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Science, research and development European Commission
LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH
Applications of knowledge and technologies
in the field of genomics and biotechnology
for healthAlfredo Aguilar
Head of Unit Biotechnology and Applied Genomics
Directorate Life Sciences EDirectorate General Research
European Commission
NCPs FP6, Theme 1Brussels, 23 October 2002
Science, research and development European Commission
LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH
Strategic objective:
To foster the competitiveness of Europe’s biotechnology industry by exploiting the wealth of biological data produced by genomics and advances in biotechnology.
Applications of knowledge and technologiesin the field of genomics and biotechnology for
health
Science, research and development European Commission
LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH
• Rational and accelerated development of new, safer and more effective drugs including pharmacogenomics approaches
Applications of knowledge and technologiesin the field of genomics and biotechnology for
healthTechnology Platforms will focus their research
activities on:
• Development of new diagnostics• Development of new in vitro tests to replace animal
experimentation• Testing of new preventive and therapeutic tools such as somatic gene and cell tehrapies (in particular stem cell therapies) and immunotherapies• Innovative research in post-genomics (novel products from genomics and biotechnology)
Technology platforms are particularly suited for SME.
Science, research and development European Commission
LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH
How the objective is to be achieved ?
Applications of knowledge and technologiesin the field of genomics and biotechnology for
health
“TRANSLATIONAL APPROACH”
Application stage to enablereal, consistent and coordinated
progress at European level in medicine, competitiveness
and in the quality of life
Bringing basic
knowledge
Science, research and development European Commission
LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH
Is basic research ? Applied research ?Successful projects must develop
an Integrated Multidisciplinary Research
Applications of knowledge and technologiesin the field of genomics and biotechnology for
health
Integration
• Biology and Technology• Technology producers and Technology users• Stakeholders (Extended Audiences)• SME in the projects (15% of budget for SME!)• Innovation and exploitation
Science, research and development European Commission
LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH
Is basic research ? Applied research ?Successful projects must develop
an Integrated Multidisciplinary Research
Applications of knowledge and technologiesin the field of genomics and biotechnology for
health
Multidisciplinary
• Cutting across S&T disciplines• Approaching lateral issues• Interphase between disciplines
Science, research and development European Commission
LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH
Is basic research ? Applied research ?Successful projects must develop
an Integrated Multidisciplinary Research
Applications of knowledge and technologiesin the field of genomics and biotechnology for
health
ResearchProjects may include basic, applied research,demonstration activities provided that...
• is transnational research (clear deliverables; basic knowledge to application stage)• address major societal needs• increases EU competitiveness
Science, research and development European Commission
LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH
How to combine improvement of Europe’s biotechnology industry and precompetitive projects ?
Applications of knowledge and technologiesin the field of genomics and biotechnology for
health
TECHNOLOGICAL PLATFORMS
IntegratedMultidisciplinaryResearch
EU project
- Health care progress- Increased quality of life- Cost reduction- Precise diagnostics- Individualised treatments- New drugs and therapies- Novel products from genomicsand biotechnology
Socio-economic deliverables, competitive projects
• Industry• SME• Academics• Stakeholders
Civil society
Through the development of technological platforms
Science, research and development European Commission
LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH
TOTAL NoE IPFundamental Genomics 523 30 10 20Applied Genomics and
Biotechnology401 40* 11 20
Medical Application Oriented Genomics
Approaches702 33* 13 18
Combating Cancer 302 14 5 9Poverty related Diseases 69 10 2 8
TOTAL 1997 127* 41 75
Total EoI Received
Selected Topics
Priority 1Research topics of European strategic
importancefor possible implementation via a new
instrument
* some of which addressed by NoE and/or IP
Science, research and development European Commission
LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH
From EoI analysis to the work probramme for the first FP6 call
• Preparation of the work programme for the first call of FP6 is based on EoI analysis but will require further focusing due to budgetary limitations and…
• Strategic input from inter-service consultations, Expert Advisory Groups and the Programme Committee
• A conference marking the launch of the FP6 will take place in Brussels on November 11-13/2002
• Publication first calls for proposals in the Official Journal expected on 17 December 2002 (deadline 17 March 2003)
Science, research and development European Commission
LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH
From the Expressions of Interest to the Draft Workprogramme:
Applications of knowledge and technologiesin the field of genomics and biotechnology for
health
Relevant topics stemming from the EoI
- Blood substitutes- Antiviral therapeutics- New drugs from novel sources- Genome based individualised medicines- Novel therapies for neurodegenerative disorders in CNS and PNS- Genome-based anti-psychotic therapies- Signal transduction pathways as targets for disease detection and treatment- Development of medicines in pediatrics- Computer assisted modeling for drug discovery and clinical trials
Rational and accelerated development of new, safer and more effective drugs including pharmacogenomics approaches
Science, research and development European Commission
LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH
From the Expressions of Interest to the Draft Workprogramme:
Applications of knowledge and technologiesin the field of genomics and biotechnology for
health
Relevant topics stemming from the EoI
- In vivo molecular imaging- Reference systems for genetic testing- Non-invasive (including prenatal) diagnostics; development of markers for ante- and neo-natal screening
Development of new diagnostics
Science, research and development European Commission
LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH
From the Expressions of Interest to the Draft Workprogramme:
Applications of knowledge and technologiesin the field of genomics and biotechnology for
health
Relevant topics stemming from the EoI
In vitro alternatives to animal and human toxicology testing:
- Development of innovative methods, technology, strategies- Application of in vitro methods
Development of new in vitro tests to replace animal experimentation
Science, research and development European Commission
LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH
From the Expressions of Interest to the Draft Workprogramme:
Applications of knowledge and technologiesin the field of genomics and biotechnology for
health
Relevant topics stemming from the EoI
- Connective tissue disorders: bone diseases, osteoarthritis- Organ repair: hepatic, hemopoietic, neural tissue- Biobanks- Translation of stem cell biology into new cell-based therapies and novel targets for drug development and other therapeutic products- Stem cell development for the regeneration of hemopoietic, hepatic, cardiac, neural, mesenchymal and connective tissues- Sem cell development, technical standardisation, benchmarking, development of reference materials- Stem cell therapies: standardisation, characterisation and protocol validation
Development and testing of new preventive and therapeutic tools such as somatic, gene and cell therapies (in particular stem cell
therapies) and immunotherapies (i)
Science, research and development European Commission
LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH
From the Expressions of Interest to the Draft Workprogramme:
Applications of knowledge and technologiesin the field of genomics and biotechnology for
health
Relevant topics stemming from the EoI
- New improved vaccine technologies- Immunotherapy for auto-immune diseases- Plant based vaccines - plant biotechnology for global health- Viral and non-viral delivery systems- Cell targeting- Standardisation and characterisation in gene therapy- Gene therapy for genetic diseases- Dendritic cells, chemokines, cytokines- Allergy, autoimmunity, inflammatory disease- Prevention and treatment of disease through modulation of the immune system
Development and testing of new preventive and therapeutic tools such as somatic, gene and cell therapies (in particular stem cell
therapies) and immunotherapies (ii)
Science, research and development European Commission
LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH
From the Expressions of Interest to the Draft Workprogramme:
Applications of knowledge and technologiesin the field of genomics and biotechnology for
health
Relevant topics stemming from the EoI- Functional analysis of human genome and its application to diagnosis and therapy of diseases, including mitochondrial disorders- Adverse reactions to drugs, in particular those of immunological origin- Quality and safety control of new tools (gene vectors, stem cells) for clinical use- Optimisation, standardisation and quality assessment and assurance of post- genomic technology- Post-genomic approaches for allergy and autoimmune diseases: * for complex multifactorial diseases * for the development of new tools for the rapid diagnosis of pathogenic infection and new targets for anti-microbial agents - New strategies for large scale analysis and high throughput screening in the postgenomic- RNA tools for gene function analysis
Innovative research in post-genomics
Science, research and development European Commission
LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH
Networks of Excellence: Objectives
To structure the EU research potential
by integrating research capacities• Joint research activities• Integrating activities• Spreading of excellence• Common management
Management Group
Eu
rop
ean
Com
mis
sion
Research team leader
Management Group
• Joint research activities• Integrating activities• Spreading of excellence (training)• Common management
To structure the EU research potential by integrating existing research capacities
Governing Council Funding Bodies Representatives
Partner Organisation Representative
Scientific Council
Science, research and development European Commission
LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH
Integrated projects: Objectives
Training
Ethical aspects, science-society dialogueEthical aspects, science-society dialogue
Technology transfer, exploitationTechnology transfer, exploitation
strong managementstructure
ImplementationPlan
RTD 4
RTD 1
RTD 2
RTD 3
RTD 5
Demonstration
ManagementManagement
addressing major societal needs increasing EU competitiveness
predefined S/Tresults and
clear deliverables
To integrate the critical mass of activities/resources needed for :
Science, research and development European Commission
LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH
Main challenges:
• To guarantee a higher success rate than in FP5
• To attract SME (4% industries in the EoI for TP1, 10% for this
area)
• To attract oustanding IP and NoE (FP6 projects are not “big” FP5
projects)
Applications of knowledge and technologiesin the field of genomics and biotechnology for
health
Science, research and development European Commission
LIFE SCIENCES, GENOMICS AND BIOTECHNOLOGY FOR HEALTH
Ongoing and coming trends...• 17 December 2002, First Call for Proposals, Framework
Programme 6To keep you informed with the latest news…
www.cordis.lu/fp6/eoi-instruments
… and with the new instruments, rules for participation,…
http://europa.eu.int/comm/research/nfp/networks-ip.html
Help and information :
for Priority “Life Sciences, Genomics and Biotechnology for Health”: [email protected]
Opportunities for Life Sciences, Genomics and Biotechnology for Healthin Framework Programme 6 (2002-2006)