SelamatBogor2008 Mr. Van Egmond - WUR...Hans van Egmond, RIVM O O CH 3 O O O O Terima Kasih ! Title...
Transcript of SelamatBogor2008 Mr. Van Egmond - WUR...Hans van Egmond, RIVM O O CH 3 O O O O Terima Kasih ! Title...
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1SELAMAT open seminar, 25th June 2008
Aflatoxins: risks, regulations and limits
Hans van Egmond, RIVM
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Half a century ago... Turkey-X disease:the discovery of aflatoxins
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25th June 2008 3
Turkey-X: Quotationsfrom the correspondence
• “We are fairly certain that this ‘toxic factor’ in groundnuts is not a new problem”
• “We do not know the chemical composition of the‘toxic factor’, but the source of toxicity is likely relatedto fungal contamination at a stage before processing”
• “We think the whole problem is serious from a human and animal health point of view and from economic aspects”
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• Introduction• Effects and occurrence of aflatoxins • The EU’s RASFF system: focus on aflatoxins• Risk assessment of aflatoxins • The process of setting regulations for aflatoxins• Worldwide limits for aflatoxins • Summary
Outline of presentation
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25th June 2008 5
• Introduction• Effects and occurrence of aflatoxins• The EU’s RASFF system: focus on aflatoxins• Risk assessment of aflatoxins• The process of setting regulations for aflatoxins• Worldwide limits for aflatoxins • Summary
Outline of presentation
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25th June 2008 6
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aflatoxin B1 aflatoxin M1
Chemical structures of aflatoxins B1 and M1
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25th June 2008 7
Effects aflatoxin B1
• Strong acute toxin in various experimental animals• Potent liver carcinogen in various experimental animals• Possible role in human liver cancer in Asia and Africa• Possible role in kwashiorkor• Stunted growth in children• Kenya 2004, 2005: outbreak of aflatoxicosis
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25th June 2008 8
317 people in Kenyan villages got ill; 127 died,including many children
The Kenya outbreak of aflatoxicosis, 2004
Photo: courtesy Henry Njapauand Masja Straetemans
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• Village-grown maize suspected to play acausal role
• FDA emergency teamconfirmed hypothesis of human aflatoxicosis
• New outbreak occurred in 2005
Kenya aflatoxicosis, 2004
Photo: courtesy Henry Njapauand Masja Straetemans
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25th June 2008 10
Aflatoxins: pre- and post- harvest problems
• Produced primarily by strains of Aspergillus flavus,A. parasiticus and A. nomius
• A. flavus: more adapted to aerial parts of plants (leaves, flowers), dominant on maize, cotton seed, tree nuts (aflatoxins B1, B2)
• A. parasiticus: well adapted to a soil environment, prominent on peanuts (aflatoxins B1, B2, G1 and G2)
• A. nomius: found on various cereals and nuts, e.g. producer of B and G aflatoxins in Brazil nuts
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Aflatoxin M1: the milk-aflatoxin
• Approx. 1-6 % of the aflatoxin B1 in animal feedstuffs is transferred to aflatoxin M1 in milk
• A seasonal trend is noted in many surveys, with lower levels occurring in summer months
• The toxin is found in human breast milk, sometimes at rather high levels in samples from tropical and subtropical regions
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• Introduction• Effects and occurrence of aflatoxins • The EU’s RASFF system: focus on aflatoxins• Risk assessment of aflatoxins• The process of setting regulations for aflatoxins• Worldwide limits for aflatoxins • Summary
Outline of presentation
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RASFF in the EU
• Quick information-exchange in the EU on risks to human health
• Allows MS to identify potential problems and take measures
• In 2006: near to 900 mycotoxin issues
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25th June 2008 14
RASFF 2006: information notifications
Information notifications 2006
Rest37%
Veterinary medicine products
4%
Pathogenic micro-
organisms7%
Food additives
8%
Compositions4%
Mycotoxins40%
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cereal(s) coffee & baby fruits & herbs & fruit nuts & products cocoa food veg. spices juices products
Mycotoxin Notifications [RASFF 2006]
fumonisins
patulin
ochratoxin A
aflatoxins 5 1 69 37 684
14 1
11 12 27 4
1 1 5
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• Introduction• Effects and occurrence of aflatoxins • The EU’s RASFF system: focus on aflatoxins• Risk assessment of aflatoxins • The process of setting regulations for aflatoxins• Worldwide limits for aflatoxins • Summary
Outline of presentation
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25th June 2008 17
International bodies involvedin assessing risks on aflatoxins
• IARC: International Agency for Research on Cancer- Classified aflatoxins as group I: known human carcinogens
• JECFA: Joint FAO/WHO Expert Committeeon Food Additives
- Assessment of carcinogenic potency of aflatoxin B1
• EFSA: European Food Safety Authority- Opinion on the potential increase of risk by a possible increase of maximum levels for aflatoxins in tree nuts
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25th June 2008 18
International bodies involvedin assessing risks on aflatoxins
• IARC: International Agency for Research on Cancer- Classified aflatoxins as group I: known human carcinogens
• JECFA: Joint FAO/WHO Expert Committeeon Food Additives
- Assessment of carcinogenic potency of aflatoxin B1
• EFSA: European Food Safety Authority- Opinion on the potential increase of risk by a possible increase of maximum levels for aflatoxins in tree nuts
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25th June 2008 19
JECFA: safety evaluation of mycotoxins
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25th June 2008 20
Risk assessment process
• Hazard identification – Use of all data to establish that a compound has the capacity to cause an adverse effect
• Hazard characterization – Assessment of the relationship between dose, and the incidence or severity of an effect
• Exposure assessment – Estimation of the dose, to which various individuals or populations, are exposed
• Risk characterization – Estimation of the incidence and severity of the adverse effects that are liable to occur ina population due to actual or predicted exposure
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Contaminants without identifiedthresholds of toxicity (e.g. aflatoxins)
• The ideal way to evaluate substances withoutidentified thresholds: quantitative risk assessment
• Difficult with most contaminants because sufficientdose-response data are lacking
• Aflatoxins were the first carcinogenic contaminants evaluated by JECFA
• The Committee advised Codex Alimentarius that theybe present in the food supply at ‘irreducible levels’
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25th June 2008 22
Risk assessment versus risk management
• Codex did not find ‘irreducible level’ (ALARA) to be a useful endpoint for risk management:- difficult to manage: health effects are not quantified- creates difficulty: widely varying levels around the world
• JECFA re-evaluated aflatoxins: calculation of population risks, based on hypothetical standards:
-10 µg AFB1/kg groundnuts or maizeor
- 20 µg AFB1/kg groundnuts or maize
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25th June 2008 23
Lower-risk group – population risks(no HBV prevalent)
• 20 µg/kg standard- 0.0041 cancers per year per 100 000 people
• 10 µg/kg standard- 0.0039 cancers per year per 100 000 people
• Reducing the hypothetical standard from 20 to 10 µg/kg yields a reduction in estimated population risk by 2 cancers per year per billion people
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25th June 2008 24
Higher-risk group – population risks(HBV prevalent)
• 20 µg/kg standard- 0.17 cancers per year per 100 000 people
• 10 µg/kg standard- 0.14 cancers per year per 100 000 people
• Reducing the hypothetical standard from 20 to 10 µg/kg yields a reduction in estimated population risk by 300 cancers per year per billion people
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25th June 2008 25
Aflatoxin conclusions
• Establishment of a standard is more important thanits actual level, because a majority of the risk is borne by those consuming highly contaminated product
• Reduction in AFB1 intake in populations with a high incidence of hepatitis B will result in a greater reduction in liver cancer than reduction of the AFB1intake in populations with low incidence of hepatitis B
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• Introduction• Effects and occurrence of aflatoxins • The EU’s RASFF system: focus on aflatoxins• Risk assessment of aflatoxins by JECFA• The process of setting regulations for aflatoxins• Worldwide limits for aflatoxins • Summary
Outline of presentation
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toxicity data, survey analytical data, methods of sampling
and analysis
trade contacts with other countries, sufficiency of
food supply
Factors influencing regulations
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The mycotoxin regulatory puzzle
TOXICITY
OCCURRENCE
TRADE
ANALYSIS
SAMPLING FOOD SUPPLY
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Weighing the various factors: not trivial
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International inquiry 2003
• Inquiry 2003: FAO-contracted activity of RIVM• Information: Dutch Embassies and personal contacts • Details asked a.o. about tolerance limits, legal bases,
responsible authorities, methods of sampling and analysis• Results: regulations exist in 100 countries and for 13 toxins• FAO FNP 81: recently published in 4 different languages
Questionnaire February 2003For an Update of
“Worldwide regulations for mycotoxins 1995”FAO Food and Nutrition Paper 64
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Various translations of FNP 81 available
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• Introduction• Effects and occurrence of aflatoxins • The EU’s RASFF system: focus on aflatoxins• Risk assessment of aflatoxins by JECFA• The process of setting regulations for aflatoxins• Worldwide limits for aflatoxins• Summary
Outline of presentation
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Ranges and typical limitsfor total aflatoxins in food
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North Am erica 2003
Latin Am erica 2003
Europe 2003
Asia/Oceania 2003
Africa 2003
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Aflatoxin B1 in food
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29
21
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2
3
1 µg/kg
2 µg/kg
5 µg/kg
10 µg/kg
15 µg/kg
20 µg/kg
number of countries
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Total aflatoxins in food
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1
1
28
2
7
8
18
7
2
0 µg/kg
1 µg/kg
3 µg/kg
4 µg/kg
5 µg/kg
10 µg/kg
15 µg/kg
20 µg/kg
30 µg/kg
35 µg/kg
number of countries
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Aflatoxin M1 in milk
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1
22
1
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not detectable
0.05 µg/kg
0.2 µg/kg
0.5 µg/kg
5 µg/kg
15 µg/kg
number of countries
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Aflatoxin B1 in feed for dairy cattle
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1
3
1
2
5 µg/kg
10 µg/kg
15 µg/kg
20 µg/kg
25 µg/kg
50 µg/kg
number of countries
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Summary
• Aflatoxins: significant adverse effects on humans • RASFF notifications: largely caused by aflatoxins• Reduction of HBV prevalence will result in significant
reduction of liver cancer due to aflatoxins• Many factors involved in setting aflatoxin regulations• Worldwide limits for aflatoxins vary widely• Finally......................
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25th June 2008 39
Half a century ago... a young boy and his sister in Jambi, Sumatra
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40SELAMAT open seminar, 25th June 2008
Aflatoxins: risks, regulations and limits
Hans van Egmond, RIVM
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