Segmentation

outward

inward

Three Conformations

Myosin-V with ADP (PDB - 1W7I)

pre-power stroke state in scallop muscle (PDB - 1QVI)

F-actin

pre-power stroke state in smooth muscle (PDB - 1BR1)

CC= 0.64 CC= 0.53

CC= 0.42

CC= 0.58

CC= 0.42CC= 0.41

outward

inward

Docking by SITUS (colores)

ADPmyosin-V

Scallop-like pre-power stroke

smooth muscle-like pre-power stroke

outward

inward

ADPmyosin-V

Scallop-like pre-power stroke

smooth muscle-like pre-power stroke

Docking by SITUS (colores)

CC= 0.64 CC= 0.53

CC= 0.42

CC= 0.58

CC= 0.42CC= 0.41

CC= 0.64outward

Docking by SITUS (myoV-ADP)

ADPmyosin-V

CC= 0.82outward

Normal Mode Flexible Fitting (myoV-ADP)

ADPmyosin-V

CC= 0.58

Docking by SITUS (scallop-like)

outward

Scallop-like pre-power stroke

CC= 0.77

Normal Mode Flexible Fitting (scallop-like)

outward

Scallop-like pre-power stroke

Fitted “scallop-like” on F-actin

F-actin F-actin Myosin-V with ADP (PDB - 1W7I)

pre-power stroke state in scallop myosin (PDB - 1QVI)

pre-power stroke state in smooth muscle myosin (PDB - 1BR1)