SEMESTER II PHARMACEUTCAL ENGINEERING (BP203TP) …

Ms. Grishma Dalal, Assistant Professor, Faculty of Pharmacy,Dr. Subhash Technical Campus, Junagadh

SEMESTER II

PHARMACEUTCAL ENGINEERING

(BP203TP)

Multiple Choice Questions

PHARMACEUTICAL ENGINEERING II (BP203TP)

Faculty of Pharmacy,Dr. Subhash Technical Campus, Junagadh

1. The working of Fluid energy mill is based on principle of

a. Impact

b. Attrition

c. Cutting

d. Both a & b

Ans: b

2. Size reduction is also known as:

a. Comminution

b. Pulverization

c. Diminution

d. All of the above

Ans: a

3. The bell crank lever arrangement is major part of which of the following………:

a. Cyclone separator

b. Edge runner Mill

c. End runner Mill

d. Bag filter

Ans: d

4. The hammer mill operates on the principle of:

a. Impact

b. Attrition

c. Compression

d. Cutting

Ans: a

5. Ball Mill operates at the speed of?

a. Low speed

b. High speed

c. Optimum speed

d. All of the above

Ans: c

6. Fluid Energy Mill works on the principle of:

a. Impact & Attrition

b. Rotor & Stator

c. Compression

d. Attrition

Ans: a

7. Fibrous drugs are milled by using:

a. Cutter Mill

b. Hammer Mill

c. Fluid Energy Mill

d. Ball Mill

Ans: a



8. Mills are not suitable for Friable (heat sensitive) materials?

a. Cutter Mill

b. Hammer mill

c. Colloidal Mill

d. All of the above

Ans: d

9. In Azeotropic distillation __________ remains low:

a. Heat

b. Volatility

c. Relativity Volatility

d. None of these

Ans: c

10. In Vacuum Distillation, Substance boils at a/an:

a. Exact temperature

b. temperature slightly above its boiling point

c. temperature below its boiling point

d. High Pressure

Ans: c

11. In the fractionating column of fraction distillation, as we go higher in the column the…..?

a. Temperature becomes lower

b. Temperature becomes higher

c. minimum absorption occurs

d. Sublimation risk increases

Ans: a

12. Rate of evaporation is______:

a. directly proportional to temperature of liquid

b. inversely proportional to temperature of liquid

c. independent of temperature of liquid

d. directly proportional to humidity of surrounding air

Ans: a

13. Which of the following factors do not affect the rate of evaporation?

a. Temperature of liquid

b. Humidity of surrounding air

c. Depth of liquid

d. Surface of liquid

Ans: c

14. Which of the following is a characteristic of a horizontal tube evaporator?

a. Agitation is provided only by bubbles leaving the evaporator as vapor

b. The tube bundle is arranged vertically, with the solution inside the tubes condensing outside

c. To handle viscous solution a pump is used to force liquid upwards

d. Also called short vertical tube evaporator

Ans: a



15. The (emissivity) of a black body is:

a. 1

b. 1.5

c. 2

d. None

Ans: a

16. Lyophilization is also known as:

a. Drying by sublimation

b. Freeze drying

c. Both a & b

d. None

Ans: b

17. Mean free path is associated with which type of distillation?

a. Steam

b. Evaporative

c. Azeotropic

d. Fractional

Ans: a

18. Which one of the following rate is observed in mixing of solids?

a. First order law

b. zero order law

c. Second order law

d. none

Ans: a

19. Unit of the rate of heat transfer is

a. Joule

b. Newton

c. Pascal

d. Watt

Ans: d

20. Which type of mixture is easily formed?

a. Positive

b. Negative

c. Neutral

d. Ampholytic

Ans: a



21. Mechanism not used in solid-solid Mixing:

a. Connective

b. Shear Mixing

c. Diffusion

d. Tumbling

Ans: d

22. Mechanism of mixing in sigma blade mixer:

a. Connective

b. Tumbling

c. Shearing

d. Diffusion

Ans: c

23. Mechanism of mixing in silverson mixer is:

a. Connective

b. laminar

c. Random

d. Turbulent

Ans: d

24. Degree of mixing is also known as:

a. Degree of Homogeneity

b. Extent of mixing

c. Ordered Mixing

d. Random Mixing

Ans: a

25. __________ states that the rate of heat flow through a uniform material is proportional to the area and

temperature and inversely proportional to the length of the path of flow.

a. Newton’s law

b. Kick’s law

c. Fourier’s law

d. Chatelier’s law

Ans: c

26. A body whose absorptivity is constant at all wavelengths of radiation, at a given temperature is

known as

a. Black Body

b. Grey body

c. White Body

d. Shinning body

Ans: b



27. Total amount of radiation emitted by a black body is given by equation q=bAT4. Value of b for black

body is:

a. 5.67 ×10-8 W/m2. K4

b. 5.67 ×108 W/m2. K4

c. Zero

d. 1 W/m2. K4

Ans. a

28. Which of the following is used for drying blood plasma:

a. Spray drying

b. Freeze drying

c. Vacuum Drying

d. Fluid Bed drying

Ans. B

29. Which equipment is used for mixing of immiscible liquids?

a. Airjet Mixer

b. Jet Mixer

c. Silverson Mixer

d. Sigma Mixer

Ans. C

30. Which one of these drying techniques is used for drying antibiotics and plant extract?

a. Vacuum Dryer

b. Freeze dryer

c. Spray dryer

d. None of these

Ans: b

31. ____________ method of distillation is used for the purification & separation of chemicals of low

vapor pressure

a. Steam Distillation

b. Destructive distillation

c. Simple Distillation

d. Molecular Distillation

Ans. D

32. Rectification is another name of:

a. Fractional distillation

b. Molecular distillation

c. Simple distillation

d. Destructive distillation

Ans. A

33. In which dryer, hot air jets are used for drying purpose?

a. Vacuum Dryer

b. Spray Dryer

c. Roller Dryer

d. Fluidized Bed dryer

Ans. D



34. A black body is perfect

a. Emitter only

b. Absorber only

c. emitter and absorber

d. none of the above

Ans. C

35. What are advantages of the spray drying process:

a. Evaporation is very rapid

b. Most of the heat being used as latent heat of vaporisation

c. The powder will have uniform and controllable particle size

d. All of the above

Ans. D

36. What are physical factors affecting in the selection of the materials for the construction of

pharmaceutical plant:

a. Strength

b. Weight

c. Ease of fabrication

d. All of the above

Ans. D

37. Which is not a non-ferrous metal?

a. Copper

b. Aluminum

c. Steel

d. Lead

Ans. C

38. Which is used as a placing to protect steel?

a. Asbestos

b. Chromium

c. Glass

d. Rubber

Ans. B

39. For ease in size reduction, the material should be.

a. Hard, brittle

b. Soft, tough

c. Hard, tough

d. Soft, brittle

Ans. A

40. Which of the following factor does NOT affect the size reduction?

a. Hardness

b. Stickiness

c. Viscosity

d. Abrasiveness

Ans. C



41. Product size achieved by Ball mill?

a. 4-325 mesh

b. 20-200 mesh

c. 20-80 mesh

d. 1-30 microns

Ans. B

42. Product size achieved by hammer mill is

a. 4-325 mesh

b. 20-200 mesh

c. 20-80 mesh

d. 1-30 microns

Ans. A

43. Product size achieved by Fluid energy Mill is

a. 4-325 mesh

b. 20-200 mesh

c. 20-80 mesh

d. 1-30 microns

Ans. D

44. Which one is called coarse powder?

a. It is powder in which all the particles must pass through the sieve no. 10

b. It is powder in which all the particles must pass through the sieve no. 22

c. It is powder in which all the particles must pass through the sieve no. 44

d. It is powder in which all the particles must pass through the sieve no. 85

Ans. A

45. Number of sieve is defined as?

a. This is the number of meshes in a length of 25.4 mm in each direction, parallel to the wires

b. This is the number of meshes in a length of 24.5 mm in each direction, parallel to the wires

c. This is the number of meshes in a length of 26.5 mm in each direction, parallel to the wires

d. This is the number of meshes in a length of 28.4 mm in each direction, parallel to the wires

Ans. A

46. Which of these is not a mechanism of size separation?

a. Agitation

b. Brushing method

c. Centrifugal force

d. Compression

Ans. D



47. Heat transfer takes place according to

a. First law of thermodynamics

b. Second law of thermodynamics

c. Third law of thermodynamics

d. Zeroth law of thermodynamics

Ans. B

48. Fourier law of heat conduction is based on the assumption that

a. Heat Flow through a solid in one dimension

b. Heat flow is in steady state

c. Both (A) & (B)

d. None of the options

Ans. C

49. Which of the following has maximum value of thermal conductivity?

a. Aluminum

b. Steel

c. Brass

d. Copper

Ans. A

50. Stefan Boltzmann law is applicable for heat transfer by

a. Conduction

b. Convection

c. Radiation

d. Conduction & Radiation combined

Ans. C

51. The amount of radiation mainly depends on:

a. Nature of body

b. Temperature of body

c. Type of Surface of body

d. All of the above

Ans. D

52. The distilled water is collected in _________.

a. Receiver

b. Adapter

c. Condenser

d. Round Bottom Flask

Ans. A



53. Which of the following is not a step in process of distillation?

a. Condensation

b. Heating

c. Precipitation

d. Vaporization

Ans. C

54. Calendria consists of no. of

a. Baffles

b. Jacket

c. Tubular surfaces

d. None of these

Ans. C

55. Source of heat in most of the evaporator:

a. Coal

b. Steam

c. Hot water

d. Oil bath

Ans. B

56. Solar water heaters, solar cookers, microwave ovens, microwave cookers, sonicator baths etc., are

examples of which type transfer of heat mechanism?

a. Conduction

b. Radiation

c. Convection

d. None of these

Ans. B

57. Following factor does NOT influence film coefficient:

a. Thermal conductivity of the liquid

b. Specific heat of the film

c. pH of the liquid

d. Density of the liquid

Ans. C

58. When fluid is heated, the currents set up may cause mixing of fluid. Such heat transfer is known as:

a. Forced Convection

b. Natural Convection

c. Conduction

d. None of these

Ans. B



59. Which is NOT a Mode of Size Reduction?

a. Cutting

b. Compression

c. Vaporization

d. Attrition

Ans. C

60. Following is the example of hammer mill used in Pharmaceutical Industry:

a. Fitzpatrick comminuting machine (Fitz mill)

b. Hardinge Mill

c. Centrifugal impact pulverizer

d. None of these

Ans. A

61.E = KR (Sn - Si) belongs to which law/Theory?

a. Bond’s theory

b. Lacey Theory

c. Kick’s Theory

d. Rittinger’s Theory

Ans. D

62. Bond’s work Index is the work required to reduce a unit weight from a theoretical infinite size to 80%

passing ______µm.

a. 10

b. 100

c. 25

d. None of these

Ans. B

63. A powder, all the particles of which pass through sieve no. 44 is called?

a. Coarse powder

b. Moderately fine powder

c. Fine powder

d. Very fine powder

Ans. B

64. Herringbone screen recommends use of which type of material for separation?

a. Slurries

b. Fibrous materials

c. Amorphous & crystalline materials

d. Only slurries with coarse particles

Ans. C



65. The main principle of Sieve shaker is:

a. Attrition

b. Centrifugation

c. Agitation

d. Compression

Ans. C

66. Sonic sifter is a variant/modification of which of the following equipment?

a. Sieve Shaker

b. Cyclone separator

c. Air separator

d. Bag Filter

Ans. A

67. Dorrclone is a separator used for separating solid suspended in a liquid such as water, is a

modification of which separator?

a. Bag filter

b. Cyclone separator

c. Air separator

d. None of these

Ans. B

68. In mechanism of mixing, which is also known as Macromixing?

a. Shear Mixing

b. Diffusive mixing

c. Both (a) & (b)

d. Convective mixing

Ans. D

69. Ideally in mixing equipment, powder should be filled:

a. Not more than 40%

b. Not more than 50%

c. Not more than 60%

d. Not more than 70%

Ans. C

70. In V-Cone Blender, if the speed is increased to high speed, what is observed?

a. Segregation

b. Sedimentation

c. Separation

d. None of these

Ans. A



71. In ribbon blender, the mechanism of mixing follows

a. Trituration

b. Shear

c. Both of these

d. None of these

Ans. B

72. Ribbon blender is used to mix:

a. Solid Mixing

b. Liquid mixing-Liquid Mixing

c. Solid-Solid Mixing

d. Both (b) or (c)

Ans. D

73. The biggest disadvantage of Sigma Blade mixer is:

a. Size reduction

b. Size separation

c. Fixed speed

d. Dead spots

Ans. C

74. In comparison to Ribbon blender, Planetary Mixer has advantage of:

a. High Shear

b. Fixed speed drive

c. Less headspace requirement

d. No Dead space

Ans. D

75. Aerosol preparations have which phase of mixing?

a. Solid-Liquid Mixing

b. Liquid-Liquid Mixing

c. Liquid-Gas Mixing

d. None of these

Ans. C

76. Which of the following is not a part of mixing vessel?

a. Impeller

b. Baffle

c. Calendria

d. Propellers

Ans. C



77. In silverson emulsifier, what is the only disadvantage?

a. Poor Mixing

b. Clogging of pores of the mesh

c. Separation

d. Size reduction

Ans. B

78. Hormones, antibiotics & enzymes are:

a. Heat-sensitive

b. Cold-sensitive

c. Volatile

d. None of these

Ans. A

79. Greater the surface area of the liquid, the evaporation will be:

a. Slow

b. Greater

c. Not affected

d. Both (a) & (b)

Ans. B

80. The following Equipment is best for evaporating concentrated aqueous and thermostable liquors:

a. Horizontal Tube evaporator

b. Triple effect evaporator

c. Climbing Film Evaporator

d. Evaporating Pan

Ans. D

81. Evaporator used to manufacture cascara extract, sugar, salt, caustic soda etc:

a. Vertical Tube evaporator


c. Climbing Film Evaporator

d. None of these

Ans. A

82. Vertical Tube evaporator is also known as:

a. Horizontal Tube evaporator

b. Basket type evaporator

c. Short Tube Evaporator

d. Rising Film Evaporator

Ans. C



83. Entrainment separator is part of which evaporator?

a. Climbing Film Evaporator


c. Horizontal Tube Evaporator

d. Evaporating Pan

Ans. A

84. When the feed is high viscosity, following evaporator should be used:


b. Falling Film evaporator


d. Short Tube evaporator

Ans. B

85. Evaporator working on basis of Pump or pressure:




d. Forced Circulation Evaporator

Ans. D

86. Which evaporator can be modified to Triple effect Evaporator/ Multiple effect evaporator?

a. Vertical Tube Evaporator

b. Forced Circulation evaporator


d. None of the above

Ans. A

87. In distillation process is the separation of the components of a liquid mixture by process involving

vaporization and subsequent condensation at another place. What is the feed liquid called?

a. Distillate

b. Condensate

c. Distilland


Ans. C

88. In which process, concentrated liquid remains as final product?

a. Distillation

b. Evaporation

c. Crystallization

d. Drying

Ans. B



89. Solution in which there is no change in the properties of the components other than dilution, when

they are mixed to form a solution is known as?

a. Ideal Solution

b. Real Solution

c. Fake Solution

d. Partial Solution

Ans. A

90. The correct equation/Expression of Dalton’s Law is:

a. pA = poA XA, pB = po

B XB

b. P = pA + pB

c. pA = YA.P, pB = YB.P


Ans. B

91. Differential Distillation is also known as:

a. Simple Distillation

b. Fractional Distillation

c. Molecular Distillation

d. Steam Distillation

Ans. A

92. Which process is widely used to obtain Water for Injection/Purified Water?

a. Steam Distillation


c. Simple Distillation

d. All of the above

Ans. C

93. A process in which the entire liquid mixture is suddenly vaporized by passing the feed from a high

pressure zone to a low pressure zone:



c. Steam Distillation

d. Flash Distillation

Ans. D

94. In which process a part of the vapor is condensed and returned as liquid?

a. Fractional Distillation

b. Molecular Distillation


d. Simple Distillation

Ans. A



95. Absolute alcohol can be prepared by which method?

a. Molecular Distillation

b. Azeotropic Distillation

c. Fractional Distillation

d. Steam Distillation

Ans. B

96. Which process is based on the principle of Simple Distillation with some modifications?

a. Fractional Distillation

b. Steam Distillation

c. Distillation under reduced Pressure

d. None of these

Ans. C

97. Double neck Distillation Flask is known as?

a. Claisen Flask

b. Round Bottom Flask

c. Florentine Flask


Ans. A

98. High Boiling liquids cannot be purified by simple distillation, since the constituents in the mixture

tend to_________________ at higher temperatures.

a. Loose moisture

b. Decompose

c. Become Volatile


Ans. B

99. Which process is also known as Short-Path Distillation?




d. Molecular Distillation

Ans. D

100. Talc has equilibrium Moisture Content (EMC) of practically:

a. One

b. Zero

c. Variable

d. High

Ans. B



101. Which of the following type of product is having equilibrium moisture content (EMC) of practically

Zero?

a. Non-Porous & Insoluble

b. Non-Porous & Soluble

c. Porous & Insoluble

d. Porous & Soluble

Ans. A

102. Dry spots are formed during one of the following period?

a. Constant Rate period

b. First Falling period

c. Initial Adjustment period

d. Second falling period

Ans. B

103. Eutectic Point is an important factor for one of the following drying processes?

a. Drum Drying

b. Fluidized Bed Drying

c. Tray drying

d. Freeze Drying

Ans. D

104. Filtration is a unit operation that is commonly used for collecting:

a. Filtrate

b. Particulate matter

c. Precipitate

d. Slurry

Ans. A

105. Who has proposed that the filtration process is similar to the streamline flow of a liquid under

pressure through capillaries?

a. Carman

b. Darcy

c. Kozeny

d. Poiseuilli

Ans. D

106. Which is the principle difference in the properties that influences centrifugation?

a. Densities

b. Interfacial Tensions

c. Particle size

d. Viscosities

Ans. A



107. Centrifugal method is used for one of the following process:

a. Mixing

b. Purification

c. Separation

d. Sizing

Ans. C

108. Water Attack test is performed on glass in order to find the limits of one of the following?

a. Acid liberated

b. Alkali liberated

c. Conductivity

d. Metal ions

Ans. B

109. In Pharmaceutical packing, collapsible tubes made from lead are not used as such, for one of the

following reason.

a. Costly metal

b. Difficulty in packing

c. Risk of Poisoning

d. Soft in strength

Ans. C

110. One of the following glass containers is used for the storage of light sensitive pharmaceuticals.

a. Air-Tight

b. Amber Colored

c. Unit Dose

d. Well closed

Ans. B

111. Containers meant for storage of injections (buffered & unbuffered aqueous solutions) are made from

one of the following type of glasses.

a. Borosilicate

b. General Purpose

c. Lime soda

d. Neutral

Ans. A

112. Hermetic sealed containers are also known as:

a. Air-Tight Containers

b. Multi-dose containers

c. Single-Dose containers

d. Well-closed containers

Ans. A



113. Which metal makes steel corrosion resistant?

a. Copper and selenium

b. Tantalum and molybdenum

c. Chromium and Nickel

d. Titanium and Niobium

Ans. C

114. The ability of a metal surface to withstand repeated cycles of corrosion is known as:

a. Cavitation erosion

b. Corrosion fatigue

c. Erosion

d. Stress of corrosion cracking

Ans. B

115. Corrosion of metals is fairly high in one of the following medium:

a. Acidic

b. Alkaline

c. Neutral

d. Non-Aqueous

Ans. A

116. Galvanic Corrosion is observed, when external electric current in solution is passed between one of

the following combinations:

a. Gold & Platinum

b. Iron & hydrogen

c. Iron & Iron

d. Zinc & Copper

Ans. D

117. In Cyclone separator, the separation depends on:

a. Size & Shape

b. Shape and Surface area

c. Size & Density

d. Surface texture & Size

Ans. C

118. One of the theories is NOT applicable to distillation:

a. Graham’s law of diffusion

b. Law of conservation of energy

c. Law of conservation of matter

d. Raoult’s Law

Ans. A



119. Which product is NOT dried by spray dryer?

a. Serum

b. Fruit Juice

c. Lactose

d. Bacterial & viral cultures

Ans. D

120. The correct definition of filtration is:

a. When solids are present in a very low concentration, i.e., not exceeding 1.0% w/v, the process

of its separation from liquids

b. When solids are present in a very low concentration, i.e., not exceeding 5.0% w/v, the process


c. When solids are present in a very low concentration, i.e., not exceeding 2.0% w/v, the process


d. When solids are present in a very low concentration, i.e., not exceeding 7.0% w/v, the process


Ans. A

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