Telakivi T, Salmi T. Tilvis R. Sleep apnea in multi-infarct dementia and Alzheimer's disease. Sleep, 1987:10;419-425

• 19. Telakivi T, Partinen M, Koskenvuo M, Salmi T, Kaprio J. Periodic breathing and hypoxia in snorers and controls: validation of snoring history and association with blood pressure and obesity. Acta Neurol Scand, 1987:76:69‑75

• 22. Salmi T, Sovijärvi ARA, Brander P, Piirilä P. Long-term recording and automatic analysis of cough by using filtered acoustic signals and movements of static charge sensitive bed. Chest, 1988;94:970-75

• 23. Salmi T, Telakivi T, Partinen M. Validation of automatic analysis of oxygen saturation, air-flow and respiratory movements in diagnosis of sleep related apneas. Chest, 1989;96:255-61

• 24. Telakivi T, Kajaste S, Partinen M, Koskenvuo M, Salmi T, Kaprio J. Cognitive function in middle-aged snorers and controls: role of excessive daytime somnolence and sleep-related hypoxic events. Sleep 1989

• 25. Telakivi T, Kajaste S, Partinen M, Salmi T, Koskenvuo M, Kaprio J. Snoring history, periodic breathing and hypoxia during sleep. in: Sleep 86, 430-431, ed: WP Koella, F Obal, H Schulz, P Visser. G Fischer, Stuttgart 1988.

• 33. Partinen M, Telakivi T, Kaukiainen A, Salmi T, Färkkilä M, Saijonmaa O, Fyhrquist F. Atrial natriuretic peptide in habitual snorers. Ann Medicine 23:147-51,1991

• 36. Brander PE, Salmi T. Nocturnal oxygen saturation and sleep quality in patients with advanced chronic obstructive pulmonary disease during treatment with moderate dose CR-theophylline. Eur J Clin Pharmacol 1992, 43:125-9.

• 37. Brander PE, Kuitunen T, Salmi T, Partinen M. Nocturnal oxygen saturation in advanced obstructive pulmonary disease after a moderate dose of ethanol. Eur Respir J 1992, 5: 308-312.

• 39. Brander PE, Salmi T, Partinen M, Sovijärvi ARA. Nocturnal oxygen saturation and sleep quality in long-term survivors of thoracoplasty. Respiration 1993;60:325-331.

• 42. Salmi T, Brander PE. Computer assisted detection of REM and non-REM sleep for analysis of nocturnal hypoxaemia in patients with ventilatory impairment. Int J Clin Mon Comp 1994;11:63-70

• 43. Hublin C, Partinen M, Heinonen EH, Puukka P, Salmi T. Selegiline in the treatment of narcolepsy. Neurology 1994;44:2095-2101

• 44. Koskenvuo M, Partinen M, Kaprio J, Vuorinen H, Telakivi T, Kajaste S, Salmi T, Heikkilä K. Snoring and cardiovascular risk factors. Ann Med 1994;26:371-6

• 46. Jokinen T, Salmi T, Ylikoski A, Partinen M. Use of computerized visual performance test in assessing day-time vigilance in patients with sleep apneas and restless sleep. Int J Clin Monitor Computing 1995;12:225-230

• 47. Lojander J, Maasilta P, Partinen M, Brander PE, Salmi T, Lehtonen H. Nasal-CPAP, Surgery, and Conservative Management for Treatment of Obstructive Sleep Apnea Syndrome. A Randomized Study. Chest 1996; 110:114-119.

• 51. Lojander J, Salmi T, Maasilta P. Reproducibility of oximetry with a static-charge-sensitive bed in evaluation of obstructive sleep apnoea. Clinical Physiology 1998; 18,3:225-233

• 53. Kirveskari E, Partinen M, Salmi T, Sainio K, Hämäläinen M, Telakivi T, Larsen A, Santavuori P. Sleep alteration in juvenile neuronal ceroid lipofuscinosis. Pediatric Neurology 22(5):347-54, 2000

• 58. Virkkula P, Silvola J, Lehtonen H, Salmi T, Malmberg H The effect of esophageal pressure monitoring on nasal airway resistance. Otolaryngol Head Neck Surg 2001;125:261-264

• 60. Virkkula P, Silvola J, Maasilta P, Malmberg H, Salmi T Esophageal pressure monitoring in detection of sleep-disordered breathing. Laryngoscope 112:1264-70, 2002

• 61. Virkkula P, Maasilta P, Hytönen M, Salmi T, Malmberg H. Nasal obstruction and sleep-disordered breathing: the effect of supine bocy position on nasal measurements in snorers. Acta Otolaryngologica 123:648-654,2003

• 62. Virkkula P, Hurmerinta K, Löytönen M, Salmi T, Malmberg H, Maasilta P. Postural cephalometric analysis and nasal resistance in sleep-disordered breathing, Laryngoscope 113:1166-1774,2003

• 69. Virkkula P. Bachour A. Hytonen M. Malmberg H. Salmi T. Maasilta P. Patient- and bed partner-reported symptoms, smoking, and nasal resistance in sleep-disordered breathing. Chest 2005; 128(4):2176-82.

• 70. Virkkula P, Bachour A, Hytönen M, Salmi T, Malmberg H, Hurmerinta K, Maasilta P. Snoring is not relieved by nasal surgery despite improvement in nasal resistance. Chest 2006;129(1):81-87.

A New Tool for Sleep Disorders Screening

• Sleep disorders are very common• Sleep recordings are laborious and expensive• Screening of sleep disorders is difficult• SleepStick for a practical and economic screening and diagnosis of sleep disorders using mobile phone or MP3 player/recorder

-> New business opportunities

SLEEP DISORDERS are extremely common

Breathing disorders• snoring 10% -20%• breathing pauses during sleep = sleep apneas /

hypopneas 1-2-5-8% (10% in obese males?)

Periodic movements of legs, restless legs syndrome RLS 3% (young adults) - 10% (middle age) -.. %

Insomnia, restless sleep 10% -20% -Interest in sleep, well-being etc - 100%Awakening in the morning – almost 100%

SLEEP DISORDERS: diagnosis is difficult, recordings are expensive

• patient history is not always available

Sleep recordings are expensive• Sleep Lab Polysomnography -1000€• Home studies 200-300€

->Simple screening and follow-up methods are required

SmartValley - Devices for sleep recording: Nokia Mobile Phone and MP3 recorder / player

Recording and analysis of voice and sound signals generated by movements during sleep• Voices are typically considered as artifacts like

“Mobile cell phone in the pocket”, “Blowing to the microphone”

• Cheap, universally available devices (mobile cell phone, MP3 player), sensitive for voices

• No electrical contact to the subject, not disturbing sleep

• Millions of devices are owned by people all over the world

REAL PATIENT DATA - Restless legs syndromeUpper graph: 60 minutes of leg movements (SleepStick MP3)

Simultaneous control EMG recording

Note: the sensitivity is excellent!

SmartValley business plan

• Sampling (recording) of the night time signals using Nokia mobile phone or MP3 device.

• Simple graphic output – free.• Detailed graphic output and quantitative analysis – one

night or one week license.• Diagnosis of sleep disorders: snoring, RLS, apneas,

activity, duration of sleep etc• Transmission of personal data to the physician’s office or

to a centralized server like Microsoft HealthVault® - sponsored mode

HappyWakeUp – a Smart Alarm Clock for Nokia mobile phone

by Smart Valley Software

Available: www.happywakeup.com

From medical sleep research we know that sleep is

fragmented during last minutes of the sleep.

HappyWakeUp monitors your sleep using the microphone of the Nokia mobile phone. It listens to your sleep and movements.

It detects if you are awake or almost-awake in the morning during the 20 last minutes and gives you a mild alarm signal!

HappyWakeUp is extremely easy to be used: Set the regular Nokia wake up time and start HappyWakeUp!

Locate Nokia Mobile phone near to you and enjoy the night sleep!

In the morning you get a natural and refreshed awakening and extra active minutes because your brain is already awake. No harmful stress!

SmartValley vision:

Our reseach based monitoring technology is used to monitor and diagnose the very common sleep disorders (snoring, sleep apnea, restless legs, insomnia) using Nokia mobile phone.

The new technology will promote people’s health in all countries, especially in developing countries without resources in sleep medicine.

HappyWakeUp is a smart alarm clock for everybody using alarm clock - to make your every morning happy!