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Y. Qiu1, R. Abila1, H.H.Win2

1. OIE SRR-SEA

2. Myanmar LBVD

SEACFMD Vaccination Campaign in Central Myanmar

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Central Myanmar- the significant role in regional FMD control

Cattle density map, FAO

Major movement pathways of large ruminants

Myanmar

Thailand

Laos

Cambodia

Vietnam

China

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Central Myanmar- the significant role in regional FMD control

• FMD outbreak hotspots (dark orange)(2011-2014: O/SEA/Myanmar-98)

• Significant socio-economic burden - USD 5-20 per drought cattle- USD 81 per infected cow

• PCP progression requirement

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FMD Vaccination Project

February and March 2015:

• 18 townships in Central Myanmar

• 1127 villages vaccinated

• Benefiting >54,000 owners

• >210,000 large ruminants vaccinated 2x

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FMD Vaccination Project

Parallel FMD education campaign:

• FMD recognition and reporting

• Biosecurity

• Outbreak responses

• Cleaning and disinfection

• Benefits of vaccination

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Post-Vaccination Monitoring

0

100

200

300

400

0 30 60 90 120 150 180 210 Days

1st 2nd Vacc

LP E

LISA

Ab

tit

er (

GEM

)

NSP negative throughout the study period Tested against a Thai reference strain O189/87

– antigenically equivalent to O/3039 Protective threshold not defined

N=53

N=50

N=37

Vaccine: O1/Manisa + O/3039>6PD50

Moderate antibody level at 5 months after the boost vaccination

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Village with type O FMD Village with type A FMDVillage with untyped FMD

Post-Vaccination Monitoring

O/Ind2001

O/Mya-98A/SEA-97

• FMD was reported in 226 villages in 2015

• 75% outbreaks occurred during Aug-Oct (after flooding)

• Outbreaks in close proximity to major rivers/roads

• (re)emergence of new strains (A/SEA-97, O/Ind2001)

0

20

40

60

80

Jan

Fe

b

Ma

r

Ap

r

Ma

y

Jun

Jul

Aug

Se

p

Oct

No

v

De

c

No. o

f o

utb

reaks

RoadRiverBoundary

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14 out of 226 outbreaks occurred in vaccinated villages (n=1127):

• waned immunity (>5 months after the last vaccination)

• serotype A virus

• antigenically variant viruses

• vaccination coverage

• vaccination failure

Post-Vaccination MonitoringVaccinated villageVillage with type O FMD Village with type A FMDVillage with untyped FMD

The majority of vaccinated villages were clinically protected against FMD

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Expanded Vaccination Campaign

• Additional 5 rounds of vaccinations implemented since 2016

• Expanded to another 6 townships

• Updated vaccine composition:+ A/Malaysia/97 and A22/Iraq in 2016 + Asia 1/Shamir in 2017/18

• Vaccination coverage

• Public awareness campaign

• Animal identification and tracing

• VAHW capacity building

• Biosecurity

• Outbreak response

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Trade opportunities stimulate FMD Control

220,000

365,000

74,000

• >1 million large ruminants from SEA enter China annually

• Significant costs associated with unofficial movements (500 USD/head in Myanmar)

• 3 pilot trade zones to be established between China-Myanmar/Laos borders

• Vaccinate-to-move: reduce risks along movement pathways

• Challenges:- steady supply of high-quality vaccines- increase buy-in from farmers & traders- infrastructure- monitoring

Proposed trade zones and estimated annual trade volumes

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Acknowledgement

Co-workers: Donors:

• Myanmar LBVD

• Corissa Miller

• Phillipe Widders

• Karan Kukreja

• Scott Zaari

• Ian Dacre

• Polly Smith

• Bolortuya Purevsuren

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Thank you for your

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