Sites of Action in Coagulation System

Novel Factor Xa and DT Inhibitors

Brief Overview of NOACs

NOACsImportant Comparative Features

Effect on NOAC Plasma Levels from D-D Interactions, and Recommendations

Sites of Action in Coagulation System

Novel Factor Xa and DT Inhibitors

Brief Overview of NOACs

Ethnic Differences in Rate of ICH

Estimated Levels of Exposurein White and Japanese Patients

Primary Efficacy End Point (Stroke/SEE) mITT Population While on Treatment

Main Safety ResultsSafety Cohort on Treatment

Lower NOAC DoseClinical Implications

Incidence of Stroke or Systemic Embolism

Abbreviations

Abbreviations (cont)

Abbreviations (cont)

References

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