Sheraton Overland Park Hotel 6100 College Blvd.

4th Annual • September 16-17, 2016 • Sheraton Overland Park Hotel,Overland Park, Kansas

Midwest Conference on Cell Therapy and Regenerative Medicine

Buddhadeb Dawn, MD, Director, Midwest Stem Cell Therapy Center; Maureen and Marvin Dunn Professor and Director, Cardiovascular Division, Department of Medicine; Director, Cardiovascular Research Institute; University of Kansas Medical Center, Kansas City, KS

The purpose of this conference is to update physicians, scientists, nurses and other healthcare professionals, trainees, and the general public in the greater Midwest region on:1) the past, present, and future of adult stem cell therapy;2) new developments in adult stem cell research;3) diagnosis and treatment guidelines related to cell therapy for various medical conditions;4) management of patients using these new cell transplantation technologies; and5) the ethical use of regulated adult stem cells.Various clinical trials that have contributed to the advancement of this ÿeld will be presented. The progress and hurdles toward translation of adult stem cell therapy on a broader scale will be discussed. The participants will learn about advances in therapy with adult stem cells. Participants will examine the latest trends in regenerative medicine and gain a greater understanding of adult stem cell biology, the procedures and processes for translation, and the overall potential for tissue and organ regeneration.

The Midwest Conference on Cell Therapy and Regenerative Medicine is designed for physicians, scientists, nurses, trainees, other healthcare professionals as well as the general public.

At the completion of this conference, participants should be able to: • Describe new findings with adult stem cells and what is necessary to translate these observations into potential

patient therapies

• Identify and discuss past, ongoing, as well as possible future clinical trials using adult stem cells for repair/regeneration of various tissues and organs

Describe various disease categories for which adult stem cell therapy may prove beneficial, and the globalefforts to facilitate wider applications of such potential therapy

•

NING COMMITTEEOmar Aljitawi, MD, Assistant Professor, Division of Hematology & Oncology, The University of Kansas Medical Center, Kansas City, KSRichard Barohn, MD, Gertrude and Dewey Ziegler Professor and Chairman, Department of Neurology, University Distinguished Professor and Vice Chancellor for Research, University of Kansas Medical Center, Kansas City, KS Michael Detamore, PhD, Professor, Department of Chemical and Petroleum Engineering, Courtesy Professor of Mechanical Engineering, University of Kansas, Lawrence, KS Monya Floyd, Program Manager, Continuing Education & Professional Development, University of Kansas Medical Center, Kansas City, KSJan Foecke, MS, RN, ONC, Director of Nursing Continuing Education, Clinical Assistant Professor, University of Kansas School of Nursing, Kansas City, KSBarbara MacArthur, RN, MN, FAAN, Vice President of Cardiac Services, The University of Kansas Hospital, Kansas City, KS Joseph McGuirk, MD, Professor of Medicine Schutte-Speas Professor of Hematology-Oncology Division Director, Hematologic Malignancies and Cellular Therapeutics, Medical Director, Blood and Marrow Transplant, Department of Internal Medicine, The University of Kansas Medical CenterRobert Simari, MD, Executive Dean, University of Kansas School of Medicine, Chair, Cardiovascular Cell Therapy Research Network, Kansas City, KSPeter Smith, PhD, Professor, Department of Molecular and Integrative Physiology Senior Associate Dean for Research Co-Director, Kansas Intellectual and Developmental Disabilities Research Center Founding Director, Institute for Neurological Disorders University of Kansas Medical CenterDana Winegarner, DO, Neurologist, Rowe Neurology Institute, Lenexa KS

COURSE DIRECTOR

OVERVIEW

TARGET AUDIENCE

OBJECTIVES

PLANNING COMMITEE

September 16-17, 2016 • Sheraton Overland Park Hotel, 6100 College Blvd., Overland Park, KS

4th Annual Midwest Conference onCell Therapy and Regenerative Medicine

Payment is required at the time of registration. Only registrations accompanied with payment will be accepted. Please register in advance. Fees include online course materials, continental breakfast, lunch, refreshments and continuing education credit as applicable. (*indicates CE credit included.)• Physicians $125*• Physicians in Training, Students, Trainees, or Post-Doctoral Researchers $20*• Research Scientists, PhDs, $100*• LPN, RN, APRN and Other Health Care Professionals $75*• Laboratory Technician $50*• Industry Representative $375 • Day 1 or Day 2 General Public/Non-Healthcare (without meals) No cost• Day 1 or Day 2 General Public/Non-Healthcare (with meals) $45• Day 1 and Day 2 General Public/Non-Healthcare (without meals) No cost• Day 1 and Day 2 General Public/Non-Healthcare (with meals) $90

All events will take place at the Sheraton Overland Park Hotel, 6100 College Blvd, Overland Park, KS. For information on parking or directions for the Overland Park Sheraton, please call 816-513-5000 or visit conference website at http://www.kumc.edu/msctc/annual-conference.html. For more information about Kansas City area events, call the Visitor Information Line, 816-691-3800.

All participants are required to sign attendance rosters at the beginning of each day. A certiÿcate of completion will be provided to all participants based on completion of the program evaluation, documentation of actual attendance time, and payment in full. If you are not paid in full, a link to complete the evaluation and obtain your certiÿcate will be emailed to you upon receipt of payment.Physicians: The University of Kansas Medical Center O°c e of Continuing Medical Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The KU Medical Center Office of Continuing Medical Education designates this live activity for a maximum of 16.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses: Up to 16.0 contact hours will be awarded to all individuals based on completion of the program evaluation, documentation of actual attendance time, and payment in full.

The University of Kansas School of Nursing is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center's Commission on Accreditation.

Commercial vendors are invited to exhibit at this meeting. Limited exhibit space is available. Call Rebecca Potter at 913-945-6316 or email at rpotter2@kumc.edu for more information.

Financial contributions and supporters of this program will be acknowledged in print at the symposium.

ACCREDITATION

EXHIBITS

REGISTRATION & FEES

LOCATION, PARKING & LODGING

ACKNOWLEDGMENTS

Mail:The University of Kansas Medical Center Continuing Education Registrations 3901 Rainbow Blvd. Kansas City, KS 66160 Phone: 913-588-4488 Fax 913-588-4486

Web: http://www.kumc.edu/msctc/annual-conference Web: www.kumc.edu/ce

September 16-17, 2016 • Sheraton Overland Park Hotel, Overland Park, KS

4th Annual Midwest Conference onCell Therapy and Regenerative Medicine

FACULTYJulie Allickson, PhDDirector, Translational Research

Institute for Regenerative Medicine Wake Forest School of Medicine Winston-Salem, NC

Brian Annex, MDProfessor of Medicine and Biomedical Engineering, Division Chief, Cardiovascular Medicine, University of Virginia Charlottesville, VA

Richard Barohn, MDUniversity Distinguished Professor and Chairman Department of Neurology Gertrude & Dewey Ziegler Professor Vice Chancellor for Research, University of Kansas Medical Center

Atta Behfar, MD, PhD Assistant Professor of Medicine Senior Associate Consultant Division of Cardiovascular Diseases Mayo Clinic, Rochester, MN

Wei Liang, PhDOffice of Cellular, Tissue and Gene Therapies (OCTGT) Center for Biologics Evaluation and Research Pharm/Tox Branch Food and Drug Administration,Silver Springs, MD

Gov. Sam BrownbackGovernor, the State of Kansas

Paul Camarata, MDAssociate Professor and Chairman Department of NeurosurgeryUniversity of Kansas Medical Center Kansas City, KS

William Chang, MD, PhDClinical Instructor, Associate Research Scientist, Section of NephrologyDepartment of Medicine Yale University, New Haven, CT

Theresa Deisher, PhDFounder, President, CEO & CSO, AVM Biotechnology, Seattle, WA

Gary Dunbar, PhDProfessor, Department of Experimental Psychology and Neuroscience Program Director, Neuroscience ProgramDirector, Brain Research and Integrative Neuroscience (BRAIN) Center, Central Michigan University, Mt. Pleasant, MI

Dan Gincel, PhD Vice President for University Partnerships Executive DirectorMaryland Stem Cell Research Fund

Justin Ichida, PhDAssistant Professor Stem Cell Biology and Regenerative Medicine Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research University of Southern California

Marcin Majka, PhD, DSc Professor Department of Transplantation Jagiellonian University Krakow, Poland

Eduardo Marban, MD, PhDDirector, Cedars-Sinai Heart Institute

Professor of Medicine, University of California, Los Angeles

Joseph McGuirk, DOProfessor of Medicine Schutte-Speas Professor of Hematology-Oncology Division Director, Hematologic Malignancies and Cellular Therapeutics, Medical Director, Blood and Marrow Transplant, Department of Internal Medicine, The University of Kansas Medical Center

C. Randal Mills, PhDPresident and CEOCalifornia Institute for Regenerative Medicine

Hiroshi Nishimune, PhD Associate Professor Department of Anatomy and Cell Biology, University of Kansas Medical Center Kansas City, KS

Arghya Paul, PhDAssistant Professor, Department of Engineering, University of Kansas, Lawrence, KS

Rajasingh Johnson, M.Phil, PhD, HCLD Assistant ProfessorCardiovascular Research Institute, University of Kansas Medical Center, Kansas City, KS

Linheng Li, PhDInvestigator, Stowers Institute for Medical Research, Kansas City MO, Professor, Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City, KS

David Prentice, PhDVice President, Director of ResearchCharlotte Lozier InstituteAdjunct Professor of Molecule Genetics at St. Paul II Institute Advisory Board Member for the Midwest Stem Cell Thearpy Center, Washington, DC

Gangjian Qin, MD, FAHA Associate ProfessorFeinberg Cardiovascular Research Institute Department of Medicine – Cardiology Department of Pharmacology Northwestern University Feinberg School of Medicine, Chicago, IL

Arshed Ali Quyyumi, MD, FRCP, FACC Professor of Medicine, Division of Cardiology Co-Director of Clinical Cardiovascular Research Institute, Emory University School of Medicine Atlanta, GA

Robert Simari, MDExecutive Dean University of Kansas School of Medicine Chair, Cardiovascular Cell Therapy Research Network, Kansas City, KS

Lisa Stehno-Bittel, PhDProfessor, Department of Physical Therapy and Rehabilitation Science, President and Founder, Likarda

Andre Terzic, MD, PhDMichael S. and Mary Sue Shannon Director, Mayo Clinic Center for Regenerative Medicine Marriott Family Professor of Cardiovascular Research Professor of Medicine and Pharmacology, Medical Genetics Director, J. Willard, Jr. and Donna Marriott Heart Disease Research Program Director, National Institutes of Health Training Program in “Cardiovasology” Chair, Discovery-Translation Scientific Advisory Board Board of Directors, Mayo Collaborative Services, LLC Mayo Clinic, Rochester, MN

Rupal Soder, PhDQuality Assurance SupervisorMidwest Stem Cell Therapy CenterUniversity of Kansas Medical Center, Kansas City, KS

Taro Takami, PhDSenior Assistant Professor, Department of Gastroenterology and Hepatology, Yamaguchi University, Graduate School of Medicine, Yamaguchi, Japan

Monsignor Tomasz Trafny, PhD Head of Science and Faith Department Pontifical Council for Culture, The Vatican

Deryl Troyer, PhDProfessor of Anatomy & Physiology, Kansas State University, Manhattan, KS

Jay L. Vivian, PhDScientific DirectorKUMC Transgenic Facility and Gene Targeting Facility Research Associate Professor, University of Kansas Medical Center, Kansas City, KS

Joseph C. Wu, MD, PhDDirector, Stanford Cardiovascular InstituteSimon H. Stertzer, MD Professor of Medicine & Radiology, Stanford University School of MedicineStanford, CA

Xiaoyang Wu, PhDAssistant Professor, Ben May Department for Cancer Research, University of Chicago, Chicago, IL

Phillip C. Yang, MDAssociate Professor of Medicine (Cardiovascular Medicine) Stanford University Medical Center Stanford, CA

Thomas Yankee, PharmD, PhD Associate Professor Department of Microbiology, Molecular Genetics and ImmunologyDirector, Inflammation & Immunity Module University of Kansas Medical Center

Ewa Zuba-Surma, PhD, D.Sc, Prof. JU Associate Professor Department of Cell Biology Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian UniversityKrakow, Poland

Peter Smith, PhDProfessor, Department of Molecular and Integrative Physiology Senior Associate Dean for Research Co-Director, Kansas Intellectual and Developmental Disabilities Research Center Founding Director, Institute for Neurological Disorders University of Kansas Medical Center

Keith March, MD, PhDProfessor of MedicineProfessor of Cellular and Integrative Physiology Director, Indiana Center for Vascular Biology and Medicine University of Indiana Bloomington, Indiana

Clay Quint, MDAssistant Professor, General Surgery, University of Kansas Medical Center, Kansas City, KS

7:00 - 7:45 am7:45 - 7:55 am

Registration and Breakfast Welcome Remarks

Session I: New Concepts in Cardiovascular Cell Therapy Moderators: Arshed Quyyumi and Brian Annex

8:00 - 8:20 am

Cardiac Microvascular Endothelium as a Target for Regenerative Therapy - Brian Annex

8:20 - 8:40 amStem Cell Metabolism Relevant for Cardiovascular Repair - Gangian Qin

AGENDAFriday, September 16, 2016

Saturday, September 17, 2016

Midwest Conference on Cell Therapy and Regenerative Medicine

Extracellular vesicles: Cell therapy Sans Cells Ewa Zuba-Surma

8:40 - 9:00 am

Personalized Regenerative Medicine: Role of Autologous Exosomes - Phillip Yang

9:00 - 9:20 amCell Therapy for Neuronal Injury - Jay Vivian

9:20 - 9:40 am

Coffee Break10:10 - 10:20 am

10:200 - 10:40 am Preclinical Cell Therapy of Cancer

Session II: Cell Therapy in Hematology and Cancer Moderators: Joseph McGuirk and Linheng Li

Panel Discussion - Quyyumi, Annex, Qin, Zuba-Surma, March, Yang

10:00- 10:10 am

Deryl Troyer /Tom Yankee10:40 - 11:00 am Targeting Drug-Resistant Leukemia Stem Cells

Linheng Li11:00 - 11:15 am Preparing Cells for Therapy in Humans - Rupal Soder

11:35 - 11:45 am Patient Story - Patient 111:45 - 11:55 am Patient Story - Patient 211:55 - 12:05 pm

Session III: Exciting Multisystem Cell Therapy Possibilities Moderators: Ewa Zuba-Surma and Deryl Troyer

Panel Discussion - McGuirk, Li, Troyer, Yankee, Soder

Rescue of Femoral Head During Avascular Necrosis - Atta Behfar

12:45 - 1:00 pm

Wharton's Jelly MSCs for Graft vs. Host Disease 11:15 - 11:35 am Joseph McGuirk

12:05 - 12:45 pm

Nano Bioactive Materials for Cardiac Repair - Arghya Paul

Regenerative Potential of Skin Stem Cells - Xiaoyang Wu

Replicating Kidney Tissue with Cells and Biomaterials William Chang

Panel Discussion - Zuba-Surma, Troyer, Behfar, Quint, Johnson, Vivian, Paul, Wu, Chang

2:40 - 2:50 pm Coffee Break

Session IV: Heart Repair: Bench to Bedside to Community Moderators: Joseph Wu and Randy Mills2:50 - 3:10 pm iPSCs for Precision Cardiovascular Medicine- Joseph Wu

Wharton’s Jelly MSCs for Acute Myocardial Infarction Marcin Majka

Facilitating stem cell translation: The CIRM experience C. Randy Mills

Keynote Address: Therapeutic regeneration of the “irreversibly” injured myocardium- Eduardo Marban

Panel Discussion - Wu, Mills, Majka, Marban

Poster Session

3:10 - 3:30 pm

3:30 - 3:50 pm

3:50 - 4:50pm

4:50- 5:10 pm

7:00 - 7:45 am Registration and Breakfast

7:45 - 8:00 am Welcome RemarksSession V: Cell-Based Approaches for Neurological Diseases Moderators: Richard Barohn and Peter Smith

New Approaches for Direct Conversion of Patient Fibroblasts into Neural Cells - Justin Ichida

8:00 - 8:20 am

Mesenchymal Stem Cells for ALS Therapy Hiroshi Nishimune

8:20 - 8:40 am

Healing the Brain with Bone Marrow Cells Paul Camarata

Use of Adult Stem Cells as Potential Therapy for Huntington’s Disease - Gary Dunbar

Panel Discussion - Barohn, Smith, Ichida, Nishimune, Camarata, Dunbar

Coffee Break

Keynote Address: Regenerative medicine buildout Andre Terzic

Session VI: Road to Translation Andre Terzic and Lisa Stehno-Bittel

Encapsulation Promotes Cells as Therapy and Cells as Reagents - Lisa Stehno-BittelCell therapy for liver regeneration - Taro Takami

Hurdles and Opportunities for Stem Cell Cell Translation - Theresa DeisherSuccessful conversion of concepts into tissues and organs - Julie Allickson

8:40 - 9:00 am

9:00 - 9:20 am

9:20 - 9:30 am

9:30 - 9:40 am

9:40 - 10:40 am

10:40 - 11:00 am

11:00 - 11:20 am

11:20 - 11:40 am

11:40 - 12:00 pm

12:00 - 12:40 pm Lunch Break

12:40 - 1:00 pm Preclinical assessment of cell therapy productsWei Liang

1:00 - 1:15 pm Panel Discussion - Terzic, Stehno-Bittel, Takami, Deisher, Allickson, Liang

1:15 - 1:20 pm Introduction

Special Guest Speaker - Kansas Governor 1:20 - 1:50 pm

Keynote Address: Global Advances and Opportunities for Stem Cell Revolution - Monsignor Tomasz Trafny,

Sam Brownback 1:55 - 2:00 pm Introduction

2:00 - 3:00 pm

The Vatican 3:00 - 3:10 pm Coffee Break

Session VII: Collaborative and Global Initiatives on Stem Cell Therapy Msgr. Tomasz Trafney and David Prentice

Cardiovascular Cell Therapy Research Network 3:10 - 3:30 pm

Accelerating cures: The Maryland initiative to augment stem cell research - Dan Gincel

3:30 - 3:50 pm

3:50 - 4:10 pm

Global outlook for stem cell therapy - David Prentice4:10 - 4:30 pmPanel Discussion - Msgr. Trafny, Prentice, Simari, Gincel, Dawn

Midwest stem cell therapy center: A unique approach in Kansas- Buddhadeb Dawn

4:30 - 5:00 pm

Adjournment

Adjournment

1:30 - 1:45 pm

1:45 - 2:00pm2:00 - 2:15 pm

2:15 - 2:30 pm

5:10 - 6:30 pm

Adipose stem cell-derived exosome-rich concentrate provides broad rescue from ischemia: from brain to kidney and heart - Keith March

Regenerative capacity as a new risk factor- Arshed Quyyumi

9:40 - 10:00 am

Lunch Break

Electrospinning scaffolds for Tissue Engineered Blood Vessels Clay Quint

Adult Stem Cell Derived Functional Cardiomyocytes for Cell Therapy - Rajasingh Johnson

1:00 - 1:15 pm

1:15 - 1:30 pm

2:30 - 2:40 pm

Please PrintFull name (First, MI, Last, Su˜x)________________________________________________________________________________________________

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Your conÿrmation and evaluation/CE certiÿcate link will be sent to this email address.

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Please do not include my information on the participant roster. Please remove my name from the mailing list.

Fees

Physician...............................................................................................................$125 Research Scientist and PhD............................................................................$100 Registered Nurse................................................................................................$75 Other Health Care Professional.....................................................................$75 Laboratory Technician......................................................................................$50

Student, Trainee, or Post-doctoral Researcher........................................$20

Day 1: General Public/Non-Healthcare (without meals)......................No cost Day 2: General Public/Non-Healthcare (without meals)......................No cost Day 1 & Day 2: General Public/Non-Healthcare (without meals)......No cost

Total due $_____________

Special AccommodationIf you will need special accommodation, please mark the box above, and a member of the KU Medical Center Continuing Education staff will contact you. CM173007

PaymentRegistrations will not be processed until payment is received. Check enclosed, payable to KU Medical Center. MasterCard VISA (no other cards accepted)

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Easy Ways to RegisterWeb http://www.kumc.edu/msctc/annual-conferenceMail Complete the registration form and mail

with payment to:The University of Kansas Medical Center Continuing Education Registrations3901 Rainbow Bvd., 2003 Student CenterKansas City, Kansas 66160

Phone 913-588-4488Fax 913-588-4486

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REFUND AND CANCELLATION POLICYA full refund of registration fees, less a $15 administrative fee, will be available if requested in writing and received by September 3, 2016. No refunds will be made after that date. A $30 fee also will be charged for returned checks. (Please note that if you fail to cancel by the deadline and do not attend, you are still responsible for payment.) KUMC Continuing Education reserves the right to cancel the Fourth Annual Midwest Conference on Cell Therapy and Regenerative Medicine and return all fees in the event of insufficient registration. The liability of the University of Kansas Medical Center is limited to the registration fee. The University of Kansas Medical Center will not be responsible for any losses incurred by registrants, including but not limited to airline cancellation charges or hotel deposits.

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NONDISCRIMINATION POLICYThe University of Kansas Medical Center prohibits discrimination on the basis of race, color, ethnicity, religion, sex, national origin, age, ancestry, disability, status as a veteran, sexual orientation, marital status, parental status, gender identity, gender expression and genetic information in the University's programs and activities. The following person has be designated to handle inquiries regarding the non-discrimination polices: Natalie Holick, Director, Equal Opportunity Office, NHolick@kumc.edu, Mail Stop 2014, 4330 Shawnee Mission Parkway, Fairway, KS 66205, 913-588-8011, 711TTY

PROGRAM ACCESSIBILITY We accommodate persons with disabilities. Please call 913-588-4488 or mark the space on the registration form, and a KU Medical Center Continuing Education & Professional Development representative will contact you to discuss your needs. To ensure accommodation, please register at least two weeks before the start of the conference. See the nondiscrimination policy above.

The University of Kansas Medical Center is an AA/EO Title IX institution.

4th Annual • September 16-17, 2016 • Sheraton Overland Park Hotel, 6100 College Blvd., Overland Park, KSMidwest Conference on Cell Therapy and Regenerative Medicine

Physician in Training.........................................................................................$20

Day 1: General Public/Non-Healthcare (with meals).............................$45 Day 2: General Public/Non-Healthcare (with meals).............................$45

Day 1 & Day 2: General Public/Non-Healthcare (with meals).............$90

Industry Representative..................................................................................$375