Sharing Data via Established Policies and …...MESA AIR “Pragmatic” PM 2.5 Estimates MESA Air...
Transcript of Sharing Data via Established Policies and …...MESA AIR “Pragmatic” PM 2.5 Estimates MESA Air...
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Sharing Data via Established Policies and Procedures in NHLBI
Cardiovascular Cohort Studies Lessons from MESA for
Environmental Health Research
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Context
• Long History of Cohort Studies at NHLBI • Major Federal Investments • Intramural Research Program • Established Policies and Procedures
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Data Sharing Through at Least Three Mechanisms
• Limited Data Sets • Investigator-Directed Scientific Collaboration
– Ancillary Study Processes – Publication and Presentation Processes
• Genomics Data Sharing – dbGaP – Genomics Consortia
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Limited Data Sets
• Publicly available – biolincc.nhlbi.nih.gov
• Limited individual-level covariates – Does have quite a bit of information
• No tradition of including “environmental” exposure information
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Investigator-Directed Scientific Collaboration
• Ancillary Study Processes • Publication and Presentation Processes
• Anticipate a sponsor from the existing group of investigators • Review by standing committee and by cohort steering committee
– Ensure scientific merit – Discourage overlap / competitive projects – Limit participant and staff burden – Engage proper collaborators within cohort’s investigative team
• Insures proper credit to investigators who created the resource • Avoids inappropriate use of datasets unfamiliar with details of the population
under study – Permit data sharing after reasonable opportunity for publication by
investigator leading analysis or generating new data – DMDA
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Genomics Data Sharing
• dbGaP
• Cross-cohort consortia (e.g., CHARGE)
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Data Use Agreements
• Data Distribution Agreement for Affiliated Investigators
• Data and Materials Distribution Agreement for Collaborating Investigators (with local IRB approval)
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MESA Air
• Data Sharing As Two-Way Street • Joining MESA community of investigators • Strategies to properly share efforts with other
investigators
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MESA Air experience
• Worked within MESA Ancillary Studies Process • Extraordinary investment in this project • Know background of re-analysis challenges to
prior work in this field • Limits of participant consent • We re-consented all for our planned work • Tiered consent for geocoding work, genetic
studies, and monitoring activities
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Our Approach
• Pair state-of-the-art cardiovascular epidemiology with state-of-the-art exposure estimation – Unusual dedication of resources
• Encourage extensive collaborations and promote opportunities for ancillary studies – MESA Air as research platform
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Adjudicated Clinical Events
• Myocardial Infarction • Stroke/TIA • Congestive Heart Failure • Coronary Revascularization
– PTCA – CABG
• Angina • Peripheral Vascular Disease • Cardiovascular Death
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Primary Subclinical Outcomes
• Coronary Artery Calcium (CAC) • Carotid Artery Intima Medial Thickness
(IMT)
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Extensive Interview Data
• Medical History • Medications • Personal History • Family History • Health and Life • Physical Activity
• Diet • Neighborhood
Characteristics • Residential History • Sleep History • Cognitive Assessment
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Other Measures and Specimens • Anthropometry • Resting Blood Pressure • Ankle/Brachial Blood
Pressure Index • ECG • Spirometry (MESA Lung)
• Cardiac MRI • Retinal Photography
(MESA Eye) • Quantitative Lung CTs
(MESA Lung)
• Urine Collection • Blood Collection
• Genomics/Epigenomics
– MESA Family – Candidate Genes – CARe – SHARe – DNA methylation – Gene Expression
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Outdoor Pollutant
Measurements
Indoor Pollutant
Measurements Geographic Data
Reported Housing
Characteristics
Observed Housing
Characteristics Deterministic Models
Spatio-temporal Hierarchical
Modeling
Infiltration Modeling
Predicted Outdoor Concentrations
at Homes
Reported Time/Location Information
Predicted Indoor Concentrations
at Homes
Weighted Average
Personal Exposure Predictions for Each Subject
Measurements Questionnaires Predictions
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Example: NOX in Los Angeles
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Example: NOX in Los Angeles
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Significant Small-Scale Spatial Resolution
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Long-Term PM10
UN
IVER
SITY
O
F M
ICH
IGA
N
2006
AQS 1982 – 2002
Road Network Data
“Land Use” Variables
Meteorology
MES
A A
IR
“Pragmatic” PM2.5 Estimates
MESA Air Monitoring Data 2005-06 AQS 2000-06 Census Road Network Geographic Data (Land use, pop density, etc.) Baseline residences
MESA Air Monitoring Data 2005-09 AQS 1999-09 TeleAtlas Road Network Geographic Data (extended land use buffers, NDVI, etc.) Deterministic Model Outputs (CALINE) Long-term residential histories
MESA Air Monitoring 2005-09 AQS 1982-2011 Geographic data (truck routes, etc.) Air Quality Model Integration (?) Long-term and historic residential histories
Final Exposure Predictions for Each Subject
Long-Term PM2.5
2011 2008 2012
Final “Pragmatic” PM2.5 Estimates
Final Likelihood-Based Estimates (All Pollutants)
Nearest Monitor/
Distance to Nearest
Road
Spatio-Temporal Exposure Modeling Estimates
Infiltration & Time-Location Information
Initial Likelihood-Based NOX Estimates
&
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Special issues
• Recognition that participant residence locations must be protected as with other identifiers
• MESA has sample repository • Created MESA Environmental Health Working
Group, fostering EHS research projects other than air pollution – New investigators welcome
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Geographic Data
• Can’t release actual participant locations • Linkage options
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Principles we follow
• MESA Air is an unusual dedication of resources and data-sharing is expected
• Precise geocoding is identifying of participants and must be treated like other identifying information
• Exposure data we generate needs to be well-documented and quality-assured so that endusers can use appropriately. Develop analytical recommendations
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MESA Air P&P process
• Formal data request process for exposure information – Relies on approved manuscript proposal
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Participation in SHARe
• MESA Air is full partner • Sharing environmental data to dbGaP as
finalized, as appropriate • NIH: “Secondary data users not conducting
human subjects research” (?)
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dbGaP MESA SHARe
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Next steps
• Data Linkages that remove all concerns? • Collaborations through MESA Environmental
Health Working Group • Ongoing collaborations • Preparation for reanalysis requests?