SELF-MADE GLASS TUBE REACTORS FOR SCHOOL ORGANIC SYNTHESIS
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Transcript of SELF-MADE GLASS TUBE REACTORS FOR SCHOOL ORGANIC SYNTHESIS
SELF-MADE GLASS TUBE REACTORS FOR SCHOOL
ORGANIC SYNTHESIS
Denis Zhilin,Moscow Institute for Open Education,School #192,
RATIONALEOrganic synthesis is a learning task
Nobody needs Many of the reagentsits products and products are stinky
Requirements for small scale
Organics dissolves in rubber
No rubber joints! Small glassware is difficult to wash
Throwaway glassware
RATIONALESmall scaleNo jointsThrowaway
+ Does not need water cooling+ Easy to heat+ Requires 0.5-1 g of reactants
Glass tube ( 5mm)reactors!
DIDACTIC BENEFITS+ Skills of glassblowering
EQUIPMENT
Gas burner (camping gas burner gives better flame than Bunsen)
Glass tube 5 mmTest-tube, beaker
And that’s all!
THE SIMPLEST ONE
Replaces heating with condenserExample: esterificationTwo operations, 7-10 minutes to makeUse syringe to fill with liquid or to separate
products
heating
m ixture cooling on air
FURTHER DEVELOPMENT
Replaces heating with distillationExamples: decarboxylation; ketone
synthesis of calcium carboxilates15-20 minutes to make
coolingwater
clamp
reaction m ixture
1
2
3
EVEN MORE COMPLICATED
For reaction of vapour at heatingExamples: dehydration of alcohols;
cracking; bromination of hexane30-40 minutes to make
ANOTHER CONSTRUCTION
The purpose is the same, but the heating of the solid state is more gentle
WHERE?Extracurricular course of organic
synthesis:10th grade (15-16 y.o.), accelerated
classes
HAZARDS1. About a half of the novices (15-16 y.o
students) got finger burnsdespite they were warned.
But they didn’t care!2. If the tube is clogged with solid
products or reagents while heating it can collapse with inflammation
3. Wear goggles!!!
DISAPPOINTMENTSWhen the reactor is crashed at the last
bending
HOW TO AVOID DISAPPOINTMENT
From simple to complicated apparatus
but
It conflicts with reasonable concept development
THANK YOU FOR YOUR ATTENTION
Denis Zhilin,Moscow Institute for Open Education,School #192,