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![Page 1: SG KB 2009 NIGMS Workshop: Enabling Technologies for Structural Biology Section on Structural Analysis Helen M. Berman March 4, 2009 How to use the PSI.](https://reader035.fdocuments.us/reader035/viewer/2022070610/5a4d1ba77f8b9ab0599c9983/html5/thumbnails/1.jpg)
SGKB
2009 NIGMS Workshop:Enabling Technologies for Structural Biology
Section on Structural AnalysisHelen M. Berman
March 4, 2009
How to use the PSI Structural Genomics Knowledgebase for Research
Part I: Introduction
![Page 2: SG KB 2009 NIGMS Workshop: Enabling Technologies for Structural Biology Section on Structural Analysis Helen M. Berman March 4, 2009 How to use the PSI.](https://reader035.fdocuments.us/reader035/viewer/2022070610/5a4d1ba77f8b9ab0599c9983/html5/thumbnails/2.jpg)
Know
ledgebase
The PSI Structural Genomics Knowledgebase will turn the products of the PSI effort into major advances in knowledge that can be used to understand living systems and human disease.
![Page 3: SG KB 2009 NIGMS Workshop: Enabling Technologies for Structural Biology Section on Structural Analysis Helen M. Berman March 4, 2009 How to use the PSI.](https://reader035.fdocuments.us/reader035/viewer/2022070610/5a4d1ba77f8b9ab0599c9983/html5/thumbnails/3.jpg)
Knowledgebase Goals
It will provide a “marketplace of ideas” that connects protein sequence information to 3D structures and homology models enhances functional annotations provides access to new experimental protocols and materialsIt will enable advancements in structural genomics by communicating and providing visibility and accessibility of information and technology advances of the PSI through presentation and discussion of the most provocative challenges with the general community by fostering community collaborations
![Page 4: SG KB 2009 NIGMS Workshop: Enabling Technologies for Structural Biology Section on Structural Analysis Helen M. Berman March 4, 2009 How to use the PSI.](https://reader035.fdocuments.us/reader035/viewer/2022070610/5a4d1ba77f8b9ab0599c9983/html5/thumbnails/4.jpg)
To capture, make accessible, and highlight elements of the high-throughput pipelines for use by various scientific communities To leverage such information through the generation of molecular models and functional annotation
Scope
GenomicBased Target
Selection
DataCollection
StructureDetermination
Isolation, Expression,Purification,
Crystallization
PDB Deposition & Release
ModelsAnnotationsPublications
Metrics
Technology
Experimental TrackingTarget Selection Materials
![Page 5: SG KB 2009 NIGMS Workshop: Enabling Technologies for Structural Biology Section on Structural Analysis Helen M. Berman March 4, 2009 How to use the PSI.](https://reader035.fdocuments.us/reader035/viewer/2022070610/5a4d1ba77f8b9ab0599c9983/html5/thumbnails/5.jpg)
Knowledgebase Users
Biologists Biochemists Functional Genomicists Pharmacologists Bioinformatics Chemists Clinical Researchers and
Physicians Teachers and Students
![Page 6: SG KB 2009 NIGMS Workshop: Enabling Technologies for Structural Biology Section on Structural Analysis Helen M. Berman March 4, 2009 How to use the PSI.](https://reader035.fdocuments.us/reader035/viewer/2022070610/5a4d1ba77f8b9ab0599c9983/html5/thumbnails/6.jpg)
Navigating the PSI SGKB Homepage
Database searchable by sequence, text, and PDB ID and delivers aggregate reports, inventories
Links to PSI projects, external resources, and publications
Link to central Community-Nominated Targets Proposal system
SG Gateway with Nature delivers research findings, technologies, news and events related to the PSI and structural genomics
Publicizes recently solved PSI structures or new editorial content
![Page 7: SG KB 2009 NIGMS Workshop: Enabling Technologies for Structural Biology Section on Structural Analysis Helen M. Berman March 4, 2009 How to use the PSI.](https://reader035.fdocuments.us/reader035/viewer/2022070610/5a4d1ba77f8b9ab0599c9983/html5/thumbnails/7.jpg)
Tour of the PSI SGKB
In today’s tutorial, we will demonstrate:
How to navigate the site and its interactive features
How to search the PSI SGKB for information
How to find walkthroughs and exercises about this site
![Page 8: SG KB 2009 NIGMS Workshop: Enabling Technologies for Structural Biology Section on Structural Analysis Helen M. Berman March 4, 2009 How to use the PSI.](https://reader035.fdocuments.us/reader035/viewer/2022070610/5a4d1ba77f8b9ab0599c9983/html5/thumbnails/8.jpg)
Acknowledgements
KB Group PSI Resources Wendy Tao Andrei Kouranov (Exp. Data Tracking)Raship Shah Torsten Schwede (Models)James Chun Paul Adams (Technology) Margaret Gabanyi Josh La Baer (Materials)John Westbrook Wladek Minor (Publications)
Access Informationhttp://kb.psi-structuralgenomics.org
NatureMatthew Day
Boyana Konforti
SGKB
PSI SGKB Steering CommitteeEaton E. Lattman, Chair