Search Committee Executive Vice-President for Health ... · DUKE UNIVERSITY MEDICAL CENTER...

DUMC 3810, DURHAM, NC 27710Tel (919) 681-6581 Fax (919) 684-7124 [email protected]

April 24, 2017

Search Committee Executive Vice-President for Health AffairsUniversity of Kentucky and UK Healthcare

Dear Search Committee:

Thank you for your interest in my candidacy for the position of Executive Vice-President for Health Affairs (EVPHA) of the University of Kentucky and UK Healthcare. This position is a unique opportunity to support the development and growth of one of the nation’s renowned institutions of higher learning and clinical care as well as return to my home state. The last decade has seen UK Healthcare evolve into a system with the focus and the flexibility to grow and build on its reputation while advancing the health of the state of Kentucky. I believe that my background as a clinician-scientist, chairman, hospital leader and president of a large multispecialty physician group gives me a unique insight into the entities that both collaborate with and report to the EVPHA.

Effective leaders develop strong teams with a clear, collective vision, and have the strength of will to carry that vision forward. My observation of those leaders and my own experiences have shown me that the focus clearly must be advancing the institution, and not on achieving personal or career goals. The summary of accomplishments in my current and recent positions outlines a pattern of early acceptance of leadership roles. In each case I was able to develop a clear inventory of the group strengths, weaknesses and leadership capabilities and then work collaboratively to build a strategic plan with clearly defined goals and implementation plans. The most important final piece is holding both my team and myself accountable to those plans and goals.

The work that I have done to assess other institutions, (see Summary of Accomplishments) and to build our own, has shown me that regardless of the structure of the institution, the ability of the leader to develop trust, effective interaction, and successful communication is the key factor in the success of the enterprise. Having also been a faculty leader during the creation of the Duke Health System, the design of the new Duke Medical Pavilion (Duke Hospital) and updating of Duke’s next generation school of medicine (SOM) curriculum, gives me an appreciation for the complexity of the EVPHA position and the necessity to build a strong cohesive leadership team with all constituents that will ensure the success of this large academic clinical enterprise in a time of unprecedented change in healthcare.

While my commitment and vision for the success of the institution is key, my background fills in the rest of the picture. I grew up in Kentucky as part of a farming family with a strong focus on education (teachers). The strong education allowed me to receive multiple college scholarship offers from around the country, but I attended college in state so that I could be close to my father who was ill and support my family. I had grown up working on the farm, and continued that in college as I began running our farm after my father died from complications of sepsis. I accepted scholarship support for attending medical school, receiving the Air Force Health Professions Scholarship to support my medical education at the University of Louisville.

The Air Force was extremely supportive of my career progression, allowing me to complete medical school, pursue Anesthesiology, and a Cardiothoracic Anesthesiology Fellowship all the while providing me with leadership training and feedback (really an assessment of my interaction with others). I completed my residency in the Air Force and a fellowship in Cardiothoracic Anesthesiology and

DUMC 3810, DURHAM, NC 27710Tel (919) 681-6581 Fax (919) 684-7124 [email protected]

Transesophageal Echocardiography at Duke University Medical Center before returning to active duty at Wilford Hall USAF Medical Center. The military provided me with a great opportunity to grow as I was deployed for Operation “Just Cause” and then for “Desert Shield” and “Desert Storm.” I advanced as both a team member and leader. I balanced my hands-on, lead from the front approach, with strategic planning and organization. I learned a great deal about my interactions, my style of leadership and made mistakes in a learning environment appreciative of focused effort and commitment.

My experiences have been both challenges and opportunities. They have allowed me to accelerate my acceptance of responsibility and leadership. With each step of my career, opportunities were offered or demanded for movement into leadership roles often as the most junior member of the group I was to lead. After only two years as an Assistant Professor at Duke, I was selected to be the Division Chief of Cardiothoracic Anesthesiology. This occurred with strong support from the senior members, but initial skepticism from my similarly junior colleagues. Clear team growth and success as well as rapid career development of my faculty and trainees were soon my defining characteristics. The pattern repeated itself several years later. My Chairman was selected to be Dean and Senior Vice-President at Medical University of South Carolina and I was selected for Interim Chair and then Permanent Chair of the Anesthesiology Department at Duke. I built on a strong foundation to develop one of the top departments in the country building perioperative multi-center research capabilities and increased productivity that allowed the department to grow in size and reputation. My pattern of early progression to leadership continued in 2004 with my election by the Board of our physician practice to serve as the Chairman of the Board. I was the youngest chair, but one that was felt could represent our faculty with institutional leadership and define an innovative path for success. Lastly, after a national search, my colleagues asked me to accept the role of President in our faculty practice (the Duke Private Diagnostic Clinic) with the objective to build our capabilities as an integrated practice to continue to lead in healthcare for another 85 years.

My strengths include understanding and building the academic business to support the growth of the overall enterprise and the missions it supports. It is my knowledge of the important intersection between academics, healthcare and the associated business and my ability to build teams and instill trust that permits me to develop the synergistic relationships that allow the enterprise to flourish. It is the dogged determination to hold myself, my team and my institution accountable for the lofty goals that we set for ourselves and to do the same for the health of a state that defines my leadership potential.

Building, inspiring, advancing and partnering with dedicated and talented individuals is what makes academic medicine a great career and a great life. I enjoy building and working with great teams to create an environment where the best and brightest come to work, learn and grow. I look forward to discussing this opportunity with you. I have enclosed my curriculum vitae and a summary of accomplishments for your consideration.

Sincerely,

President and Merel H. Harmel ProfessorDuke Private Diagnostic Clinic, PLLCPhone: 919.681.6581Fax: 919.684.7124E-Mail: [email protected]

mailto:[email protected]

DUKE UNIVERSITY MEDICAL CENTER

CURRICULUM VITAEfor

Permanent Record and the

Appointments and Promotions Committee

Date RevisedMarch 24, 2017

Name: Mark F. Newman, M.D.

Primary Academic Appointment: Anesthesiology

Secondary Academic Appointment: Medicine

Social Security: XXX-XX-XXXX

Present Academic Rank and Title: President, Private Diagnostic Clinic, PLLC (Duke Physician Practice Organization)Merel H. Harmel Professor of AnesthesiologyPast Chairman, Department of AnesthesiologyProfessor of MedicineDuke University Medical Center, Durham, NC

Date and rank of first Duke Assistant Professor, July 6, 1992University faculty appointment: Department of Anesthesiology

Medical licensure: North Carolina, June 6, 1992, #35450

DEA Registration #: XXXXXXXXX

Specialty certification and dates: American Board of AnesthesiologyOctober 11, 1991, #20301

Date of birth: October 7, 1959

Place of birth: Owensboro, Kentucky

Citizen of: The United States

Education: Place Date Degree

Daviess Co. H.S. Owensboro, KY 1977 HS degree

Western Kentucky University Bowling Green, KY 1981 B.S. (Biology)

University of Louisville Louisville, KY 1985 M.D.

Curriculum Vitae of Mark F. Newman, MDPage 2

Scholarly Societies

Alpha Epsilon DeltaAlpha Omega AlphaAssociation of Cardiac AnesthesiologistsAssociation of University AnesthetistsBeta Beta BetaMorton SocietyOmicron Delta KappaPhi Eta Sigma

Professional Training and Academic Career

Rotating InternshipWilford Hall USAF Medical CenterSan Antonio, TexasJuly 1, 1985 – June 30, 1986

Resident in AnesthesiologyWilford Hall USAF Medical CenterSan Antonio, TexasJuly 1, 1986 – June 30, 1988

Chief Resident in AnesthesiologyWilford Hall USAF Medical CenterSan Antonio, TexasJuly 1, 1987 – June 30, 1988

Fellow in Cardiac AnesthesiologyDuke University Medical CenterDurham, North Carolina 27710July 1, 1988 – June 30, 1989

Chief, Cardiothoracic AnesthesiaDirector of ResearchDepartment of AnesthesiaWilford Hall USAF Medical CenterSan Antonio, Texas July 4, 1989 – July 3, 1992

Clinical Assistant Professor of AnesthesiologyUniversity of Texas Health Sciences CenterSan Antonio, Texas December 1989 – July 1992

Assistant Professor of AnesthesiologyDepartment of AnesthesiologyDuke University Medical CenterDurham, North CarolinaJuly 6, 1992 – December 1, 1996


Chief, Division of Cardiothoracic AnesthesiaDepartment of AnesthesiologyDuke University Medical CenterDurham, North CarolinaJune 1, 1994 – July 1, 2001

Assistant Professor of MedicineDepartment of MedicineDuke University Medical CenterDurham, North CarolinaFebruary 1, 1995 – June 30, 1999

Senior FellowCenter for the Study of Aging and Human DevelopmentDuke University Medical CenterDurham, North CarolinaJuly 1, 1996 – Present

Associate Professor of AnesthesiologyDepartment of AnesthesiologyDuke University Medical CenterDurham, North CarolinaDecember 1, 1996 – June 1, 1999

Multicenter Outcomes Research FacultyDuke Clinical Research Institute (DCRI)Duke University Medical CenterDurham, North CarolinaJuly 1, 1997 – Present

Associate Professor of MedicineDepartment of MedicineDuke University Medical CenterDurham, North CarolinaJune 1, 1999 – June 30, 2003

Professor of AnesthesiologyDepartment of AnesthesiologyDuke University Medical CenterDurham, North CarolinaJune 1, 1999 – Present

Vice-ChairmanDepartment of AnesthesiologyDuke University Medical CenterDurham, North CarolinaJune 1, 1999 – April 2001


Acting ChairmanDepartment of AnesthesiologyDuke University Medical CenterDurham, North CarolinaApril 1, 2001 – December 2001

Medical DirectorGlobal Perioperative Research OrganizationDuke University Medical CenterDurham, North CarolinaJuly 1, 2001 – October 1, 2009

ChairmanDepartment of AnesthesiologyDuke University Medical CenterDurham, North CarolinaDecember 2001 – April 2014

Professor of MedicineDepartment of MedicineDuke University Medical CenterDurham, North CarolinaJuly 1, 2003 – Present

Merel H. Harmel Distinguished Professor of AnesthesiologyDepartment of AnesthesiologyDuke University Medical CenterDurham, North CarolinaJuly 1, 2004 – Present

Chairman of the Board, Duke Private Diagnostic Clinic (Duke Physician Organization)Duke University Health SystemDurham, North CarolinaJanuary 1, 2005 – March 31, 2009

President, Duke Private Diagnostic Clinic (Duke Physician Organization)Duke University Health SystemDurham, North CarolinaApril 1, 2014 – Present

Fellows in Cardiothoracic Anesthesia Trained

Mark Stafford-Smith, M.D. ** 1992–1994

Barbara Tardiff, M.D. ** 1993–1996

Elliott Bennett-Guerrero, M.D. ** 1994–1996

John Jimenez, M.D. 1994–1995

Hilary Grocott, M.D. ** 1995–1998 Darryl Atwell, M.D. ** 1995–1997


Blake Wendelburg, M.D. 1996–1998

Chris Watke, M.D. 1996–1998

Mark Gerhardt, M.D., Ph.D. ** 1996–1998

Sophia Chew, M.D. ** 1997–1998

Libby Dalamangas, M.D. 1997–1998

Christopher J. East, M.D. 1998–1999

Carolyn M. Garduno, M.D. 1998–1999

James D. Gould, M.D.** 1998–1999

Alina M. Grigore, M.D.** 1998–2000

George Burkhard Mackensen, M.D.** 1998–2000

Ajeet Sharma, M.D.** 1998–2000

Gautam M. Sreeram, M.D.** 1997–1999

Maribel Gamoso, M.D. 1999–2000

Lian Kah Ti** 1999–2000

Timothy Stanley, M.D. 1999–2001

George Djaiani, M.D.** 2000–2001

Bo Wu, M.D. 2000–2001

Madhav Swaminathan, M.D. ** 2000–2002

Mihai Podgoreanu, M.D. (CT/ICU) ** 2000–2003

Willem Lombard, M.D. ** 2001–2002

William Corkey, M.D. 2003–2004

Daniel DeMeyts, M.D.** 2003–2004

John Mitchell, M.D.** 2003–2004

Ferenc Puskas, M.D.** 2004–2005

Paul Shook, M.D. 2004–2005

Philip Roman, M.D.** 2010–2011

Antonio Chiricolo, M.D.** 2011–2012 **Currently in Academic Practice


Publications:

Refereed Journals

1. Croughwell N, Lyth M, Quill TJ, Newman M, Greeley WJ, Smith LR, Reves JG. Diabetic patients have abnormal cerebral autoregulation during cardiopulmonary bypass. Circulation. 1990; 82(5 Suppl):IV407–12.

2. Croughwell N, Smith LR, Quill T, Newman M, Greeley W, Kern F, Lu J, Reves JG. The effect of temperature on cerebral metabolism and blood flow in adults during cardiopulmonary bypass. J Thorac Cardiovasc Surg. 1992; 103(3):549–54.

3. Schell RM, Kern FH, Greeley WJ, Schulman SR, Frasco PE, Croughwell ND, Newman M, Reves JG. Cerebral blood flow and metabolism during cardiopulmonary bypass. Anesth Analg. 1993; 76(4):849–65.

4. Newman M, Reves JG. Pro: Midazolam is the sedative of choice to supplement narcotic anesthesia. J Cardiothorac Vasc Anesth. 1993; 7(5):615–19.

5. Newman MF, Croughwell ND, Blumenthal JA, White WD, Lewis JB, Smith LR, Frasco P, Towner EA, Schell RM, Hurwitz BJ, Reves JG. Effect of aging on cerebral autoregulation during cardiopulmonary bypass: Association with postoperative cognitive dysfunction. Circulation. 1994; 90(5 Pt 2):II-243–49.

6. Croughwell ND, Newman MF, Blumenthal JA, White WD, Lewis JB, Frasco PE, Smith LR, Thyrum EA, Hurwitz BJ, Leone BJ, Schell RM, Reves JG. Jugular bulb saturation and cognitive dysfunction after cardiopulmonary bypass. Ann Thorac Surg. 1994; 58(6):1702–8.

7. Burker EJ, Blumenthal JA, Feldman M, Burnett R, White W, Smith LR, Croughwell N, Schell R, Newman M, Reves JG. Depression in male and female patients undergoing cardiac surgery. Br J Clin Psych. 1995; 34(1):119–28.

8. Newman MF, Croughwell ND, Blumenthal JA, Lowry E, White WD, Spillane W, Davis RD, Glower DD, Smith LR, Mahanna EP, Reves JG. Predictors of cognitive decline after cardiac operation. Ann Thorac Surg. 1995; 59(5):1326–30.

9. Blumenthal JA, Mahanna EP, Madden DJ, White WD, Croughwell ND, Newman MF. Methodological issues in the assessment of neuropsychologic function after cardiac surgery. Ann Thorac Surg. 1995; 59(5):1345–50.

10. Croughwell ND, White WD, Smith LR, Davis RD, Glower DD, Reves JG, Newman MF. Jugular bulb saturation and mixed venous saturation during cardiopulmonary bypass. J Cardiac Surg. 1995; 10(4 Suppl):503–8.

11. Burker EJ, Blumenthal JA, Feldman M, Thyrum E, Mahanna E, White W, Smith LR, Lewis J, Croughwell N, Schell R, Newman M, Reves JG. The mini mental state exam as a predictor of neuropsychological functioning after cardiac surgery. Int J Psychiatry Med. 1995; 25(3):263–76.

12. Newman MF, Kramer D, Croughwell ND, Sanderson I, Blumenthal JA, White WD, Smith LR, Towner EA, Reves JG. Differential age effects of mean arterial pressure and rewarming on cognitive dysfunction after cardiac surgery. Anesth Analg. 1995; 81(2):236–42.

13. Kern FH, Ungerleider RM, Schulman SR, Meliones JN, Schell RM, Baldwin B, Hickey PR, Newman MF, Jonas RA, Greeley WJ. Comparing two strategies of cardiopulmonary bypass cooling on jugular venous oxygen saturation in neonates and infants. Ann Thorac Surg. 1995; 60(5):1198–202.

14. Newman MF, Murkin JM, Roach G, Croughwell ND, White WD, Clements FM, Reves JG and the CNS Subgroup of McSPI. Cerebral physiologic effects of burst suppression doses of propofol during nonpulsatile cardiopulmonary bypass. Anesth Analg. 1995; 81(3):452–57.


15. Newman MF, Croughwell ND, Blumenthal JA, Lowry E, White WD, Reves JG. Cardiopulmonary bypass and the central nervous system: Potential for cerebral protection. J Clin Anesth. 1996; 8(3 Suppl):53S–60S.

16. Mahanna EP, Blumenthal JA, White WD, Croughwell ND, Clancy CP, Smith LR, Newman MF. Defining neuropsychological dysfunction after coronary artery bypass grafting. Ann Thorac Surg. 1996; 61(5):1342–47.

17. Reves JG, Newman MF. The brain and cardiac surgery. Anesth Analg. 1996; 82S:94–103.

18. Jones RH, Kesler K, Phillips HR, Mark DB, Smith PK, Nelson CL, Newman MF, Reves JG, Anderson RW, Califf RM. Long-term survival benefits of coronary artery bypass grafting and percutaneous transluminal angioplasty in patients with coronary artery disease. J Thorac Cardiovasc Surg. 1996; 111(5):1013–25.

19. Bennett-Guerrero E, Jimenez JL, White WD, D’Amico EB, Baldwin BI, Schwinn DA, for the Duke T3 Study Group. Cardiovascular effects of intravenous triiodothyronine in patients undergoing coronary artery bypass graft surgery: A randomized, double-blind, placebo-controlled trial. JAMA. 1996; 275(9):687–92.

20. Newman MF. Does hemoglobin concentration affect perioperative myocardial lactate flux in patients undergoing coronary artery bypass surgery? Cardiovasc Thorac Anesth Journal Club Journal. 1996; 1:5–7.

21. Mathew JP, Parks R, Savino JS, Friedman AS, Koch C, Mangano DT, Browner WS, for the Multicenter Study of Perioperative Ischemia Research Group. Atrial fibrillation following coronary artery bypass graft surgery: Predictors, outcomes, and resource utilization. JAMA. 1996; 276(4):300–6.

22. Newman MF, Croughwell ND, White WD, Lowry E, Baldwin BI, Clements FM, Davis RD, Jones RH, Amory DW, Reves JG. Effect of perfusion pressure on cerebral blood flow during normothermic cardiopulmonary bypass. Circulation. 1996; 94(9 Suppl):II-353–57.

23. Bennett-Guerrero E, Sorohan JG, Howell ST, Ayuso L, Cardigan RA, Newman MF, Mackie IJ, Reves JG, Mythen MG. Maintenance of therapeutic plasma aprotinin levels during prolonged cardiopulmonary bypass using a large-dose regimen. Anesth Analg. 1996; 83(6):1189–92.

24. Roach GW, Kanchuger M, Mangano CM, Newman MF, Nussmeier N, Wolman R, Aggarwal A, Marschall K, Graham SH, Ley C, Ozanne G, Mangano DT, for the Multicenter Study of Perioperative Ischemia (McSPI) Research Group and the Ischemia Research and Education Foundation Investigators. Adverse cerebral outcomes after coronary bypass surgery. N Eng J Med. 1996; 335(25):1857–63.

25. Newman MF, Wolman R, Kanchuger M, Marschall K, Mora-Mangano C, Roach G, Smith LR, Aggarwal A, Nussmeier N, Herskowitz A, Mangano DT, and Participants in the Multicenter Study of Perioperative Ischemia (McSPI) Research Group. Multicenter preoperative stroke risk index for patients undergoing coronary artery bypass graft surgery. Circulation. 1996; 94(9 suppl):II-74–80.

26. Bennett-Guerrero E, Ayuso L, Hamilton-Davies C, White WD, Barclay GR, Smith PK, King SA, Muhlbaier LH, Newman MF, Mythen MG. Relationship of preoperative antiendotoxin core antibodies and adverse outcomes following cardiac surgery. JAMA. 1997; 277(8):646–50.

27. Grocott HP, Newman MF, Lowe JE, Clements F. Transmyocardial laser revascularization: An anesthetic perspective. J Cardiothorac Vasc Anesth. 1997; 11(2):206–10.


28. Croughwell ND, Newman MF, Lowry E, Davis RD, Landolfo KP, White WD, Kirchner JL, Mythen MG. Effect of temperature during cardiopulmonary bypass on gastric mucosal perfusion. Br J Anaesth. 1997; 78(1):34–38.

29. Mangano DT for the Multicenter Study of Perioperative Ischemia (McSPI) Research Group. Effects of acadesine on myocardial infarction, stroke, and death following surgery: A meta-analysis of the 5 international randomized trials. JAMA. 1997; 277(4):325–32.

30. Bennett-Guerrero E, Sorohan JG, Canada AT, Ayuso L, Newman MF, Reves JG, Mythen MG. -Aminocaproic acid plasma levels during cardiopulmonary bypass. Anesth Analg. 1997; 85(2):248–51.

31. Tardiff BE, Newman MF, Saunders AM, Strittmatter WJ, Blumenthal JA, White WD, Croughwell ND, Davis RD, Roses AD, Reves JG, The Neurologic Outcome Research Group of the Duke Heart Center. Preliminary report of a genetic basis for cognitive decline after cardiac operations. Ann Thorac Surg. 1997; 64(3):715–20.

32. Bennett-Guerrero E, Sorohan JG, Gurevich ML, Kazanjian PE, Levy RR, Barberá AV, White WD, Slaughter TF, Sladen RN, Smith PK, Newman MF. Cost-benefit and efficacy of aprotinin compared with -aminocaproic acid in patients having repeated cardiac operations: A randomized, blinded clinical trial. Anesthesiology. 1997; 87(6):1373–80.

33. Hlatky MA, Bacon C, Boothroyd D, Mahanna E, Reves JG, Newman MF, Johnstone I, Winston C, Brooks MM, Rosen AD, Mark DB, Pitt B, Rogers W, Ryan T, Wiens R, Blumenthal JA. Cognitive function 5 years after randomization to coronary angioplasty or coronary artery bypass graft surgery. Circulation. 1997; 96(9 suppl):II-11–15.

34. Grocott HP, Amory DW, Lowry E, Newman MF, Lowe JE, Clements FM. Cerebral embolization during transmyocardial laser revascularization. J Thorac Cardiovasc Surg. 1997; 114(5):856–58.

35. Grocott HP, Newman MF, Croughwell ND, White WD, Lowry E, Reves JG. Continuous jugular venous versus nasopharyngeal temperature monitoring during hypothermic cardiopulmonary bypass for cardiac surgery. J Clin Anesth. 1997; 9(4):312–16.

36. Newman MF, Croughwell ND, White WD, Sanderson I, Spillane W, Reves JG. Pharmacologic electroencephalographic suppression during cardiopulmonary bypass: A comparison of thiopental and isoflurane. Anesth Analg. 1998; 86(2):246–51.

37. Grocott HP, Amory DW, Lowry E, Croughwell ND, Newman MF. Transcranial doppler blood flow velocity versus 133Xe clearance cerebral blood flow during mild hypothermic cardiopulmonary bypass. J Clin Monitor Comput. 1998; 14(1):35–39.

38. Mangano CM, Diamondstone LS, Ramsay JG, Aggarwal A, Herskowitz A, Mangano DT, for the Multicenter Study of Perioperative Ischemia Research Group. Renal dysfunction after myocardial revascularization: Risk factors, adverse outcomes, and hospital resource utilization. Ann Intern Med. 1998; 128(3):194–203.

39. Croughwell ND, Reves JG, White WD, Grocott HP, Baldwin BI, Clements FM, Davis RD, Jones RH, Newman MF. Cardiopulmonary bypass time does not affect cerebral blood flow. Ann Thorac Surg. 1998; 65(5):1226–30.

40. Grocott HP, Croughwell ND, Amory DW, White WD, Kirchner JL, Newman MF. Cerebral emboli and serum S100 during cardiac operations. Ann Thorac Surg. 1998; 65(6):1645–50.

41. Weiss L, Grocott HP, Rosania RA, Friedman A, Newman MF, Warner DS. CASE 4—1998: Cardiopulmonary bypass and hypothermic circulatory arrest for basilar artery aneurysm clipping. J Cardiothorac Vasc Anesth. 1998; 12(4):473–79.


42. Atwell DM, Grichnik KP, Newman MF, Reves JG, McBride WT. Balance of proinflammatory and antiinflammatory cytokines at thoracic cancer operation. Ann Thorac Surg. 1998; 66(4):1145–50.

43. Booth JV, Landolfo KP, Chesnet LC, Bennett-Guerrero E, Gerhardt MA, Atwell DM, El-Moalem HE, Stafford Smith M, Funk BL, Kuhn CM, Kwatra MM, Schwinn DA, for the Duke Heart Center Perioperative Desensitization Group. Acute depression of myocardial -adrenergic receptor signaling during cardiopulmonary bypass: Impairment of the adenylyl cyclase moiety. Anesthesiology. 1998; 89(3):602–11.

44. Gerhardt MA, Booth JV, Chesnut LC, Funk BL, El-Moalem HE, Kwatra MM, Schwinn DA and the Duke Heart Center Perioperative Desensitization Group. Acute myocardial -adrenergic receptor dysfunction after cardiopulmonary bypass in patients with cardiac valve disease. Circulation. 1998; 98(19 Suppl):II-275–81.

45. Wolman RL, Nussmeier NA, Aggarwal A, Kanchuger MS, Roach GW, Newman MF, Mangano CM, Marschall KE, Ley C, Boisvert DM, Ozanne GM, Herskowitz A, Graham SH, Mangano DT, for the Multicenter Study of Perioperative Ischemia (McSPI) Research Group and the Ischemia Research and Education Foundation (IREF) Investigators. Cerebral injury after cardiac surgery: Identification of a group at extraordinary risk. Stroke. 1999; 30(3):514–22.

46. Newman MF, Laskowitz DT, Saunders AM, Grigore AM, Grocott HP. Genetic predictors of perioperative neurologic and neuropsychological injury and recovery. Sem Cardiothorac Vasc Anesth. 1999; 3(1):34–46.

47. Roach GW, Newman MF, Murkin JM, Martzke J, Ruskin A, Li J, Guo A, Wisniewski A, Mangano DT for the Multicenter Study of Perioperative Ischemia (McSPI) Research Group. Ineffectiveness of burst suppression therapy in mitigating perioperative cerebrovascular dysfunction. Anesthesiology. 1999; 90(5):1255–64.

48. Conlon PJ, Stafford-Smith M, White DW, Newman MF, King S, Winn MP, Landolfo K. Acute renal failure following cardiac surgery. Nephrol Dial Transplant. 1999; 14(5):1158–62.

49. Bennett-Guerrero E, Spillane WF, White WD, Muhlbaier LH, Gall SA, Smith PK, Newman MF. -aminocaproic acid administration and stroke following coronary artery bypass graft surgery. Ann Thorac Surg. 1999; 67(5):1283–87.

50. Wahr JA, Parks R, Boisvert D, Comunale M, Fabian J, Ramsay J, Mangano DT, for the Multicenter Study of Perioperative Ischemia Research Group. Preoperative serum potassium levels and perioperative outcomes in cardiac surgery patients. JAMA. 1999; 281(23):2203–10.

51. Body SC, Birmingham J, Parks R, Ley C, Maddi R, Shernan SK, Siegel LC, Stover EP, D'Ambra MN, Levin J, Mangano DT, Spiess BD, for the Institutions of the Multicenter Study of Perioperative Ischemia Research Group. Safety and efficacy of shed mediastinal blood transfusion after cardiac surgery: A mulitcenter observational study. J Cardiothorac Vasc Anesth. 1999; 13(4):410–16.

52. Bennett-Guerrero E, Welsby I, Dunn TJ, Young LR, Wahl TA, Diers TL, Phillips-Bute BG, Newman MF, Mythen MG. The use of a postoperative morbidity survey to evaluate patients with prolonged hospitalization following routine, moderate-risk, elective surgery. Anesth Analg. 1999; 89(2):514–19.

53. Arrowsmith JE, Grocott HP, Newman MF. Neurologic risk assessment, monitoring and outcome in cardiac surgery. J Cardiothorac Vasc Anesth. 1999; 13(6):736–43.

54. Glower DD, Komtebedde J, Clements FM, Debruijn NP, Stafford-Smith M, Newman MF. Direct aortic cannulation for port-access mitral or coronary artery bypass grafting. Ann Thorac Surg. 1999; 68(5):1878–80.


55. Grichnik KP, Ijsselmuiden AJJ, D’Amico TA, Harpole DH, White WD, Blumenthal JA, Newman MF. Cognitive decline after major noncardiac operations: A preliminary prospective study. Ann Thorac Surg. 1999; 68(5):1786–91.

56. Khatri P, Babyak M, Clancy C, Davis R, Croughwell N, Newman M, Reves JG, Mark DB, Blumenthal JA. Perception of cognitive function in older adults following coronary artery bypass surgery. Health Psychol. 1999; 18(3):301–6.

57. Hill SE, van Wermeskerken GK, Lardenoye J-WH, Phillips-Bute B, Smith PK, Reves JG, Newman MF. Intraoperative physiologic variables and outcome in cardiac surgery: Part I. In-hospital mortality. Ann Thorac Surg. 2000; 69:1070–76.

58. van Wermeskerken GK, Lardenoye J-WH, Hill SE, Grocott HP, Phillips-Bute B, Smith PK, Reves JG, Newman MF. Intraoperative physiologic variables and outcome in cardiac surgery: Part II. Neurologic Outcome. Ann Thorac Surg. 2000; 69:1077–83.

59. Newman MF, Stanley TO, Grocott HP. Strategies to protect the brain during cardiac surgery. Sem Cardiothorac Vasc Anesth. 2000; 4(2):53–64.

60. Chew STH, Newman MF, White WD, Conlon PJ, Saunders AM, Strittmatter, WJ, Landolfo K, Grocott HP, Stafford-Smith M. Preliminary report on the association of apolipoprotein E polymorphisms, with postoperative peak serum creatinine concentrations in cardiac surgical patients. Anesthesiology. 2000; 93(2):325–331.

61. Arrowsmith JE, Grocott HP, Reves JG, Newman MF. Central nervous system complications of cardiac surgery. Br J Anaesth. 2000; 84:378–393.

62. Kilts JD, Gerhardt MA, Richardson MD, Sreeram G, Mackensen GB, Grocott HP, White WD, Davis RD, Newman MF, Reves JG, Schwinn DA, Kwatra MM. 2-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both Gs and Gi. Circ Res. 2000; 87:705–9.

63. Gamoso MG, Phillips-Bute B, Landolfo KP, Newman MF, Stafford-Smith M. Off-pump versus on-pump coronary artery bypass surgery and postoperative renal dysfunction. Anesth Analg. 2000; 91:1080–84.

64. Stafford-Smith M, Phillips-Bute B, Reddan DN, Black J, Newman MF. The association of -aminocaproic acid with postoperative decrease in creatinine clearance in 1502 coronary bypass patients. Anesth Analg. 2000; 91:1085–90.

65. Grigore AM, Grocott HP, Newman MF. Anesthetic management of a patient with a brain tumor for cardiac surgery. J Cardiothorac Vasc Anesth. 2000; 14(6):702–4.

66. Grocott HP, Mackensen GB, Newman MF, Warner DS. Neurological injury during cardiopulmonary bypass in the rat. Perfusion. 2001; 16:75–81.

67. Newman MF, Kirchner JL, Phillips-Bute B, Gaver V, Grocott H, Jones RH, Mark DB, Reves JG, Blumenthal JA for the Neurological Outcome Research Group and the Cardiothoracic Anesthesiology Research Endeavors Investigators. Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery. N Eng J Med. 2001; 344(6):395–402.

68. Khatri P, Babyak M, Croughwell ND, Davis R, White WD, Newman MF, Reves JG, Mark DB, Blumenthal JA. Temperature during coronary artery bypass surgery affects quality of life. Ann Thorac Surg. 2001; 71:110–16.

69. Mathew JP, Rinder CS, Howe JG, Fontes M, Crouch J, Newman MF, Phillips-Bute B, Smith BR, and the Multicenter Study of Perioperative Ischemia (McSPI) Research Group. Platelet PlA2 polymorphism enhances risk of neurocognitive decline after cardiopulmonary bypass. Ann Thorac Surg. 2001; 71:663–66.


70. Newman MF, Laskowitz DT, White WD, Kirchner JL, Grocott HP, Stafford-Smith M, Sketch MH, Jones RH, Reves JG, Saunders AM. Apolipoprotein E polymorphisms and age at first coronary artery bypass graft. Anesth Analg. 2001; 92:824–29.

71. Howie MB, Cheng D, Newman MF, Pierce ET, Hogue C, Hillel Z, Bowdle TA, Bukenya D. A randomized double-blinded multicenter comparison of remifentanil versus fentanyl when combined with isoflurane/propofol for early extubation in coronary artery bypass graft surgery. Anesth Analg. 2001; 92:1084–93.

72. Cheng DCH, Newman MF, Duke P, Wong DT, Finegan B, Howie M, Fitch J, Bowdle TA, Hogue C, Hillel Z, Pierce E, Bukenya D. The efficacy and resource utilization of remifentanil and fentanyl in fast-track coronary artery bypass graft surgery: A prospective randomized, double-blinded controlled, multi-center trial. Anesth Analg. 2001; 92:1094–1102.

73. Ti LK, Mathew JP, Mackensen GB, Grocott HP, White WD, Reves JG, Newman MF for the C.A.R.E. Investigators. Effect of apolipoprotein E genotype on cerebral autoregulation during cardiopulmonary bypass. Stroke. 2001; 32:1514–19.

74. Grocott HP, Newman MF, El-Moalem H, Bainbridge D, Butler A, Laskowitz DT. Apolipoprotein E genotype differentially influences the proinflammatory and anti-inflammatory response to cardiopulmonary bypass. J Thorac Cardiovasc Surg. 2001; 122(3):622–23.

75. Bainbridge DT, Mackensen GB, Newman MF, Landolfo KP, Grocott HP. Off-pump coronary artery bypass surgery in a patient with C1 esterase inhibitor deficiency. Anesthesiology. 2001; 95(3):795–96.

76. Newman MF, Grocott HP, Mathew JP, White WD, Landolfo K, Reves JG, Laskowitz DT, Mark DB, Blumenthal JA, the Neurologic Outcome Research Group and the Cardiothoracic Anesthesia Research Endeavors (CARE) Investigators of the Duke Heart Center. Report of the substudy assessing the impact of neurocognitive function on quality of life 5 years after cardiac surgery. Stroke. 2001; 32(12):2874–81.

77. Swaminathan M, East C, Phillips-Bute B, Newman MF, Reves JG, Smith PK, Stafford-Smith M. Report of a substudy on warm versus cold cardiopulmonary bypass: Changes in creatinine clearance. Ann Thorac Surg. 2001; 72(5):1603–9.

78. Mackensen GB, Sato Y, Nellgård B, Pineda J, Newman MF, Warner DS, Grocott HP. Cardiopulmonary bypass induces neurologic and neurocognitive dysfunction in the rat. Anesthesiology. 2001; 95(6):1485–91.

79. Grigore AM, Mathew J, Grocott HP, Reves JG, Blumenthal JA, White WD, Smith PK, Jones RH, Kirchner JL, Mark DB, Newman MF, Neurological Outcome Research Group and C.A.R.E. Investigators of the Duke Heart Center. A prospective randomized trial of normothermic versus hypothermic cardiopulmonary bypass on cognitive function after coronary artery bypass graft surgery. Anesthesiology. 2001; 95(5):1110–19.

80. Grigore AM, Grocott HP, Mathew JP, Phillips-Bute B, Stanley TO, Butler A, Landolfo KP, Reves JG, Blumenthal JA, Newman MF, and the Neurologic Outcome Research Group of the Duke Heart Center. The rewarming rate and increased peak temperature alter outcome after cardiac surgery. Anesth Analg. 2002; 94(1):4–10.

81. Stanley TO, Mackensen GB, Grocott HP, White WD, Blumenthal JA, Laskowitz DT, Landolfo KP, Reves JG, Mathew JP, Newman MF, Neurologic Outcome Research Group and C.A.R.E. Investigators of the Duke Heart Center. The impact of postoperative atrial fibrillation on neurocognitive outcome after coronary artery bypass graft surgery. Anesth Analg. 2002; 94(2):290–95.


82. Grocott HP, Mackensen GB, Grigore AM, Mathew J, Reves JG, Phillips-Bute B, Smith PK, Newman MF, and the Neurologic Outcome Research Group (NORG) and Cardiothoracic Anesthesiology Research Endeavors (CARE) Investigators of the Duke Heart Center. Postoperative hyperthermia is associated with cognitive dysfunction after coronary artery bypass graft surgery. Stroke. 2002; 33:537–41.

83. Welsby IJ, Bennett-Guerrero E, Atwell D, White WD, Newman MF, Smith PK, Mythen MG. The association of complication type with mortality and prolonged stay after cardiac surgery with cardiopulmonary bypass. Anesth Analg. 2002; 94(5):1072–78.

84. Sato Y, Laskowitz DT, Bennett ER, Newman MF, Warner DS, Grocott HP. Differential cerebral gene expression during cardiopulmonary bypass in the rat: Evidence of apoptosis? Anesth Analg. 2002; 94(6):1389–94.

85. Savino JS, Ley C, Boisvert D, Friedman A, Mathew J, Koch C, Starr N, Mangano CM, Herskowitz A, Browner WS, Mangano DT, and the Multicenter Study of Perioperative Ischemia (McSPI) Research Group and the Ischemia Research and Education Foundation (IREF). Practice pattern variability for myocardial revascularization: Impact on resource use across 24 centers. J Cardiothorac Vasc Anesth. 2002; 16(2):149–56.

86. Amory DW, Grigore A, Amory JK, Gerhardt MA, White WD, Smith PK, Schwinn DA, Reves JG, Newman MF and the Duke University Perioperative Organ Protection Consortium. Neuroprotection is associated with β-andrenergic receptor antagonists during cardiac surgery: Evidence from 2,575 patients. J Cardiothorac Vasc Anesth. 2002; 16(3):270–77.

87. O’Connor CM, Velazquez EJ, Gardner LH, Smith PK, Newman MF, Landolfo KP, Lee KL, Califf RM, Jones RH. Comparison of coronary artery bypass grafting versus medical therapy on long-term outcome in patients with ischemic cardiomyopathy (A 25-year experience from the Duke Cardiovascular Disease Databank). Am J Cardiol. 2002; 90:101–7.

88. Swaminathan M, McCreath BJ, Phillips-Bute BG, Newman MF, Mathew JP, Smith PK, Blumenthal JA, Stafford-Smith M, and the Perioperative Outcomes Research Group. Serum creatinine patterns in coronary bypass patients with and without postoperative cognitive dysfunction. Anesth Analg. 2002; 95:1–8.

89. Sharma AD, Slaughter TF, Clements FM, Sreeram G, Newman MF, Phillips-Bute B, Bredehoeft SJ, Smith PK, Stafford-Smith M. Association of leukocyte-depleted blood transfusions with infectious complications after cardiac surgery. Surgical Infect (Larchmt). 2002; 3(2):127–33.

90. Hill SE, Leone BJ, Faithfull NS, Flaim KE, Keipert PE, Newman MF. Perflubron emulsion (AF0144) augments harvesting of autologous blood: A phase II study in cardiac surgery. J Cardiothorac Vasc Anesth. 2002; 16(5):555–60.

91. Reynolds JD, Amory DW, Grocott HP, White WD, Newman MF. Change in plasma glutamate concentration during cardiac surgery is a poor predictor of cognitive outcome. J Cardiothorac Vasc Anesth. 2002; 16(4):431–36.

92. Ti LK, Mackensen GB, Grocott HP, Laskowitz DT, Phillips-Bute BG, Milano CA, Hilton AK, Newman MF, Mathew JP, and the Neurological Outcome Research Group. Apolipoprotein E4 increases aortic atheroma burden in cardiac surgical patients. J Thorac Cardiovasc Surg. 2003; 1125(1):211–13.

93. Mathew JP, Grocott HP, Phillips-Bute B, Stafford-Smith M, Laskowitz DT, Rossignol D, Blumenthal JA, Newman MF, the Neurologic Outcome Research Group (NORG) and Cardiothoracic Anesthesiology Research Endeavors (CARE) Investigators of the Duke Heart Center. Lower endotoxin immunity predicts increased cognitive dysfunction in elderly patients after cardiac surgery. Stroke. 2003; 34(2):508–13.


94. Scarborough JE, White W, Derilus FE, Mathew JP, Newman MF, Landolfo KP. Neurologic outcomes after coronary artery bypass grafting with and without cardiopulmonary bypass. Semin Thoracic Cardiov Surg. 2003; 15(1):52–62.

95. Hagen SA, Kondyra AL, El-Moalem H, Bainbridge D, Mathew JP, Newman MF, Reves JG Schwinn DA, Kwatra MM. Cardiopulmonary bypass decreases G protein-coupled receptor kinase activity and expression in human peripheral blood mononuclear cells. Anesthesiology. 2003; 98(2):343–48.

96. Albahrani MJ, Swaminathan M, Phillips-Bute B, Smith PK, Newman MF, Mathew JP, Stafford-Smith M. Postcardiac surgery complications: Association of acute renal dysfunction and atrial fibrillation. Anesth Analg. 2003; 96(3):637–43.

97. Stanley TO, Grocott HP, Phillips-Bute B, Mathew JP, Landolfo KP, Newman MF, Neurological Outcome Research Group, and C.A.R.E. Investigators of the Duke Heart Center. Preliminary evaluation of the Arctic Sun™ temperature-controlling system during off-pump coronary artery bypass surgery. Ann Thorac Surg. 2003; 75(4):1140–44.

98. Djaiani GN, Phillips-Bute B, Blumenthal JA, Newman MF, the Neurologic Outcome Research Group, and the CARE Investigators of the Duke Heart Center. Chronic exposure to nicotine does not prevent neurocognitive decline after cardiac surgery. J Cardiothorac Vasc Anesth. 2003; 17(3):341–45.

99. Swaminathan M, Phillips-Bute BG, Conlon PJ, Smith PK, Newman MF, Stafford-Smith M. The association of lowest hematocrit during cardiopulmonary bypass with acute renal injury after coronary bypass surgery. Ann Thorac Surg. 2003; 76(3):784–92.

100. Booth JV, Phillips-Bute B, McCants CB, Podgoreanu MV, Smith PK, Mathew JP, Newman MF. Low serum magnesium level predicts major adverse cardiac events after coronary artery bypass graft surgery. Am Heart J. 2003; 145:1108–13.

101. Blumenthal JA, Lett HS, Babyak MA, White W, Smith PK, Mark DB, Jones R, Mathew JP, Newman MF for the NORG Investigators. Depression as a risk factor for mortality after coronary artery bypass surgery. Lancet. 2003; 362:604–9.

102. Mackensen GB, Ti LK, Philips-Bute BG, Mathew JP, Newman MF, Grocott HP and the Neurologic Outcome Research Group (NORG). Cerebral embolization during cardiac surgery: Impact of aortic atheroma burden. Br J Anaesth. 2003; 91(5):656–61.

103. Kilts JD, Akazawa T, El-Moalem HE, Mathew JP, Newman MF, Kwatra MM. Age increases expression and receptor-mediated activation of Gαi in human atria. J Cardiovasc Pharmacol. 2003; 42(5):662–70.

104. Scarborough JE, White W, Derilus FE, Mathew JP, Newman MF, Landolfo KP, the Neurologic Outcome Research Group (NORG). Combined use of off-pump techniques and a sutureless proximal aortic anastomotic device reduces cerebral microemboli generation during coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2003; 126(5):1561–67.

105. Gaynor JW, Gerdes M, Zackai EH, Bernbaum J, Wernovsky G, Clancy RR, Newman MF, Saunders AM, Heagerty PJ, D’Agostino JA, McDonald-McGinn D, Nicolson SC, Spray TL, Jarvik GP. Apolipoprotein E genotype and neurodevelopmental sequelae of infant cardiac surgery. J Thorac Cardiovasc Surg. 2003; 126(6):1736–45.

106. Phillips-Bute B, Mathew J, Blumenthal JA, Welsh-Bohmer K, White WD, Mark D, Landolfo K, Newman MF, Neurological Outcome Research Group and C.A.R.E. Investigators of the Duke Heart Center. Female gender is associated with impaired quality of life 1 year following coronary artery bypass surgery. Psychosom Med. 2003; 65(6):944–51.

107. Lynch JR, Blessing R, White WD, Grocott HP, Newman MF, Laskowitz, DT. Novel diagnostic test for acute stroke. Stroke. 2004; 35(1):57–63.


108. Grocott HP, Mathew JP, Carver EH, Phillips-Bute B, Landolfo KP, Newman MF, and the Neurologic Outcome Research Group (NORG) of the Duke Heart Center. A randomized controlled trial of the arctic sun temperature management system versus conventional methods for preventing hypothermia during off-pump cardiac surgery. Anesth Analg. 2004; 98(2):298–302.

109. Djaiani G, Phillips-Bute B, Podgoreanu M, Messier RH, Mathew JP, Clements F, Newman MF. The association of patent foramen ovale and atrial fibrillation after coronary artery bypass graft surgery. Anesth Analg. 2004; 98(3):585–89.

110. Kong DF, Eisenstein EL, Sketch MH, Zidar JP, Ryan TJ, Harrington RA, Newman MF, Smith PK, Mark DB, Califf RM. Economic impact of drug-eluting stents on hospital systems: a disease-state model. Am Heart J. 2004; 147(3):449–56.

111. Galli KK, Zimmerman RA, Jarvik GP, Wernovsky G, Kuypers MK, Clancy RR, Montenegro LM, Mahle WT, Newman MF, Saunders AM, Nicolson SC, Spray TL, Gaynor JW. Periventricular leukomalacia is common after neonatal cardiac surgery. J Thorac Cardiovasc Surg. 2004; 127(3):692–704.

112. Verrier ED, Shernan SK, Taylor KM, Van de Werf F, Newman MF, Chen JC, Carrier M, Haverich A, Malloy KJ, Adams PX, Todaro TG, Mojcik CF, Rollins SA, Levy JH for the PRIMO-CABG Investigators. Terminal complement blockade with pexelizumab during coronary artery bypass graft surgery requiring cardiopulmonary bypass. JAMA. 2004; 291:2319–27.

113. Booth JV, Ward EE, Colgan KC, Funk BL, El-Moalem H, Smith MP, Milano C, Smith PK, Newman MF, Schwinn DA. Metoprolol and coronary artery bypass grafting surgery: does intraoperative metoprolol attenuate acute beta-adrenergic receptor desensitization during cardiac surgery? Anesth Analg. 2004; 98:1224–31.

114. Lett HS, Blumenthal JA, Babyak MA, Sherwood A, Strauman T, Robins C, Newman MF. Depression as a risk factor for coronary artery disease: evidence, mechanisms, and treatment. Psychosom Med. 2004; 66(3):305–15.

115. Taekman JM, Hobbs G, Barber L, Phillips-Bute BG, Wright MC, Newman MF, Stafford-Smith M. Preliminary report on the use of high-fidelity simulation training of study coordinator conducting a clinical research protocol. Anesth Analg. 2004; 99:521–27.

116. Mackensen GB, Swaminathan M, Ti LK, Grocott HP, Phillips-Bute BG, Mathew JP, Newman MF, Milano CA, Stafford-Smith M and the Perioperative Outcomes Research Group and Cardiothoracic Anesthesiology Research Endeavor (C.A.R.E.) Investigators of the Duke Heart Center. Preliminary report on the interaction of apolipoprotein E polymorphism with aortic atherosclerosis and acute nephropathy after CABG. Ann of Thorac Surg. 2004; 78(2):520–26.

117. Sreeram GM, Grocott HP, White WD, Newman MF, Stafford-Smith M. Transcranial doppler emboli count predicts rise in creatinine following coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth. 2004; 18(5):548–51.

118. McKinlay KH, Schinderle DB, Swaminathan M, Podgoreanu MV, Milano CA, Messier RH, El-Moalem H, Newman MF, Clements FM, Mathew JP, and the Cardiothoracic Anesthesiology Research Endeavors (CARE) Investigators of the Duke Heart Center. Predictors of Inotrope use during separation from cardiopulmonary bypass. J Cardiothor Vasc Anesth. 2004; 18(4):404–8.


119. Bar-Yosef S, Mathew JP, Newman MF, Landolfo KP, Grocott HP, and The Neurological Outcome Research Group and C.A.R.E. Investigators of the Duke Heart Center. Prevention of cerebral hyperthermia during cardiac surgery by limiting on-bypass rewarming in combination with post-bypass body surface warming: A feasibility study. Anesth Analg. 2004; 99(3):641–46.

120. Mathew JP, Shernan SK, White WD, Fitch JCK, Chen JC, Bell L, Newman MF. Preliminary report of the effects of complement suppression with pexelizumab on neurocognitive decline after coronary artery bypass graft surgery. Stroke. 2004; 35(10):2335–39.

121. Bar-Yosef S, Anders M, Mackensen GB, Ti LK, Mathew JP, Phillips-Bute B, Messier RH, Grocott HP, and the Neurological Outcome Research Group and CARE Investigators of the Duke Heart Clinic. Aortic atheroma burden and cognitive dysfunction after coronary artery bypass graft surgery. Ann Thorac Surg. 2004; 78:1556–62.

122. Welsby IJ, Newman MF, Phillips-Bute B, Messier RH, Kakkis ED, Stafford-Smith M. Hemodynamic changes after protamine administration: Association with mortality after coronary artery bypass surgery. Anesthesiology. 2004; 102(2):308–14.

123. Stafford-Smith M, Podgoreanu M, Swaminathan M, Phillips-Bute B, Mathew JP, Hauser EH, Winn MP, Milano C, Nielsen DM, Smith M, Morris R, Newman MF, Schwinn DA for the Periperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. Association of genetic polymorphisms with risk of renal injury after coronary artery bypass graft surgery. Am J Kidney Dis. 2005; 45(3):519–30.

124. Conlon PJ, Crowley J, Stack R, Neary J, Stafford-Smith M, White WD, Newman MF, Landolfo K. Renal artery stenosis is not associated with the development of acute renal failure following coronary artery bypass grafting. Ren Fail. 2005; 27(1):81–86.

125. Mathew JP, Grocott HP, McCurdy II JR, Ti LK, Davis RD, Laskowitz DT, Podgoreanu MV, Swaminathan M, Lynch J, Stafford-Smith M, White WD, Newman MF, and the Neurological Outcome Research Group (NORG) of the Duke Heart Center. Preoperative statin therapy does not reduce cognitive dysfunction after cardiopulmonary bypass. J Cardiothor Vasc Anesth. 2005; 19(3):294–99.

126. Welsby IJ, Podgoreanu MV, Phillips-Bute B, Mathew JP, Smith PK, Newman MF, Schwinn DA, Stafford-Smith M for the Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. Genetic factors contribute to bleeding after cardiac surgery. J Thrombosis & Haemostasis. 2005; 3(6):1206–12.

127. Corkey WB, Phillips-Bute P, Baudet B, Mathew JP, Newman MF, Grocott HP. The declining incidence of cerebral hyperthermia during cardiac surgery: A seven-year experience in 6,334 patients. Can J Anaesth. 2005; 52(6):626–29.

128. Lei B, Morris DP, Smith MP, Svetkey LP, Newman MF, Rotter JI, Buchanan TA, Beckstrom-Sternberg SM, Green ED, Schwinn, DA. Novel Human 1a – adrenoceptor single nucleotide polymorphisms alter receptor pharmacology and biological function. Naunyn Schmiedebergs Arch Pharmacol. 2005; 371(3):229–39.

129. Stafford-Smith M, Lefrak EA, Qazi AG, Welsby IJ, Barber L, Hoeft A, Dorenbaum A, Mathias J, Rochon JJ, Newman MF, and Members of the Global Perioperative Research Organization. Efficacy and safety of heparinase I versus protamine in patients undergoing coronary artery bypass grafting with and without cardiopulmonary bypass. Anesthesiology. 2005; 103(2):229–40.

130. Clark JA, Bar-Yosef S, Mathew J, Anderson A, Newman MF, Landolfo K, Grocott HP. Postoperative hyperthermia following off-pump versus on-pump coronary artery bypass surgery. J Cardiothorac Vasc Anesth. 2005; 19(4):426–29.


131. Grocott HP, White WD, Morris RW, Podgoreanu MV, Mathew JP, Nielsen DM, Schwinn DA, Newman MF, for the Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. Genetic polymorphisms and the risk of stroke after cardiac surgery. Stroke. 2005; 36:1854–58.

132. Hill SE, Grocott HP, Leone BJ, White WD, Newman MF, and the Neurologic Outcome Research Group of the Duke Heart Center. Cerebral physiology of cardiac surgical patients treated with the perfluorocarbon emulsion, AF0144. Ann of Thorac Surg. 2005; 80(4):1401–7.

133. Moretti EW, Morris RW, Podgoreanu M, Schwinn DA, Newman MF, Bennett E, Moulin VG, Mba UU, Laskowitz DT for the Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. APOE polymorphism is associated with risk of severe sepsis in surgical patients. Crit Care Med. 2005; 33(11):2521–26.

134. Wright MC, Taekman JM, Barber L, Hobbs G, Newman MF, Stafford-Smith M. The use of high-fidelity human patient simulation as an evaluative tool in the development of clinical research protocols and procedures. Contemp Clin Trials. 2005; 26(6):646–59.

135. Fleisher LA, Newman MF, St. Aubin LB, Cropp AB, Billing CB, Bonney S, Mackey WC, Poldermans D, Corbalan R, Pereira AH, Coriat P for the Perioperative Myocardial Ischemic Injury Investigators. Efficacy of zoniporide and Na/H exchange ion inhibitor, for reducing perioperative cardiovascular events in vascular surgery patients. J Cardiothorac Vasc Anesth. 2005; 19(5):570–76.

136. Carrier M, Ménasché P, Levy JH, Newman MF, Taylor KM, Haverich A, Chen JC, Shernan SK, Van de Werf F, van der Laan M, Todaro TG, Adams PX, Verrier ED. Inhibition of complement activation by pexelizumab reduces death in patients undergoing combined aortic valve replacement and coronary artery bypass surgery. J Thorac Cardiovasc Surg. 2006; 131(2):352–56.

137. Phillips-Bute B, Mathew JP, Blumenthal JA, Grocott HP, Laskowitz DT, Jones RH, Mark DB, Newman MF. Association of neurocognitive function and quality of life 1 year after coronary artery bypass graft (CABG) surgery. Psychosom Med. 2006; 68(3):369–75.

138. Hill SE, Keller RA, Stafford-Smith M, Grichnik K, White WD, D’Amico TA, Newman MF. Efficacy of single-dose, multilevel paravertebral nerve blockade for analgesia after thoracoscopic procedures. Anesthesiology. 2006; 104(5):1047–53.

139. Mathew JP, Rinder HM, Smith BR, Newman MF, Rinder CS. Transcerebral platelet activation after aortic cross-clamp release is linked to neurocognitive decline. Ann Thorac Surg. 2006; 81(5):1644–49.

140. Podgoreanu MV, White WD, Morris RW, Mathew JP, Stafford-Smith M, Welsby IJ, Grocott HP, Milano CA, Newman MF, Schwinn DA, Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery. Circulation. 2006; 114(1 Suppl):I-275–81.

141. Moretti EW, Newman MF, Muhlbaier LH, Whellan D, Petersen RP, Rossignol D, McCants CB Jr, Phillips-Bute B, Bennett-Guerrero E. Effects of decreased preoperative endotoxin core antibody levels on long-term mortality after coronary artery bypass graft surgery. Arch Surg. 2006; 141(7):637–41.

142. Haverich A, Shernan SK, Levy JH, Chen JC, Carrier M, Taylor KM, Van de Werf F, Newman MF, Adams PX, Todaro TG, van der Laan M, Verrier ED. Pexelizumab reduces death and myocardial infarction in higher risk cardiac surgical patients. Ann Thorac Surg. 2006; 82(2):486–93.

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WMF-4J3CNBW-J&_coverDate=02%2F28%2F2006&_alid=366444006&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=6933&_sort=d&view=c&_acct=C000004358&_version=1&_urlVersion=0&_userid=38557&md5=b8f464b34f6a40ee399b344582159cdc#vt1#vt1http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WMF-4J3CNBW-J&_coverDate=02%2F28%2F2006&_alid=366444006&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=6933&_sort=d&view=c&_acct=C000004358&_version=1&_urlVersion=0&_userid=38557&md5=b8f464b34f6a40ee399b344582159cdc#aff12#aff12http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Mathew+JP%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Blumenthal+JA%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Grocott+HP%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Laskowitz+DT%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Jones+RH%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Mark+DB%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Newman+MF%22%5BAuthor%5Djavascript:AL_get(this,%20'jour',%20'Psychosom%20Med.');


143. Newman MF, Mathew JP, Grocott HP, Mackensen GB, Monk T, Welsh-Bohmer KA, Blumenthal JA, Laskowitz DT, Mark DB. Central nervous system injury associated with cardiac surgery. Lancet. 2006; 368(9536):694–703.

144. Stafford-Smith M, Newman MF. What effects do hemodilution and blood transfusion during cardiopulmonary bypass have on renal outcomes? Nat Clin Pract Nephrol. 2006; 2(4):188–89.

145. Bennett-Guerrero E, Grocott HP, Levy JH, Stierer KA, Hogue CW, Cheung AT, Newman MF, Carter AA, Rossignol DP, Collard CD. A phase II, double-blind, placebo-controlled, ascending-dose study of eritoran (E5564), a Lipid A antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass. Anesth Analg. 2007; 104 (2):378–83.

146. Newman MF. Open heart surgery and cognitive decline. Cleve Clin J Med. 2007; 74(Suppl 1):S52–55.

147. Mathew JP, Podgoreanu MV, Grocott HP, White WD, Morris RW, Stafford-Smith M, Mackensen GB, Rinder CS, Blumenthal JA, Schwinn DA, Newman MF for the PEGASUS Investigative Team. Genetic variants in p-selectin and c-reactive protein influence susceptibility to cognitive decline after cardiac surgery. J Am Coll Cardiol. 2007; 49(19):1934–42.

148. Doraiswamy PM, Babyak MA, Hennig T, Trivedi R, White WD, Mathew JP, Newman MF, Blumenthal JA. Donepezil for cognitive decline following coronary artery bypass surgery: A pilot randomized controlled trial. Psychopharmacol Bull. 2007; 40(2):54–62.

149. Mitchell JD, Grocott HP, Phillips-Bute B, Mathew JP, Newman MF, Bar-Yosef S. Cytokine secretion after cardiac surgery and its relationship to postoperative fever. Cytokine. 2007; 38(1):37–42.

150. Levy JH, Mancao MY, Gitter R, Kereiakes DJ, Grigore AM, Aronson S, Newman MF. Clevidipine effectively and rapidly controls blood pressure preoperatively in cardiac surgery patients: The results of the randomized, placebo-controlled efficacy study of clevidipine assessing its preoperative antihypertensive effect in cardiac surgery-1. Anesth Analg. 2007; 105(4):918–25.

151. Mathew JP, Mackensen GB, Phillips-Bute B, Stafford-Smith M, Podgoreanu MV, Grocott HP, Hill SE, Smith PK, Blumenthal JA, Reves JG, Newman MF for the Neurologic Outcome Research Group (NORG) of the Duke Heart Center. Effects of extreme hemodilution during cardiac surgery on cognitive function in the elderly. Anesthesiology. 2007; 107(4):577–84.

152. Puskas F, Grocott HP, White WD, Mathew JP, Newman MF, Bar-Yosef S. Intraoperative hyperglycemia and cognitive decline after CABG. Ann Thorac Surg. 2007; 84(5):1467–73.

153. Swaminathan M, Morris RW, De Meyts DD, Podgoreanu MV, Jollis JG, Grocott HP, Milano CA, Newman MF, Mathew JP. Deterioration of regional wall motion immediately after coronary artery bypass graft surgery is associated with long-term major adverse cardiac events. Anesthesiology. 2007; 107(5):739–45.

154. Welsby IJ, Jones R, Pylman J, Mark JB, Brudney CS, Phillips-Bute B, Mathew JP, Campbell ML, Stafford-Smith M; for members of Cardiothoracic Anesthesiology Research Endeavours (C.A.R.E.), Department of Anesthesiology, Duke University Medical Center. ABO blood group and bleeding after coronary artery bypass graft surgery. Blood Coagul Fibrinolysis. 2007; 18(8):781–85.

155. Shaw AD, Stafford-Smith M, White WD, Phillips-Bute B, Swaminathan M, Milano C, Welsby IJ, Aronson S, Mathew JP, Peterson ED, Newman MF. The effect of aprotinin on outcome after coronary-artery bypass grafting. New Engl J Med. 2008; 358(8):784–93.


156. Singla N, Warltier DC, Gandhi SD, Lumb PD, Sladen RN, Aronson S, Newman MF, Corwin HL for the ESCAPE-2 Study Group. Treatment of acute postoperative hypertension in cardiac surgery patients: An efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2), a randomized, double-blind, placebo-controlled trial. Anesth Analg. 2008; 107(1):59–67.

157. Aronson S, Dyke CM, Stierer KA, Levy JH, Cheung AT, Lumb PD, Kereiakes DJ, Newman MF. The ECLIPSE trials: Comparative studies of clevidipine to nitroglycerin, sodium nitroprusside, and nicardipine for acute hypertension treatment in cardiac surgery patients. Anesth Analg. 2008; 107(4):1110–21.

158. Phillips-Bute B. Mathew JP, Blumenthal JA, Morris RW, Podgoreanu MV, Smith M, Stafford-Smith M, Grocott HP, Schwinn DA, Newman MF for the Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team. Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgery. Psychosom Med. 2008; 70:953–59.

159. Mathew JP, Mackensen GB, Phillips-Bute B, Grocott HP, Glower DD, Laskowitz DT, Blumenthal JA, Newman MF for the Neurologic Outcome Research Group (NORG) of the Duke Heart Center. Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery. Stroke. 2009; 40:880–87.

160. Bennett-Guerrero E, Stafford-Smith M, Waweru PM, Bredehoeft SJ, Campbell ML, Haley NR, Phillips-Bute B, Newman MF, Bandarenko N. A prospective, double-blind, randomized clinical feasibility trial of controlling the storage age of red blood cells for transfusion in cardiac surgical patients. Transfusion. 2009; 49(7):1375–83.

161. Nikolov NM, Fontes ML, White WD, Aronson S, Bar-Yosef S, Gaca JG, Podgoreanu MV, Stafford-Smith M, Newman MF, Mathew JP. Pulse pressure and long-term survival after coronary artery bypass surgery. Anesth Analg. 2010; 110(2): 335–40.

162. McDonagh DL, Mathew JP, White WD, Phillips-Bute B, Laskowitz DT, Podgoreanu MV, Newman MF for the Neurologic Outcome Research Group. Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injury. Anesthesiology. 2010; 112(4):852–59.

163. Swaminathan M, Hudson CCC, Phillips-Bute BG, Patel UD, Mathew JP, Newman MF, Milano CA, Shaw AD, Stafford-Smith M. Impact of early renal recovery on survival after cardiac surgery–associated acute kidney inury. Ann Thorac Surg. 2010; 89(4):1098–105.

164. Hudson CCC, Welsby IJ, Phillips-Bute B, Mathew JP, Lutz A, Hughes GC, Stafford-Smith M for members of the Cardiothoracic Anesthesiology Research Endeavors (C.A.R.E.) Group. Glycosylated hemoglobin levels and outcome in non-diabetic cardiac surgery patients. Can J Anaesth. 2010; 57(6):565–72.

165. Aronson S, Stafford-Smith M, Phillips-Bute B, Shaw A, Gaca J, Newman M for the Cardiothoracic Anesthesiology Research Endeavors. Intraoperative systolic blood pressure variability predicts 30-day mortality in patients having aortocoronary bypass surgery. Anesthesiology. 2010; 113(2):305–12.

166. Welsby IJ, Lockhart E, Phillips-Bute B, Campbell ML, Mathew JP, Newman MF, Peterson E, Milano CA, Stafford-Smith M for the members of the Cardiothoracic Anesthesiology Research Endeavors (C.A.R.E.). Storage age of transfused platelets and outcomes after cardiac surgery. Transfusion. 2010; 50(11):2311–17.

167. Welsby IJ, Podgoreanu MV, Phillips-Bute B, Morris R, Mathew JP, Smith PK, Newman MF, Schwinn DA, Stafford-Smith M for the Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. Association of the 98T ELAM-1 polymorphism with increased bleeding after cardiac surgery. J Cardiothoracic Vasc Anesth. 2010; 24(3):427–33.


168. Welsby IJ, Troughton M, Phillips-Bute B, Ramsey R, Campbell ML, Bandarenko N, Mathew JP, Stafford-Smith M for members of the Cardiothoracic Anesthesiology Research Endeavors (C.A.R.E.). The relationship of plasma transfusion from female and male donors with outcome after cardiac surgery. J Thorac Cardiovasc Sur. 2010; 140:1353–60.

169. Taekman JM, Stafford-Smith M (co-first authors), Velazquez EJ, Wright MC, Phillips-Bute BG, Pfeffer MA, Sellers MA, Pieper KS, Newman MF, Van de Werf F, Diaz R, Leimberger J, Califf RM. Departures from the protocol during conduct of a clinical trial: A pattern from the data record consistent with a learning curve. Qual Saf Health Care. 2010; 19:405–10.

170. Aronson S, Dyke CM, Levy JH, Cheung AT, Lumb PD, Avery EG, Hu MY, Newman MF. Does perioperative systolic blood pressure variability predict mortality after cardiac surgery? An exploratory analysis of the ECLIPSE trials. Anesth Analg. 2011; 113(1):19–30.

171. Swaminathan M, Nicoara A, Phillips-Bute BG, Aeschlimann N, Milano CA, Mackensen GB, Podgoreanu MV, Velazquez EJ, Stafford-Smith M, Mathew JP, and the Cardiothoracic Anesthesia Research Endeavors (CARE) Group. Utility of a simple algorithm to grade diastolic dysfunction and predict outcome after coronary artery bypass graft surgery. Ann Thorac Surg. 2011; 91:1844–51.

172. Smith PK, Shernan SK, Chen JC, Carrier M, Verrier ED, Adams PX, Todaro TG, Muhlbaier LH, Levy JH, for the PRIMO-CABG II Investigators. Effects of C5 complement inhibitor pexelizumab on outcome in high-risk coronary artery bypass grafting: Combined results from the PRIMO-CABG I and II trials. J Thorac Cardiovasc Surg. 2011; 142(1):89–98.

173. Hsu YW, Somma J, Newman MF, Mathew JP. Population pharmacokinetics of lidocaine administered during and after cardiac surgery. J Cardiothorac Vasc Anesth. 2011; 25(6):931–36.

174. Lobato RL, White WD, Mathew JP, Newman MF, Smith PK, McCants CB, Alexander JH, Podgoreanu MV for the Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team. Thrombomodulin gene variants are associated with increased mortality after coronary artery bypass surgery in replicated analyses. Circulation. 2011; 124(suppl 1):S143–48.

175. Newman MF, Ferguson TB, White JA, Ambrosio G, Koglin J, Nussmeier NA, Pearl RG, Pitt B, Wechsler AS, Weisel RD, Reece TL, Lira A, Harrington RA for the RED-CABG Steering Committee and Investigators. Effect of adenosine-regulating agent acadesine on morbidity and mortality associated with coronary artery bypass grafting: The RED-CABG randomized controlled trial. JAMA. 2012; 308(2):157–64.

176. Bartels K, McDonagh DL, Newman MF, Mathew JP. Neurocognitive outcomes after cardiac surgery. Curr Opin Anaesthesiol. 2013; 26(1):91–97.

177. Fontes MT, Swift RC, Phillips-Bute B, Podgoreanu MV, Stafford-Smith M, Newman MF, Mathew JP, and the Neurologic Outcome Research Group of the Duke Heart Center. Predictors of cognitive recovery after cardiac surgery. Anesth Analg. 2013; 116(2):435–42.

178. Klinger RY, James OG, Wong TZ, Newman MF, Doraiswamy PM, Mathew JP. Cortical β-amyloid levels and neurocognitive performance after cardiac surgery. BMJ Open. 2013; 3(9):3:e003669.

179. Mathew JP, White WD, Schinderle DB, Podgoreanu MV, Berger M, Milano CA, Laskowitz DT, Stafford-Smith M, Blumenthal JA, Newman MF for the Neurologic Outcome Research Group (NORG) of the Duke Heart Center. Intraoperative magnesium administration does not improve neurocognitive function following cardiac surgery. Stroke. 2013; 44:3407–13.


180. Aronson S, Phillips-Bute B, Stafford-Smith M, Fontes M, Gaca J, Mathew JP, Newman MF. The association of post-cardiac surgery acute kidney injury with intraoperative systolic blood pressure hypertension. Anesthesiol Res Pract. 2013; 174091.

181. Fontes MT, McDonagh DL, Phillips-Bute B, Welsby IJ, Podgoreanu MV, Fontes ML, Stafford-Smith M, Newman MF, Mathew JP, the Neurologic Outcome Research Group of the Duke Heart Center. Arterial hyperoxia during cardiopulmonary bypass and postoperative cognitive dysfunction. J Cardiothoracic Vasc Anesth. 2014; 28(3):462-6.

182. Kertai MD, Esper SA, Akushevich I, Voora D, Ginsburg GS, Stafford-Smith M, Grichnik K, Newman MF, Fontes M, Smith P, Podgoreanu MV, Mathew JP, Cardiothoracic Anesthesia Research Endeavors (CARE) Group. Preoperative CYP2D6 metabolism-dependent β-blocker use and mortality after coronary artery bypass grafting surgery. J Thorac Cardiovasc Surg. 2014; 147(4):1368–75.

183. McDonagh DL, Mathew JP, Graffagnino C, Newman MF. Neurologic complications of cardiovascular surgery: A clinically focused review. Lancet Neurol. 2014; 13 (5):490-502.

184. Welsby IJ, Phillips-Bute B, Mathew JP, Newman MF, Becker R, Rao S, Milano CA, Stafford-Smith M, the Cardiothoracic Anesthesiology Research Endeavors (C.A.R.E.). ABO blood group influences survival after cardiac surgery. Thrombosis and Thrombolyis. 2014; 38(3):402-408.

185. Kertai MD, Li Y-W, Li Y-J, Shah SH, Kraus WE, Fontes ML, Stafford-Smith M, Newman MF, Podgoreanu MV, Mathew JP. G Protein-Coupled Receptor Kinase 5 Gene Polymorphisms Are Associated with Postoperative Atrial Fibrillation Following Coronary Artery Bypass Graft Surgery in Patients Receiving Beta-Blockers. Circ Cardiovasc Genet. 2014 Oct; 7(5):625-33.

186. Weisel RD, Nussmeier N, Newman MF, Pearl RG, Wechsler AS, Ambrosio G, Pitt B, Clare RM, Pieper KS, Mongero L, Reece TL, Yau TM, Fremes S, Menasch P, Lira A, Harrington RA, Ferguson B, RED-CABG Executive and Steering Committees. Predictors of Contemporary CABG Outcomes. J Thorac Cardiovasc Surg. 2014; 148(6):2720-2726.e2.

187. Bartels K, Li Y, Li Y, White WD, Laskowitz DT, Kertai M, Stafford-Smith M, Podgoreanu MV, Newman MF, Mathew JP, NORG. Apolipoprotein E4 genotype is associated with less improvement in cognitive function five years after cardiac surgery: a retrospective cohort study. Can J Anesth. 2015; 62:618-626.

188. Kertai M, Li Y, Li Y, Ji Y, Alexander J, Newman MF, Smith P, Joseph D, Mathew J, Podgoreanu M. Genome-wide Association Study of Perioperative Myocardial Infarction After Coronary Artery Bypass Surgery. BMJ Open. 2015 May 6;5(5):e006920.

189. Stafford-Smith M, Li Y, Mathew JP, Li Y, Ji Y, Phillips-Bute B, Milano C, Goldstein D, Newman MF, Krauss WE, Kertai MD, Shah SH, Podgoreanu MV for the Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. Genome-Wide Association Study of Acute Kidney Injury after Coronary Bypass Graft Surgery Identifies Susceptibility Loci at 3p21.6 and in the BBS9 Gene. Kidney Int. 2015 Oct;88(4):823-32.

190. Klinger R, Thunberg CA, White WA, Podgoreanu MV, Stafford-Smith M, Newman MF, Mathew JP. Intraoperative Magnesium Administration Does Not Reduce Postoperative Atrial Fibrillation after Cardiac Surgery. Anesth Analg 2015 2015 Oct 121(4):861-867.

191. Kertai M, Li Y, Qu W, Ji Y, Qi W, Lombard F, Shah S, Kraus W, Stafford-Smith M, Newman MF, Milano C, Waldron N, Podgoreanu M, Mathew M for the Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. Genome-Wide Association Study of New-Onset Atrial Fibrillation after Coronary Artery Bypass Grafting Surgery. Am Heart J. 2015 Sep 170:580-590.e28.


192. Reves J, Newman MF. Merel Harmel - Portrait of an Anesthesiology Pioneer. Anesth Analg. 2016 Feb:22(2):539-541.

193. Kertai M, Qi W, Li YJ, Lombard FW, Liu Y, Smith MP, Stafford-Smith M, Newman MF, Milano CA, Mathew JP, Podgoreanu M, Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team. Gene signatures of postoperative atrial fibrillation in atrial tissue after coronary artery bypass grafting surgery in patients receiving β-blockers. J Mol Cell Cardiol. J Mol Cell Cardiol. 2016 Mar 92:109-115.

194. Berger M, Nadler JW, Friedman A, McDonagh DL, Bennett ER, Cooter M, Qi W, Laskowitz DT, Ponnusamy V, Newman MF, Shaw LM, Warner DS, Mathew JP, James ML. The effect of Propofol versus Isoflurane Anesthesia on Human CSF Markers of Alzheimer’s Disease: Results of a Randomized Controlled Trial. J Alzheimers Dis. 2016 Apr 15;52(4):1299-1310.

195. Kertai M, Ji Y, Li YJ, Mathew JP, Daubert J, Podgoreanu MV, for the PEGASUS investigative team. Interleukin-1b gene variants are associated with QTc interval prolongation following cardiac surgery. Can J Anaesth. 2016 Apr;63(4):397-410.

196. Klinger RY, Cooter M, Beger M, Podgoreanu MV, Stafford-Smith M, Ortel TL, Welsby IJ, Levy JH, Rinder HM, Newman MF, Mathew JP. Neurologic Outcomes Research Group (NORG). Effect of Intravenous Lidocaine on the Transcerebral Inflammatory Response During Cardiac Surgery: a randomized controlled trial. Can J Anaesth. 2016 Nov;63(11):1223-32.

197. Browndyke J, Berger M, Harshbarger T, Smith P, White W, Bisanar T, Alexander J, Gaca J, Welsh-Bohmer K, Newman MF, Mathew J for the Neurologic Outcome Research Group of the Duke Heart Center. Associated postoperative changes in resting-state functional connectivity and cognition following major cardiac surgery in older adults. J Am Geriatr Soc. 2017 Jan;65(1):e6 – e12.

Submitted

1. Klinger RY, Low Y, Cooter M, Terrando N, Berger M, Podgoreanu MV, Stafford-Smith M, Newman MF, Levy JH, Mathew JP. Tranexamic Acid is Associated with Decreased Odds of Early Postoperative Cognitive Dysfunction after Cardiac Surgery Compared with Aminocaproic Acid. BJA. Submitted 2017.

2. Browndyke, JN, Berger M, Smith PJ, Harshbarger TB, Monge Z, Panchal V, Bisanar TL, Glower DD, Alexander JH, Cabeza R, Welsh-Bohmer K, Bohmer K, Newman MF, Mathew JP. Working Memory Load-related Brain Functional Connectivity Changes After Cardiac Surgery in Older Adults. Hum Brain Mapp. Submitted 2017.

3. Waldron NH, Cooter M, Piccini JP, Anstrom KJ, Klinger RY, Kertai MD, Podgoreanu MV, Stafford-Smith M, Newman MF, Mathew JP. Predictive Ability of Perioperative Atrial Fibrillation Risk Indices. Am Heart J. Submitted 2017.

4. Giattino CM, Gardner JE, Sbahi FM, Roberts KC, Cooter M, Moretti E, Browndyke J, Mathew JP, Woldorff MG, Berger M, MADCO-PC Investigators. Intraoperative Frontal Alpha-Band Power Correlates with Preoperative Neurocognitive Function in Older Adults. Front Neurosci. Submitted 2017.

Non-refereed Publications

1. Croughwell ND, Newman MF. A venous application: Continuous jugular bulb blood gas monitoring. Biosentry Horizons. 1993; 2(2):1–2.

2. Based on interview with Newman MF. Risk factors for cognitive dysfunction after cardiopulmonary bypass. Adv in Cardiovas Surg and Anesth. 1995; 2:1–8.


3. Newman MF, Croughwell ND, Blumenthal JA, Lowry E, White WD, Kirchner J, Landolfo K, Shearer I, Smith PK, Reves JG. Pharmacologic interventions to minimize cerebral damage during open-heart surgery. Proceedings of the American Academy of Cardiovascular Perfusion. 1996; 17:29–36.

4. Kurusz M (Moderator), Hill AG, Newman MF, Newman SP, Raskin SA, Stump DA, Taylor KM. Panel discussion. The brain and cardiopulmonary bypass. Proceedings of the American Academy of Cardiovascular Perfusion. 1996; 17:50–60.

Chapters in Books

1. Newman MF, Reves JG, McKay RD. Cardiovascular therapy. In: Newfield P, Cottrell JE, eds. Neuroanesthesia: Handbook of Clinical and Physiologic Essentials, 2nd ed. Boston, MA: Little, Brown and Co.; 1991:129–160.

2. Newman MF, McKenzie EB, Stanley TE, Reves JG. Vasoactive drugs. In: Fragen RJ, ed. Drug Infusions in Anesthesiology, 2nd ed. New York, NY: Raven Press Ltd; 1991:225–67.

3. Newman MF, Croughwell N, Greeley W, Kern F, Aladj J, Brusino G, Lyth M, Smith LR, Reves JG. Cerebral blood flow regulation during cardiopulmonary bypass: correlation with postoperative neurologic and neuropsychologic deficits. In: Willner AE, Rodewald G, eds. The Impact of Cardiac Surgery on the Quality of Life: Neurological and Psychological Aspects. New York, NY: Plenum Publishing; 1990:137–43.

4. Newman M, Frasco P, Kern F, Greeley WJ, Blumenthal JA, Reves JG. Central nervous system dysfunction after cardiac surgery. In: Karp RB, Laks H, Wechsler AS, eds. Advances in Cardiac Surgery. Vol. 3. St. Louis, MO: Mosby; 1992:243–84.

5. Newman MF, Martin TJ. Anesthesia for interventional cardiac catheterization. In: Romanoff ME, Mirenda JV, eds. Anesthesia for Remote Locations. Part 2. Philadelphia, PA: J. B. Lippincott; 1992:443–74. Kirby RR, Brown DL, eds. Problems in Anesthesia. Vol 6(4).

6. Stanley TE, Newman MF. Monitoring of the cardiac surgery patient. In Estafanous FG, Barash PG, Reves JG, eds. Cardiac Anesthesia: Principles and Clinical Practice, Philadelphia, PA: J. B. Lippincott; 1994:185–220.

7. Newman MF, McKenzie EB, Stanley TE, Reves JG. Infusions of vasoactive drugs. In: Fragen RJ, ed. Drug Infusions in Anesthesiology. 2nd ed. New York, NY: Raven Press; 1995:225–67.

8. Schell RM, Newman M, Reves JG. Interventional therapy to palliate coronary artery disease in the elderly. In: McLeskey CH, ed. Geriatric Anesthesiology. Baltimore, MD: Williams & Wilkins; 1997:609–35.

9. Anstadt MP, Newman MF. Use of the intra-aortic balloon pump for post cardiotomy support. In: Maccioli GA, ed. Intra-aortic Balloon Pump Therapy. Baltimore, MD: Williams & Wilkins; 1997:107–25.

10. Newman MF. Cardiovascular management in the patient with neurologic dysfunction. In: Albin MS, ed. Textbook of Neuroanesthesia: With Neurosurgical and Neuroscience Perspectives. New York, NY: McGraw Hill; 1996:347–67.

11. Newman MF, Grocott HP, Croughwell N, Amory DW. Strategies for the reduction of neurological injury after cardiopulmonary bypass. In: Blanck TJJ, ed. Neuroprotection. Baltimore, MD: William & Wilkins; 1997:163–95.

12. Grichnik KP, Newman MF, Reves JG. Aging Central Nervous System. In Fleisher LA, Prough DS, eds. Problems in Anesthesia. Vol. 9. Philadelphia, PA: Lippincott-Raven Publishers; 1997:513–24.


13. Clements F, deBruijn N, Bennett-Guerrero E, Newman M, Reves JG. Anesthesia for cardiac surgery. In: Subspecialty Care. Miller RD, series ed. Atlas of Anesthesia, Vol. V. Philadelphia, PA: Churchill Livingstone; 1998:1.2–1.19.

14. Reves JG and Newman MF: History, practice management, and education. In: Reves JG, ed. Cardiothoracic Anesthesia. Miller RD, series ed. Atlas of Anesthesia, Vol. VIII. Philadelphia, PA: Churchill Livingstone; 1999:12.1–12.10.

15. Kramer D, Newman MF. Organ system effects of anesthetics. In: Youngberg JA, Lake CL, Roizen MF, Wilson RS, eds. Cardiac, Vascular and Thoracic Anesthesia. Philadelphia, PA: Churchill Livingstone; 2000:165–215.

16. Grocott HP, Laskowitz DT, Newman MF. Markers of cerebral injury. In: Newman SP, Harrison MJG, eds. The Brain and Cardiac Surgery: Causes of Neurological Complications and Their Prevention. Amsterdam, The Netherlands: Hardwood Academic Publishers; 2000:113–41.

17. Croughwell N, Newman MF. Jugular bulb monitoring. In: Newman SP, Harrison MMJG, eds. The Brain and Cardiac Surgery: Causes of Neurological Complications and Their Prevention. Amsterdam, The Netherlands: Hardwood Academic Publishers; 2000:165–71.

18. Stafford-Smith M, Newman MF. Perioperative organ protection. In: Thys DM, Hillel Z, Schwartz AJ, eds. Textbook of Cardiothoracic Anesthesiology. New York, NY: McGraw Hill; 2001:445–87.

19. Newman MF, Newman MF, Booth JV, Laskowitz DT, Schwinn G, Grocott HP, Mathew JP. Genetic predictors of perioperative neurological and cognitive injury and recovery. In: Body SC, Shernan SK, eds. Best Practice & Research: Clinical Anaesthesiology. London, England: Harcourt Publishers Ltd.; 2001:247–76.

20. Mathew JP, Arrowsmith JE, Newman MF. Neurological Injury Following Cardiac Surgery: Incidence, Significance and Risk Factors. In: Newman MF, eds. Perioperative Organ Protection. Baltimore, MD: Lippincott Williams & Wilkins; 2003:29–46.

21. Grocott HP, Mackensen GB, Newman MF. Perioperative Neuroprotection in Cardiac Surgery: Current Strategies and Future Directions. In: Newman MF, eds. Perioperative Organ Protection. Baltimore, MD: Lippincott Williams & Wilkins; 2003:47–74.

22. Hughes GC, Newman MF, Landolfo KP. Is OPCAB superior to CABG? In: Fleisher L, eds. Evidence-Based Practice of Anesthesia. Philadelphia, PA: WB Saunders; 2004:353–58.

23. Mackensen B, Grocott HP, Newman MF. Cardiopulmonary bypass and the brain. In: Kay PH, Munsch CM, eds. Techniques in Extracorporeal Circulation. Br Oxford, UK, Butterworth-Heinemann Publishers; 2004:148–76.

24. Fleisher LA, Newman MF. Implications of Perioperative Morbidity on Long-Term Outcomes. In: Newman MF, Fleisher LA, Fink MP, eds. Perioperative Medicine: Managing for Outcome. Philadelphia, PA: Saunders/Elsevier; 2008:3–10.

25. Newman MF. Cognitive Dysfunction after Anesthesia and Surgery. In: Longnecker DE, Newman MF, Brown D, Zapol WM, eds. Principles and Practice of Anesthesiology. New York, NY: McGraw-Hill; 2008:1912–24.

26. Hathaway J, Newman MF, Mathew J. Cognitive Dysfunction after Anesthesia and Surgery. In: Longnecker DE, Newman MF, Brown D, Zapol WM, eds. Anesthesiology, 2E. New York, NY: McGraw-Hill; 2012: 1453–62.

27. Berger M, Newman MF, Mathew JP. Cognitive Dysfunction after Anesthesia and Surgery. In: Longnecker DE, Mackey S, Newman MF, Sandberg W, Zapol WM, eds. Anesthesiology, 3E. New York, NY: McGraw-Hill; Submitted 2017.


Books

1. Newman MF, ed. Perioperative Organ Protection. Baltimore, MD: Lippincott Williams & Wilkins; 2003.

2. Longnecker DE, Brown DL, Newman MF, Zapol WM, eds. Anesthesiology, First Edition. New York, NY: McGraw-Hill; 2008.

3. Newman MF, Fleisher LA, Fink M, eds. Perioperative Medicine: Managing for Outcome. Philadelphia, PA: Saunders/Elsevier; 2008.

4. Longnecker DE, Brown DL, Newman MF, Zapol WM, eds. Anesthesiology, Second Edition. New York, NY: McGraw-Hill; 2012.

5. Fleisher LA, Davis, PJ, Hawkins, J, McGoldrick KE, Newman M, Wiener-Kronish JP, eds. Clinical Decision Support: Anesthesiology. Wilmington, DE: Decision Support in Medicine, LLC; 2013.

6. Longnecker DE, Mackey, S, Newman MF, Sandberg W, Zapol WM, eds. Anesthesiology, Third Edition. New York, NY: McGraw-Hill; In Press 2017.

7. Newman MF, Fleisher LA, Ko CY, Mythen MG, eds. Perioperative Medicine: Managing for Value, Second Edition. Philadelphia, PA: Elsevier; In Press 2018.

Non-authored Publications

1. Jauhar S. Saving the heart can sometimes mean losing the memory. The New York Times. September 19, 2000.

2. White M. Out for the count: When anaesthetists put us under, we risk not coming all the way back. New Zealand Listener. March 15, 2014; 46–47.

Selected Abstracts

1. Newman MF, Leslie JB, Maccioli GA, Reves JG. Determination of optimal bolus dose esmolol for prevention of intraoperative hypertension and tachycardia. Society of Cardiovascular Anesthesiologists (SCA), May 1989.

2. Newman MF, deBruijn NP, Sheikh K, Kisslo J. Transesophageal pulsed Doppler assessment of diastolic function: Immediate changes status post cardiopulmonary bypass. Anesthesiology. 1989; 71:A285.

3. Newman MF, Leslie JB, Maccioli GA, Reves JG. Determination of the optimal bolus dose of esmolol for prevention of hypertension and tachycardia associated with tracheal intubation. Anesthesiology. 1989; 71:A45.

4. Croughwell ND, Quill T, Newman MF, Lu J, Smith LR, Reves JG. The Q10 for cerebral oxidative metabolism during CPB in man. SCA 11th Annual Meeting. Seattle, WA, 101, 1989.

5. Croughwell ND, Newman MF, Quill T, Blumenthal J, Schniebolk S, Robinson M, White W, Lu J, Moon R, Reves JG. Warming during cardiopulmonary bypass is associated with jugular bulb desaturation. Anesth Analg. 1990; 70:S72.

6. Croughwell ND, Lyth M, Quill T, Newman MF, Lu J, White W, Reves JG. Diabetic patients lose pressure-flow cerebral autoregulation. SCA 12th Annual Meeting. Orlando, FL, 106, 1990.

7. Blumenthal JA, Burker EJ, Schneibolk S, Newman MF, Croughwell ND, Lu J, Smith LR, Reves JG. The effects of cardiac surgery of neuropsychologic functioning. SCA, 12th Annual Meeting. Orlando, FL, 217, 1990.


8. Quill TJ, Croughwell ND, Lu J, Newman MF, Greeley W, Reves JG. Comparison of curve analysis methodology for 133Xe cerebral blood flow during CPB. Anesthesiology. 1990; 73:A718.

9. Stanley TE, Smith LR, White WD, Morrison L, Blumenthal J, Burker EJ, Schniebolk S, Newman MF, Croughwell ND, Reves JG. Effect of cerebral perfusion pressure during cardiopulmonary bypass on neuropsychiatric outcome following coronary artery bypass grafting. Anesthesiology. 1990; 73:A93.

10. Frasco P, Newman MF, Croughwell N, Smith LR, Will C, Greeley WJ, Reves JG. Estimation of cerebral metabolic autoregulation during cardiopulmonary bypass. SCA 13th Annual Meeting. San Antonio, TX, 227, 1991.

11. Burker E, Feldman M, White W, Smith LR, Schell R, Croughwell ND, Lewis J, Newman MF, Reves J, Blumenthal J. The mini mental status exam as a predictor of neuropsychological functioning after cardiac surgery. Psychosom Med. 1993; 55(1):119–20.

12. Spillane WF, Newman MF, Croughwell ND, Frasco P, Hurwitz B, Reves JG. A prospective examination of neurologic dysfunction after cardiopulmonary bypass. SCA 15th Annual Meeting. San Diego, CA 302, 1993.

13. Spillane WF, Newman MF, Croughwell ND, Frasco P, Schell R, Hurwitz B, Reves JG. Failure of hypothermic bypass to protect against CNS injury after CPB. Anesthesiology. 1993; 79:A168.

14. Croughwell ND, Newman MF, White B, Schell R, Lewis J, Baldwin B, Reves JG. Correlation of pump venous and jugular venous saturation during CPB. Anesthesiology. 1993; 79:A143.

15. Reves JG, Newman MF, Blumenthal J, Croughwell ND, Towner E, Feldman M, Lewis J, White W, Smith LR, Wiener D. Age and cognition after CABG surgery: Role of blood flow autoregulation. Gerontologist. 1993; 33:230.

16. Croughwell ND, Newman MF, Blumenthal JA, Towner EA, Baldwin BI, Schell RM, Burker EJ, Frasco PE, Feldman ME, Lewis JB, White WD, Smith LR, Reves JG. Jugular venous saturation and cerebral arterial venous oxygen difference predict cognitive dysfunction after cardiac surgery. Circulation. 1993; 88:1545.

17. Wolman RL, Kanchuger MS, Newman MF, Roach GW, Nussmeier NA, for the McSPI CNS Subgroup, The McSPI Research Group, San Francisco, CA: Adverse neurologic outcome following cardiac surgery. Anesth Analg. 1994; 78:S484.

18. Burker E, Blumenthal J, White W, Lewis J, Croughwell ND, Smith L, Newman MF, Reves JG. Coping style predicts depression in patients undergoing cardiac surgery. Soc Behavioral Medicine. Boston, MA, 1994.

19. Kramer D, Stanley TE, Sanderson I, White WD, Lewis JB, Croughwell ND, Blumenthal JA, Smith LR, Townsend EA, Hutton AC, Reves JG, Newman MF. Failure to demonstrate relationship between mean arterial pressure during cardiopulmonary bypass and postoperative cognitive dysfunction. Anesthesiology. 1994; 81:A156.

20. Tardiff B, Newman MF, Saunders A, Strittmatter W, White W, Smith LR, Roses A, Reves JG, The Neurologic Outcome Research Group of Duke Heart Center. Apolipoprotein E allele frequency in patients with cognitive deficits following cardiopulmonary bypass. Circulation. 1994; 90:(IV):1078.

21. Thyrum E, Mahanna E, Fraser H, White W, Smith LR, Lewis J, Croughwell ND, Newman MF, Reves JG, Blumenthal J. Post-operative depression in cardiac surgery patients. Soc Behavioral Medicine. Boston, MA, 1994.


22. Wolman RL, Aggarwal A, Mora-Mangano C, Roach G, Newman MF, Nussmeier N, McSPI Research Group. Adverse neurologic outcome following cardiac surgery: Propofol/Sufentanil versus Sufentanil/Midazolam. Anesth Analg. 1995; 80(4S):SCA88.

23. Wolman RL, Aggarwal A, Kanchuger M, Ley C, Newman MF, Roach G, Marschall K, Mora-Mangano C, Nussmeier NA, McSPI Research Group. Risk factors for adverse neurologic outcome following intracardiac surgery. Anesth Analg. 1995; 80(4S):SCA58.

24. Newman MF, Kramer D, Croughwell ND, Sanderson I, White W, Smith LR, Hurwitz B, Thyrum E, Reves JG, Blumenthal JA, Mahanna E. Mean arterial pressure and rewarming affects cognitive function after cardiac surgery in older but not younger patients. Soc Behav Med San Diego. CA, March, 1995.

25. Amory D, Chen B, Bonni P, Croughwell ND, Lowry E, Newman MF. Comparison of jugular venous oxygen saturation and cerebral oxygen saturation measured by near infrared spectroscopy. Anesthesiology. 1995; 83:A474.

26. Jones RH, Kesler K, Phillips HR, Mark DB, Smith PK, Nelson CL, Newman MF, Reves JG, Anderson RW, Califf RM. Long-term survival benefit of CABG and PTCA in patients with coronary artery disease. The American Assoc for Thorac Surg. Boston, MA, 1995.

27. Hasson AM, Grichnik KP, Sanderson I, White, WD, Newman MF, Reves JG. Age affects the response to heparin. Gulf Atlantic Resident Research Conference. May 1996.

28. Sorohan JG, Newman MF, Croughwell ND, Lowry E, Sladen RN. Blood product requirements in normothermic versus hypothermic cardiopulmonary bypass in patients. Anesth Analg. 1996; 82:SCA84.

29. Sorohan JG, Newman MF, Croughwell ND, Kirchner J, Sladen RN. Postoperative mechanical ventilation in hypothermic versus normothermic cardiopulmonary bypass patients. Anesth Analg. 1996; 82:SCA90.

30. Croughwell ND, Lowry E, Mythen MG, White WD, Kirchner J, Clements F, Grichnik K, Newman MF. Changes in serum biochemical markers of cerebral injury during cardiac surgery: S-100 levels and CABG. Anesth Analg. 1996; 82:SCA40.

31. Grocott HP, Croughwell ND, Lowry E, White W, Newman MF. Comparison between jugular venous bulb and nasopharyngeal temperatures during cardiac surgery. Anesth Analg. 1996; 82:SCA85.

32. Grocott HP, Croughwell ND, White WD, Lowry E, Newman MF. Predictors of jugular venous desaturation during rewarming from hypothermic cardiopulmonary bypass. Anesth Analg. 1996; 82:SCA35.

33. Mythen MG, Croughwell ND, Lowry E, Kirchner JL, Newman MF. The relationship between gut mucosal

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