Significance of Unofficial Ibogaine Treatment Scenes

7/31/2019 Significance of Unofficial Ibogaine Treatment Scenes

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Significance of Unofficial

Ibogaine Treatment Scenes The existence of these scenes indicates demand for

alternatives to existing treatment options.

Averse events including fatalities indicate the need forappropriate prospective medical evaluation of patients,monitoring within the treatment, and reliableformulations of ibogaine.

Anecdotal or case report evidence suggests apossible neurobiological drug action.

All of the above strongly support the need forappropriate clinical trials to evaluate safety and

efficacy in order to gain official approval


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US and European Ibogaine Scenes Through the Year 2000

Scene, yr.

began-

N Indication Dose Comments

US, New York

City, 1962-63

20 Psychological

insight, self-

experimentati

on

6-19 mg/kg Initial cohort on whom H.

Lotsofs observation of putative

effect on opioid withdrawal was

made1,2,3

Netherlands,

1989-93

~40-45 Addiction,

mainly opioidsand cocaine

15-29 mg/kg Treatments arranged by H.

Lotsof and Dutch and U.S. addictself-help groups

1,2,3,4

St. Kitts, West

Indies 1996-

~150 as

of 2000

Addiction,

mainly opioids

and cocaine

600-1200 mg Medical model including MD

supervised pretreatment

evaluation and monitoring1,5

U.S. West

Coast 1950s-?

? Psychological

insight

150-300 mg Highly secretive scene involving

significant involvement of

credentialed hea lth

professionals1,6

Eric Taub

1992-

~310 as

of 2000

Psychological

insight,

addiction

(mg/kg)

Insight: 9-12;

Addiction:cocaine, 12-

18, heroin,

20-24

Majority of treatments for

indication of psychological

insight, conducted in Caribbeanin informal setting

1

Netherlands

1999-

22

addicts,

4 non-

addicts

Addiction

(heroin,

cocaine

alcohol),

psychological

insight

3 to 6 g

extract (unk.

% iboga ine),

sometimes

with 3-500 mg

ibogaine

Individual providing treatments

in setting of her own home1

Slovenia 1995- ~150 as

of 2000

Addiction,

psychologicalinsight

? Loosely organized; the Iboga

Foundation in Ljubljana providesinformation and assists in

arranging treatments1,7

U.K. 1998- ~1/week

as of

2000

Addiction,

psychological

insight

? Very loosely organized, ibogaine

available via internet or certain

small retail shops1

Italy 1994- 35-40 Addiction,

psychological

insight

? Small scene involving a s ingle

individual working with his own

extract from iboga root bark1

Czech Republic

2000-2001

~60 non-

addicts,

18addicts

psychological

insight,

addiction(heroin)

(mg/kg)

Insight,

13-18;Addiction, 20-

22

Treatment p rovider discontinued

activity after approximately one

year due to perception of limitedbenefit w/o systematic afterca re

1


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1. Alper, K.R., Beal D., and Kaplan C.D. (2001). A Contemporary History of Ibogaine in the

United States and Europe. InIbogaine:Proceedings of the First International Conference (The Alkaloids

Volume 56), pp. 249-281. Academic Press, San Diego, California.

2. Lotsof, H.S., and Alexander N.E. (2001). Case studies of ibogaine treatment: implications

for patient management strategies. InIbogaine:Proceedings of the First International Conference (The

Alkaloids Volume 56), pp. 293-313. Academic Press, San Diego, California.

3. Alper, KR, Lotsof, HS, Frenken, GMN, Luciano, DJ, and Bastiaans, J. Treatment of Acute

Opioid Withdrawal with Ibogaine. American Journal on Addictions 8: 234-242, 1999.

4. Frenken G. (2001). From the roots up: ibogaine and addict self-help. InIbogaine:

Proceedings of the First International Conference (The Alkaloids Volume 56), pp. 283-292, Academic

Press, San Diego, California.

5. Mash, D.C., Kovera A. , Pablo J., Tyndale R., Ervin F.R., Kamlet J.D., and Hearn W.L.

(2001). Ibogaine in the Treatment of Heroin WithdrawalIbogaine:Proceedings of the First

International Conference (The Alkaloids Volume 56), (K. Alper and S.D. Glick Eds.), pp. 155-171.

Academic Press, San Diego, California.

6. Stolarof MJ. The Secret Chief. (1997) Multidisciplinary Association for Psychedelic Studies,

Charlotte NC, 144 pages.

7. Kastelic , A. Self-Help Use of ibogaine in Slovenia Presented at the First International

Conference on Ibogaine. New York, NY, Nov. 5 1999.


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Published Ibogaine Case

Studies One paper describing 33 treatments for opioid

dependence; complete resolution of withdrawalsigns and absence of drug-seeking behavior in 25(76%)1.

Total of 13 treatments, mainly for opioid

dependence, in four additional papers2,3,4,5.1. Alper, KR, Lotsof, HS, Frenken, GMN, Luciano, DJ, and Bastiaans, J (1999). Treatment of Acute Opioid Withdrawalwith Ibogaine. American Journal on Addictions 8: 234-242.2. Cantor, M. (1990). ``Interviews: ibogaine treated addicts''. The Truth Seeker 117(5), 23-26.3. Luciano, DJ. (1998). Observations on treatment with Ibogaine. American Journal on Addictions 7, 89-90.4. Sheppard, S.G. (1994). A preliminary investigation of ibogaine: case reports and recommendations for further study.J.Subst.Abuse Treat. 11, 379-385.

5. Sisko, B. (1993). Interrupting drug dependency with ibogaine: a summary four case histories. MultidisciplinaryAssociation For Psychedelic Studies (MAPS) Newsletter 4: 15-24.


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Drug Abstinence Following Ibogaine

Treatment (unpublished, presented to

NIDA March 1995)

Reported Time Interval of Post-

treatment Drug Abstinence N (%)


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Table 1 from: Alper, KR, Lotsof, HS, Frenken, GMN, Luciano, DJ, and Bastiaans, J.

Treatment of Acute Opioid Withdrawal with Ibogaine. American Journal on Addictions 8:

234-242, 1999.

Retrospective Case Series From Early1960s U.S. and

Late 1980s-Early 1990s Dutch Informal Scenes:

Subjects


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Table 2 from: Alper, KR, Lotsof, HS, Frenken, GMN, Luciano, DJ, and Bastiaans, J.

Treatment of Acute Opioid Withdrawal with Ibogaine. American Journal on Addictions 8:

234-242, 1999.

Retrospective Case Series From Early1960s U.S. and

Late 1980s-Early 1990s Dutch Informal Scenes:

Outcomes


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Prospective Open Label Study (Mash et al.

2001) 1

32 patients treated for opioid (heroin or methadone) withdrawal. Withdrawal Symptoms measured using the Objective Opiate Withdrawal Scale

(OOWS)

Fixed dose of 800 mg ibogaine HCl given approximately 12 hours after the lastopiate dose

OOWS significantly reduced at 12 and 24 hours post ibogaine administration; thelevel of discomfort at these acute relative to post-treatment time points was as low asthe level seen 1 week later. Objective signs of opiate withdrawal rarely seen andnone increased at later time points.

Decreased craving at


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Disease-SpecificAdvocacy


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Examples of Disease Specific

Advocacy

HIV: Aids Coalition to Unleash Power(ACT UP); Treatment Action Group (TAG)

Opiate Dependence: Dutch Junkiebond,

Danish Drug Users Union Psychiatric Disorders: National Alliance for

the Mentally Ill (NAMI)


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Nico Adriaansorganizer

Dutch Addict Self-Help


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14/14Political Advocacy Graphics

Significance of Unofficial Ibogaine Treatment Scenes

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