Single molecule manipulation: magnetic tweezers
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Transcript of Single molecule manipulation: magnetic tweezers
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Single molecule manipulation: magnetic tweezers
INESC-MN
Magnets(NdFeB)
Magnets(NdFeB)
Resolution5 nm
[ ] Seidel et al, Nature Structural & Molecular Biology 11, 838-843 (2004)
52nd MMM Conference – Tampa FL November 2007 FA-05 3/38
EcoR124I
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INESC-MN53rd MMM Conference – Austin TX November 2008
CG-05Micro Fabricated Structures (Without Fluidic Chamber)Spin Valves & Magnetic Tunnel Junctions
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Magnetic Tweezer, DNA manipulation, DNA translocation
IAC
IDC
V+, I+ V-, I-
10m
M.R.
ATP
FP6 BioMolSwitch
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INESC-MN
Optical Scope – Vertical Switch
52nd MMM Conference – Tampa FL November 2007 FA-05 28/38
45 mA
IMT
0 mA
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INESC-MN53rd MMM Conference – Austin TX November 2008
CG-05
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Micro Fabricated Structures (Without Fluidic Chamber)Spin Valves & Magnetic Tunnel Junctions
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INESC-MN53rd MMM Conference – Austin TX November 2008
CG-05Bead DetectionIntermixing frequency
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