Selenium metabolism and its clinical significance
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Transcript of Selenium metabolism and its clinical significance
Seleniummetabolism• StimulantofGrowth• Requirement:50-100microgram/day• NormalserumSeleniumlevel:63-160micrograms/L(adults)and16-71(<2yrsofage)
Seleniumdependentenzymes SiteofenzymeGlutathioneperoxidase Human(RBC)Formatedehydrogenase E.ColiGlycinereductase Clostridium
Functions of Selenium1.SynthesisofT₃fromT₄: T₄T₃Deiodinase +Selenium(seleniumdeficiency-Hypothyroidism)
2.Preventlivercirrhosis,musculardystrophy
3.Seleniumessentialfordevelopmentofspermatozoa(middlepiece)
4.Seleno –Cysteinerequiredforterminationofproteinbiosynthesis
5.Antioxidant(vitaminEdecreasesseleniu requirement )à preventslipidperoxidationà maintainscellmembraneintegrity )
6.SeleniumPreventscarcinogenesis(bindsMercury,cadmiumpreventstoxiceffect)
7.preventsKeshan’s diseaseàmultifocalmyocardialinfarction,cardiacenlargement
Selenosis :SeleniumToxicityqSelenosis :dietaryintake>900micrograms/day• Causes :metalpolishes&antirustcompounds• Symptoms :hairloss,fallingofnails,weightloss,diarrhea,Garlicodor
methylation(AdenosylMethionine)H+Se HydrogenSeDimethylSelenide
vManagement of Selenosis with Halogenated Hydroselenium