Scientific Fraud - Suan Dusit Rajabhat...
Transcript of Scientific Fraud - Suan Dusit Rajabhat...
ScientificFraudLEE CHU KEONG, NANYANG TECHNOLOGICAL UNIVERSITY
ScientificFraudinSingapore
ScientificFraudinSingapore
ScientificFraudinSingapore
ReportedintheNewspapers
DealtWithByTheHighestLevelsDavid Goodstein
California Institute of Technology’s vice provost.
Looks into all allegations of scientific fraud.
Drew up Caltech’s PolicyonResearchMisconduct.
SevereRepercussions Sacked / asked to leave the organisation
PhD revoked
Papers retracted
Why is it so serious?
At a personal level, it destroys careers.
Funds, valuable resources and time are wasted when other researchers attempt to build on or replicate erroneous research.
In 1999, a team of physicists at the Lawrence Berkeley National Laboratory in California announced element 118 (which would have been the world’s heaviest atom).
Scientists in Germany and Japan failed to replicate the results, and the Berkeley lab team re-analysed their data. They retracted their claims, and sacked physicist as Victor Ninov (the first author on the paper) for falsification of data.
It makes a mockery of the scientific enterprise.It is a violation of the scientific method.
Destroys trust
Society contributes to the advancement of knowledge through public funding. Public trust can be betrayed.
An organisation’s reputation can be severely damaged. It will be difficult to attract funding and students in the future.
The public can be put at risk.
Stephen Breuning was a psychologist at the University of Pittsburgh studying the effects of drugs such as Ritalin on patients. In 1987, it was determined that he had fabricated data. His case was particularly bad because protocols for treating patients based on his “results” were already being practised.
The scientific field will be damaged.
Scientists guilty of misconduct are found in every field, at every kind of research institution and with a variety of social and educational backgrounds.
Gross (2011)
Scientific misconduct is often difficult to detect.Gross (2011)
If someone is determined to be unethical, it is not easy to detect.
Murray & Das (2003)
The great majority of scientists are honourable people who will fiercely protect the validity of the science they do. Nevertheless, every once in a while, along comes someone who would undermine the enterprise.
Goodstein (2010)
No matter how small the percentage of scientists who might be fakers of data, it required only one case to surface every few months or so for the public credibility of science to be severely damaged.
Broad & Wade (1982)
TheModal ScientificMiscreant
A bright and ambitious young man working in an elite institution in a rapidly moving and highly competitive branch of modern biology or medicine, where results have important theoretical, clinical or financial implications.
He has been mentored and supported by a senior and respected establishment figure who is often the co-author of many of his papers but may have not been closely involved in the research.
ThreeRiskFactorsIn nearly all cases, the perpetrators:
1. were under career pressure;
2. knew, or thought they knew, what the answer to the problem they were considering would turn out to be, if they went to all the trouble of doing their work properly; and
3. were working in a field where individual experiments are not expected to be precisely reproducible.
AgendaResearch
Forms of Scientific Fraud
The Reality in Universities
Prominent Cases of Scientific Fraud◦ Philip Felig & Vijay Soman
◦ Hwang Woo Suk
◦ Diederik Stapel
Preventing Scientific Fraud
WhatisResearch?
The systematic production of (new) knowledge about some aspect of the world.
TheResearchCycle(1) conceiving a research question
(2) designing the method of investigating the question
(3) getting permission to conduct the investigation
(4) collecting the requisite data and materials
(5) analysing this data, and inferring conclusions
(6) presenting or writing up the results
(7) publishing those findings
MainBenefitofResearch
Research enables us to acquire a deeperunderstanding of how we come to know what we know about the world. This understanding can lead to a deep shift in one’s thinking and a different relationship with knowledge and the world around us.
RobertMerton(1942)Four sets of institutional imperatives – universalism, communism, disinterestedness, organised scepticism – are taken together as the ethos of modern science.
Communism refers to the free sharing of one’s discoveries with others.
What makes this level of altruism possible is the reward system of science.
Honour, position, power and money go to those who make discoveries first –and who claim priority by promptly publishing their findings.
BenefitsNotMentionedPrestige, Fame, Visibility … Perks
Reputation and Recognition, Glory
Promotion and Career Success
Influence
Immortality
Financial Gain
Prestige,Fame,VisibilityA few scientists have attained celebrity status, and are more recognisable than some actors and actresses.
Marie Curie, Stephen Hawking, Alan Turing, Srinivasa Ramanujan, John Nash and Charles Darwin have got movies made about their lives! Stephen Hawking, a scientific celebrity
PerksThe apparent success propelled Hwang to almost God-like status.
He was dubbed “the pride of Korea”, and Korean Air offered him first class tickets for life.
The government issued Hwang Woo Suk commemorative postage stamps and gave him millions of dollars of funding to pursue the research.
ReputationandRecognition
CareerSuccessPublish or perish.
Publication is the means of survival for the scientist, a kind of a monument.
Research papers are the currency of our world. The one who has the most is the richest.
Immortality
ImmortalityThe photo of James Watson and Francis Crick with their model of part of a DNA molecule is very well known.
Generations of students will learn that they discovered the structure of DNA at the Cavendish Laboratory (Cambridge University) in 1953.
FinancialGain
Plan BudgetNational Technology Plan 1995 $2 billionNational Science & Technology Plan 2000 $4 billionScience & Technology 2005 Plan $6 billionScience & Technology 2010 Plan $13.5 billionResearch, Innovation and Enterprise 2015 Plan $16 billionResearch, Innovation and Enterprise 2020 Plan $19 billion
UniquenessofScience
Science relies on empirical evidence, and on testing ideas against the facts in nature.
source of scientific fraud
TypologyofScientificFraudForging: complete (or wholesale) fabrication – the recording of observations that were never made
Trimming: manipulating the data to make them look better (“in clipping off little bits here and there from those observations which differ most in excess from the mean and in sticking them on to those which are too small”)
Cooking: choosing the data that fitted the researcher’s hypothesis and the discarding of those that did not
(Babbage, ReflectionsontheDeclineofScience, 1830)
NIHandNSFTypologyFabrication is making up data.
Falsification is altering or selecting data.
Plagiarism is presenting someone else’s work or ideas as your own, with or without their consent, by incorporating it into your work without full acknowledgement.
FabricationIn 2012, University of Kentucky biomedical researcher Eric Smart was discovered to have falsified or fabricated 45 figures over the course of 10 years. His research on the molecular mechanisms behind cardiovascular disease and diabetes was well-regarded, despite his having used data from knockout mouse models that never existed.
Smart resigned from his university post in 2011.
FalsificationJapanese anaesthesiologist Yoshitaka Fuji fabricated data in a whopping 172 papers. His falsification started in 1993 at the Tokyo Medical and Dental University, and he continued doing it at the University of Tsukuba, and at Toho University in Tokyo. Fuji never actually saw the patients he reported in his clinical studies.
He used the publications to further his career, publishing a total of 249 papers.
PlagiarismJamal Farooqui was an associate professor at the University of Cincinnati. In 1996, he plagiarised material on hormone expression in human skin from a grant application submitted to the National Science Foundation (NSF).
ViolationofSharedValuesHonesty: convey information truthfully and honouring commitments
Accuracy: report findings precisely and take care to avoid errors
Efficiency: use resources wisely and avoid waste
Objectivity: let the facts speak for themselves and avoid improper bias
TheUniversity:AResearchFactory
The lures of careerism and big money and the huge research factories common in modern science frequently lead scientists to betray their commitment to the discovery of truth and to abandon the lofty ideals of their profession.
CaseNo.1PHILIP FELIG & VIJAY SOMAN, YALE UNIVERSITY
November1978Helena Wachslicht-Rodbard (“W-R”) submits an article, “Insulin Receptors in Anorexia Nervosa” to TheNewEnglandJournalofMedicine.
The editors there sent it to three reviewers for peer review.
January1979Two and a half months later, W-R received her manuscript back.
She was told that if she would revise it in accordance with three enclose three critiques by anonymous reviewers (one of whom had recommended rejection rather than revision), it would be considered for publication.
She immediately started to revise the paper.
AFewDaysLater…Jesse Roth (W-R’s boss) asks W-R to review a manuscript from TheAmericanJournalofMedicine.
Roth mentioned that the manuscript was on the same subject as the one she submitted earlier, but had been written by Vijay Soman and Philip Felig.
She was shocked to discover that a number of passages were identical to those in her article. They also used a mathematical formula she devised.
She guessed (correctly) that the reviewer that rejected her paper was Philip Felig.
ThisIsWhatHappenedWhen W-R’s paper came to Philip Felig for review, he asked Soman to comment on it first. After that, he looked the paper over, and wrote the adverse review.
He and Soman had an almost identical study nearing completion, and he should have at least told Arnold Relman, the editor of TheNewEnglandJournalofMedicine about the conflict of interest.
He did not!
February1979Philip Felig received a call from Arnold Relman (the editor).
Relman had learned that Soman and Felig had submitted an article elsewhereon the very same topic as W-R’s – after Felig had received and read her paper.
Relman wanted to know whether Felig’s review had been influenced by this conflict of interest and was concerned about the similarity of the papers.
Felig assured Relman that his review had been based on the paper’s merits alone.
LaterThatDay…Philip Felig got a call from Jesse Roth, whom he had known since they were boyhood friends and schoolmates in Brooklyn.
Roth told him what had been behind Relman’s call: While Roth was away, W-R had sent back her revised manuscript, along with a letter to Relmanaccusing Soman and Felig of plagiarism.
She enclosed photocopies of her original manuscript and theirs with the parallel passages underlined.
AFewDaysLater…Roth suggested that if he and Felig compared the two papers when they met in a few days at a National Institute of Health conference.
When they did so, they found that plagiarism was indeed committed.
W-R had told Roth she now believed that the Soman-Felig paper might have been wholly fabricated from her own.
The two men (Roth and Felig) worked out a plan to make amends for the wrong they now saw Soman had committed.
ThePlanFelig would insert in his and Soman’s paper an indication that Dr. W-R’s work had come first. They would not publish their paper until hers had appeared. In fact, they would withhold it as long as any “reasonable doubt” remained about the independence of its research.
Felig phoned W-R the next day, told her he was annoyed by what had happened and outlined his plan to put things right.
W-R was not happy about the outcome.
W‐RisNotAppeasedA couple of days later, Roth wrote a letter to his old friend (Felig) outlining the agreed plan of redress and expressing his satisfaction with it.
He asked W-R to co-sign it, but, as he noted at the bottom of the letter, but she refused.
She remained unappeased even when her revised paper was scheduled for early publication in TheNewEnglandJournalofMedicine.
W-R felt that a serious wrong had been done by both Felig and Soman, that something should be done about it, and that her own superior (Roth) was trying to shut her up.
Soman AdmitsWrongdoingAfter the meeting with Roth, Felig returned to Yale and confronted Soman, who, abashed, admitted that he had kept a copy of the W-R paper and borrowed a number of phrases from it, because, he said, he was not comfortable with the English language and felt under pressure to get his paper published soon.
He also admitted that he had based his calculation on an equation in the W-R paper.
Felig StillTrustsSomanAside from Soman’s having naively used another’s words, Felig still considered him perfectly trustworthy.
Felig says he never doubted that the paper to which his name was joined reported work that Soman had done independently and scrupulously.
“I had worked with him for years,” Felig says, “and I fully believed that my colleague was an honest person. I accepted his explanation and did not feel that what he had done tarnished his entire character.”
W‐RWritestotheDeanW-R, meanwhile, outraged that what she believed to be a piece of scientific fraud would never be exposed, wrote to Dean Berliner of the Yale School of Medicine in late March, expressing her doubt about the authenticity of the Soman-Felig work and asking for an audit.
DeanBerlinerGetsInvolvedDean Berliner asked Felig to verify that the studies had actually been done.
Felig asked Soman for such verification, and Soman brought him a list of the patients’ names and dates (but not their hospital charts), plus data sheets bearing figures that, he said, were averages compiled from the blood studies of the six patients.
Felig looked no further. He told Dean Berliner that the work had been done as represented, and Berliner wrote to W-R, “There is no question that the studies of Soman and Felig were done as described in their manuscript,” adding that he hoped she would now consider the matter closed.
AuditorNo.1SelectedShe would not.
Roth and Felig selected an auditor, but their designee never seemed able to find the time to visit Yale.
Weeks and months passed, nothing happened, and at both the N.I.H. and Yale people seemed to think the problem would simply evaporate.
Felig HasAppliedtoP&SFelig had good reason to hope it would, for the greatest opportunity of his career had just materialised.
A search committee at “P. & S.” – Columbia University’s prestigious College of Physicians and Surgeons – had recommended that Felig be appointed Samuel Bard Professor and chairman of the Department of Medicine, a key post in medical education in the United States.
Felig RecommendsSoman toP>he W-R charges were still confidential and no one at P. & S. had heard about them.
By now, in fact, Felig apparently felt so confident the storm had blown over that he took Soman to P. & S. in January 1980, introduced him to administrators and faculty there and recommended that he be appointed an assistant professor.
Soman‐Felig PaperIsPublishedWith uncanny timing, the challenged Soman-Felig paper appeared in TheAmericanJournalofMedicine that very month.
Felig had promised W-R that he would withhold it while any reasonable question remained about it. He felt that no such question remained.
But W-R called Roth in such a fury that he agreed to act at once.
Roth phoned Felig and said it was necessary to find another auditor.
They decided on Jeffrey Flier of Harvard.
AuditorNo.2ArrivestoAuditJeffrey Flier arrives in Yale to conduct an “audit”.
Soman was waiting on the station platform. During the audit, Somanadmitted to fudging the data, and suppressing some discordant data.
Soman said he’d been under great pressure to publish as soon as possible so as to obtain priority for the finding.
He said that the laboratory he worked in was oriented toward productivity and success.
Felig MakesTwoPhoneCallsFirst, to Samuel Thier, chairman of the department of internal medicine at Yale.
Felig told Thier that Soman accused Flier was prejudiced against the two of them and had found some things wrong.
Felig also telephoned Flier, who told him there was no doubt that Soman had falsified data in the just-published anorexia nervosa paper co-signed by Felig, who realised that his reputation and, to some degree, that of the Yale Medical School itself were in peril.
MajorAuditisPerformedSoman finally admitted: “I smoothed out the data. I took the curves and smoothed them out.”
Thier told him that the best choice was to resign and to give up research. Soman agreed to do so, and to leave Yale within a few weeks.
Jerrold Olefsky, University of Colorado performed an extensive audit (14 Soman papers).
Olefsky was able to give a clean bill of health to only two.
TheAftermathPhilip Felig lost his professorship at Columbia University.
He was careless (poor record-keeping) and spread too thin. He cut corners. He had a lust for publications.
Vijay Soman left the Yale Medical School, and went back to Poona, India.
Helena Wachslicht-Rodbard (“W-R”) gave up research.
CausesofScientificFraudThe spirit of fierce competition fostered by research centres for grant money with which to support their laboratories.
Inflation and cutbacks that threaten to end many programs, thereby increasing the pressure on scientists to make up impressive data for their papers and grant proposals.
Inability of the peer-review system to cope with the flood of scientific articles (there is more room than formerly for fraud to get by).
DetailsoftheStoryBroad, W., & Wade, N. (1982). BetrayersoftheTruth:FraudandDeceitintheHallsofScience. New York: Simon & Schuster. (Chapter 9: Immunity from Scrutiny)
Hunt, M. (2008). A fraud the shook the world of science. New York Times.
TheEffectofScientificFraudThe spread of the misinformation, innocently restated by others in their own publications.
The waste of time, effort and money by honest scientists who base their work, in some part, on the fraudulent material.
The co-authors of the fraudulent research papers, whose resources also are wasted and whose careers may be blighted, by perhaps unjustified guiltbyassociation.
Jump to Case No. 2 Jump to Fraud Reduction
Scientific fraud is not a new thing …
Other Feligs and Somans in history …
ClaudiusPtolemy, known as “the greatest astronomer of antiquity,” did most of his observing not at night on the coast of Egypt but during the day, in the great library at Alexandria, where he appropriated the work of a Greek astronomer and proceeded to call it his own.
GalileoGalilei is often hailed as the founder of modern scientific method because of his insistence that experiment, not the works of Aristotle, should be the arbiter of truth. But his colleagues had difficulty reproducing his results and doubted he performed certain experiments.
IsaacNewton, who formulated the laws of gravitation, relied in his magnum opus on an unseemly fudge factor in order to make the predictive power of his work seem much greater than it was.
JohnDalton, the great nineteenth-century chemist who discovered the laws of chemical combination and proved the existence of different types of atoms, published elegant results so that no present-day chemist has been able to repeat.
GregorMendel, the Austrian monk who founded the science of genetics, published papers on his work with peas in which the statistics are too good to be true.
RobertMillikan, who won the Nobel Prize for being the first to measure the electric charge of an electron. Between 20 November 1911 and 16 April 1912, he took data from 175 drops, but reported the results of measurements on only 58 drops.
CaseNo.2HWANG WOO SUK, SEOUL NATIONAL UNIVERSITY
TwoPapersThatDestroyedHwangHwang, W.S., Ryu, Y.J., Park, J.H., Park, E.S., Lee, E.G., Koo, J.M., Jeon, H.Y., Lee, B.C., Kang, S.K., Kim, S.J., Ahn, C., Hwang, J.H., Park, K.Y., Cibelli, J.B., Moon, S.Y. (2004). Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst. Science,303, 1669–1674.
Hwang, W.S., Roh, S.I., Lee, B.C., Kang, S.K., Kwon, D.K., Kim S., Kim S.J., Park S.W., Kwon H.S., Lee, C.K., Lee, J.B., Kim, J.M., Ahn, C., Paek, S.H., Chang, S.S., Koo, J.J., Yoon, H.S., Hwang J.H., Hwang, Y.Y., Park, Y.S., Oh, S.K., Kim, H.S., Park, J.H., Moon S.Y., Schatten, G. (2005). Patient-specific embryonic stem cells derived from human SCNT blastocysts. Science,308, 1777–83.
IfValidIf these two papers had been valid, they would have represented a significant step forward in human embryonic stem cell research, since they would have demonstrated the feasibility of therapeuticcloning, a technique which holds great promise as a medical therapy.
Hwang’s research put South Korea on the map as a biotechnology epicentre and made Hwang a national hero.
February2005Korea Post issued a postage stamp in Hwang’s honour on 12 February 2005.
Designed by Roh Jung-hwa, with a denomination of 220 won and printed in a quantity of 1.6 million, it was, the stamp tells us, specially issued to commemorate “the successful establishment of human cloned embryonic stem cells”.
November2005Gerald Schatten accused Hwang of misleading him about the sources of the oocytes used in the 2004 paper.
Hwang indicated that the oocytes had come from 16 donors.
Actually, if came from two junior members of Hwang’s laboratory.
Subordinate participation in a research project is considered ethically problematic because it can be coercive.
Hwang denied the allegations.
December2005Hwang admits allegations.
University of Pittsburgh investigates Schatten’s role in the scandal, and found that he had not committed misconduct.
However, he was found guilty of research misbehaviour for failing to catch the inconsistencies in the paper, and also failed to ensure that each co-author had approved the paper before it was submitted to Science.
GiftAuthorshipHe also did not deserve to be an author on the 2005 paper, since his only contribution was to suggest that the authors hire a professional photographer to take a photo of the dog!
They also found the US$40,000 consulting fees that Schatten accepted for working with Hwang’s team excessively high.
Mid‐December2005An anonymous researcher sent Science a tip-off that two of the photos of the stem cells in the 2005 paper were duplications.
Sung Roh (a co-author) told the media that Hwang has confessed to fabricating evidence.
An investigation committee found that the data of the 2004 and 2005 papers were fabricated, and only the paper on Sunppy, the world’s first cloned dog, which was published in Nature, was authentic.
TheEndHwang resigned from his position at the Seoul National University.
Hwang was removed as the ResearchLeaderoftheYear on the 2005ScientificAmerican50 list by the editors of ScientificAmerican.
The field of embryonic stem cell research was set back as political support for this controversial research was withdrawn.
PrisonSentenceHwang was sentenced to two years in prison at the Seoul Central District Court on 26 October, after being found guilty of embezzlement and bioethical violations but cleared of fraud.
The court did, however, find Hwang guilty of buying human eggs in violation of the country’s bioethics law and of embezzling 830 million won (US$700,000) of government money.
WastedTimeofOtherResearchersResearcher Ryuzo Torii of the Shiga University of Medical Science in Japan used large amounts of grant money, time and monkey eggs trying to reproduce Hwang’s technique in non-human primates in 2004 and 2005.
He says that forgiving Hwang and recognising him as a researcher would be “a mistake”.
CaseNo.3DIEDERIK STAPEL, TILBURG UNIVERSITY
Diederik StapelA Dutch social psychologist, and dean, School of Social and BehavioralSciences, Tilburg University
He faked or manipulated data in at least 55 publications, found “indications” of fraud in 11 other papers from his work fired last year by Tilburg university after his fraud was first revealed.
Fraud was uncovered when three graduate students became suspicious of data he supplied them without allowing them to participate in the actual research. When they ran statistical tests on it themselves they found it too good to be true and went to Tilburg University’s dean with their suspicions.
AcademicScience=BusinessToday, academic science is a business. There are scarce resources, you need grants, you need money, there is competition. Normal people go to the edge to get that money. Science is of course about discovery, about digging to discover the truth. But it is also communication, persuasion, marketing. I am a salesman.
Stapel’s FrustrationStapel loved social psychology but had been frustrated by the messiness of experimental data, which rarely led to clear conclusions.
Possible reasons for fraud: laziness, ambition, a short attention span
ReducingFraud
RCRisanInternationalIssueDifferent countries have different definitions of research misconduct as well as different procedures for investigating allegations of unethical or illegal research.
The research community has to develop standards, guidelines and best practices for the responsible conduct of research (RCR).
The procedures should include rules for protecting whistleblowers, and also for maintaining confidentiality during investigations and guaranteeing due process.
RCREducationisImportantAll graduate students should receive RCR education.
Many institutions have started to offer online courses in research ethics.
Unfortunately, RCR education is not well-suited for online training, but works best in interactive settings.
RCR education will not prevent misconduct from occurring, but it can raise awareness about ethical issues and problems in science and how to address them.
PeerReviewCanBeImprovedThe peer review process almost always fails to detect research misconduct.
This is because the peer review system was not designed to detect misconduct, which requires access to research materials that are not usually sent to reviewers, such as laboratory notebooks, standard operating procedures, biological samples, scientific instruments, etc.
Peer reviewers only examine manuscripts to determine the novelty and significance of the research, the soundness of the research methods, the consistency of the data, the quality of the writing, etc.
AuditDataandResearchRecordsThe best way to detect research misconduct is to have some quality control before a paper is submitted for publication, such as auditing data and research records and materials.
Auditing should occur for a cause, such as suspected misconduct, and on a random basis, although this this will be inconvenient for most researchers.
Auditing expenses should be included when applying for grants.
One a culture of auditing takes root, it will be less intimidating for researchers.
TightenAuthorshipandAccountabilityAuthorship needs to be granted only to those who have participated sufficiently in the work to take responsibility for appropriate portions of the content.
Holding authors accountable for their contributions will not prevent misconduct, but it will promote integrity, accountability, and responsibility in research.
Authorship should be earned, and not granted as a gift or a favour.
UseTechnologyPlagiarism checking tools
Image similarity checking tools
Thankyou
ReferencesGoodstein, D. (2010). OnFactandFraud:CautionaryTalesFromtheFrontLinesofScience. Princeton: Princeton University Press.
Reich, E.S. (2009). PlasticFantastic. New York: Palgrave.
Broad, W., & Wade, N. (1982). BetrayersoftheTruth:FraudandDeceitintheHallsofScience. New York: Simon & Schuster.