Silk Fibroin Wound Dressings
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Transcript of Silk Fibroin Wound Dressings
SILK FIBROIN WOUND DRESSINGS
Used for Regenerative Healing TherapiesSierra ObiApril 1, 2013
Cutaneous Wounds
Include severe burns, animal bites, skin tears There are numerous wound dressing biomaterials
on the market today Tested against an air permeable and a commercial
wound dressing product
Silk Fibroin
Promising biomaterial Versatile for various biomedical healing
applications Mechanical robustness Controllable degradability Safe in acute dermal toxicity
How They Work
Silk Fibroin derivative is tested on a full thickness skin wound model or an in vitro human skin model
controlled release of signaling molecules Addition of in vivo epidermal growth factor and
silver sulfadiazine
Wound Healing Model
Relationship of Wound Size
References
http://onlinelibrary.wiley.com/doi/10.1002/adhm.201200444/full
http://onlinelibrary.wiley.com/doi/10.1002/adhm.201200192/full
http://www.sciencedirect.com/science/article/pii/S1742706108004054
http://www.nejm.org/doi/full/10.1056/NEJMra0707253