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SCHOOL OF PHARMACY

REPORT 2OO9/2O1O

TE KURA MÄTAURAKA WAI-WHAKAORA

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School of Pharmacy Report 2009/2010

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coNTENTS

Introduction from the Dean 3

Organisational Structure of the School 5

Current Staff 6

Teaching Programmes 2009 | 2010 40

Enrolments in 2009 | 2010 44

Graduates in 2009 | 2010 45

Research in the School 48

Research Statistics 50

Current Postgraduate Research Students 51

Summer Studentships 55

Publications 59

Grants 90

Conference Leave 94

Seminars 101

Service External to the University 110

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INTroducTIoN from ThE dEaN

It is with great pleasure that I present this report that covers the teaching, research and service activities of New Zealand’s National School of Pharmacy for the period of 2009-2010. The School continues to grow in terms of all three activities. Perhaps the greatest change to the School over the last two years has been the completion of Professor Ian Tucker’s term as Dean of the School. Professor Tucker, the School’s second Dean, has led the School over the last 11 years and has contributed in many diverse ways to the benefit of both the School and the wider pharmacy community in New Zealand. During this time Professor Tucker maintained a highly active research group and now returns to his role as Professor of Pharmaceutical Sciences. The School warmly thanks Professor Tucker for his leadership and personal sacrifice. In June 2010, I took over the role as Dean and found the School in very good shape. The School continues its three areas of teaching, research and service strength, which are the pharmaceutical sciences, clinical pharmacy and social pharmacy and is currently developing a fourth area of biopharmaceutical sciences.

The School strives to provide the best possible pharmacy education. We have a strong belief in providing education that is underpinned by high quality research and we believe that the School’s success in research directly underpins and enhances its teaching programmes. The Undergraduate Programmes is led by Associate Professor Natalie Medlicott and during Associate Professor Medlicott’s Research and Study Leave by Professor Pauline Norris. The Postgraduate Professional Programmes is led by Professor Stephen Duffull.

The School has seen an increase in enrolments in both its undergraduate and postgraduate taught programmes of study. This growth for the undergraduate programmes is subsequent to the School developing close liaisons with Malaysia through a scholarship network and through the International Medical University of Malaysia. Through these links we now have a steady intake of international students which increases the cultural diversity of our undergraduate programmes. Many of these international students will complete their intern training year in Malaysia. The postgraduate programmes in clinical pharmacy have developed and refined themselves over the last few years. We have seen a pleasing increase in numbers of students with now over 40 students enrolled in the postgraduate professional programmes. In addition the School is pleased to announce that shortly we will be introducing Australasia’s first postgraduate taught course in Social Pharmacy {PGCertPharm(Soc)}. This has been developed under the leadership of Professor Pauline Norris, our first Professor of Social Pharmacy.

The School’s research has gone from strength to strength in the last two years. Research is well supported in the School by the Research Committee which is chaired by Professor Thomas Rades. The Research Committee provides the necessary mechanism for support and infrastructure that helps to underpin our research needs. The School has a vibrant research culture as is reiterated in Professor Rades’ report (see Research in the School). In 2010 we celebrated Professor Thomas Rades’ achievement of authoring more than 200 papers published in internationally peer-reviewed Journals.

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In the last two years we have seen our staff change and numbers grow. We now have two new Associate Professor positions; Associate Professor Sarah Hook (Pharmaceutical Sciences) and Associate Professor Natalie Medlicott (Clinical Pharmacy). We also have made a new appointment in the clinical pharmacy area. The School currently has 13 staff with annual practicing certificates. Also, and importantly, the School’s staff embrace a wide range of disciplines outside of pharmacy including, anthropology, chemistry, engineering, history, immunology, psychology, sociology, zoology (alphabetical). The combination of these disciplines provides an excellent melting pot of new ideas and approaches to research and teaching.

In 2009 the School underwent an accreditation review from the Australian Pharmacy Council. The results of this review were positive and the School is now fully accredited for five years.

This report provides an overview of the staff, research activities, teaching programmes and service activities of its staff members. We are proud of our staff ’s achievements and hope you enjoy reading about them.

Stephen DuffullProfessor of Clinical Pharmacy and Dean

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orgaNISaTIoNal STrucTurE of ThE School

Responsibilities within the School are allocated on a functional basis among Associate Deans for Admissions and Undergraduate Programmes, Postgraduate Professional Programmes and Research.

The activities of the School are informed by our stakeholders through the Pharmacy Advisory Committee and Heads of Schools and Professional Organisations in Pharmacy (HOSPOP) which have representatives from the various professional bodies, industry, students and staff; the staff/student liaison meetings whereby students can provide feedback through the class representative system; and the staff General Assembly which is one avenue by which staff provide input into the functions of the School.

OrganiSatiOnal Structure

Board of Studiesfor Pharmacy

Managementteam

Health and Safety committee

researchcommittee

academic

Management

undergraduateProgrammes committee

Postgraduate Professional Programmes committee

examinations Board

impairments committee

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currENT STaff

Professor and DeanStephen Duffull, DipPharm (CIT) MClinPharm PhD (Otago) RegPharmNZ MPS

ProfessorsPauline Norris, BA MA (Cant) PhD (Well) Thomas Rades, BSc(Pharm) (Hamburg) PhD (Braunschweig)Ian Tucker, BPharm(Hons) PhD (Qld) RegPharmNZ MPS

associate ProfessorPaul Fawcett, BSc PhD (Lond) ARCS MNZICSarah Hook, BSc(Hons) PhD (Otago) ASI NZFSSNatalie Medlicott, BPharm PhD (Otago) RegPharmNZ

teaching academicsHesham Al-Sallami, BPharm PGDipClinPharm MClinPharm (Otago) ANZCP RegPharmNZ MPS Rhiannon Braund, BSc BPharm PhD (Otago) ANZCP RegPharmNZ MPSKate Chesney, BPharm (Otago) RegPharmNZ MPS Carolyn Coulter, BSc(Hons) BPharm (Otago) PhD (Cant) RegPharmNZ MPSJohn Fraser, MPS BSc(Otago)James Green, BA(Hons) PhD (Otago)Nicky Hewson, BPharm (Otago) RegPharmNZ Susan Heydon, BA(Hons) DHMSA (London) MA PhD (Otago)Arlene McDowell, BSc(Hons) MSc (Melb) PhD (Otago)Anita Olivier, DipPharm (Natal) PGCertTertT (Otago) RegPharmNZ MPSAynsley Peterson, BPharm PGCertPharm (Otago) RegPharmNZ MPSDorothy Saville, BPharm(Hons) MSc PhD (Syd)David Schmierer, BAppSci (Swinburne) MAACB CChem MRACI MRSCClare Strachan, BPharm PhD (Otago) RegPharmNZ June Tordoff, BPharm(Hons) MPharm (Brad) PhD (Otago) MRPharmS RegPharmNZ MPS Joel Tyndall, BSc(Hons) (Monash) PhD (Qld)James Windle, DipPharm (CIT) DipBusAdmin MBS (Massey) BPharm MClinPharm (Otago) AFAIPM MNZCP RegPharmNZ MPS Helen Winter, BPharm(Hons) Otago PhD (Washington) RegPharmNZ MPS

research StaffOlaf Bork, Dip Engineering PhD (Bremen)Pavan Kumar Vajjah, BPharm (Nagarjuna), MPharm(Hons) (BITS, Pilani) PhD (Otago)Lin Yang, BEng (China Pharmaceutical University) PGDipPharm PhD (Otago)Hu Zhang, MD (Anhui) PhD (Otago)

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research assistant/OtherGerald Sides, BTour GDipTour MTour (Otago)Pummy Krittaphol, BSc(Hons) RPharm (Rangsit) MSc (Mahidol) PGDip MSc PhD (Otago)Patti Napier, BPharm PGCertTertT PGDipHealSc (Otago)Katie Young, BSc MSc (Otago)

administrative StaffDenise BottingLea DoughtyKathy Ferguson, DipPolNicky Hunt, BCom (Otago)Jane McAuslan, BCom (MANT) NZCE (Civil)Laura McNeil, Cert BASCNirusha Phillips, BEng(Hons) ASB Dip (Associate of the NZ Speech Board) Samantha Veale

technical StaffMichael Broughton, MSc (Otago)Tim Campbell, BSc (Information Science) (Otago)Kevin Crump, BSc (Otago)Julie Harwood, NDSVicky McLeod, Nat Cert Pharm TechJoanne Preston, NZCS BSc (Massey)Lisa Reid, Cert Disp Tech Len Stevenson, NZCS PGCertHSci (Otago)Rachael Tyrer, BTechBrian Young, NZCE

contracted teaching StaffLinda Bryant, BPharm MClinPharm (Otago) PhD (Auck) MPSKeith Crump, DipPharm (CIT) RegPharmNZAlison Davies, DipPharm (CIT) DipHospPharm (Syd) MMedSci (Newcastle)John Dunlop, PGDipPharm MPharm (Otago) FACPP MCPP FNZCP MRPharm

DPharm (Auck) MPSSunita Goyal, BSc DipPharm MClinPharm (Otago) MPSDavid Woods, BSc(Hons) (Manch) MPharm (Otago) MPS

Honorary ProfessorJohn Murphy, PharmD (Florida) FCCP FCP

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Mr HeSHaM al-SallaMiBPharm PGDipClinPharm MClinPharm (Otago) ANZCP RegPharmNZ MPS

Tel: +64 3 479 7295Email: [email protected]

PositionLecturer

research interests• Data modelling and simulation• Optimal dosing of heparins in patients with thrombosis

Selected refereed Journal articles Al-Sallami, H.S., Barras, M., Green, B., Duffull, S.B. Routine plasma anti-Xa monitoring is required for low molecular weight heparins. Clinical Pharmacokinetics 49(9), 567-571 (2010)

Al-Sallami, H.S., Jordan, S., Ferguson, R., Medlicott, N.J., Schollum, J., Duffull, S.B. Current enoxaparin dosing guidelines have dubious credibility. New Zealand Medical Journal 123(1313), 62-67 (2010)

Al-Sallami, H.S., Pavan Kumar, V.V., Landersdorfer, C.B., Bulitta, J.B., Duffull, S.B. The time course of drug effects. Pharm Stat 8(3), 176-85 (2009)

Al-Sallami, H.S., Ferguson, R., Wilkins, G., Gray, A., Medlicott, N.J. Bleeding events in patients receiving enoxaparin for the management of non-ST-elevation acute coronary syndrome (NSTEACS) at Dunedin Public Hospital. New Zealand Medical Journal 121(1285), 87-95 (2008)

teaching involvementClinical pharmacy to undergraduate studentsMedicines information to postgraduate students

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Dr Olaf BOrkPhD (Bremen)


Position Senior Research Fellow

research interests• Drug Delivery Systems• Nano & Microencapsulation• Process Technology• Product Design• Formulation Technology• Mass Transfer• Hydrodynamics• Multiphase Flows• Bioengineering• Nanomedicine

Selected refereed Journal articlesBork, O., Schlüter, M., Räbiger, N. The Impact of Local Phenomena on Mass Transfer in Gas-Liquid Systems, The Canadian Journal of Chemical Engineering, 83,S. 658-666, (2003)

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Dr rHiannOn BraunDBSc BPharm PhD (Otago) FNZCP RegPharmNZ MPS


PositionSenior Lecturer

research interests• Quality use of medicines: From prescription to disposal and

beyond• Consequences of unused medications: Patients, Financial and

Environmental

Selected refereed Journal articles Braund, R., Furlan, H.M., George, K., Havell, M.M.A., Murphy, J.L., West, M.K. Interventions performed by community pharmacists while dispensing prescription medications. Pharmacy World and Science 32(1), 22-25 (2010)

James, T., Helms, M., Braund, R. Analysis of medication returns – indicators of adherence? Annals of Pharmacotherapy 43(10), 1631-1635 (2009)

Braund, R., Gn, G., Matthews, R. Identifying reasons for medication wastage. Pharmacy World and Science 31, 664–669 (2009)

Braund, R., Peake, B., Shieffelbien, L. Disposal practices for unused medications in New Zealand. Environment International 35, 952-955 (2009)

teaching involvementReproduction Module Co-ordinatorPatient Assessment to undergraduate studentsPostgraduate Research Students

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Mr Sree cHary*BSc MSc (Kerala) MPhil (Cochin) PGDipPharm (Otago)

PositionAssistant Research Fellow

research interests• Pre-formulation studies of new compounds.• Method development and validation of assays in both non-

biological and biological samples using HPLC and LCMS. • Permeability studies using Caco-2 cell monolayers.

Selected refereed Journal articles Liu, P., Chary, S., Devaraj, R., Jing, Y., Darlington, C.L., Smith, P.F., Tucker, I.G. & Zhang, H. Effects of aging on agmatine levels in memory-associated brain structures. Hippocampus, 18, 853-856, (2008)

Liu, P., Collie, N. D., Chary, S., Jing, Y., & Zhang, H. Spatial learning results in elevated agmatine levels in the rat brain. Hippocampus, 18, 1094-1098 (2008)

*Resigned from the School in May 2009

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MS kate cHeSneyBPharm (Otago) RegPharmNZ MPS


PositionProfessional Practice Fellow

Selected refereed Journal articles Chesney, K., Barazanchi, N., Billy, R., Koo, J., Rabih, N., Slaimankhel, J., Tordoff, J. Pharmacoeconomics: a Reliable Tool for Decisions on New Medicines? Journal of Pharmacy Practice and Research, 36(1), 12-15 (2006)

teaching involvementClinical pharmacy to undergraduate studentsPharmacy law to undergraduate students Prescription writing to undergraduate medical & nursing students

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Dr carOlyn cOulterBSc(Hons) BPharm (Otago) PhD (Cant) RegPharmNZ MPS


PositionLecturer

research interests• Drug toxicity and prevention and/or treatment of this• Renal and hepatic function and how these impact on

pharmacological treatments• Medication safety

Selected refereed Journals articlesCoulter, C.V., Smith, R.A.J. & Murphy, M.P. Synthesis, Characterisation, and Biological Properties of a Fullerene Triphenylphosphonium Salt. Fullerene Science and Technology, 9, 339-350 (2001)

Coulter, C.V., Kelso, G.F., Lin, T-K., Smith, R.A.J. & Murphy, M.P. Mitochondrially Targeted Antioxidants and Thiol Reagents. Free Radical Biology & Medicine 28, 1547-1554 (2000)

Coulter, C.V., Gerrard, J.A., Kraunsoe, J.A.E. & Pratt, A.J. Escherichia coli dihydrodipicolinate synthase and dihydrodipicolinate reductase: kinetic and inhibition studies of two putative herbicide targets. Pesticide Science, 55, 887-895 (1999)

Coulter, C.V., Gerrard, J.A., Kraunsoe, J.A.E., Moore, D.J., Pratt. A.J. (S)-Aspartate Semi-Aldehyde: Synthetic and Structural Studies. Tetrahedron, 52, 7127-7136 (1996)

teaching involvementClinical pharmacy to undergrad studentsPaper Co-ordinator for principles of pharmacy practice

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PrOfeSSOr StePHen DuffullDipPharm (CIT) MClinPharm PhD (Otago) RegPharmNZ MPS


PositionDean (May 2010)Chair in Clinical PharmacyAssociate Dean, Postgraduate Professional Programmes

research interests• Pharmacometrics – the quantitative design, analysis and

inference from pharmacological studies, particularly those involving PKPD

Selected refereed Journal articles McGree, J.M., Eccleston, J.A., Duffull, S.B. Compound optimal design criteria for nonlinear models. Journal of Biopharmaceutical Statistics, 18, 646-661 (2008)

Tanos, P.P., Isbister, G.K., Lallo, D.G., Kirkpatrick, C.M.J., Duffull, S.B. A model for venom-induced consumptive coagulopathy in snake bite. Toxicon, 52, 769-780 (2008)

Han, P.Y., Duffull, S.B., Kirkpatrick, C.M.J., Green, B. Dosing in Obesity: A simple solution to a big problem. Clinical Pharmacology & Therapeutics, 82(5), 505-508 (2007)

Yeo, T.W., Lampah, D.A., Gitawati, R., Tjitra, E., Kenangalem, E., McNeil, Y.R., Darcy, C.J., Granger, D.L., Weinberg, J.B., Lopansri, B,K., Price, R.N., Duffull, S.B., Celermajer, D.S., Anstey, N.M. Impaired nitric oxide bioavailability and L-arginine-reversible endothelial dysfunction in adults with falciparum malaria. The Journal of Experimental Medicine, 204(11), 2693-2704 (2007)

teaching involvementClinical pharmacy to undergraduate and postgraduate students; including undergraduate papers on Principles of Pharmacy Practice and Quality Use of MedicinesPaper Co-ordinator of Advanced Clinical Pharmacy as part of the Masters in Clinical Pharmacy course

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aSSOciate PrOfeSSOr Paul fawcettBSc PhD (Lond) ARCS


PositionAssociate Professor

research interests• Pharmaceutical analysis, drug development• Pharmacokinetics, drug metabolism• Drug transporters, blood-brain barrier • Drugs of abuse, chiral drugs

Selected refereed Journal articlesNumata, M., Fawcett, J.P., Rosengren, R.J. Induction of in vitro EROD activity and in vivo caffeine metabolism in two species of New Zealand birds. Environmental Toxicology and Pharmacology, 25, 358-364, (2008)

Li, Y., Fawcett, J.P., Zhang, H.,Tucker, I.G. Transport and metabolism of MitoQ10, a mitochondria-targeted antioxidant, in Caco-2 cell monolayers. Journal of Pharmacy and Pharmacology, 59, 503-511, (2007)

Shi, X.G., Fawcett, J.P., Chen, X.Y., Zhong, D.F. Structural identification of bitespiramycin metabolites in rat: A single oral dose study. Xenobiotica, 35, 343-358, (2005)

Guo, Y., Zhang, Y., Wang, Y., Chen, X., Si, D., Zhong, D., Fawcett, J.P., Zhou, H. Role of CYP2C9 and its variants (CYP2C9*3 and CYP2C9*13) in the metabolism of lornoxicam in humans. Drug Metabolism and Disposition, 33, 749-753, (2005)

teaching involvementPharmaceutical analysis and medicinal chemistry to undergraduate students

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Mr JOHn fraSerBSc(Otago) RegPharm NZ MPS



teaching involvementDispensing and patient assessment to undergraduate students

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Dr anJa graf*BPharm (Marburg) PGCertPharm PhD (Otago)

PositionLecturer

research interestsFormulation and oral drug delivery with emphasis on lipophilic drugs and lipid-based drug delivery systems

Selected refereed articles Graf, A., Jack, K., Whittaker, A., Hook, S., Rades, T. Protein delivery using nanoparticles based on microemulsions with different structure-types. European Journal of Pharmaceutical Sciences, 33(4-5), 434-444 (2008)

Graf, A., Ablinger, E., Peters, S., Zimmer, A., Hook, S., Rades, T. Microemulsions containing lecithin and sugar-based surfactants: nanoparticle templates for delivery of proteins and peptides, International Journal of Pharmaceutics, 350(12), 351-360, (2008)

Boonme, P., Krauel, K., Graf, A., Rades, T., Junyaprasert, V.B. Characterization of microemulsion structures in the pseudoternary phase diagram of isopropyl palmitate /water/Brij 97:1-Butanol, AAPS PharmSciTech, 7(2), E1-E6, (2006)

Krauel, K., Graf, A., Hook, S.M., Davies, N.M., Rades, T. Preparation of poly (alkylcyanoacrylate) nanoparticles by polymerisation of water-free microemulsions. Journal of Microencapsulation, 23(5), 499-512, (2006)

teaching involvement Teaching of physicochemical principles of formulation, drug delivery and sterile dispensing techniques to undergraduate students

*Resigned from the School in June 2010

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Dr JaMeS greenBA(Hons) PhD (Otago)

Tel: +64 3 479 7325 Email: [email protected]

Position Senior Lecturer

research interests• Communication• Lay perceptions of medicines• Direct-to-consumer advertising of medicines• Healthcare decision-making

Selected refereed Journal articlesGreen, J.A. Partying on? Life after BZP-based party pills. New Zealand Medical Journal, 121(1283), 35-42, (2008)

Halberstadt, J., and Green, J. Carryover effects of analytic thought on preference quality. Journal of Experimental Social Psychology, 44, 1199-1203, (2008)

Capstick, S., Green, J.A., Beresford, R. Choosing a course of study and career in pharmacy -student attitudes and intentions across three years at a New Zealand School of Pharmacy. Pharmacy Education, 7, 359-373, (2007)

Parr, W.V., Green, J.A., White, K.G., Sherlock, R.R. The distinctive flavour of New Zealand Sauvignon Blanc: Sensory characterisation by wine professionals. Food Quality and Preference, 18, 849-861, (2007)

teaching involvement CommunicationHauora Mäori, health behaviour change, experiences of illnessResearch Methods

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MrS nicky HewSOnBPharm (Otago) PGCertTerTchng(end) RegPharmNZ MPS



teaching involvementP2 Dispensing Co-ordinatorPatient assessment workshops

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Dr SuSan HeyDOnBA(Hons) DHMSA (London) MA PhD (Otago)


PositionLecturer

research interestsChanges in medicines use over time, the place of medicines in primary health care services both in international/global and New Zealand contexts, and medicines in the context of people’s lives. Its focus is the broader historical, social, political and economic context in which sickness is experienced and healthcare services are provided.

Selected refereed PublicationsHeydon, S. Celebrating and Reflecting on the Centenary of Tropical Medicine in Australia, 1910-2010, Annals of the ACTM, 11, 5-7, (2010)

Heydon, S. Modern Medicine and International Aid: Khunde Hospital, Nepal 1966–1998 New Delhi: Orient BlackSwan, (2009)

Heydon, S. High Places: Sir Edmund Hillary, the Sherpa and Health Services in the Mt Everest Area of Nepal, New Zealand Journal of Asian Studies, 9(1), 33–55 (2007)

Heydon, S. Sherpa Beliefs and Western Medicine: Providing Health Care at Khunde Hospital, Nepal in Soundings in Tibetan Medicine: Historical and Anthropological Perspectives; Schrempf, M. (Ed); Boston, 65-87, (2007)

teaching involvement Social pharmacy to undergraduate and postgraduate students placing medicines and pharmacy in a broader context of society and healthcare

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aSSOciate PrOfeSSOr SaraH HOOkBSc(Hons) PhD (Otago) ASI NZFSS


PositionAssociate ProfessorExaminations and Assessments Co-ordinator 2009-2010

research interests• Understanding T cell immune responses and how it is

possible to modulate these responses. T cells play a central role in fighting infections and preventing diseases such as cancer. T cells also play an important part in the development of autoimmune diseases such as diabetes.

• Developing novel vaccine delivery systems• Understanding the role of T cells in the development of type

I diabetes• Modelling T cell immune responses to vaccination • Establishing community pharmacy based influenza

immunisation

Selected refereed Journal articlesGordon, S., Teichmann, E., Young, K., Finnie, K., Rades, T., Hook, S. In vitro and in vivo investigation of thermosensitive chitosan hydrogels containing silica nanoparticles for vaccine delivery. Eur J Pharm Sci 41(2), 360-668, (2010)

Rizwan, S., Dong, Y., Boyd, B., Rades, T., Hook, S. Liquid crystalline systems of phytantriol and glyceryl monooleate containing a hydrophilic protein: characterisation, swelling and release kinetics. J Pharm Sci, 98 (11), 4191-4204, (2009)

Graf, A., Rades, T., Hook, S. Protein delivery using nanoparticles based on microemulsions with different structure types: Optimisation and in vivo evaluation. Eur J Pharm Sci, 37: 53-61, (2009)

McBurney, W., Lendemans, D., Hennessy, T., Myschik, J., Rades, T., Hook, S. In vivo activity of cationic immune stimulating complexes (ISCOMs) Vaccine, 26, 4549-4556, (2008)

teaching involvementImmunology and infectious diseases to undergraduate students

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Dr Simon Horsburgh*BA(Hons) MA (Cant) PhD (Otago)

PositionResearch Fellow

research interests• Public health• Epidemiological methods• Use of routinely-collected data in research• Technology and pharmacy practice• Equity issues in medicines access• Measurement of socio-economic deprivation

Selected refereed Journal articlesFeyer, A-M., Langley, J., Howard, M., Horsburgh, S., Wright, C., Alsop, J., Cryer, P.C. The work-related fatal injury study: Numbers, rates and trends of work-related fatal injuries in New Zealand 1985-1994. New Zealand Medical Journal, 114, 6-10 (2001)

Horsburgh, S., Feyer, A-M., Langley, J. Fatal work-related injuries in the agricultural production and services to agricultural sectors of New Zealand, 1985-1994. Occupational and Environmental Medicine, 58(8), 489-495 (2001)

Langley, J., Feyer, A-M., Wright, C., Alsop, J., Horsburgh, S., Howard, M., Cryer, P.C. Work-related fatal injuries in New Zealand: Can a reliable electronic work-related fatality `register’ be established? Journal of Occupational Health and Safety - Australia and NZ, 16(2), 145-153 (2000)

teaching involvementP-values and confidence intervals to both undergraduate and postgraduate students.

*Now staff member of Department of Preventive & Social Medicine, Dunedin School of Medicine

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Dr arlene McDOwellBSc(Hons) MSc (Melb) PhD (Otago)



research interests• Biological activity of antioxidant phytochemicals• Veterinary pharmaceutics• Application of pharmaceutical drug delivery to wildlife• Polymeric nanoparticles for delivery of peptides and proteins• Oral delivery of biocontrol agents to the brushtail possum• In vivo evaluation of formulations

Selected refereed Journal articles Kafka, A.P., Kleffmann, T., Rades, T., & McDowell, A. (2010). Characterisation of peptide polymer interactions in poly(alkylcyanoacrylate) nanoparticles: A mass spectrometric approach. Current Drug Delivery, 7, 208-215

McDowell, A. & McLeod, B. (2007). Physiology of the brushtail possum gastrointestinal tract: Relationship to the human gastrointestinal tract. Advanced Drug Delivery Reviews 59, 1121-1132.

McDowell, A., McLeod, B.J., Rades, T., & Tucker, I.G. (2006). Application of pharmaceutical drug delivery for biological control of the common brushtail possum in New Zealand: a review. Wildlife Research, 33, 679-689.

McDowell, A., Nicoll, J.J., McLeod, B.J., Tucker, I.G., Davies, N.M. Gastrointestinal transit in the common brushtail possum measured by gamman scintigraphy. International Journal of Pharmaceutics, 302, 125-132 (2005)

teaching involvement Co-ordinator for drug delivery systems paperDrug delivery systems to undergraduate studentsCo-ordinator of the Summer Studentship Programme

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aSSOciate PrOfeSSOr natalie MeDlicOttBPharm PhD (Otago) RegPharmNZ MPS


PositionSenior Lecturer, 2009 Associate Professor, appointed 2010Associate Dean, Admissions and Undergraduate Programmes 2009-2010

research interests• Formulation and drug delivery:• Parenteral delivery systems for small molecule drugs and

proteins• Topical delivery systems for administration of growth factors

to wounds; and oral cavity• Clinical Pharmacy – Application of bioanalytics for

pharmacokinetic/pharmacodynamic studies of drugs administered with conventional and novel drug delivery systems

Selected refereed Journal articles Wu, Z., Tucker, I.G., Yang, L., McSporren, K., Razzak, M., Medlicott, N.J. Tissue compatibility and pharmacokinetics of three potential subcutaneous injectables for low pH drug solutions. J. Pharm. Pharmacol. (2010)

Sherwin, C.M.T., McCaffrey, F., Broadbent, R., Reith, D.M., Medlicott, N.J. Discrepencies between predicted and observed rates of intravenous gentamicin delivery for neonates. Journal of Pharmacy and Pharmacology, 61, 465-471 (2009)

Reith, D., Medlicott, N.J., De Silva, R.K., Yang, L., Hickling, J., Zacharias, M. Simultaneous modelling of the Michaelis-Menten kinetics of paracetamol sulphation and glucuronidation. Clinical and Experimental Pharmacology and Physiology, 36, 35-42 (2009)

Tantipolphan, R., Rades, T., Medlicott, N.J. Swelling lecithin: cholesterol implants for the controlled release of proteins. Journal of Liposome Research, 19, 37-48 (2009)

teaching involvementPhysical pharmacy, drug delivery systems and quality use of medicines to undergraduate students

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Dr MOMir MikOv *MSc MD PhD (Novi Sad)


research interests• Research on drug metabolism in vivo and in vitro• Development of analytical methods for metabolic studies• Design and clinical investigation (bioequivalence and

controlled clinical trials)• Therapeutic applications of bile acids

Selected refereed Journal articles Al-Salami, H., Butt, G., Tucker, I., Mikov, M. Influence of the semisynthetic bile acid MKC on the ileal permeation of gliclazide in vitro in healthy and diabetic rats treated with probiotics. Methods & Findings in Experimental & Clinical Pharmacology, 30(2), 107-13 (2008)Posa, M., Kevresan, S., Mikov, M., Cirin-Novta, V., Kuhajda, K. Critical micellar concentrations of keto derivatives of selected bile acids: Thermodynamic functions of micelle formation. Colloids Surfaces B: Biointerfaces, 64(2), 151-61 (2008)

Mikov, M., Boni, N.S., Al-Salami, H., Kuhajda, K., Kevresan, S., Golocorbin-Kon, S., Fawcett, J.P. Bioavailability and hypoglicaemic activity of the semisynthetic bile acid 3alfa, 7alfa-dihydroxy-12-oxo-5beta-cholanate, in healthy and diabetic rats. European Journal of Drug Metabolism and Pharmacokinetics, 32 (1), 7-12 (2007)

Book Mikov, M. & Fawcett, J.P. (Eds) Bile acids: Chemistry, biosynthesis, analysis, chemical and metabolic transformations and pharmacology. Geneva, Switzerland: Mediset Publisher, 226p (2007)

*Resigned from staff in March 2010

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PrOfeSSOr Pauline nOrriSBA MA (Cant) PhD (Well)


PositionChair in Social Pharmacy

research interests• Health services research• Pharmacy practice research• Qualitative and quantitative methods

Selected refereed Journal articlesAaltonen, K., Ragupathy, R., Tordoff, J., Reith, D., Norris, P. The impact of pharmaceutical cost containment policies on the range of medicines available and subsidised in Finland and New Zealand, Value in Health 13(1) 148-156 (2009)

Norris, P., Fa’alau, F., Va’ai , C., Churchward, M., Arroll, B. Navigating between illness paradigms: treatment-seeking by Samoan people in Samoa and New Zealand, Qualitative Health Research 19(10): 1466-1475 (2009)

Tordoff, J.M., Norris, P., Reith, D.M. Price management and its impact on hospital pharmaceutical expenditure and the availability of medicines in New Zealand hospitals. Value in Health, 11(7), 1214-1226 (2008)

Balakrishnan, K., Tordoff, J., Norris, P., Reith, D. Establishing a baseline for the monitoring of medicines availability for children in the UK: 1998-2002. British Journal of Clinical Pharmacology, 63(1), 85-91 (2007)

Teaching InvolvementPharmacy practice, sociology and research methods to undergraduate and postgraduate students

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MrS anita OlivierDipPharm (Natal) PGCertTertT (Otago) RegPharmNZ MPS



teaching involvementDispensing and patient assessment to undergraduate students

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Dr aarti Patel*MPharm (Durban-W) PhD (Otago)

PositionLecturer

research interests• Access to essential medicines: • Drug supply management • Pricing of essential medicines • Rational use and quality

Selected refereed Journal articles Patel, A., Gauld, R., Norris, P., Rades, T. Quality of Medicines: Perceptions of the South African Consumer. International Journal of Pharmacy Practice, 16(2), 20 -21 (2008)

Patel, A., Norris, P., Gauld, R. Generic medicines and their use: Perceptions of South African consumers. The New Zealand Medical Journal, 120(1262), 7-8 (2007)

Kishuna (Patel), A. Drug Pricing Survey in KwaZulu-Natal. Essential Drugs Monitor, 32, 4-5 (2003)

Kishuna (Patel), A., Smit, J. Assessing Pharmaceutical Services at primary care clinics in KwaZulu-Natal: An indicator-based approach. International Journal of Pharmacy Practice, 7 (3), 143-147 (1999)

teaching involvementPharmacotherapy to postgraduate nursesCo-ordinator of the Medicines Management modulePatient assessment and therapeutics to undergraduate students

*Resigned from staff in November 2010

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MS aynSley PeterSOnBPharm PGCertPharm (Otago) RegPharmNZ MPS



teaching involvementAseptic dispensing, therapeutics and patient assessment to undergraduate studentsHospital Placements Programme Co-ordinator

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PrOfeSSOr tHOMaS raDeSBSc(Pharm) (Hamburg) PhD (Braunschweig)


PositionChair in Pharmaceutical SciencesAssociate Dean, Research

research interests• Formulation and drug delivery• Colloidal delivery systems for bioactives• Physical characterisation of the solid and liquid crystalline

state of matter• The solid state of drugs and dosage forms

Selected refereed Journal articles Müllertz, A., Ogbonna, A., Ren, S., Rades, T. New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs. Journal of Pharmacy and Pharmacology, 62, 1622-1636 (2010)

Chieng, N., Aaltonen, J., Saville, D., Rades, T. Physical characterization and stability of amorphous indomethacin and ranitidine hydrochloride binary systems prepared by mechanical activation. European Journal of Pharmaceutics and Biopharmaceutics, 71, 47 – 54 (2009)

Graeser, K., Strachan, C.J, Patterson, J.E., Gordon, K.C., Rades. T. Physico-chemical properties and stability of two differently prepared amorphous forms of simvastatin. Crystal Growth & Design, 8, 128-135 (2008)

Zeitler, J.A., Shen, Y., Baker, C., Taday, P.F., Pepper, M., Rades, T. Analysis of coating structures and interfaces in solid oral dosage forms by three dimensional terahertz pulsed imaging. Journal of Pharmaceutical Sciences, 96, 330-340 (2007)

teaching involvementPharmaceutics, pharmaceutical technology, formulation and drug delivery to undergraduate students

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Dr DOrOtHy SavilleBPharm(Hons) MSc PhD (Syd)



research interests• Solid state pharmaceutics• Formulation and drug delivery• Pharmacokinetics and drug metabolism

Selected refereed Journal articles Chieng, N., Aaltonen, J., Rades, T., Saville, D. Physical characterization and stability of amorphous indomethacin and ranitidine hydrochloride binary systems prepared by mechanical activation. European Journal of Pharmaceutics and Biopharmaceutics 71(1), 47-54 (2009)

Chieng, N., Hubert, M., Saville, D., Rades, T., Aaltonen, J. Formation Kinetics and stability of Carbamazepine/Nicotinamide Cocrystals prepared by Mechanical Activation. Journal of Crystal Growth and Design, 9 (5), 2377-2386 (2009)

Chieng N, Rehder S, Saville D, Rades T, Aaltonen J. Quantitative solid-state analysis of three solid forms of ranitidine hydrochloride in ternary mixtures using Raman spectroscopy and X-ray powder diffraction. Journal of Pharmaceutical and Biomedical Analysis 15, 49(1),18-25 (2009)

Zhang, F., Tian, F., Saville, D.J., Rades, T. Influence of Particle Size and Preparation methods on the Physical and Chemical Stability of Amorphous Simvastatin. European Journal of Pharmaceutics and Biopharmaceutics 71(1), 64-70 (2009)

teaching involvementPharmacokinetics and pharmaceutics to undergraduate and postgraduate students

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Mr DaviD ScHMiererBAppSci (Swinburne) MAACB CChem MRACI MRSC


PositionSenior Teaching Fellow

research interests• Antimicrobials, antibiotics• Plant drug analysis• Plant hormone analysis• Bioactivity screening

Selected refereed Journal articles Hee Ji Lee, Rosmary D. Waller, Simon Stebbings, John Highton, David A. Orlovich, David Schmierer and J. Paul Fawcett, “The effects of an orally administered probiotic on sulfasalazine metabolism in individuals with rheumatoid arthritis: a preliminary study” International Journal of Advances in Rheumatology, 13(1), 48-54 (2010)

Schep, L., Schmierer, D. & Fountain, J. Veratrum poisoning in humans – a review. Toxicology Review, 25(2), 73-78 (2006)

teaching involvementPharmaceutical analysis and medicinal chemistry to undergraduate and postgraduate students

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Dr clare StracHanBPharm PhD (Otago) RegPharmNZ



research interests• Preparation and characterisation of solid state drugs and

dosage forms• Solid state behaviour• Process analytical technology applications of Raman,

infrared, near-infrared, and terahertz spectroscopies• In situ analysis of drugs and dosage forms during dissolution

testing using Raman spectroscopy and coherent anti-Stokes Raman scattering (CARS) microscopy

• Design of experiments and multivariate analysis• Quantum chemical calculations

Selected refereed Journal articles Windbergs, M., Haaser, M., McGoverin, C.M., Gordon, K.C., Kleinebudde, P., Strachan, C.J. Investigating the relationship between drug distribution in solid lipid matrices and dissolution behavior using Raman spectroscopy and mapping. Journal of Pharmaceutical Sciences 99(3),1464 – 1475 (2010)

Windbergs, M., Jurna, M., Offerhaus, H.L., Herek, J.L., Kleinebudde, P., Strachan, C.J. Chemical imaging of oral solid dosage forms and changes upon dissolution using coherent anti-Stokes Raman scattering microscopy. Analytical Chemistry 81(6), 2085–2091 (2009)

Heinz, H., Savolainen, M., Rades, T., Strachan, C.J. Quantifying ternary mixtures of different solid state forms of indomethacin by Raman and near infrared spectroscopy. European Journal of Pharmaceutical Sciences, 32, 182-192 (2007)

Zeitler, J., Kogermann, K., Rantanen, .J, Rades, T., Taday, P.F., Pepper, M., Aaltonen, J., Strachan, C, J. Drug hydrate systems and dehydration processes studied by terahertz pulsed spectroscopy. International Journal of Pharmaceutics, 334, 78-84 (2007)

teaching involvementQuality of medicines paper to undergraduate students

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Dr June tOrDOffBPharm(Hons) MPharm (Brad) PhD (Otago) MRPharmS RegPharmNZ MPS



research interests• Medicines use in older people• Access to medicines for adults and children• Quality use of medicines• Medicines policy and pharmacoeconomics

Selected refereed Journal articlesTordoff, J.M., Bagge, M.L., Gray, A.R., Campbell, A.J., Norris, P.T. Medicine-taking practices in community-dwelling people aged > or =75 years in New Zealand. Age Ageing 39(5), 574-80 (2010)

Ragupathy, R., Aaltonen, K., Tordoff, J., Norris, P., Reith, D. Access to Children’s medicines in the United Kingdom Australia and New Zealand in 1998, 2002 and 2007. Pharmacy World and Science 33(3), 386-393 (2010)

Tordoff, J., Simonsen, K., Thomson, W.M., Norris, P.T. “It’s just routine.” A qualitative study of medicine-taking amongst older people in New Zealand. Pharm World Sci; 32 (2), 154-161 (2010)

Aaltonen, K., Ragupathy, R., Tordoff, J., Norris, P., Reith, D. The Impact of Pharmaceutical Cost Containment Policies on the Range of Medicines available and subsidised in Finland and New Zealand. Value in Health 13(11), 148-156 (2010)

teaching involvementClinical pharmacy to undergraduate students

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PrOfeSSOr ian tuckerBPharm(Hons) PhD (Qld) RegPharmNZ MPS FNZCP FCRS


PositionChair in Pharmaceutical Sciences

research interestsMy research aims to improve drug therapy through appropriate formulation and delivery of medicines. It combines physical and biological sciences to optimally formulate drugs for human and veterinary uses. I am interested in fundamental understanding of formulations and their behavior in the biological environment and the mechanisms by which bioactives cross, or are prevented from crossing, biological membranes (e.g. blood brain barrier, blood milk barrier).

Specific projects:• Delivery of drugs to the brain via the blood brain barrier and

the potential use of novel bile salts and nano-delivery systems• Optimal delivery of drugs for the treatment/prevention of

mastitis in dairy cattle and the role of the blood milk barrier• Polymeric matrix delivery systems and their changes on

thermal treatment• Nano-systems for delivery of peptides via the oral route

Selected refereed Journal articles Yang, L., Zhang, H., Fawcett, J.P., Mokov, M., Tucker, I.G. Effect of bile salts on the transport of morphine-6-glucuronide in rat brain endothelial cells. Journal of Pharmaceutical Sciences, (2010)

Chatterjee, L., Rades, T., Tucker, I.G. Mechanical properties of excipients do not affect polymer matrix formulation. International Journal of Pharmaceutics, 384(1/2), 87-92 (2010).

Yang, L., Zhang, H., Mikov, M., Tucker I.G. Physicochemical and Biological Characterization of Monoketocholic Acid, a Novel Permeability Enhancer. Molecular Pharmaceutics, 6(2), 448-456 (2009)

teaching involvementPharmaceutics, formulation and drug delivery to undergraduate students

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Dr JOel tynDallBSc(Hons) (Monash) PhD (Qld)



research interests• Molecular modeling and drug design: • Molecular recognition and molecular interactions • Proteases: their endogenous and exogenous ligands • GPCRs: agonists and antagonists • Homology modeling of drug targets • Structure and analogue based drug design • X-ray crystallographic analysis of enzyme inhibitor

complexes • Small molecule database mining for drug leads • Pharmacophore mapping, analysis and QSAR • Investigation of small molecule (and peptide) structure

Selected refereed Journal articles Sawant, P.M., Tyndall, J.D.A., Holland, P.T., Peake, B.M., Mountfort, D.O., Kerr, D.S. In vivo seizure induction and affinity studies of domoic acid and isodomoic acids D, E and F. Neuropharmacology, Apr 20 59, 129-138 (2010)

Brown, K.K., Blaikie, F.H., Smith, R.A.J., Tyndall, J.D.A., Lue, H., Bernhagen, J., Winterbourn, C.C., Hampton, M.B. Direct Modification of the Pro-Inflammatory Cytokine MIF by Dietary Isothiocyanates. J Biol Chem 284(47), 32425-32433 (2009)

Westphal, D., Ledgerwood, E.C., Tyndall, J.D.A., Ueda, N., Fleming, S.B., Mercer, A.A., Orf virus protein ORFV125 inhibits a subset of BH3-only proteins, and also binds and neutralizes active Bax. Apoptosis, Sep 25 14(11), 1317–1330 (2009)

Lamping, E., Ranchod, A., Nakamura, K., Tyndall, J.D., Niimi, K., Holmes, A.R., Niimi, M., Cannon, R.D., ABC1p is a multidrug efflux transporter that tips the balance in favour of innate azole resistance in Candida krusei. Antimicrob Agents Chemother. 53(2), 354-69 (2009)

Teaching InvolvementMedicinal Chemistry to undergraduate and postgraduate students

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Mr JaMeS winDleDipPharm (CIT) DipBusAdmin MBS (Massey) BPharm MClinPharm PGDipTertT

(Otago) MNZCP RegPharmNZ MPS



teaching involvementPharmacoeconomics, pharmacy management and pharmacy practice to undergraduate studentsCommunity Pharmacy Placement Co-ordinator

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Dr Helen winterBPharm(Hons) Otago NZ, PhD (Pharmaceutics, University of Washington, Seattle,

USA), MPS, RegPharmNZ


PositionSenior Lecturer in Clinical Pharmacology

research interests• Discovery and development of new drugs with focus on

neglected diseases• Characterizing PKPD relationships of drugs with respect to

efficacy and safety• Optimising drug therapy with respect to drug and dose

selection• PK/PD model development for TB drugs and TB biomarkers

Selected refereed Journals articlesWinter, H.R., Earley, W.E., Hamer-Maansson, J.E., Smith, M.A. The Steady-state Pharmacokinetics, Safety and Tolerability Profiles of Quetiapine in Pediatric and Adult Patients with Psychotic Disorders. Journal of Child and Adolescent Psychopharmacology 18(1) 81-98, (2008)

Winter, H.R., DeVane, C.L., Figueroa, C., Ennis, D.J., Hamer, J.E., Smith, M.A. Open-label steady-state pharmacokinetic drug interaction study on co-administered quetiapine fumarate and divalproex sodium in patients with schizophrenia, schizoaffective disorder, or bipolar disorder. Human Psychopharmacology 22(7), 469-476 (2007)

teaching involvementClinical pharmacy and pharmacology to undergraduate students Endocrine Module Co-ordinator

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Dr Hu ZHangMD (Anhui) PhD (Otago)


PositionSenior Research Fellow

research interests• Biopharmaceutical analysis, pharmacokinetics, drug

metabolism, toxicity, drug discovery and development

• Preclinical study of bioactives, especially anti-aging agents in various animal models and the extrapolation of these results to humans, uptake of drugs into the brain, and the transport and metabolism of xenobiotics

Selected refereed Journal articles Li, Y., Zhang, H., Fawcett, J.P., Tucker, I.G. Effect of cyclosporin A on the pharmacokinetics of mitoquinone (MitoQ10), a mitochondria-targeted antioxidant, in rat. Asian Journal of Pharmaceutical Sciences 5(3), 106-113 (2010)

Gupta, N., Zhang, H., Liu, P. Behavioral and neurochemical effects of acute putrescine depletion by difluoromethylornithine in rats. Neuroscience 161, 691-706 (2009)

Liu, P., Chary, S., Devaraj, R., Jing, Y., Darlington, C.L., Smith, P.F., Tucker, I.G., Zhang, H. Effects of aging on agmatine levels in memory-associated brain structures. Hippocampus 18, 853-856 (2008)

Li, Y., Zhang, H., Fawcett, J.P., Tucker, I.G. Quantitation and metabolism of mitoquinone, a mitochondria-targeted antioxidant, in rat by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry 21, 1958-1964 (2007)

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TEachINg ProgrammES 2009 | 2010

BacHelOr Of PHarMacy Degree (BPHarM) 2010

Associate Dean, Admissions & Undergraduate Programmes: Dr Natalie Medlicott Pre-QUM Co-ordinator: Dr Dorothy SavilleQUM Co-ordinator: Mr David Schmierer

ScHeDule

level Paper Short title Points

First Year BIOC192 Foundations of Biochemistry 18 CELS191 Cell and Molecular Biology 18 CHEM191 The Chemical Basis of Biology and Human Health 18 HEAL192 Foundations of Epidemiology 18 HUBS191 Human Body Systems 1 18 HUBS192 Human Body Systems 2 18 PHSI191 Biological Physics 18 (Common Health Sciences First Year)

Second Year PHCY219 Microbiology and Immunology (for BPharm) 12 Dr Judith Bateup (Department of Microbiology) PHCY231 Biochemistry (for BPharm) 7 Dr Alan Carne (Department of Biochemistry) PHCY251 Physiology (for BPharm) 17 Dr Phil Sheard (Department of Physiology) PHCY254 Physical Pharmacy A 12 Professor Thomas Rades PHCY255 Physical Pharmacy B 12 Dr Dorothy Saville PHCY256 Biopharmaceutical Chemistry 12 Mr David Schmierer PHCY258 Introduction to Drug Action 12 Associate Professor Paul Fawcett PHCY259 Quality of Medicines 12 Dr Clare Strachan PHCY263 Principles of Pharmacy Practice 24 Dr Susan Heydon

Third Year PHCY315 Human Disease 12 Dr Noelyn Hung (Department of Pathology) PHCY340 Essentials of Drug Action 12 Mr Martin Le Nedelec (Department of Pharmacology) PHCY342 Drug Delivery Systems 12 Dr Arlene McDowell PHCY343 Drug Disposition and Pharmacokinetics 12 Dr Dorothy Saville

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PHCY344 Professional Pharmacy Practice A 12 Professor Pauline Norris PHCY345 Quality Use of Medicines A 50 Mr David Schmierer Gastrointestinal Disorders Module Dr June Tordoff Infectious Diseases Module Associate Professor Sarah Hook Respiratory Disorders Module Professor Stephen Duffull Endocrine Disorders Module Associate Professor Paul Fawcett Cardiovascular Module Mr David Schmierer PHCY346 Professional Pharmacy Practice B 10 Mr James Windle

Fourth Year PHCY470 Elective Study 12 Dr James Green PHCY471 Quality Use of Medicines B 46 Associate Professor Sarah Hook Oncology & the Immunocompromised Patient Module Associate Professor Sarah Hook Reproduction Module Dr Rhiannon Braund Musculoskeletal Disorders & Pain Module Dr Joel Tyndall PHCY472 Professional Pharmacy Practice C 16 Professor Pauline Norris PHCY473 Quality Use of Medicines C 46 Dr June Tordoff Central Nervous System Disorders Module Dr Dorothy Saville Dermatology Module Professor Thomas Rades Haematology/Coagulation Module Mr Hesham Al-Sallami Special Populations Module Dr Carolyn Coulter Medicines Management Module Ms Aynsley Peterson

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POStgraDuate PrOfeSSiOnal PrOgraMMeS

Associate Dean, Postgraduate Professional Programmes: Professor Stephen Duffull

Master of clinical Pharmacy (MclinPharm)The degree may be achieved either:

by passing PHCX506 and PHCX512, and submitting a research dissertation (PHCX590) OR by passing PHCX506 and submitting a thesis (PHCY5A) having previously passed PHCX512.

PHCX506 Research Methods 30 Professor Pauline Norris PHCX512 Advanced Clinical Pharmacy 30 Professor Stephen DuffullPHCX590 Dissertation 30 Professor Stephen DuffullPHCY5A Thesis 90 Professor Stephen Duffull

Postgraduate Diploma in clinical Pharmacy (PgDipclinPharm)The diploma may be achieved by passing any four of PHCX522, PHCX523, PHCX524, PHCX541, PHCX542; or by passing PHCX512, PHCX525, PHCX541, PHCX542.

PHCX522 Applied Clinical Pharmacy 1 30 Dr Linda BryantPHCX523 Applied Clinical Pharmacy 2 30 Professor John MurphyPHCX524 Pharmacoeconomics and Drug Evaluation 30 Ms Alison DaviesPHCX525 Core Clinical Pharmacy 30 Dr Linda Bryant/ Professor John MurphyPHCX541 Medicines Information 30 Mr David WoodsPHCX542 Medicines Management 30 Mr David Woods

Postgraduate certificate in Pharmacy (PgcertPharm)The programme shall consist of an approved paper or papers to the value of 60 points, which must be as specified in the schedule of endorsed options if the certificate is to be endorsed in an area of specialisation.

Endorsed Option Medicines Management (PGCertPharm (MEMA))

PHCX541 Medicines Information 30 Mr David WoodsPHCX542 Medicines Management 30 Mr David Woods

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reSearcH-BaSeD Degree PrOgraMMeS

Associate Dean, Research: Professor Thomas Rades

Doctor of Philosopy (PhD)The degree of Doctor of Philosophy is awarded on the basis of the submission of a thesis. The thesis should give evidence of the candidate’s ability to carry out research, that the candidate has shown originality and independence, and that the candidate has made a significant contribution to knowledge in the particular field. It is expected that some of the work in the thesis would be worthy of publication. The research should be of a kind which a diligent and competent student might reasonably be expected to complete within three years of full-time study.

Master of Pharmacy (MPharm)The degree may be awarded in any area of Pharmacy.

The degree may be achieved by passing PHCY501-504, and submitting a thesis (PHCY5). In place of one of the papers PHCY501-504, candidates may take either PHCX506 or any two of HASX411, HASX412 and HASC413.

Postgraduate Diploma in Pharmacy (PgDipPharm)The degree may be awarded in any area of Pharmacy.

The degree may be achieved by passing PHCY501-504.

PHCY501 Elective Studies 30PHCY502 Elective Studies 30PHCY503 Elective Studies 30PHCY504 Elective Studies 30

Postgraduate certificate in Pharmacy (PgcertPharm)A non-endorsed option has been undertaken by graduate students who complete a 60-point research dissertation (PHCY590) for the award of PGCertPharm.

44

ENrolmENTS IN 2009/2010

unDergraDuate

2009 2010

Year 1 not applicable* not applicable*

Year 2 134 140

Year 3 112 128

Year 4 117 111

*selection into the BPharm programme occurs at the end of the first year

POStgraDuate

courses 2009 2010

Postgraduate Certificate in Pharmacy

Medicines Management 20 28

Research 14 17

Postgraduate Diploma in Clinical Pharmacy 12 10

Master of Clinical Pharmacy 4 5

Postgraduate Diploma in Pharmacy* 0 0

Master of Pharmacy* 0 0

PhD 41 50

*currently not enrolling students into these programmes

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graduaTES IN 2009/2010

Doctor of Philosophy (PhD) Hani AL-SALAMIAnshul AWASTHILipika CHATTERJEEGong CHENMajd DAMEHKristina FERDERBERSarah GORDONKirsten GRAESERLouise HO (awarded Exceptional Thesis status)Alexandra KAFKAHee-Ji LEEAarti PATELShakila RIZWANLin YANG

Postgraduate certificate in Pharmacy (not endorsed)Katja ADENils BRUMMERFeifei FENGAndrew FUSSELLJulia GRIESSINGERMiriam HAASERJohn HANDFORTHKatharina HESSELBACHChristian HILDERBRANTMadlen HUBERTFranziska HUSCHMANNJovis JOYSebastian KAPPJulia KORELLKorbininan LOEBMANNMilena MADRYHimang MUJOOHendrik NIEMANNAynsley PETERSONNora PFISTERPetra PRIEMELVanda SYMONCarl WAGNERMargaret WALSHAnne-Katrin WEISENMAIER

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Master in clinical Pharmacy (MclinPharm) Gillian SWANNICK (Credit)

Postgraduate Diploma in clinical Pharmacy (PgDipclinPharm)Miguel CARBAJAL GUERRERO (Credit)Alexander DE ROO (Distinction)Brendan DUCK (Distinction)Rachel GRAY (Distinction)Zoe HAGENSON (Distinction)Angela HARWOOD (Distinction)Joanna HIKAKA (Distinction)Olivia JOHNSON (Distinction)Quink Che LIU (Distinction)Ngov Jeremy LY (Credit)Jennifer McELROY (Credit)Rajeshni NAIDU (Credit)Jessica NAND (Credit)Catherine OLIVER (Distinction)Adele PETHERICK (Distinction)Paul ROSEMAN (Distinction)Radhika SANDILYA (Distinction)Claire SHEERIN (Distinction)Heshini Sulakshi de SILVA (Credit)Cathryn Julie WELLS (Credit)Felicity WILLIAMSON (Distinction)Kristel YEE (Credit)Mary YOUNG (Credit)

Postgraduate certificate in Pharmacy (endorsed in Medicines Management)Nadine BAILEYHsin-Ning Amy CHAUChia Eng Joanne CHONGQian Yi CHUAHEunice CUPaul DOBSONMichelle FANGJoshua FREEMANAnita FREWReshma GILBERTPatricia HAMMONDIvana JOVICICLisa KREMERHsiang-Yu Johnny LAIKristen LANGFORDHsuan-Yu Jenny LIN

47

Fiona McNABBAnthea MACHINJean-Pierre MEYERJane MOONHong Anh NGUYENLeanna PEACHEYKristen PENNYJoanne ROGERSSara SALMANVidhya SRITHARANJudith TAMBLYNWhiter TANGTessy THOMASJohn THRUPPSala TIKOIMALEYAJulie VICKERSKirsha WOODAdam WRIGHT-ST CLAIRKristel YEEDaniel YIPSarah YOUNGYing Cecina YU

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rESEarch IN ThE School

Although the years 2007/8 saw unprecedented increase in research activity and quality in our School, in the last School of Pharmacy Report (2007 and 2008) I concluded that we were expecting a further significant increase in the research outputs of our academic staff members in the future. Today, I am happy to report that this expectation has indeed been fulfilled. The years 2009/10 have been the most successful for research in the School’s history!

All academic staff members are actively participating in pharmaceutical research. The strong research ethos in the School of Pharmacy has further strengthened our position as a leading research and teaching institution that uses its research to provide and underpin excellence in teaching and learning. The key indicators for success in research over the last two years are:

• an increased number of papers and conference contributions published from staff members of the School;

• an increased number of PhD students involved in research;

• an increased amount of grant money obtained by members of the School;

The School has maintained its role as the leading pharmaceutical research organisation in the country with strong leadership in the areas of Pharmaceutical Sciences, Clinical Pharmacy and Social Pharmacy.

A total number of 161 publications in international peer reviewed journals (up from 146 in the last reporting period) and 221 conference contributions at international and national conferences (up from 212 in the last reporting period) have been produced by our staff. Moreover, publications have once again been in the leading journals, such as Journal of Controlled Release, Molecular Pharmaceutics, Journal of Pharmaceutical Sciences, European Journal of Pharmaceutics and Biopharmaceutics, International Journal of Pharmaceutics and other high impact journals. 15 PhD students graduated in 2009/10. This number is up from 10 in the 2007/8 period. The years 2009/10 have also seen a further increase in postgraduate activity. The School now has 40 PhD students working in all areas of research strength in the School (up from 35 in the last reporting period). The quality of our postgraduate students also meant that the number of University scholarships won by our PhD students has further increased over the last two years. At the same time, the Research Committee of the School has maintained its own postgraduate scholarship programme and put in place many other measures to increase research quality and productivity of our postgraduate students. In 2006 the New Zealand government changed the regulations regarding study fees for international PhD students, enabling them to study at Otago at the domestic fee level. This positive development has created opportunities for students from many different countries to study at the School. At the same time, many of our PhD students also had the opportunity to spend extended periods of their PhD time at highly regarded international research institutions with which we have active collaborations.

49

These very encouraging developments were made possible through over $1.75 million that has been obtained by our staff from very competitive grants (up from $1 million in the last reporting period).

The strategic research goals for the School for the next reporting period are once again to continue to achieve research excellence, to encourage research-informed teaching and to further strengthen our international presence.

Professor thomas radesAssociate Dean, Research

50

rESEarch STaTISTIcS

Publications 2009 2010

Authored Book – Research 2 0

Chapter in Book 0 1

Edited Book – Textbook & Other 0 0

Edited Journal 0 0

Journal – Research Articles 95 66

Journal – Research Other 6 1

Journal – Professional & Non-Research 0 0

Conference Contributions

- Full Paper in Conference Proceedings 14 5

- Published Proceedings and Poster Presentations 48 58

- Verbal Presentation & Other Outputs 66 30

grant funding (approximately) 2009 2010 total

Research GST exclusive $557,852 $132,674 $690,526

Contract funding (2009-2010) $1,378,491

51

currENT PoSTgraduaTE rESEarch STudENTS

PhD

Student Supervisors Topic

AL-SALLAMI Hesham Prof Stephen Duffull Optimising patient care by Assoc Prof Natalie Medlicott individualizing dosages of drugs

ANWAR Muddasir Dr James Green Responses of people to Prof Pauline Norris illness: a comparative study between New Zealand and Pakistan

ARAFAT Mousab Prof Ian Tucker Bilosomes as oral delivery Assoc Prof Paul Fawcett systems for biomolecules and bioavailability enhancers

BAGGE Michael Prof Pauline Norris Medicines in the context of Dr June Tordoff older peoples’ lives Dr Susan Heydon

CHUI Jasper Dr Arlene McDowell Formulation of peptide Prof Ian Tucker fertility control agents for Dr Doug Eckery the brushtail possum in Dr Bernie McLeod New Zealand

FENG Feifei Prof Ian Tucker Delivering drugs through Assoc Prof Paul Fawcett the blood brain barrier Dr Hu Zhang

FOO Lee Prof Stephen Duffull The optimal design of Prof John Eccleston population PFPD studies Dr James McGree

GULATI Abhishek Prof Stephen Duffull Individualisation of anti- Dr Geoff Isbister coagulant dosing

GUZMAN Paulina Assoc Prof Natalie Medlicott Stablisation of protein Dr Stefania Baldursdottir drugs in phospholipid Prof Thomas Rades delivery systems

HAASER Miriam Prof Thomas Rades Chemical analysis using Prof Keith Gordon terahertz pulsed imaging Dr Clare Strachan

HANNING Sara Assoc Prof Natalie Medlicott Oil based Xerostomia Prof Jules Kieser formulations Prof Thomas Rades

HUBERT Madlen Assoc Prof Sarah Hook Formulation and Prof Thomas Rades immunological Assoc Prof David Larsen characterisation of novel carbohydrate containing immune-pharmaceuticals

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HUSCHMANN Franziska Dr Joel Tyndall Elucidation of a new anti- Dr Erwin Lamping cancer drug target Prof Kurt Krause

JAIN Rohit Prof Ian Tucker Formulation and Dr Olaf Bork evaluation of stable penethamate intramuscular injection for treatment of mastitis

KARMWAR Pranav Prof Thomas Rades Investigating solid- Dr Clare Strachan state transformations of Prof Keith Gordon differently prepared amorphous materials in the presence of excipients during storage and dissolution

KEOWN Shirley Prof Pauline Norris Prescription medicines use Dr Simon Horsburgh among Mäori in Gisborne: equity and access

KOJARUNCHITT Assoc Prof Sarah Hook Preclinical studies to Thunjiradasiree Prof Thomas Rades improve potency and practicality of peptide cancer vaccines

KORELL Julia Prof Stephen Duffull Simulation of red blood cell Dr Carolyn Coulter survival and assessment of markers of glycaemic control in diabetic patients with chronic kidney disease

LAGISHETTY Chakradhar Dr Carolyn Coulter Renal function in the Prof Stephen Duffull elderly

LOEBMANN Korbinian Prof Thomas Rades Co-amorphous binary drug Prof Yvonne Perrie mixtures: preparation and Dr Clare Strachan characterization

MD HATAH Ernieda Dr Rhiannon Braund Examining medicine use Dr June Tordoff reviews Prof Stephen Duffull

NGUYEN Albert Dr Joel Tyndall Investigating the Protease Dr Brian Monk tex31

NEUMANN Silke Assoc Prof Sarah Hook Single-shot hydrogel Prof Thomas Rades vaccines: increasing success Dr Roslyn Kemp and decreasing costs of global immunization campaigns

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OU Ellen Dr Arlene McDowell Formulation of Prof Thomas Rades antioxidant phytochemicals Mr David Schmierer from “Sonchus” species

OWENS Katie Assoc Prof Natalie Medlicott Dose individualisation of Assoc Prof David Reith paracetamol in children

PIRAYAVARAPORN Prof Ian Tucker Polymer matrix formation Chompak Prof Thomas Rades in tablets prepared by direct compression

PRIEMEL Petra Dr Clare Strachan Investigations into the Prof Thomas Rades chemical degradation of Dr Holgar Grohganz amorphous drugs and amorphous drug/polymer mixtures

RAGUPATHY Rajan Prof Pauline Norris Access to medicine in New Assoc Prof David Reith Zealand, Australia, the Dr June Tordoff United Kingdom and the Unites States

RATTANAPAK Teerawan Assoc Prof Sarah Hook Transdermal delivery of Prof Thomas Rades peptide vaccines

SALIS Emma Assoc Prof Natalie Medlicott Insulin pharmacokinetics Assoc Prof David Reith and pharmacodynamics (PKPD) in paediatrics and neonates

SHANKAR Madhu Dr Joel Tyndall Riboflavin biosynthesis Dr Brian Monk pathway as an antifungal drug target

SURWASE Sachin Dr Dorothy Saville Stabilisation of drug in a Dr Clare Strachan suspension in order to metastable form in achieve higher bioavailability

THOMAS Nicky Prof Thomas Rades Optomisation and in-vitro/ Prof Anette Muellertz in-vivo correlation of lipid- based drug delivery systems

TONG Alfred Dr Rhiannon Braund Use and disposal of Assoc Prof Barrie Peake pharmaceuticals in New Zealand

VOLPE Nicolo Dr Olaf Bork Particle engineering for the Prof Ian Tucker pharmaceutical industry

54

VOS Friederike Prof Robert Walker Insulin – insulin resistance, Dr Carolyn Coulter oxidative stress and markers of glycaemic control in chronic kidney disease

WRIGHT Daniel Prof Stephen Duffull Individualisation of Prof Nick Holford warfarin treatment

ZADEHVAKILI Bettina Assoc Prof Paul Fawcett Design, synthesis Dr Gregory Giles and structure-activity relationshps of some novel glutathione peroxiodase mimics

ZEESHAN Farrukh Assoc Prof Natalie Medlicott Investigating protein Assoc Prof Lene Jorgensen stabilization in controlled release lipid matricesZHANG Fang Dr Dorothy Saville Discovery and Prof Thomas Rades characterization of pharmaceutical polyamorphs

55

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Edu

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Fo

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59

PublIcaTIoNS

eDiteD BOOkS & BOOk cHaPterS – reSearcH

Heydon, S. Modern medicine and international aid: Khunde Hospital, Nepal, 1966-1998. Hyderabad, India: Orient BlackSwan, 380p (2009)

Lovelock, K., & Leopold, T. The political economy of temporary migration: Seasonal workers, tourists and sustaining New Zealand’s labour force. In J. Mosedale (Ed.), Political economy and tourism: A critical perspective . Routledge. (2010)

Perrie, Y., Rades, T. FASTtrack: Pharmaceutics - Drug Delivery and Targeting. Pharmaceutical Press ISBN 978 0 85369 762 6 (2010)

JOurnal – reSearcH & OtHer articleS

Aaltonen, J., Rades, T. Towards physio-relevant dissolution testing: the importance of solid state analysis in dissolution. Dissolution Technologies, 47-54 (2009)

Aaltonen, K., Ragupathy, R., Tordoff, J., Reith, D., Norris, P. The impact of pharmaceutical cost containment policies on the range of medicines available and subsidized in Finland and New Zealand. Value in Health, 13(1), 148-156 (2010)

Al-Salami, H., Butt, G., Tucker, I., Fawcett, P.J., Golocorbin-Kon, S., Mikov, I. & Mikov, M. Gliclazide reduces MKC intestinal transport in healthy but not diabetic rats. European Journal of Drug Metabolism and Pharmacokinetics, 34, 43-50 (2009)

Al-Sallami, H., Jordan, S., Ferguson, R., Medlicott, N.J., Schollum, J., Duffull, S.B. Current enoxaparin dosing guidelines have dubious credibility [Viewpoint]. New Zealand Medical Journal, 123(1313), (2010)

Al-Sallami, H.S., Kumar, V.V.P., Landersdorfer, C.B., Bulitta, J.B., Duffull, S.B. The time course of drug effects. Pharmaceutical Statistics, 8, 176-185 (2009)

Al-Sallami, H.S., Barras, M.A., Green, B., Duffull, S.B. Routine plasma anti-Xa monitoring is required for low-molecular-weight heparins. Clinical Pharmacokinetics, 49(9), 567-571 (2010)

Alleso, M., Chieng, N., Rehder, S., Rantanen, J., Rades, T., Aaltonen, J. Enhanced dissolution rate and synchronized release of drugs in binary systems through formulation: Amorphous naproxen-cimetidine mixtures prepared by mechanical acitviation. Journal of Controlled Release, 136, 45-53 (2009)

Baeumer, B., Chatterjee, L., Hinow, P., Rades, T., Radunskaya, A., Tucker, I. Predicting the drug release kinetics of matrix tablets. Discrete and Continuous Dynamical Systems Series B, 12, 261-277 (2009)

Barras, M., Duffull, S., Atherton, J., Green, B. Modelling the occurrence and severity of enoxparin-indused bleeding and bruising Events. British Journal of Clinical Pharmacology, 68, 700-711 (2009)

60

Barras, M.A., Duffull, S.B., Atherton, J.J. Green, B. Individualized dosing of Enoxaparin for subjects with renal impairment is superior to conventional dosing at achieving therapeutic concentrations. Therapeutic Drug Monitoring, 32(4), 482-488 (2010)

Bork, O. Is there a need for further research on intramammary drug delivery systems for treating bovine mastitis? Controlled Release Society Newsletter, 26(2), 14-15 (2009)

Boyd, B.J., Dong, Y., Rades, T. Nonlamellar liquid crystalline nanostructured particles: advances in materials and structure determination. Journal of Liosome Research, 19, 12-28 (2009)

Braund, R., Gn, G., Matthews, R. Investigating unused medications in New Zealand. Pharmacy World and Science, 31, 664-669 (2009)

Braund, R., Hook. S.M., Greenhill, N., Medlicott, N. Distribution of fibroblast growth factor-2 (FGF-2) within model excisional wounds following topical application. Journal of Pharmacy & Pharmacology, 61, 193-200 (2009)

Braund, R., Peake, B.M., Shieffelbien, L. Disposal practices for unused medications in New Zealand. Environment International, 35, 952-955 (2009)

Braund, R., Furlan, H.M., George, K., Havell, M.M.A., Murphy, J.L., West, M.K. Interventions performed by New Zealand community pharmacists while dispensing prescriptions medications. Pharmacy World and Science, 32, 22-25 (2010)

Brown, K., Blaikie, F., Smith, R., Tyndall, J., Lue, H., Bernhagen, J., Winterbourn, C., Hampton, M. Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates. The Journal of Biological Chemisty, 284, 32425-32433 (2009)

Bulitta, J.B., Duffull, S.B., Landersdorfer, C.B., Kinzig, M., Holzgrabe, U., Stephan, U., Drusano, G.L. & Sorgel, F. Comparison of the pharmacokinetics and pharmacodynamic profile of carumonam in cystic fibrosis patients and healthy volunteers. Diagnostic Microbiology and Infectious Disease, 65, 130-141 (2009)

Bushby, S.K., Anderson, R.J., Braund, R. New Zealand parents’ perceptions of the use and safety of over the counter liquid analgesics. Pharmacy Practice, 8(4), 238-242 (2010)

Capstick, S., Norris, P., Sopoaga, F., Tobata, W. Relationships between health and culture in Polynesia – A review. Social Science & Medicine, 68, 1341-1348 (2009)

Chao, Z., Wang, L., Guan, X., Fawcett, J.P., Zhao, L., Sun, Y., GU, J. Rapid determination of ranitidine in human plasma by liquid chromatography-tandem mass spectrometry and its application to a clinical pharmacokinetic study. Chemical Research Chinese Universities, 26(6), 910-914 (2010)

Chatterjee, L., Rades, T., Tucker, I.G. Mechanical properties of excipients do not affect polymer matrix formation. International Journal of Pharmaceutics, (384), 87-92 (2010)

Chen, G., Fawcett, J.P., Mikov, M., Tucker, I.G. Monoketocholate can decrease transcellular permeation of methotrexate across caco-2 cell monolayers and reduce its intestinal absorption in rat. Journal of Pharmacy and Pharmacology, 61, 953-959 (2009)

61

Chen, G., Fawcett, J.P., Mikov, M., Tucker, I.G. Simultaneous determination of methotrexate and its polyglutamate metabolites in Caco-2 cells by liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 50, 262-266 (2009)

Chieng, N., Aaltonen, J., Saville, D., Rades, T. Physical characterization and stability of amorphous indomesthancin and ranitidine hydrochloride binary systems prepared by mechanical activation. Journal of Pharmaceutical and Biomedical Analysis, 71, 47-54 (2009)

Chieng, N., Hubert, M., Saville, D., Rades, T., Aaltonen, J. Formation kinetics and stability of carbamazepine – Nicotinamide cocrystals prepared by mechanical activation. Crystal Growth & Design, 9, 2377-2386 (2009)

Chieng, N., Rehder, S., Saville, D., Rades, T., Aaltonen, J. Quantitative solid-state analysis of three solid forms of ranitidine hydrochloride in ternary mixtures using Raman spectroscopy and x-ray powder diffraction. Journal of Pharmaceutical and Biomedical Analysis, 49, 18-25 (2009)

Daines, A.M., Greatrex, B.W., Hayman, C.M., Hook, S.M., McBurney, W.T., Rades, T., Rendle, P.M., Sims, I.M. Mannosylated saponins based on oleanolic and glycyrrhizic acids. Towards synthetic colloidal antigen delivery systems. Bioorganic & Medicinal Chemistry, 17, 5207-5218 (2009)

Dameh, M., Green, J., Norris, P. Over-the-counter sales of antibiotics from community pharmacies in Abu Dhabi. Pharmacy World and Science, 32, 643-650 (2010)

Eriksson, E.J., Sullivan, K.P.H., Zetterholm, E., Czigler, P.E., Green, J., Skagerstrand, Å., van Doom, J. Detection of imitated voices: Who are reliable earwitnesses? International Journal of Speech Language and the Law, 17(1), 25-44 (2010)

Ferderber, K., Hook, S.M., Rades, T. Phosphatidyl choline-based colloidal systems for dermal and transdermal drug delivery. Journal of Liposome Research, 19, 267-277 (2009)

Foo, L-K., Duffull, S. Methods of robust design of nonlinear models with an application to pharmacokinetics. Journal of Biopharmaceutical Statistics, 20(4), 886-902 (2010)

Fry, B.G., Roelants, K., Champagne, D.E., Scheib, H., Tyndall, J.D.A., King, G.F., Nevalainen, T.J., Norman, J.A., Lewis, R.J., Norton, C.R., Rodriquez de la Vega., R.C. The toxicogenomic multiverse: Convergent recruitment of proteins into animal venoms. The Annual Review of Genomics and Human Genetics, 10, 483-511 (2009)

Gauld, R., Goldfinch, S. Horsburgh, S. Do they want it? Do they use it? The demand-side of e-government in Australia and New Zealand. Government Information Quarterly, (27), 177-186 (2010)

Glaessl, B., Siepmann, F., Tucker, I., Siepmann, J., Rades, T. Characterisation of quaternary polymethacrylate films containing tartaric acid, metoprolol free base or metoprolol tartrate. European Journal of Pharmaceutics and Biopharmaceutics, 73, 366-372 (2009)

62

Glaessl, B., Siepmann, F., Tucker, I., Rades, T., Siepmann, J. Deeper insight into the drug release mechanisms in Eudragit RL-based delivery systems. International Journal of Pharmaceutics, 389, 139-146 (2010)

Glaessl, B., Siepmann, F., Tucker, I., Rades, T., Siepmann, J. Mathematical modelling of drug release from Eudragit RS-based delivery systems. Journal of Drug Delivery Science and Technology, 20(2), 127-133 (2010)

Gordon, S., Teichmann, E., Young, K., Finnie, K., Rades, T., Hook, S. In vitro and in vivo investigation of thermosensitive chitosan hydrogels containing silica nanoparticles for vaccine delivery. European Journal of Pharmaceutical Sciences, 41, 360-368 (2010)

Graeser, K., Patterson, J., Rades, T. Applying thermodynamic and kinetic parameters to predict the physical stability of two differently prepared amorphous forms of simvastatin. Current Drug Delivery, 6, 374-382 (2009)

Graeser, K., Patterson, J., Zeitler, J.A., Gordon, K., Rades, T. Correlating thermodynamic and kinetic parameters with amorphous stability. European Journal of Pharmaceutical Sciences, 37, 492-498 (2009)

Graeser, K.A., Patterson, J.E., Zeitler, J.A., Rades, T. The role of configurational entropy in amorphous systems. Pharmaceutics, 2, 224-244 (2010)

Graf, A., McDowell, A., Rades, T. Poly(alkycyanoacrylate) nanoparticles for enhanced delivery of therapeutics – is there real potential? Expert Opinion on Drug Delivery, 6, 371-387 (2009)

Graf, A., Rades, T., Hook, S.M Oral insulin delivery using nanoparticles based on microemulsions with different structure-types: Optimisation and in vivo evaluation. European Journal of Pharmaceutical Sciences, 37, 53-61 (2009)

Greatrex, B.W., Brodie, S.J., Furneaux, R.H., Hook, S.M., McBurney, W.T., Painter, G.F., Rades, T., Rendle, P.M. The synethesis and immune stimulating action of mannose-capped lysine-based dendrimers. Tetrahedron, 65, 2939-2950 (2009)

Gupta, N., Zhang, H., Liu, P. Behavioral and neurochemical effects of acute putrescine depletion by difluoromethylornithine in rats. Neuroscience, 161, 691-706 (2009)

Han, J., Jiang, S., Cui, X., Sun, Y., Li, G., Zhang, J., Fawcett, J.P., Gu, J. Quantitation of the tacrine analogue octahydroaminoacridine in human plasma by liquid chromatography – tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 50, 171-174 (2009)

Han, P.Y., Duffull, S.B., Kirkpatrick, C.M.J., Green, B. Response to “Influence of lean body weight on anticancer drug clearance” [Letter to the Editor]. Clinical Pharmacology and Therapeutics, 85(1) 24 (2009)

Heinz, A., Gordon, K.C., McGoverin, C.M., Rades, T., Strachan, C.J. Understanding the solid-state forms of fenofibrate – A spectroscopic and computational study. Journal of Pharmaceutical and Biomedical Analysis, 71, 100-108 (2009)

63

Heinz, A., Strachan, C.J., Gordon, K.C., Rades, T. Analysis of solid-state transformations of pharmaceutical compounds using vibrational spectroscopy. Journal of Pharmacy and Pharmacology, 61, 971-988 (2009)

Heydon, S. Celebrating and reflecting on the centenary of tropical medicine in Australia, 1910-2010. Annals of the ACTM: An International Journal of Tropical & Travel Medicine, 11(1), 5-7 (2010)

Ho, L., Cuppok, Y., Muschert, S., Gordon, K.C., Pepper, M., Shen, Y., Siepmann, F., Siepmann, J., Taday, P.F., Rades, T. Effects of film coating thickness and drug layer uniformity on in vitro drug release from sustained-release coated pellets: A Case Study Using Terahertz Pulsed Imaging. International Journal of Pharmaceutics, 392, 151-159 (2009)

Ho, L., Muller, R., Kruger, C., Gordon, K.C., Kleinebudde, P., Pepper, M., Rades, T., Shen, Y., Taday, P.F., Zeitler, J.A. Investigating dissolution performance critical areas on coated tablets: A case study using terahertz pulsed imaging. Journal of Pharmaceutical Sciences, 99, 392-402 (2009)

Ho, L., Muller, R., Kruger, C., Gordon, K.C., Kleinebudde, P., Pepper, M., Rades, T., Shen, Y., Taday, P.F., Zeitler, J.A. Monitoring the film coating unit operation and predicting drug dissolution using terahertz pulsed imaging. Journal of Pharmaceutical Sciences, 98, 4866-4876, (2009)

Ho, Louise., Muller, R., Gordon, K.C., Kleinebudde, P., Pepper, M., Rades, T., Shen, Y., Taday, P.F. & Zeitler, J.A. Terahertz pulsed imaging as an analytical tool for sustained-release tablet film coating. Journal of Pharmaceutical and Biomedical Analysis, 71, 117-123 (2009)

Ho, L., Müller, R., Krüger, C., Gordon, K.C., Kleinebudde, P., Pepper, M., Rades, T., Shen, Y., Taday, P.F., Zeitler, J.A. Investigating dissolution performance critical areas on coated tablets: A case study using terahertz pulsed imaging. Journal of Pharmaceutical Sciences, 99(1), 392-402 (2010)

Horsburgh, S., Norris, P., Becket, G., Crampton, P., Arroll, B., Cumming, J.M., Herbison, P., Sides, G. The Equity in Prescription Medicines Use study: Using community pharmacy databases to study medicines utilisation. Journal of Biomedical Informatics, 43, 982-987 (2010)

Isbister, G.K., Duffull, S.B. Quetiapine Overdose: Predicting intubation, duratino of ventilation, cardiac monitoring and the effect of activated charcoal. International Clinical Psychopharmacology, 24, 174-180 (2009)

Isbister, G.K., Duffull, S.B., Brown, S.G.A. Failure of antivenom to improve receovery in Australian snakebit coagulopathy. Q J Med, an International Journal of Medicine, 102, 563-568 (2009)

Isbister, G.K., Balit, C.R., Macleod, D., Duffull, S.B. Amisulpride overdose is frequently associated with QT prolongation and Torsades de pointes. Journal of Clinical Psychopharmacology, 30(4), 391-395 (2010)

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Jain, R., Wu, Z., Tucker, I.G. A stability-indicating HPLC assay with diode array detection for the determination of a benzylpenicillin prodrug in aqueous solutions. Journal of Pharmaceutical and Biomedical Analysis, 50, 841-846 (2009)

James, T.H., Helms, M.L., Braund, R. Analysis of medications returned to community pharmacies. The Annals of Pharmacotherapy, 43, 1631-1635 (2009)

Jurna, M., Windbergs, M., Strachan, C.J., Hartsuiker, L., Otto, C., Kleinebudde, J.L., Herek, J.L., Offerhaus, H.L. Coherent anti-Stokes Raman scattering microscopy to monitor drug dissolution in different oral pharmaceutical tablets. Journal of Innovative Optical Health Sciences, 2, 37-43 (2009)

Kafka, A.P., Kleffmann, T., Rades, T., McDowell, A. Histidine residues in the peptide D-Lys6-GnRH: Potential for copolymerization in polymeric nanoparticles. Molecular Pharmaceutical, 6, 1483-1491 (2009)

Kafka, A.P., Kleffmann, T., Rades, T., McDowell, A. Characterization of peptide polymer interactions in poly(alkylcyanoacrylate) nanoparticles: A mass spectrometric approach. Current Drug Delivery, 7(3), 208-215 (2010)

Kafka, A.P., Rades, T., McDowell, A. Rapid and specific high-performance liquid chromatography for in vitro quantification of D-Lys6-GnRH in a microemulsion-type formulation in the presence of peptide oxidation products. Biomedical Chromatography, (24), 132-139 (2010)

Khunawattanaku, W., Puttipipatkhachorn, S., Rades, T., Pongjanyakul, T. Chitosan-magnesium aluminum silicate nanocomposite files: Physiochemical characterization and drug permeability. International Journal of Pharmaceutical, 393, 219-229 (2010)

Krittaphol, W., McDowell, A., Thomson, C.D., Tucker, I.G., Fawcett, J.P., Mikov, M. An Improved HPLC method for the investigation of L-selenomethionine metabolism in rat gut contents. Biomedical Chromatography, 23, 1169-1174 (2009)

Kumar, V.V.P., Oscarsson, S., Friberg, L.E., Isbister, G.K., Hackett, L.P., Duffull, S.B. The effect of decontamination procedures on the pharmacokinetics of venlafaxine in overdue. Clinical Pharmacology & Therapeutics, 86, 403-410 (2009)

Lamping, E., Ranchod, A., Nakamura, K., Tyndall, J.D.A., Niimi, K., Holmes, A.R., Niimi, M., Cannon, R.D. Abclp is a multidrug efflux transporter that tips the balance in favour of innate azole resistance in candida krusei. Antimicrobial Agents and Chemotherapy, 53, 354-369 (2009)

Lee, E., Braund, R., Tordoff, J. Examining the first year of medicines use review services provided by pharmacists in New Zealand: 2008. The New Zealand Medical Journal, 122, 26-35 (2009)

Lee, H.J., Orlovich, D., Tagg, J., Fawcett, J.P. Detection and specific enumeration of multi-strain probiotics in the lumen contents and mucus layers of the rat intestine after oral administration. Probiotics and Antimicrobial Proteins, 1, 113-120 (2009)

65

Lee, H.J., Waller, R.D., Stebbings, S., Highton, J., Orlovich, D.A., Schmierer, D., Fawcett, J.P. The effects of an orally administered probiotic on sulfasazine metabolism in individuals with rheumatoid arthritis: a preliminary study. International Journal of Rheumatic Diseases, 13, 48-54 (2010)

Li, H., Zhang, C., Wang, J., Jiang, Y., Fawcett, J.P., Gu, J. Simultaneous quantitation of paracetamol, caffeine, pseudoephedrine, chlorpheniramine and cloperastine in human plasma by liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 51, 716-722 (2010)

Li, Y., Zhang, H., Fawcett, J.P., Tucker, I.G. Effect of cyclosporin A on the pharmacokinetics of mitoquinone (MitoQ10), a mitochondria-targeted antioxidant, in rat. Asian Journal of Pharmaceutical Sciences, 5(3), 106-113 (2010)

Liu, P., Jing, Y., Collie. N.D., Chary, S., Zhang, H. Memory-related changed in L-citrulline and agmatine in rat brain. Hippocampus, 19, 597-602 (2009)

Liu, P., Jing, Y., Zhang, H. Age-related changes in arginine and its metabolites in memory-associated brain structures. Neuroscience, 164, 611-628 (2009)

Liu, P., Zhang, H., Devaraj, R., Ganesalingam, G., Smith, P.F. A multivariate analysis of the effects of aging on glutamate, GABA and arginine metabolites in the rat vestibular nucleus. Hearing Research, 269(1-2), 122-133 (2010)

Loughlin, W.A., Tyndall, J.D.A., Glenn, M.P., Hill. T.A., Fairlie, D.P. Update 1 of: Beta-Strand mimetics. Chemical Reviews, 110, PR32-PR69 (2010)

Lovelock, B., Lovelock, K., Normann, Ø. The big catch: Negotiating the transition from commercial fisher to tourism entrepreneur in island environments. Asia Pacific Journal of Tourism Research, 15(3), 267-283 (2010)

Lovelock, K. Conceiving reproduction: New reproductive technologies and the redefinition of the kinship narrative in New Zealand society. Anthropological Forum, 20(2), 125-146 (2010)

Madala, P.K., Tyndall, J.D.A., Nall, T., Fairlie, D.P. Update 1 of: Proteases universally recognize beta stands in their active sties. Chemical Reviews, 110, PR1-PR31 (2010)

McDowell, A., McLeod, B.J., Rades, T., Tucker, I. Polymeric nanoparticles as an oral delivery system for biocontrol agents for the brushtall possum (Trichosurus vulpecula). New Zealand Veterinary Journal, 57, 370-377 (2009)

McGree, J.M., Eccleston, J.A., Duffull, S.B. Simultaneous versus sequential optimal design for pharmacokinetic-pharmacodynamic models with FO and FOCE considerations. Journal of Pharmacokinetics and Pharmacodynamics, 36, 101-123 (2009)

Mould, D.R., Sweeney, K., Duffull, S.B., Neylon, E., Horwitz, S., Sirotnak, F., Fleisher, M., Saunders, M.E., O’Connor, O.A. A population pharmacokinetics and pharmacodynamics evaluation of pralatrexate in patients with relapsed or refractory non-hodgkin’s or hodgkin’s lymphoma. Clinical Pharmacology & Therapeutics, 86, 190-196 (2009)

66

Müllertz, A., Ogbonna, A., Ren, S., Rades, T. New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs. Journal of Pharmacy and Pharmacology, 62(11), 1622-1636 (2010)

Myschik, J., Rades, T., Hook, S. Advances in lipid-based subunit vaccine formulation. Currently Immunology Reviews, 5, 42-48 (2009)

Nath, C.E., Shaw, P.J., Trotman, J., Zeng, L., Duffull, S.B., Hegarty, G., McLachlan, A.J., Gurney, H., Kerridge, I., Kwan, Y.L., Presgrave, P., Tiley, C., Joshua, D., Earl, J. Population pharmacokinetics of melphalan in patients with multiple myeloma undergoing high dose therapy. British Journal of Clinical Pharmacology, 69, 484-497 (2010)

Nisa, S., Blokpoel, M.C.J., Robertson, B.D., Tyndall, J.D.A., Lun, S., Bishai, W.R., O’Toole, R. Targeting the chromosome partitioning protein ParA in tuberculosis drug discovery. Journal of Antimicrobial Chemotherapy, 65(11), 2347-2358 (2010)

Norris, P. Challenges Facing Social Pharmacy. Research in Social and Administrative Pharmacy, 5, 195-196(2009)

Norris, P., Chong, C., Chou, A., Hsu, T-H., Lee, C., Kuei-Lien, C., Wang, Y. Knowledge and reported use of antibiotics amongst school-teachers in New Zealand. Pharmacy Practice, 7, 238-241 (2009)

Norris, P., Churchward, M., Fa’alau, F., Va’ai, C. Understanding and use of antibiotics amongst Samoan people in New Zealand. Journal of Primary Health Care, 1, 30-35 (2009)

Norris, P., Fa’alau, F., Va’ai, C., Churchward, M. & Arroll, B. Navigating between illness paradigms: Treatment seeking by Samoan people in Samoa and New Zealand. Quantitative Health Research, 19, 1466-1475 (2009)

Norris, P., Horsburgh, S., Padukkage, P., Baik, N.Y., Kim, D., Fussell, A., Hutchinson, S., Ragupathy, R. Coverage and accuracy of ethnicity data on three Asian ethnic groups in New Zealand. Australian and New Zealand Journal of Public Health, 34, 258-261 (2010)

Norris, P., Ng, L.F., Kershaw, V., Hanna, F., Wong, A., Talekar, M., Oh, J., Azer, M., Cheong, L. Knowledge and reported use of antibiotics amongst immigrant ethnic groups in New Zealand. Journal of Immigrant and Minority Health, 12, 107-112 (2010)

O’Shea, S., Duffull, S., Johnson, D.W. Aminogylcosides in hemodialysis patients: Is the current practice of post dialysis dosing appropriate? {Editorial] Seminars in Dialysis, 22, 225-230 (2009)

Page, C.B., Duffull, S.B., Whyte, I.M., Isbister, G.K. Promethazine overdose: clinical effects, predicting delirium and the effect of charcoal. Q J Med 2009, 102, 123-131 (2009)

Parr, W.V., Valentin, D., Green, J.A., Dacremont, C. Evaluation of French and New Zealand Sauvignon wines by experienced French wine assessors. Food Quality & Preference, 21(1), 56-64 (2010)

67

Patel, A., Norris, P., Gauld, R., Rades, T. Drug quality in South Africa: perceptions of key players involved in medicines distribution. International Journal of Health Care Quality Assurance, 22, 547-560 (2009)

Patel, A., Gauld, R., Norris, P., Rades, T. “This body does not want free medicines”: South African consumer perceptions of drug quality. Health Policy and Planning, 25, 61-69 (2010)

Peake, B., Braund, R. Environmental aspects of the disposal of pharmaceuticals in New Zealand. Chemistry in New Zealand, April 58-63 (2009)

Ragupathy, R., Tordoff, J., Norris, P., Reith, D. Access to children’s medicines in the United Kingdom, Australia and New Zealand in 1998, 2002 and 2007. Pharmacy World Science, 32, 386-393 (2010)

Reith, D., Medlicott, N.J., Kumara De Silva, R., Yang, L., Hickling, J., Zacharias, M. Simultaneous modelling of the Michaelis-Menten kinetics of paracetamol sulphation and glucuronidation. Clinical and Experimental Pharmacology and Physiology, 36, 35-42 (2009)

Rizwan, S.B., Hanley, T., Boyd, B.J., Rades, T., Hook, S. Liquid crystalline systems of phytantriol and glyceryl monooleate containing a hydrophilic protein: Characterisation, swelling and release kinetics. Journal of Pharmaceutical Sciences, 98, 4191-4204 (2009)

Rizwan, S.B., Boyd, B.J., Rades, T., Hook, S. Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins. Expert Opinion Drug Delivery, 7(10), 1133-1144 (2010)

Ruiz-Gomez, G., Tyndall, J.D.A., Pfeiffer, B., Abbenante, G., Fairlie, D.P. Update 1 of: Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure. Chemical Reviews, 110, PR1-PR41 (2010)

Sassene, P.J., Knopp, M.M., Hesselkilde, J.Z., Koradia, V., Rades, T., Müllertz, A. Precipitation of a poorly soluble model drug during in vitro lipolysis: Characterization and dissolution of the precipitate. Journal of Pharmaceutical Sciences, 99(12), 4982-4991(2010)

Savolainen, M., Kogermann, K., Aaltonen, J., Peltonen, L., Strachan, C., Ylirussi, J. Better understanding of dissolution behaviour of amorphous drugs by in situ solid-state analysis using Raman spectroscopy. European Journal of Pharmaceutical and Biopharmaceutics, 71, 71-79 (2009)

Sawant, P.M., Tyndall, J.D.A., Holland, P.T., Peake, B.M., Mountford, D.O., Kerr, D.S. In vivo seizure induction and affinity studies of domoic acid and isodomoic acids-D, -E and –F. Neuropharmacology, 59, 129-138 (2010)

Sherwin, C., Broadbent, R., Medlicott, N.J., Reith, D.M. Individualised dosing of amikacin in neonates. [Letter to the Editor] European Journal of Clinical Pharmacology, 65, 1267-1268 (2009)

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Sherwin, C.M.T., Kostan, E., Broadbent, R.S., Medlicott, N.J., Reith, D.M. Evaluation of the effect of intravenous volume expanders upon the volume of distribution of gentamicin in septic neonates. Pharmaceutics and Drug Disposition, 30, 276-280 (2009)

Sherwin, C.M.T., McCaffrey, F., Broadbent, R.S., Reith, D.M., Medlicott, N.J. Discrepancies between predicted and observed rates of intavenous gentamicin delivery for neonates. Journal of Pharmacy and Pharmacology 61, 465-471 (2009)

Sherwin, C.M.T., Svahn, S., Van Der Linden, A., Broadbent, R.S., Medlicott, N.J., Reith, D.M. Individualised dosing of amikacin in neonates: a pharmacokinetic/pharmacodynamic analysis. European Journal of Clinical Pharmacology, 65(7) 705-713 (2009)

Si, D., Wang, Y., Zhou, Y., Guo, Y., Wang, J., Zhou, H., Ze-Sheng, L., Fawcett, J.P. Mechanism of CYP2C9 inhibition by flavones and flavonols. Drug Metabolism and Disposition 37, 629-634 (2009)

Simovic, S., Heard, P., Hui, H., Song, Y., Peddie, F., Davey A., Lewis, A., Rades, T., Prestidge, C. Dry hybrid lipid-silica microcapsules engineered from submicron lipid droplets and nanoparticles as a novel delivery system for poorly soluble drugs. Molecular Pharmaceutics, 6, 861-872 (2009)

Simovic, S., Hui, H., Song, Y., Davey, A.K., Rades, T., Prestidge, C.A. An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles. Journal of Controlled Release, 143, 367-373 (2010)

Simpson, J.A., Jamsen, K.M., Price, R.N., White, N.J., Lindegardh, N., Tarning, J., Duffull, S.B. Towards optimal design of anti-malarial pharmacokinetic studies. Malaria Journal, 8, 1-7 (2009)

Songkro, S., Rades, T., Becket, G. Effects of some terpenes on the in vitro permeation of LHRH through newborn pig skin. Pharmazie, 64, 110-115 (2009)

Sun, Y., Liu, M., Zhang, Jiang, J., Yu, W., Fawcett, J.P., Gu, J. Rapid and sensitive assay for trantinterol, a novel β2-adrenceptor agonist, in human plasma using liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 49, 1056-1059 (2009)

Tan, A., Simovic, S., Davey, A.K., Rades, T., Prestidge, C.A. Silica-liquid hybrid (SLH) microcapsules: A novel oral delivery system for poorly soluble drugs. Journal of Controlled Release, 134, 62-70 (2009)

Tan, A., Simovic, S., Davey, A.K., Rades, T., Boyd, B.J., Prestidge, C.A. Silica nanoparticles to control the lipase-mediated digestion of lipid-based oral delivery systems. Molecular Pharmaceutics, 7, 522-532 (2010)

Tantipolphan, R., Rades, T., Medlicott, N.J. Swelling lecithin: cholesterol implants for the controlled release of proteins. Journal of Liposome Research, 19, 37-48 (2009)

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Tordoff, J.M., Bagge, M.L., Gray, A.R., Campbell, A.J., Norris, P.T. Medicine-taking practices in community-dwelling people aged ≥75 years in New Zealand. Age and Ageing, 39(5), 574-580 (2010)

Tordoff, J., Simonsen, K., Thomson, W.M., Norris, P. “It’s just routine.” A qualitative study of medicine-taking amongst older people in New Zealand. Pharmacy World and Science, (32), 154-161 (2010)

Tsin, W., Lampah, D.A., Tjitra, E., Gitawati, R., Kenangalem, E., Peira, K., Granger, D.L., Lopansri, B.K., Weinberg, J.B., Price, R.N., Duffull, S.B., Celemajer, D.S., Anstey, N.M. Relationship of cell-free haemoglobin to impaired endothelial nitric oxide bioavailability and perfusion in severe falciparum malaria. The Journal of Infectious Diseases, 200, 1522-1529 (2009)

Tyndall, J.D.A., Kelso, M.J., Ranson, M. Inhibitors of the plasminogen activation system – Promising new agents for suppressing breast cancer metastasis. Frontiers in Anti-Cancer Drug Discovery, 1, 55-78 (2010)

Wajima, T., Isbister, G., Duffull, S.B. A comprehensive model for the humoral coagulation network in humans. Clinical Pharmacology & Therapeutics, 86, 290-298 (2009)

Waterhouse, T.H., Eccleston, J.A., Duffull, S.B. Optimal design criteria for discrimination and estimation in nonlinear models. Journal of Biopharmaceutical Statistics, 19, 386-402 (2009)

Westphal, D., Ledgerwood, E.C., Tyndall, J.D.A., Hibma, M.H., Ueda, N., Fleming, S.B., Mercer, A.A. The orf virus inhibitor of apoptosis functions in a bcl-2-like manner, binding and neutralizing a set of bh3-only proteins and active bax. Apoptosis, 14, 1317–1330 (2009)

Windbergs, M., Jurna, M., Offerhaus, H., Herek, J.L., Kleinebudde, P., Strachan, C. Chemical imaging of oral solid dosage forms and changes upon dissolution using coherent anti-Stokes Raman scatting microscopy. Analytical Chemistry, 81, 2085-2091 (2009)

Windbergs, M., Haaser, M., McGoverin, C.M., Gordon, K.C., Kleinebudde, P., Strachan, C.J. Investigating the relationship between drug distribution in solid lipid matrices and dissolution behaviour using Raman spectroscopy and mapping. Journal of Pharmaceutical Sciences, 99, 1464-1475 (2009)

Windbergs, M., Strachan, C.J., Kleinebudde, P. Influence of the composition of glycerides on the solid-state behaviour and the dissolution profiles of solid lipid extrudates. European Journal of Pharmaceutics, 381, 184-191 (2009)

Windbergs, M., Strachan, C.J., Kleinebudde, P. Influence of structural variations on drug release from lipid/polyethylene glycol matrices. European Journal of Pharmaceutical Sciences, 327, 555-562 (2009)

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Windbergs, M., Strachan, C.J., Kleinebudde, P. Investigating the principles of recrystallization from glyceride melts. AAPS PharmSciTech, 10, 1224-1233 (2009)

Windbergs, M., Strachan, C.J., Kleinebudde, P. Tailor-made dissolution profiles by extruded matrices based on lipid polyethylene glycol mixtures. Journal of Controlled Release, 137, 211-216 (2009)

Windbergs, M., Gueres, S., Strachan, C.J., Kleinebudde, P. Two-step solid lipid extrusion as a process to modify dissolution behavior. AAPS PharmSciTech, 11(1), 2-8 (2010)

Windbergs, M., Haaser, M., McGoverin, C.M., Gordon, K.C., Kleinebudde, P., Strachan, C.J. Investigating the relationship between drug distribution in solid lipid matrices and dissolution behaviour using Raman spectroscopy and mapping. Journal of Pharmaceutical Sciences, 99(3), 1464-1475 (2010)

Wiranidchapong, C., Rades, T., Kulvanich, P., Tucker, I.G. Method of preparation does not affect the miscibility between steroid hormone and polymethacrylate. Thermochimica Acta, 485, 57-64 (2009)

Wright, D.F.B., Al-Sallami, H.S., Jackson, P.M., Reith, D.M. Falsely elevated vancomycin plasma concentrations sampled from central venous implantable catheters (portacaths). British Journal of Clinical Pharmacology, 70(5), 769-772 (2010)

Wright, D.F.B., Begg, E. J. The ‘apparent clearance’ of free phenytoin in elderly vs. younger adults. British Journal of Clinical Pharmacology, 70(1), 132-138 (2010)

Wu, X., Liu, L., Zhang, M., Wu, D., Wang, Y., Sun, Y., Fawcett, J.P., Gu, J., Zhang, J. Simultaneous analysis of isomers of escin saponins in human plasma by liquid chromatography–tandem mass spectrometry: Application to a pharmacokinetic study after oral administration. Journal of Chromatography B, 878, 861-867 (2010)

Wu, Z., Tucker, I.G., Razzak, M., Medlicott, N.J. Stability of ricobendazole in aqueous. Journal of Pharmaceutical and Biomedical Analysis, 49, 1282-1286 (2009)

Wu, Z., Tucker, I.G., Razzak, M., McSporran, K., Medlicott, N.J. Tissue compatibility and pharmacokinetics of three potential subcutaneous injectables for low-pH drug solutions. Journal of Pharmacy and Pharmacology, 62, 873-882 (2010)

Wu, Z., Tucker, I. G., Razzak, M., Yang, L., McSporran, K., Medlicott, N.J. Absorption and tissue tolerance of ricobendazole in the presence of hydroxypropyl-β-cyclodextrin following subcutaneous injection in sheep. International Journal of Pharmaceutics, 397, 96-102 (2010)

Yang, J., He, Y., Du, Y., Tang, L., Wang, G., Fawcett, J.P. Pharmacokinetic properties of S-Adenosylmethionine after oral and intravenous administration of its tosylate disulfate salt: A multiple-dose, open-label, parallel-group study in healthy Chinese volunteers. Clinical Therapeutics, 31, 311-320 (2009)

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Yang, L., Zhang, H., Mikov, M., Tucker, I.G. Physicochemical and biological characterization of monoketocholic acid, a novel permeability enhancer. Molecular Pharmaceutics, 6, 448-456 (2009)

Yeo, T.W., Lampah, D.A., Tjitra, E., Gitawati, R., Darcy, C.J., Jones, C., Kenangalem, E., McNeil, Y.R., Granger, D.L., Lopansir, B.K., Weinberg, J.B., Price, R.N., Duffull, S.B., Celermajer, D.S., Anstey, N.M. Increased asymmetric dimethylarginine in severe falciparum malaria: Association with impaired nitric oxide bioavailability and fatal outcome. PLoS Pathogens, 6(4), e1000868 (2010)

Young, L., Lawes, F., Tordoff, J., Norris, P., Reith, D. Access to Prescribing Information for Paediatric Medicines in the USA: Post-Modernization. British Journal of Clinical Pharmacology, 67, 341-346 (2009)

Yu, W., Wang, Y., Zhang, Y., Zhang, D., Lan, J., Liu Z., Gu, J., Fawcett, J.P. (Quantitation of bergenin in human plasma by liquid chromatography/tandem mass spectrometry. Journal of Chromatography B, 877, 33-36 (2009)

Zhang, C., Wang, L., Yang, W., Wang, X., Fawcett, J.P., Sun, Y., Gu, J. Validated LC-MS/MS assay for the determination of felbinac: Application to a preclinical pharmacokinetics study of felbinac trometamol injection in rat. Journal of Pharmaceutical and Biomedical Analysis, 50, 41-45 (2009)

Zhang, C., Wang, L., Guan, X., Fawcett, J.P., Zhao, L-m., Sun, Y-t., Gu, J-K. Rapid determination of ranitidine in human plasma by liquid chromatography-tandem mass spectrometry and its application to a clinical pharmacokinetic study. Chemical Research in Chinese Universities, 26(6), 910-914 (2010)

Zhang, D., Wang, Y., Han, J., Yu, W., Deng, L., Fawcett, J.P., Liu, Z., Gu, J. Rapid and sensitive LC-MS/MS assay for the quantitation of 20 (S)-protopanaxadiol in human plasma. Journal of Chromatography B, 877, 581-585 (2009)

Zhang, F., Aaltonen, J., Tian, F., Saville, D., Rades, T. (Influence of particle size and preparation methods on the physical and chemical stability of amorphous simvastatin. Journal of Pharmaceutical and Biomedical Analysis, 71, 64-70 (2009)

Zimper, U., Aaltonen, J., McGoverin, C.M., Gordon, K.C., Krauel-Goellner, K., Rades, T. Quantification of process induced disorder in milled samples using different analytical techniques. Pharmaceutics, 2, 30–49 (2010)

Zimper, U., Aaltonen, J., Krauel-Goellner, K., Gordon, K.C., Strachan, C.J., Rades, T. The influence of milling on the dissolution performance of simvastatin. Pharmaceutics, 2, 419-431 (2010)

Zin, C.S., Nissen, L.M., O’Callaghan, J.P., Duffull, S.B., Smith, M.T., Moore, B.J. A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin. Journal of Pain, 11(5), 462-471 (2010)

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cOnference cOntriButiOnS

Full Paper / Abstract in Published Conference Proceedings & Verbal / Poster Publications in Edited Proceedings

Aaltonen, K., Ragupathy, R., Tordoff, J., Reith, D., Norris, P. The impact of pharmaceutical cost containment policies on the range of medicines available and subsidised in Finland and New Zealand. The 4th Nordic Social Pharmacy and Health Services Research Conference: Increasing the Impact of Social Pharmacy Research, Oslo, Norway (2009) (Verbal presentation)

Aaltonen, K., Ragupathy, R., Tordoff, J., Reith, D., Norris, P. Delay in licensing new important innovative products that provide health gain in Finland and New Zealand. Proceedings of the 16th International Social Pharmacy Workshop, Lisbon, Portugal, p85. (2010) (Poster)

Al-Sallami, H., Bell, N., Smith, A., Stevenson, J., Young, S., Duffull, S. (Evidence-based clinical pharmacy services in New Zealand hospitals. The New Zealand Hospital Pharmacists’ Association Conference, Nelson, New Zealand (2009) (Verbal presentation)

Al-Sallami, H., Duffull, S., Schollum, J. A rationale for the routine monitoring of anti-Xa concentration during enoxaparin treatment. Proceedings of the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, Los Angles, USA (2009) (Poster)

Al-Sallami, H. S., Jordan, S., Ferguson, R., Medlicott, N. J., Schollum, J., & Duffull, S. B. Are enoxaparin dosing guidelines credible? The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand (2009) (Verbal presentation)

Al-Sallami, H., La, S., Moon, J., Noh, L., Yeat, N., Medlicott, N. Assessing the physical stability of drug combinations in subcutaneous syringes. The New Zealand Hospital Pharmacists’ Association Conference, Nelson, New Zealand (2009) (Verbal presentation)

Al-Sallami, H., Barras, M.A., Green, B., Duffull, S.B. A rationale for the routine monitoring of anti-activated factor X (anti-Xa) during enoxaparin treatment. Abstracts of the 19th Meeting of the Population Approach Group in Europe (PAGE), Berlin, Germany (2010) (Poster)

Al-Sallami, H.S., Duffull, S.B. Developing a model for estimating lean body weight in children. Abstracts of the 11th Annual Scientific Meeting of the Population Approach Group in Australia and New Zealand (PAGANZ), Adelaide, Australia, (2010) (Verbal presentation)

Al-Sallami, H.S., Jordan, S., Ferguson, R., Medlicott, N.J., Schollum, J., Duffull, S.B. Current enoxaparin dosing guidelines are problematic. Proceedings of the NZ Hospital Pharmacists’ Association Conference, “Forging New Pathways”, Hamilton, New Zealand, (2010) (Poster)

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Al-Sallami, H.S., Smith, M., Patel, D., Wu, J., Kao, S. How successful are we in achieving target aPTT levels during treatment with unfractionated heparin? Proceedings of the NZ Hospital Pharmacists’ Association Conference, “Forging New Pathways”, Hamilton, New Zealand (2010) (Poster)

Arafat, M., Graf, A., Fawcett, J. P., Mikov, M., Tucker, I. G. Bilosome vesicles as a novel delivery system for cefotaxime: Formulation and characterization. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2009) (Verbal presentation)

Awasthi, A., Tyndall, J. D. A., Jeffs, A., Wilbanks, S. M. Glioma pathogenesis related protein: A survival factor for gliomas and melanomas. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2009) (Verbal presentation)

Awasthi, A., Jeffs, A., Wilbanks, S.M., Tyndall, J.D.A. GLIPR1 mediates invasive potential in melanoma cells. 10th Annual Conference of the Australasian Microarray and Associated Technologies Association (AMATA), Hobart, Tasmania, Australia (2010)

Awasthi, A., Jeffs, A., Wilbanks, S.M., Tyndall, J.D.A. GLIPR1 levels correlate with invasive potential in melanoma cells. QMB Cancer Satellite, Queenstown, New Zealand (2010)

Bagge, M., Tordoff, J.M., Norris, P., Heydon, S. Medicines over a lifetime. The Third Annual Division of Health Sciences Research Forum, Wellington, New Zealand (2009) (Poster)

Bagge, M.L., Tordoff, J.M., Heydon, S.J., Norris, P. Medicines over a lifetime. Proceedings of the 16th International Social Pharmacy Workshop, Lisbon, Portugal (2010) (Poster)

Baker, J., Green, J., Synnott, K., Stephens, M., Poynton, A., Mulhall, K. Internet use by orthopaedic outpatients. Seventh Société Internationale de Chirurgie/Recherche Orthopédique et Traumatologie (SICOT/SIROT) Annual International Conference, Gothenburg, Sweden (2010)

Bork, O. Transferring innovative (bio)active delivery systems to new products: A challenge for industry and academia. The 36th Annual Meeting & Exposition of the Controlled Release Society, Copenhagen, Denmark (2009) (Poster)

Bork, O., McDowell, A., Kafka, A.P., Tucker, I.G. Transferring innovative (bio)active delivery systems to new products: A challenge for industry and academia. The 36th Annual Meeting & Exposition of the Controlled Release Society, Copenhagen, Denmark (2009) (Poster)

Bøtker, J., Karmwar, P., Cornett, C., Strachan, C., Rantanen, J., Rades, T. Assessment of crystalline disorder in cryo-milled samples of indomethacin using atomic pair-wise distribution functions. Proceedings of the AAPS Annual Meeting, Association of American Pharmaceutical Scientists, New Orleans, Louisiana, USA [The AAPS Journal. 2010; 12(S1), 5485] (2010)

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Braund, R. Waste not, want not: Investigations of unused medication. The Third Annual Division of Health Sciences Research Forum, Wellington, New Zealand (2009) (Verbal presentation)

Chatterjee, L., Baier, A., Rades, T., Tucker, I.G. (The influence of particle size of a plastic excipient on Eudragit RLPO matrices prepared by direct compression. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2009) (Verbal presentation)

Chen, G., Fawcett, J.P., Mikov, M., Tucker, I.G. Simultaneous determination of methotrexate and its polyglutamate metabolites in Caco-2 cells by liquid chromatography-tandem mass spectrometry. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2009) (Poster)

Chen, G., Fawcett, J.P., Mikov, M., Tucker, I.G. Monoketocholate can decrease transcellular permeation of methotrexate across Caco-2 cell monolayers and reduce its systemic absorption in rat. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2009) (Verbal presentation)

Chen, G., Fawcett, J.P., Yang, L., Zhang, H., Mikov, M., Tucker, I. G. Effects of ketocholate derivatives on membrane fluidity and methotrexate uptake in CACO-2 cell monolayers. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand (2009) (Poster)

Coulter, C.V., Duffull, S., Isbister, G. Treating methanol toxicity with ethanol: A case study. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand (2009) (Verbal presentation)

Coulter, C.V., Joy, J.P., Duffull, S.B., Isbister, G.K. Prediction of Torsades de Pointes from QT interval: analysis of a case series with amisulpride. Abstracts of the 19th Meeting of the Population Approach Group in Europe (PAGE), Berlin, Germany [ISSN 1871-6032] (2010) (poster)

Coulter, C.V., Abbott, V., Creighton, M., Hannam, J., Vincent, T. Antidotes for accidental and intentional drug poisonings – What drugs do hospitals in New Zealand stock? Proceedings of the New Zealand Hospital Pharmacists Association (NZHPA), Hamilton, September (2010) (Verbal presentation)

Duffull, S. All covariates are equal but some are more equal than others. The 11th Annual Population Approach Group in Australia and New Zealand Conference, Newcastle, Australia (2009) (Invited speaker)

Duffull, S.B. Response Biomarkers: Anti-Coagulation. Abstracts of the 6th International Symposium on Measurement and Kinetics of ‘In Vivo’ Drug Effects, Leiden, The Netherlands (2010) (Verbal presentation)

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Duffull, S.B., Hegarty, G., Nath, C.E, Shaw, P.J., Trotman, J. Evaluation of an optimal design for examining melphalan pharmacokinetics in patients with multiple myeloma. Abstracts of the 11th Annual Scientific Meeting of the Population Approach Group in Australia and New Zealand (PAGANZ), Adelaide, Australia (2010) (Verbal presentation)

Eriksson, E., Green, J., Sullivan, K., Torstensson, N. Voices and Crime: Is what you hear what you perceive? 3rd Nordic Police Research Seminar, Umeå University, Sweden. November (2010)

Fawcett, J.P., Sun, Y.T., Guo, Y.J., Gao, F., Zhang, M.L., Yang, Y., Gu, J.K. Effect of trantinterol on cytochrome P450 enzymes and genes. Abstracts of the 18th International Symposium on Microsomes and Drug Oxidations. Beijing (2010)

Fawcett, J.P., Yang, L., Zhang, H., Tucker, I.G. The effect of monoketocholate on the pharmacodynamics and pharmacokinetics of morphine-6-glucuronide in rat. Abstracts of the Annual Meeting of ASCEPT (NZ Section), Christchurch (2010) (Verbal presentation)

Fawcett, J.P., Yang, L., Zhang, H., Tucker, I.G. The effect of monoketocholate on the pharmacodynamics and pharmacokinetics of morphine 6-glucuronide in rat. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting and the 6th Annual Carney Pharmacogenomics Symposium. ASCEPT, Melbourne, Australia (2010)

Ferderber, K., Rades, T., & Hook, S. Phosphatidylcholine based colloidal systems for transdermal and dermal delivery of peptides. The 36th Annual Meeting & Exposition of the Controlled Release Society, Copenhagen, Denmark (2009) (Poster)

Foo, L.K., Calver, L., Isbister, G.K., Duffull, S.B. Using optimal design methodology to determine the best sampling times to study the pharmacokinetics of droperidol and midazolam. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand (2009) (Verbal presentation)

Foo, L.K., Duffull, S. Adaptive bridging studies in pharmacokinetics. Abstracts of the 11th Annual Scientific Meeting of the Population Approach Group in Australia and New Zealand (PAGANZ), Adelaide, Australia (2010) (Verbal presentation)

Foo, L.K., Duffull, S.B. D-optimal Adaptive Bridging Studies in Pharmacokinetics. Abstracts of the 19th Meeting of the Population Approach Group in Europe (PAGE), Berlin, Germany [ISSN 1871-6032] (2010) (Verbal presentation)

Fraser, S., Oughton, J., Gordon, K., Rades, T., Strachan, C. Rapid detection of counterfeit products using Raman spectroscopy. Proceedings of the Australasian Pharmaceutical Science Association,Woolloongabba, Australia (2010)

Girardin, A., Hook, S. M., Kemp, R. A., Highton, A. J. Site specific memory T cells generated from slow antigen release vaccination. The New Zealand Australasian Society for Immunology (NZ ASI) Branch Meeting, Wellington, New Zealand (2010) (Verbal presentation)

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Gloeckl, S., Tyndall, J.D.A., Timms, P., Huston, W.M. Characterisation of the role of the chlamydial serine protease, HtrA, in growth and virulence by identifying and examining its native substrates. The Australian Society for Microbiology Conference: The Molecular Biology of Bacterial Pathogens (BacPath 10), Barossa Valley, Australia (2009) (Verbal presentation)

Gordon, K.C., McGoverin, C.M., Haaser, M., Rades, T., Strachan, C.J. Raman microscopy: Opportunities and limitations illustrated by a case study in lipid drug extrudates. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2009) (Verbal presentation)

Gordon, S., McBurney, W.T., Wilson, R., Rades, T., Hook, S. Investigation of thermosensitive chitosan hydrogels containing antigen-loaded nanoparticles for vaccine delivery. The New Zealand Australasian Society for Immunology (NZ ASI) Branch Meeting, Wellington, New Zealand (2009) (Verbal presentation)

Gordon, S., McBurney, W., Wilson, R., Rades, T., Hook, S. In vitro and in vivo investigation of chitosan hydrogels containing liposomes as vaccine delivery systems. The 36th Annual Meeting & Exposition of the Controlled Release Society, Copenhagen, Denmark (2009) (Verbal presentation)

Gordon, S., Rades, T., Hook, S. Development of thermoresponsive chitosan gels for vaccine delivery. Proceedings of the AAPS Annual Meeting, Association of American Pharmaceutical Scientists, New Orleans, Louisiana, USA [The AAPS Journal. 2010; 12(S1), 2051] (2010) (Poster)

Gordon, S., Kemp, R., Young, K., Rades, T., Hook, S. Immunogenicity of a sustained release particulate vaccine comprising antigen loaded cubosomes in a thermoresponsive chitosan gel. International Immunology Congress, Kobe (2010) (Poster)

Graeser, K., Patterson, J., Rades, T. The prediction of physically stable amorphous forms. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2009) (Verbal presentation)

Graeser, K., Patterson, J., Rades, T. Investigation of two differently prepared amorphous forms of simvastatin: Thermodynamic and kinetic stability parameters. The 36th Annual Meeting & Exposition of the Controlled Release Society, Copenhagen, Denmark (2009) (Poster)

Graeser, K., Patterson, J., McGoverin, C., Gordon, K., Rades, T. Determining amorphous stability using multivariate approach. Proceedings of the 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Valetta, Malta (2010) (Verbal presentation)

Graeser, K., Patterson, J., Rades, T. Thermodynamic and kinetic parameters of two differently prepared amorphous forms of simvastatin. Proceedings of the 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Valetta, Malta (2010) (Verbal presentation)

77

Graf, A. Formulation solutions for βgrease-ballβ molecules. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2009) (Verbal presentation)

Green, J.A., Brown, K., Burgess, J., Chong, D., Pewhairangi, K. Demographic influences on consultation time in community pharmacy. Pharmacy Practice, August 8 126(S1), University of Lisbon, Portugal (2010)

Guzman, P., Jørgensen, L., Strachan, C., Rades, T., Medlicott, N. Multivariate analysis of protein physical stability. Proceedings of the Australasian Pharmaceutical Science Association, Woolloongabba, Australia (2010)

Haaser, M., McGoverin, C., Windbergs, M., Gordon, K., Kleinebudde, P., Strachan, C. Investigation of the structure of a sustained release dosage form using Raman microscopy. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2009) (Poster)

Haaser, M., McGoverin, C., Strachan, C., Rades, T., Windbergs, M., Kleinebudde, P., Gordon, K. Analysis of matrix structures during dissolution testing using Raman microscopy. The New Zealand Chapter of the Controlled Release Society 12th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2010) (Verbal presentation)

Haaser, M., Windbergs, M., McGoverin, C.M., Kleinebudde, P., Rades, T., Gordon, K.C., Strachan, C.J. Analysis of matrix dosage forms during dissolution testing using Raman microscopy. Proceedings of the Australasian Pharmaceutical Science Association, page 107, Woolloongabba, Australia (2010)

Heydon, S. Medicines and primary health care services in the Mt Everest region of Nepal. The 2nd Otago International Health Research Network Conference, Dunedin, New Zealand (2009) (Verbal presentation)

Heydon, S.J. Changing Patterns in Medicines Use in the Mount Everest Region of Nepal. Proceedings of the 16th International Social Pharmacy Workshop, Lisbon, Portugal (2010)

Highton, A., Girardin, A., Hook, S., Kemp, R. Site Specific Memory T Cells Generated From Sustained Antigen Release Vaccination. The annual scientific meeting of the Australasian Society for Immunology, Perth, Australia (2010) (Verbal presentation)

Ho, L., Gordon, K. C., Pepper, M., Taday, P. F., Rades, T. Terahertz pulsed imaging as an analytical tool for tablet film coating. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand. (2009) (Verbal presentation)

Hook, S. New Zealand preclinical developments: Formulation of safe, immune stimulatory vaccines. The National Immunisation Conference, Auckland, New Zealand (2009) (Verbal presentation)

Hook, S. Pharmacist immunisers: A feasible concept? The National Immunisation Conference, Auckland, New Zealand (2009) (Verbal presentation)

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Hook S. Therapeutic vaccines: the way of the future? Vaccines round table session at the American Association of Pharmaceutical Scientists Annual Meeting, New Orleans, USA (2010) (Invited speaker)

Hook, S. Modifying immune responses through formulation. Recent Advance in Immune Regulation and Immunotherapy, The NZ-Riken-Chiba Joint Workshop, Japan (2010) (Verbal presentation)

Horsburgh, S., Norris, P., Cumming, J., Becket, G., Crampton, P., Arroll, B., Herbison, P. Who pays what for their medicines? Patient payments for prescription medicines in a New Zealand town. Abstracts of the 16th International Social Pharmacy Workshop (ISPW), Lisbon, Portugal (2010) (Verbal presentation)

Hubert, M., Hook S., Rades, T., Hayman, C., Painter, G., Rendle, P., Larsen, D. Formulation and immunological characterization of novel carbohydrate containing immuno-pharmaceuticals. Formulation and Delivery of Bioactives & Controlled Release Society (New Zealand Chapter) meeting, Dunedin (2010) (Poster)

Hubert, M., Hook, S., Larsen, D., Hayman, C., Painter, G., Rendle, P., Rades, T. Synthesis and physical characterisation of PIM mimetics as novel immunomodulating agents. The Australasian Pharmaceutical Science Association Annual Meeting, Brisbane, Australia (2010) (Verbal presentation)

Hussain, M. J., Seville, P. C., Rades, T., Perrie, Y. Liposomes as vehicles for vaccine delivery. Proceedings of the 36th Annual Meeting & Exposition of the Controlled Release Society, Copenhagen, Denmark (2009)

Jain, R., Wu, Z., Tucker, I.G. Degradation kinetics of penethamate in aqueous solutions determined by a stability indicating reversed phase HPLC assay. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2009) (Poster)

Kafka, A., Kleffmann, T., Rades, T., McDowell, A. Co-polymerization in poly(alkylcyanoacrylates): A matter of histidine. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2009) (Verbal presentation)

Kafka, A., Kleffmann, T., Rades, T., McDowell, A. Co-polymerization of proteins and peptides in poly(alkylcyanoacrylate) nanoparticles. The 36th Annual Meeting & Exposition of the Controlled Release Society, Copenhagen, Denmark. (2009) (Poster)

Kafka, A., McDowell, A., Rades, T. In-vitro evaluation of PACA nanoparticles for peroral delivery of the neuropeptide D-Lys6-GnRH. The New Zealand Chapter of the Controlled Release Society 12th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2010) (Verbal presentation)

Kafka,A.P., McDowell, A., Strachan, C.J., Rades, T. Preparation of PLGA nanoparticles with high entrapment efficiencies for D-Lys6-GnRH: a factorial design study using the double-emulsion solvent/evaporation technique. 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Valleta, Malta (2010)

79

Kao, J. Y., McGoverin, C. M., Graeser, K. A., Rades, T., Gordon, K.C. Raman spectroscopy as a probe for amorphous stability. The New Zealand Chapter of the Controlled Release Society 12th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2010) (Poster)

Karmwar, P., Strachan, C., Gordon, K., Rades, T. Investigating solid-state transformations of differently prepared amorphous forms. The Fourth Annual Division of Health Sciences Research Forum, Dunedin, New Zealand (2010) (Poster)

Karmwar, P., Rades, T., Gordon, K., Strachan, C. Investigating and understanding rates of solid-state transformations from amorphous samples prepared by different methods. The New Zealand Chapter of the Controlled Release Society 12th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2010) (Verbal presentation)

Karmwar, P., Bøtker, J., Graeser, K., Strachan, C., Rades, T. Investigation of effect of cooling rates on amorphous indomethacin. Proceedings of the AAPS Annual Meeting, Association of American Pharmaceutical Scientists, New Orleans, Louisiana, USA (2010)

Karmwar, P., Bøtker, J., Rantanen, J., Strachan, C., Rades, T. Applying a time-temperature-transformation (TTT) diagram to investigate differences in amorphpousb solids prepared from melts by different cooling rates. Proceedings of the Australasian Pharmaceutical Science Association, Woolloongabba, Australia (2010)

Karmwar, P., Rades, T., Gordon, K.C., Strachan, C.J. Establishing and understanding rates of recrystallisation from amorphous samples prepared by different methods. Proceedings of the International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Valetta, Malta, (2010)

Karmwar, P., Strachan, C., Gordon, K., Graeser, K., Rades, T. Investigating physicochemical properties, stability and dissolution of differently prepared amorphous solids. Proceedings of the Australasian Pharmaceutical Science Association, Woolloongabba, Australia (2010)

Karmwar, P., Strachan, C., Gordon, K., Rades, T. Investigating Solid-State Transformations of Differently Prepared Amorphous Forms. Proceedings of the 37th Annual Meeting and Exposition of the Controlled Release Society, Portland, Oregon, USA (2010)

Kaur, R., Morris, R., Bencsik, M., Vangala, A., Rades, T., Perrie, Y. Development of a novel magnetic resonance imaging contrast agent for pressure measurements using lipid coated gas filled microbubbles. The 36th Annual Meeting & Exposition of the Controlled Release Society, Copenhagen, Denmark (2009)

Khunawattanakul, W., Puttipipatkhachorn, S., Rades, T., Pongjanyakul, T. Use of chitosan-magnesium aluminium silicate nanocomposite films for modified-release tablets. Proceedings of the AAPS Annual Meeting, Association of American Pharmaceutical Scientists, New Orleans, Louisiana, USA (2010)

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Knopp, M.M., Sassese, P., Hesselkilde, J.Z., Koradia, V.S., Larsen, A., Rades, T., Mullertz, A. Dynamic In Vitro Lipolysis of SMEDDS containing Cinnarizine: Characterising solubilisation and precipitation. Proceedings of the 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Valetta, Malta (2010)

Kojarunchitt, T. Development of thermoresponsive gels containing particulates as potential vaccine formulations. The New Zealand Chapter of the Controlled Release Society 12th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2010) (Poster)

Kojarunchitt, T., Hook, S., Rizwan, S., Rades, T., Baldursdottir, S. Modified poloxamer 407 gels containing cubosomes as potential vaccine formulations. Proceedings of the AAPS Annual Meeting, Association of American Pharmaceutical Scientists, New Orleans, Louisiana, USA (2010)

Kojarunchitt, T., Baldursdottir , S., Rades, T., Hook, S. Development of sustained release of particulates as potential vaccine formulations. Formulation and Delivery of Bioactives & Controlled Release Society (New Zealand Chapter) meeting, Dunedin (2010) (Poster)

Koradia, V., Bøtker, J., Savolainen, M., Rades, T., Rantanen, J. Analysing the residual crystallinity in the amorphous phase prepared by the different routes. Proceedings of the AAPS Annual Meeting, Association of American Pharmaceutical Scientists, New Orleans, Louisiana, USA (2010)

Korell, J., Duffull, S.B., Coulter, C.V. A statistical model for red blood cell survival time. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand (2009) (Verbal presentation)

Korell, J., Coulter, C.V., Duffull, S.B. Design of survival studies for red blood cells. Abstracts of the 11th Annual Scientific Meeting of the Population Approach Group in Australia and New Zealand (PAGANZ), Adelaide, Australia (2010) (Verbal presentation: Awarded best student presentation)

Korell, J., Coulter, C.V., Duffull, S.B. Design of survival studies for red blood cells. Abstracts of the 19th Meeting of the Population Approach Group in Europe (PAGE), ISSN 1871-6032 Berlin, Germany (2010) (Verbal presentation)

Krittaphol, P., Thomson, C., McDowell, A., Wescombe, P., Tagg, J., Fawcett, J.P. Can supplemental probiotics influence L-selenomethionine metabolism in the rat intestinal tract? The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2009) (Poster)

Krittaphol, W., Thomson, C. D., McDowell, A., Wescombe, P., Tagg, J., Fawcett, J. P. Do probiotics influence L-selenomethionine and selenite metabolism by indigenous microbes in different segments of the rat intestinal tract? The 19th International Congress of Nutrition (ICN): Nutrition Security for All, Bangkok, Thailand (2009) (Poster)

81

Kumar, V.V.P., Isbister, G.K., Duffull, S.B. Pharmacodynamics of veniafaxine in overdose. Abstracts of the 11th Annual Scientific Meeting of the Population Approach Group in Australia and New Zealand (PAGANZ), Adelaide, Australia (2010)

Kumar, Vajjah, V.P.K., Duffull, S.B. Generalisatoin of T-optimality for discriminating between competing models – an application to paracetamol overdose. Abstracts of the 19th Meeting of the Population Approach Group in Europe (PAGE), ISSN 1871-6032 Berlin, Germany (2010) (Poster)

Lee, H.J., Waller, R.D., Stebbings, S., Highton, J., Orlovich, D.A., Fawcett, J.P. The effect of probiotic supplementation of sulphasalazine metabolism in patients with rheumatoid arthritis: A pilot study. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2009) (Verbal presentation)

Lee, H.J., Waller, R.D., Stebbings, S., Highton, J., Orlovich, D.A., Fawcett, J.P. The effects of an oral probiotic on sulphasalazine metabolism in rheumatoid arthritis. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand (2009) (Verbal presentation)

Lees, G., Dixon, C., Maggo, S., Clark, D., Tyndall, J., Strandell, J. Modulation of ion channels by the antiviral drug efavirenz. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand (2009) (Verbal presentation)

Loke, S.K., Duffull, S., McDonald, J., Tordoff, J., Vlugter, P., Winikoff, M. SimPharm: Authentic immersion and reading the world as a pharmacist. In R. J. Atkinson & C. McBeath (Eds.), Proceedings of the 26th Annual Australasian Society for Computers in Learning in Tertiary Education Conference: Same Places, Difference Spaces, Ascilite, Auckland, New Zealand (2009)

McDowell, A. The delivery of macromolecules to wildlife. The New Zealand Chapter of the Controlled Release Society 12th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand, (2010) (Invited speaker)

McDowell, A., Kafka, A., McLeod, B., Rades, T. PECA Nanoparticles for the peroral delivery of D-Lys6-GnRH to wildlife: in vitro and in vivo investigations. Proceedings of the AAPS Annual Meeting, Association of American Pharmaceutical Scientists, New Orleans, Louisiana, USA (2010)

Medlicott, N.J., Hildebrandt, C., Jørgensen, L., Empson, R. Formulation strategies for controlled delivery of brain derived neurotropic factor (BDNF) to the brain. The New Zealand Chapter of the Controlled Release Society 12th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2010) (Verbal presentation)

Medlicott, N. Macromolecule delivery via the oral route: Current innovations. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2009) (Verbal presentation)

82

Merriman, T., McNoe, L., Phipps-Green, M., Hollis-Moffatt, J., Hook, S., Faiz, F. The SMAD2 gene, the IDD21.1 locus and autoimmune diabetes in the non-obese diabetic mouse. The 33rd New Zealand Society for the Study of Diabetes Annual Scientific Meeting, Dunedin, New Zealand (2009) (Verbal presentation)

Nagaraja, R.Y., Reynolds, J.N.J., Medlicott, N.J., Empson, R.M. Polymeric devices for the delivery of neuroactive compounds to the cerebellum in vivo. The New Zealand Chapter of the Controlled Release Society 12th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand. (2010) (Verbal presentation)

Munk, T., Kapp, S., Rades, T., Hietala, S., Tian, F., Rantanen, J., Baldursdottir, S. The use of thermosensitive poloxamer 407 and Poly(N-Isopropyl Acrylamide) as crystallisation modifiers. Proceedings of the AAPS Annual Meeting, Association of American Pharmaceutical Scientists, New Orleans, Louisiana, USA (2010)

Naelapää, K., Boetker, J., Veski, P., Rantanen, J., Rades, T., Kogermann ,K. Insight into the recrystallisation behaviour of amorphous piroxicam under various conditions. Proceedings of the AAPS Annual Meeting, Association of American Pharmaceutical Scientists, New Orleans, Louisiana, USA (2010)

Nath, C.E., Shaw, P.J., Trotman, J., Zeng, L., Duffull, S., McLachlan, A.J., Gurney, H., Kwan, Y., Presgrave, P., Tiley ,C., Joshua, D., Kerridge, I., Earl, J. Population pharmacokinetics of total and unbound melphalan in patients with multiple myeloma. Abstracts of the 11th Annual Scientific Meeting of the Population Approach Group in Australia and New Zealand (PAGANZ) Adelaide, Australia (2010)

Nguyen, A., Milne, T., Monk, B., Tyndall, J.D.A. A model system for heterologous expression of cysteine-rich secretory proteins, antigen 5 and pathogenesis-related group 1 proteins in E. coli. 203rd Scientific meeting of OMSRS, 15 July (2010) (Verbal presentation)

Norris, P., Chamberlain, K., Madden, H., Dew, K., Hodgetts, D., Nikora, L., Radley, A., Gabe, J. What a difference a household makes: household relationships and medicine-taking, Abstracts of the 16th International Social Pharmacy Workshop, Lisbon, August (2010) (Poster)

Norris, P., Green, J. Responding To Indigenous Health Disparities: The University of Otago, New Zealand Experience Abstracts of the 16th International Social Pharmacy Workshop, Lisbon, Portugal (2010) (Poster)

Norris, P., Horsburgh, S., Becket, G., Crampton, P., Arroll, B., Herbison, P., Cumming, J. Too much for some, and not enough for others? Patterns of Antibiotic Use in a New Zealand Town. Abstracts of the 16th International Social Pharmacy Workshop, Lisbon, August (2010) (Poster)

Pan, S., Strachan, C., Rades,T., Saville, D. Optimization of carbamazepine: PVP ratio in solid dispersions. Proceedings of the Australasian Pharmaceutical Science Association, Woolloongabba, Australia (2010)

83

Patel, A., Mubangazi, P., Cepuch, C. Access to essential medicines in Africa: Partnering with civil society. The 2nd Otago International Health Research Network Conference, Dunedin, New Zealand (2009) (Verbal presentation)

Pirayavaraporn, C., Rades, T., Gordon, K.C., Tucker, I.G. States of water in eudragit RLPO polymer: A vibrational spectroscopic study. The New Zealand Chapter of the Controlled Release Society 12th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2010) (Poster)

Pirayavaraporn, C., Rades, T., Gordon, K.C., Tucker, I.G. States of water in Eudragit RLPO polymer: A vibrational spectroscopic study. The New Zealand Chapter of the Controlled Release Society 12th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2010) (Poster)

Pirayavaraporn, C., Rades, T., Tucker, I.G. The effect of moisture on coalescence of eudragit RLPO polymer particles. Proceedings of the 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Valetta, Malta (2010)

Rades, T. Electron microscopical studies on colloidal carriers for bioactives. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2009) (Verbal presentation)

Rades, T. Formulation solutions for βbrick-dustβ molecules. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2009) (Verbal presentation)

Rades, T. Formulation and delivery strategies for large molecules. The New Zealand Chapter of the Controlled Release Society 12th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2010) (Invited speaker)

Rades, T. Physical aspects of dissolution. The Australian & New Zealand Chapters of the Controlled Release Society Workshop: In Vitro Drug Release and Dissolution Testing, Auckland, New Zealand (2010) (Verbal presentation)

Rades, T. Microemulsions for drug delivery. Abstracts of the 1st Current Drug Development International Conference, Phuket, Thailand (2010) (Verbal presentation)

Ragupathy, R., Aaltonen, K., Tordoff, J., Norris, P., Reith, D. Medicines licensed for children and subsidised under single payer systems in New Zealand, Australia, the United Kingdom and the United States. The Fourth Annual Division of Health Sciences Research Forum, Dunedin, New Zealand (2010) (Poster)

Ragupathy, R., Tordoff, J., Norris, P., & Reith, D. Availability of prescription medicines licensed for adults in New Zealand, Australia, the United Kingdom and the United States, and the subsidy of medicines licensed for adults under a government funded single payer system in each country. The Third Annual Division of Health Sciences Research Forum, Wellington, New Zealand (2009) (Poster)

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Ragupathy, R., Aaltonen, K., Tordoff, J., Norris, P., Reith, D. Medicines Licensed For Children and Subsidised Under Single Payer Systems In New Zealand, Australia, The United Kingdom And The United States. Abstracts of the 16th International Social Pharmacy Workshop (ISWP), Lisbon, Portugal (2010) (Verbal presentation)

Rattanapak, T., Rades, T., Hook, S. Transcutaneous delivery of peptide vaccines using lipid carriers (liposomes, transfersomes, ethosomes and cubosomes). The New Zealand Chapter of the Controlled Release Society 12th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2010) (Poster)

Rattanapak, T., Rades, T., Hook, S. Quantitation of entrapped MPL and QuilA in lipid transcutaneous vaccines using high performance liquid chromatography and evaporate light scattering detection. Australasian Pharmaceutical Science Association Annual Meeting, Brisbane, (2010) (Poster)

Rattanapak, T., Rades, T., Hook, S. Transcutaneous delivery of peptide vaccines using lipid carriers (liposomes,transfersomes, ethosomes and cubosomes). Formulation and Delivery of Bioactives & Controlled Release Society (New Zealand Chapter) meeting, Dunedin, New Zealand (2010) (Poster)

Rattanapak, T., Rades, T., Hook, S. Transcutaneous immunisation using colloidal carriers. UK Pharmacy Science Conference, Nottingham, UK (2010) (Verbal presentation)

Rehder, S., Sakmann, A., Rades, T., Leopold, C. Stability of Triturations Containing Amorphous Ketoprofen During Tableting. Proceedings of the 37th Annual Meeting and Exposition of the Controlled Release Society, Portland, Oregon, USA (2010)

Rehder, S., Sakmann, A., Rades, T., Leopold, C. Characterisation of the sublimate of amorphous glibenclamide formed during dry heating. Proceedings of the AAPS Annual Meeting, Association of American Pharmaceutical Scientists, New Orleans, Louisiana, USA (2010)

Ren, S., Ogbonna, A., Koradia, V., Sassene, P., Rades, T., Müllertz, A. Redissolution and polymorph characterisation of a poorly water-soluble drug precipitated during in vitro lipolysis from a lipid-based formulation. Proceedings of the AAPS Annual Meeting, Association of American Pharmaceutical Scientists, New Orleans, Louisiana, USA (2010)

Rizwan, S., Young, K., Rades, T., Hook, S. Cubic liquid crystal nanoparticles ‘cubosomes’ for vaccine delivery. The Australian Vaccines and Immunotherapeutics Development conference, Melbourne, Australia (2010) (Oral presentation)

Rushaidhi, M., Zhang, H., Jing, Y., Chary, S., Liu, P. Studies on the disposition of agmatine, a novel neurotransmitter, in rat brain using in vivo microdialysis in freely moving rat. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2009) (Verbal presentation)

Rushaidhi, M., Zhang, H., Jing, Y., Liu, P. Agmatine readily and rapidly crosses blood brain barrier: An in vivo brain microdialysis study in freely moving rats. The New Zealand Chapter of the Controlled Release Society 12th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2010) (Verbal presentation)

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Salis, E., Reith, D., Medlicott, N. J. LC-MS and chemiluminescence analysis of insulin analogues for pharmacokinetic studies. The New Zealand Chapter of the Controlled Release Society 12th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2010) (Verbal presentation)

Salis, E., Reith, D., Medlicott, N.J. LC-MS and chemiluminessence analysis of insulin analogs for pharmacokinetic studies. 12th Dunedin Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2010) (Oral presentation)

Sassene, P., Knopp, M., Hesselkilde, J., Koradia, V., Larsen, A., Rades, T., Mullertz, A. Precipitation of a poorly soluble model drug during dynamic in vitro lipolysis – Characterization and dissolution of the precipitate. Proceedings of the 37th Annual Meeting and Exposition of the Controlled Release Society, Portland, Oregon, USA (2010)

Sassene, P., Michelsen, J., Koradia, V., Larsen, A., Rades, T., Müllertz, A. characterisation of precipitates formed during in vitro lipolysis of SMEDDS containing 2 poorly soluble model drugs. Proceedings of the AAPS Annual Meeting, Association of American Pharmaceutical Scientists, New Orleans, Louisiana, USA (2010)

Sawant, P. M., Tyndall, J., Mountfort, D. O., Holland, P. T., Kerr, D. S. In vivo potency, receptor binding and molecular modeling identify structure-activity relationships for domoic acid and its isomers. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand (2009) (Verbal presentation)

Singh, R., Hook, S., Rades, T., Graf, A. In situ forming liquid crystalline systems on the basis of microemulsions for sustained drug delivery. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand. (2009) (Verbal presentation)

Singh, R., Hook, S., Rades, T., Graf, A. Influence of composition variables of in situ gelling microemulsion templates on viscosity and release of FITC-Ova containing polymeric nanoparticles for sustained protein delivery. The New Zealand Chapter of the Controlled Release Society 12th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2010) (Verbal presentation)

Singh, R., Hook, S., Graf, A., Rades, T. The effect of viscosity on entrapment and in vitro release of FITC-OVA from self-gelling microemulsion templates. The Fourth Annual Division of Health Sciences Research Forum, Dunedin, New Zealand (2010) (Poster)

Singh, R., Hook, S., Rades, T., Graf, A. Influence of viscosity on entrapment and in vitro release of FITC-Ova from poly(alkylcyanoacrylate) nanoparticles dispersed in self-gelling microemulsion templates. Proceedings of the 37th Annual Meeting and Exposition of the Controlled Release Society, Portland, Oregon, USA (2010)

Singh, R., Hook, S., Graf, A., Rades, T. Polymeric nanoparticles dispersed in self-gelling microemulsion templates for sustained vaccine delivery. Proceedings of the Australasian Pharmaceutical Science Association, Woolloongabba, Australia (2010)

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Smith, P. F., Devaraj, R., Zhang, H., Ganesalingham, G., Liu, P. Multivariate analysis of neurochemical changes in the aging rat brain. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand (2009) (Verbal presentation)

Sprunk, A., Strachan, C. J., Rades, T., Graf, A. Rational formulation approach for simvastatin-containing SMEDDS. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2009) (Poster)

Sprunk, A., Strachan, C., Rades, T., Graf, A. SMEDDS as a delivery system for simvastatin: A rational formulation approach. The 36th Annual Meeting & Exposition of the Controlled Release Society, Copenhagen, Denmark (2009) (Poster)

Tan, A., Simovic, S., Davey, A.K., Boyd, B.J., Rades, T., Prestidge, C.A. Silica-lipid hybrid (SLH) microcapsules for improving oral delivery of poorly soluble drugs. The 36th Annual Meeting & Exposition of the Controlled Release Society, Copenhagen, Denmark (2009)

Strachan, C. Imaging dosage form structure and changes during dissolution using coherent anti-Stokes Raman scattering microscopy. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2009)(Verbal presentation)

Strachan, C. Pharmaceutical formulation and manufacturing: Art or science? The Fourth Annual Division of Health Sciences Research Forum, Dunedin, New Zealand (2010) (Verbal presentation)

Strachan, C. Spectroscopic aspects of dissolution. The Australian & New Zealand Chapters of the Controlled Release Society Workshop: In Vitro Drug Release and Dissolution Testing, Auckland, New Zealand (2010) (Verbal presentation)

Strachan, C. Process analytical technology. The Australian & New Zealand Chapters of the Controlled Release Society Workshop: In Vitro Drug Release and Dissolution Testing, Auckland, New Zealand (2010) (Verbal presentation)

Supriadi, I. R., Yeo, T. W., Anstey, N., Duffull, S. A model for the effects of malaria on L-arginine catabolism in endothelial cells. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand (2009) (Verbal presentation)

Supriadi, I., Duffull, S.B., Yeo, T.W., Ansty, N. A mathematical model for the effect of malaria on arginine catabolism in endothelial cells. Abstracts of the 11th Annual Scientific Meeting of the Population Approach Group in Australia and New Zealand (PAGANZ) Adelaide, Australia (2010)

Supridias, I., Duffull, S.B., Yeo, T.W., Ansty, N. A mathematical model for the effects of malaria on arginine catabolism in endothelial cells. ASEAN meeting, Singapore (2010)

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Thomas, N., Graf, A., Rades, T. Design and characterisation of lipid-based formulations for the delivery of simvastatin. The New Zealand Chapter of the Controlled Release Society 12th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2010) (Verbal presentation)

Thomas, N., Rades, T., Graf, A. Influence of lipid chain length on in vitro performance of self-nanoemulsifying drug delivery systems for simvastatin. Proceedings of the 37th Annual Meeting and Exposition of the Controlled Release Society, Portland, Oregon, USA (2010)

Thomas, N., Rades, T., Graf, A. Effect of drug load and lipid chain length of self-nanoemulsifying drug delivery systems on drug solubilisation during in vitro lipolysis. Proceedings of the AAPS Annual Meeting, Association of American Pharmaceutical Scientists, New Orleans, Louisiana, USA (2010)

Tong, A.Y.C., Braund, R., Tan, E.W., Tremblay, L.A., Stringer, T., Trought, K., Peake, B.M. UV-induced photodegradation of oseltamivir (Tamiflu™) in aqueous solution. Sixth Asian Photochemistry Conference, Wellington, New Zealand (2010)

Tordoff, J., Simonsen, K., Thomson, M., Norris, P. How do older people in New Zealand manage any adverse effects from their medicines? The New Zealand Hospital Pharmacists’ Association Conference, Nelson, New Zealand (2009) (Verbal presentation)

Tordoff, J., Bagge, M., Norris, P., Gray, A., Campbell, J. How do older people living at home in New Zealand manage their medicines? Abstracts of the 16th International Social Pharmacy Workshop, Lisbon, Portugal, (2010) (Poster)

Tucker, I. Oral drug delivery: The challenges continue. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2009) (Verbal presentation)

Tucker, I.G., Yang, L., Fawcett, J.P., Zhang, H. A novel bile salt, 12-monoketocholate, modulates p-glycoprotein in RBE4 cells. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand (2009) (Verbal presentation)

Tucker, I. Formulation and delivery strategies for getting bioactives to the brain. The New Zealand Chapter of the Controlled Release Society 12th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2010) (Invited speaker)

Tyndall, J.D.A., Timms, P., Huston, W.M. Development of an assay for testing substrate specificity determinants for Chlamydia trachomatis heat activated serine protease HtrA. The Sixth General Meeting of the International Proteolysis Society, Surfers Paradise, Australia (2009) (Verbal presentation)

Tyndall, J.D.A., Smith, R.A.J., Brown, K.K., Hampton, M.B. Inhibition of the Proinflammatory Cytokine Macrophage Migration Inhibitory Factor by Isothiocyanates. QMB Drug Discovery and Development Satellite, Queenstown, New Zealand, (2010) (Invited Speaker)

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Tyndall, J.D.A., Smith, R.A.J., Brown, K.K., Hampton, M.B. Design of enhanced isothiocyanate inhibitors of the proinflammatory cytokine macrophage migration inhibitory factor. Pacifichem, Honolulu, Hawaii (2010)

Tyndall, J.D.A., Smith, R.A.J., Brown, K.K., Hampton, M.B. Identification of second generation isothiocyanate inhibitors of the proinflammatory cytokine Macrophage Migration Inhibitory Factor, MM2010, Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia (2010)

Vajjah, V.P.K., Oscarsson, S., Friberg, L.E., Isbister, G.K., Hackett, L.P., Duffull, S.B. The effect of decontamination procedures on the pharmacokinetics of venlafaxine in overdose. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand (2009) (Verbal presentation)

Wajima, T., Isbister, G.K., Duffull, S.B. A comprehensive model for the humoral coagulation network in humans. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand (2009) (Verbal presentation)

Wajima, T., Isbister, G.K., Duffull, S.B. A quantitative model for the coagulation network. The Population Approach Group in Australia and New Zealand Scientific Meeting, Newcastle, Australia (2009) (Poster)

Wright, D., Duffull, S. Optimal designs for warfarin INR monitoring. Abstracts of the 11th Annual Scientific Meeting of the Population Approach Group in Australia and New Zealand (PAGANZ), Adelaide, Australia (2010)

Wright, D.F.B., Kumar, V.P.V., Al-Sallami, H.S., Duffull, S.B. Simvastatin dosing in the evening: does it really make a difference? The proceedings of the Australasian Society of Clinical and Experimental Pharmacologists & Toxicologists, Christchurch, New Zealand (2010)

Wu, Z., Tucker, I., Razzak, M., Medlicott, N. A water-in-oil emulsion system for parenteral delivery of an acidic drug solution. The 36th Annual Meeting & Exposition of the Controlled Release Society, Copenhagen, Denmark (2009) (Poster session)

Wu, Z., Tucker, I.G. Imaging intramammary dosage forms. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2009) (Verbal presentation)

Yang, L., Feng, F., Fawcett, J., Zhang, H., Tucker, I. Bile salts modulate lipid membrane fluidity and permeability. The 36th Annual Meeting & Exposition of the Controlled Release Society, Copenhagen, Denmark (2009) (Poster)

Yang, L., Mikov, M., Zhang, H., Tucker, I.G. The interactions between a novel bile salt with membrane models. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2009) (Poster)

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Yang, L., Østergaard, J., Fawcett, P., Zhang, H., Tucker, I. Mechanistic understanding of enhancement of rhodamine 123 uptake in RBE4 cells by bile salts. The New Zealand Chapter of the Controlled Release Society 12th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2010) (Verbal presentation)

Zhang, H. The application of microdialysis in the brain research: Early-phase discovery and development of CNS bioactives. The New Zealand Chapter of the Controlled Release Society 12th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2010) (Invited speaker)

Zimper, U., Aaltonen, J., Karen, K., Rades, T. Quantification of the amorphous content of milled drugs. The 36th Annual Meeting & Exposition of the Controlled Release Society, Copenhagen, Denmark (2009) (Poster)

Zimper, U., Aaltonen, J., Krauel-Goellner, K., Rades, T. Quantifying the amount of process induced disorder. The New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand (2009) (Verbal presentation)

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graNTS

2009

Principal title of Project granter value investigators

Carolyn Coulter Investigating glycaemic control in UORG $21,340 diabetic patients with chronic kidney disease

Stephen Duffull, Development of simulation software CALT $5,000 Hesham Al-Sallami to enhance learning of the clotting cascade

Anja Graf Investigation of colloidal formulations NZPERF $15,692 as sustained release vaccines

Anja Graf Investigation of colloidal formulations UORG $25,795 as sustained release vaccines

Sarah Hook Enhancing T cell memory responses UORG $38,000 by improving vaccine strategies

Arlene McDowell Preformulation of puha for an Laurenson $11,990 antioxidant nutritional supplement Award

Natalie Medlicott Neonatal infusions – what’s the dose? NZPERF $12,078

Thomas Rades Effects of the fatty acid, luric acid, NHMRC $260,000 on energy intake and gut motor and hormonal function in health and obesity

Clare Strachan Microscopic imaging of drug release UORG $19,572 from delivery systems: testing the uniformly receding drug boundary assumption

Clare Strachan Rapid detection of counterfeit NZPERF $8,500 and adulterated products using vibrational spectroscopy

June Tordoff Community pharmacy services to Pharmacy $29,450 older people in the community Guild of NZ

Ian Tucker How do bile salts affect drug NZPERF $6,859 transports and the absorption of methotrexate?

Ian Tucker Can bile salts improve drug delivery NZPERF $9,237 to the brain?

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Ian Tucker Investigations into the transport NZ Lottery $78,839 and metabolism of drugs Grants Board

Joel Tyndall Validating essential enzymes as targets Maurice & $12,000 for new broad spectrum antifungal Phyllis Paykel compounds Trust

Joel Tyndall Rational design of small molecule UQT Australia $3,500 inhibitor molecules to proteases Visiting involved in pathogenesis of Researcher infectious diseases

Sarah Hook Development of novel topical Douglas Industrial formulations Pharmaceuticals contract Ltd

Thomas Rades Defining methods for the prediction F. Hoffman Industrial of amorphous stability -La Roche, contract Switzerland

Thomas Rades Development of analytical test Boehringer Industrial methods and their application Ingelheim, contract Germany

Thomas Rades Determination of the Tg of Bioneer Farma, Industrial acrolimus and detection of Denmark contract crystalline tarcolimus

In addition, a number of staff are co-investigators in grants at overseas institutions.

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2010

Principal title of Project granter value investigators

Olaf Bork SOLTEC – A platform technology Otago $14,800 for controlled delivery of water Innovation sensitive drugs Limited

Rhiannon Braund Determination of levels of NZPERF $7,250 pharmaceuticals in water systems

Stephen Duffull The impact of renal tubular function Laurenson $31,908 on drug handling in the elderly Award

Stephen Duffull A comparison of two dose NZPERF $10,926 individualisation methods for warfarin therapy

Natalie Medlicott Neonatal infusions: improving drug UORG $20,935 delivery to premature babies

Natalie Medlicott Pharmacokinetic pharmacodynamics NZPERF $5,600 (PKPD) of insulin in the treatment of neonatal hyperglycaemia

Pauline Norris Access to pharmacy services: NZPERF $11,105 investigating changes over time in the number and location of pharmacies

David Schmierer Is the quality control of herbal NZPERF $7,200 Clare Strachan medicines adequate? A study of valerian (Valeriana officinalis) and milk thistle (Silybum marianum)

June Tordoff Medicines in the context of older NZPERF $3,780 people’s lives

Ian Tucker Advances in pulmonary drug carriers NZPERF $8,570 creating new opportunities for inhaling medicine

Joel Tyndall New Azoles for emerging fungal OMRF $10,600 pathogens

Thomas Rades Production of Nanocrystals of Bioneer A/S, Industrial atorvastatin calcium for use in Denmark contract fish oil products

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Thomas Rades Characterisation of differently Boehringer- Industrial prepared pellets containing the Ingelheim, contract drug BI14332CL Switzerland

Thomas Rades Quantitative determination of Douglas Industrial Clare Strachan amorphous content in acitretin Pharmaceuticals contract samples Ltd, NZ

Thomas Rades Determination of the dissolution PepsiCo Inc, Industrial profile of salt samples USA contract

Clare Strachan Development of dual anthelmintic Schering- Industrial and combination dual anthelmintic Plough Animal contract plus clostridial vaccine injectable Health formulation

keyNZPERF New Zealand Pharmacy Education and Research FoundationUORG University of Otago Research GrantOMRF Otago Medical Research FoundationHRC Health Research CouncilCALT The Committee for the Advancement of Learning & TeachingFRST Foundation of Research, Science & Technology

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coNfErENcE lEavE

The School is pleased to be able to support staff and postgraduate students to attend national and international conferences. This is essential to ensure that the academic staff are abreast of developments in their field, to allow them to network with potential international collaborators and to provide opportunity to present research data where it can be peer-reviewed and critically assessed.

PhD students are given a grant-in-aid to attend a local (Australasian) conference in the second year of their PhD and a second grant-in-aid to attend an international conference to present their PhD research in the final year of their programme. Support is also provided by the Division of Health Sciences.

Conferences attended by staff and postgraduate students | 2009

Not all were financially supported by the School.

name conference venue Dates

Hesham Al-Sallami PAGANZ Newcastle, Australia 4-6 February

Hesham Al-Sallami ASCEPT Dunedin, NZ 3-5 September

Hesham Al-Sallami NZHPA Nelson, NZ 11-13 September

Hesham Al-Sallami AAPS Los Angeles, USA 8-12 November

Mousab Arafat AAPS Los Angeles, USA 8-12 November

Michael Bagge NZ Association Wellington, NZ 7-9 October of Gerontology and Age Concern Conference

Rhiannon Braund APSA Hobart, Australia 9-11 December

Gong Chen ASCEPT Dunedin, NZ 3-5 September

Carolyn Coulter PAGANZ Newcastle, Australia 4-6 February

Carolyn Coulter ASCEPT Dunedin, NZ 3-5 September

Carolyn Coulter NZHPA Nelson, NZ 11-13 September

Stephen Duffull PAGANZ Newcastle, Australia 4-6 February

Stephen Duffull PKPD Workshop Washington, USA 4-8 May

Stephen Duffull PAGE Conference St Petersburg, Russia 24-26 June

Stephen Duffull PODE Conference St Petersburg, Russia 27 June

Stephen Duffull ASCEPT Dunedin, NZ 3-5 September

Paul Fawcett ASCEPT Dunedin, NZ 3-5 September

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Paul Fawcett APSA Hobart, Australia 9-11 December

Lee Kien Foo PAGANZ Newcastle, Australia 4-6 February

Lee Kien Foo ASCEPT Dunedin, NZ 3-5 September

Anja Graf CRS Copenhagen, Denmark 18-22 July

James Green European Health Pisa, Italy 23-26 September Psychology Society

James Green Leaders in Melbourne, Australia 2-4 December Indigenous Medical Education (LIME)

James Green APSA Hobart, Australia 9-11 December

Susan Heydon Capricornia Medical Queensland, Australia 5-8 June Science Association

Susan Heydon 18th NZ Asian Wellington, NZ 6-8 July Studies Society Conference

Sarah Hook Keystone Symposia Utah, USA 11-16 January

Sarah Hook Mobilizing Cellular Utah, USA 11-16 January Immunity for Cancer Therapy

Sarah Hook British Manchester, UK 6-9 September Pharmaceutical Conference

Sarah Hook National Auckland, NZ 19-21 November Immunisation Conference

Sarah Hook APSA Hobart, Australia 9-11 December

Rohit Jain AAPS Los Angeles, USA 8-12 November

Thunjiradasiree APSA Hobart, Australia 9-11 December Kojarunchitt

Julia Korell ASCEPT Dunedin, NZ 3-5 September

Pummy Krittaphol 19th International Bangkok, Thailand 04-09 October Congress of Nutrition Conference

Pavan Kumar PAGANZ Newcastle, Australia 4-6 February

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Pavan Kumar PAGE St Petersburg, Russia 23-26 June

Pavan Kumar ASCEPT Dunedin, NZ 3-5 September

Hee Ji Lee ARA/NZRA Wellington, NZ 3-6 May

Hee Ji Lee ASCEPT Dunedin, NZ 3-5 September

Arlene McDowell CRS Copenhagen, Denmark 18-22 July

Arlene McDowell APSA Hobart, Australia 9-11 December

Albert Nguyen ComBio Christchurch, NZ 6-10 December

Pauline Norris The Pharmaceutical Milan, Italy 21-24 September Life Cycle

Aarti Patel International Istanbul, Turkey 3-8 September Pharmaceutical Federation conference

Aynsley Peterson NZHPA Nelson, NZ 11-13 September

Chompak AAPS Los Angeles, USA 8-12 November Pirayavaraporn

Thomas Rades APS Workshop Aston University, 15-16 April Birmingham, UK

Thomas Rades Therapeutic Vaccine Varadero, Cuba 5-10 May Workshop

Thomas Rades ASSA Connecticut, USA 14-19 June

Thomas Rades CRS Copenhagen, Denmark 18-22 July

Thomas Rades AAPS Los Angeles, USA 8-12 November

Thomas Rades APSA Hobart, Australia 9-11 December

Dorothy Saville APSA Hobart, Australia 9-11 December

Rinku Singh AAPS Los Angeles, USA 8-12 November

Rinku Singh APSA Hobart, Australia 9-11 December

Clare Strachan 11 International Connecticut, USA 14-19 June Workshop on Physical Characterization of Pharmaceutical Solids

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Clare Strachan APSA Hobart, Australia 9-11 December

June Tordoff British Manchester, UK 6-9 September Pharmaceutical Conference

June Tordoff NZHPA Nelson, NZ 11-13 September

June Tordoff NZ Association of Wellington, NZ 7-9 October Gerontology and Age Concern Conference

Ian Tucker CRS Copenhagen, Denmark 18-22 July

Ian Tucker ASCEPT Dunedin, NZ 3-5 September

Ian Tucker APSA Hobart, Australia 9-11 December

Joel Tyndall 6th General Meeting Surfers Paradise, Australia 26-30 October of the International Proteolysis Society

Joel Tyndall ComBio Christchurch, NZ 5-12 December

Lin Yang CRS Copenhagen, Denmark 18-22 July

Hu Zhang Biomarker World Philadelphia, USA 27-29 May Congress

Ulrike Zimper AAPS Los Angeles, USA 8-12 November

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coNfErENcES aTTENdEd by STaff aNd PoSTgraduaTE STudENTS 2010

Not all were financially supported by the School.

name conference venue Dates

Hesham Al-Sallami PAGANZ Adelaide, Australia 8-10 February

Hesham Al-Sallami PAGE Berlin, Germany 9-12 June

Hesham Al-Sallami ASCEPT Christchurch, NZ 29-31 August

Hesham Al-Sallami NZHPA Hamilton, NZ 3-5 September

Michael Bagge International Social Lisbon, Portugal 23-26 August Pharmacy Workshop

Olaf Bork AAPS New Orleans, USA 14-18 November

Carolyn Coulter PAGANZ Adelaide, Australia 8-10 February

Carolyn Coulter PAGE Berlin, Germany 9-12 June

Carolyn Coulter ASCEPT Christchurch, NZ 29-31 August

Carolyn Coulter NZHPA Hamilton, NZ 3-5 September

Stephen Duffull PAGANZ Adelaide, Australia 8-10 February

Stephen Duffull PAGE Berlin, Germany 9-12 June

Stephen Duffull ASCEPT Christchurch, NZ 29-31 August

Paul Fawcett International Beijing, China 16-20 May Symposium on Microsomes and Drug Oxidations

Paul Fawcett ASCEPT Christchurch, NZ 29-31 August

Lee Foo PAGANZ Adelaide, Australia 8-10 February

Lee Foo PAGE Berlin, Germany 9-12 June

Lee Foo ASCEPT Christchurch, NZ 29-31 August

Abhishek Gulati PAGANZ Adelaide, Australia 8-10 February

Abhishek Gulati ASCEPT Christchurch, NZ 29-31 August

Anja Graf CRS Portland, USA 18-22 July

Paulina Guzman APSA Brisbane, Australia 6-9 December

Susan Heydon International Social Lisbon, Portugal 23-26 August Pharmacy Workshop

99

Sarah Hook FIP PSWC 2010 New Orleans, USA 10-12 November

Sarah Hook AAPS New Orleans, USA 14-18 November

Simon Horsburgh International Social Lisbon, Portugal 23-26 August Pharmacy Workshop

Thunjiradasiree GPEN North Carolina, USA 10-12 November Kojarunchitt

Thunjiradasiree AAPS New Orleans, USA 14-18 November Kojarunchitt

Julia Korell PAGANZ Adelaide, Australia 8-10 February

Julia Korell PAGE Berlin, Germany 9-12 June

Julia Korell ASCEPT Christchurch, NZ 29-31 August

Pavan Kumar PAGANZ Adelaide, Australia 8-10 February

Pavan Kumar PAGE Berlin, Germany 9-12 June

Chakradhar ASCEPT Christchurch, NZ 29-31 August Lagishetty

Kirsten Lovelock International Social Lisbon, Portugal 23-26 August Pharmacy Workshop

Arlene McDowell GPEN North Carolina, USA 10-12 November

Arlene McDowell AAPS New Orleans, USA 14-18 November

Pauline Norris International Social Lisbon, Portugal 23-26 August Pharmacy Workshop

Pauline Norris FIP Conference Lisbon, Portugal 28 August- 2 September

Thomas Rades Pharmaceutics, Valletta, Malta 8-11 March Biopharmaceutics & Pharmaceutical Technology World meeting

Thomas Rades CRS Portland, Oregon, USA 18-22 July

Thomas Rades AAPS New Orleans, USA 14-18 November

Rajan Ragupathy International Social Lisbon, Portugal 23-26 August Pharmacy Workshop

Emma Salis APSA Brisbane, Australia 6-9 December

100

Clare Strachan Pharmaceutics, Valletta, Malta 8-11 March Biopharmaceutics & Pharmaceutical Technology World meeting

Nicky Thomas GPEN North Carolina, USA 10-12 November

Nicky Thomas AAPS New Orleans, USA 14-18 November

June Tordoff International Social Lisbon, Portugal 23-26 August Pharmacy Workshop

Joel Tyndall MM2010 Melbourne, Australia 28 November- 1 December

Joel Tyndall Pacifichem 2010 Hawaii, USA 15-20 December

Dan Wright ASCEPT Christchurch, NZ 29-31 August

Bettina Zadehvakili SFRR Australasia Akaroa, NZ 29 November- 3 December

Hu Zhang BIT’s Annual Beijing, China 23-26 October Congress of International Drug Discovery Science & Technology

Hu Zhang A Dual-Track Kuala Lumpur, Malaysia 30-31 October Research Forum: Cancer Biomarkers & Neurosciences

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SEmINarS

In addition to journal clubs the School has a weekly seminar programme.

ScHOOl Of PHarMacy SeMinar PrOgraMMe 2009

Date Speaker title of Presentation

22 January Dr Robert Lancaster Pharmaceutical patent litigation – University College being deposed and the role of the London, United Kingdom expert witness

9 February Prof Paul Glue Characterising the placebo effect in Psychological Medicine anticholinergic drug trials for University of Otago overactive bladder

16 February Summer students School of Pharmacy • Sarah Qi & Sharon Yang Characterisation of liquid systems: effect of additive size in liquid crystalline behaviour • Koon Lui Dissolution characteristics of indomethancin-ranitidine hydrochloride co-milled amorphous drug • Thomas Choi Understanding and control of hydration state changes of niclosamide • Sashika Samaranayaka Gardasil: Does knowledge predict attitude?

20 February Prof Ian Larson Pharmatopia, a paradigm shifting Monash University teaching and learning solution Melbourne, Australia

23 February Summer students School of Pharmacy • Bill Lu Insurance coverage for medicines in New Zealand • Bert Lin Solid state stability of drugs in oral suspensions • Hannah Kim Investigating shelf-life parameters for total parenteral nutrition mixtures • Lillian Woung Herceptin: Does knowledge predict attitude? • Sarah Bushby The knowledge of pharmacy staff and parents of the risks of over-the counter (OTC) medications

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24 February Dr Stefania Baldursdottir Application of rheology in University of Copenhagen pharmaceutical sciences Denmark

2 March Prof Stephen Duffull Treating virtual patients in clinical School of Pharmacy pharmacy

9 March Prof John Eccleston Introduction and application of William Evans Visiting design to dose ranging studies Fellow University of Queensland Brisbane, Australia

16 March Prof Raymond M Reilly Novel Auger electron-emitting Leslie Dan Faculty of radiopharmaceuticals for breast Pharmacy University cancer and other malignancies of Toronto Canada

23 March Kristina Ferderber PhD final presentation: School of Pharmacy Phosphatidylcholine-based colloidal systems for dermal and transdermal drug delivery

30 March Prof Murray Tilyard BPAC – Service or research? Fact or CEO, BPAC NZ fallacy? Dunedin

6 April Prof Peter O’Brien The Hepatocyte inflammation model Faculty of Pharmacy for bolder screening of drug University of Toronto hepatotoxicity potential Canada

20 April Thunjiradasiree Kojarunchitt PhD 6 month presentation: School of Pharmacy Pre-clinical studies to improve potency and practicality of peptide cancer vaccines

20 April Pranav Karmwar PhD 6 month presentation: School of Pharmacy Investigating solid state transformations of differently prepared amorphous materials in the present of excipients during storage and dissolution

27 April Hani Al-Salami PhD final presentation: School of Pharmacy The combination of probiotics, MKC and gliclazide in a rat model of type 1 diabetes: hypoglycemic effects. Pharmacokinetics and transport studies

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18 May Lee Foo PhD 6 month presentation: School of Pharmacy The optimal design of PKPD studies

8 June Prof Pauline Norris & Health disparities between Mäori and Dr Simon Horsburgh non-Mäori School of Pharmacy

22 June Kirsten Graeser PhD final presentation: School of Pharmacy Investigation and characterization of amorphous systems and possibilities of their stability prediction

6 July Emma Salis PhD 6 month presentation: School of Pharmacy Liquid chromatography – mass spectrometry (LC-MS) of insulin and its analogues in human plasma

13 July Dr Graeme Hammond-Tooke Department of Medical & Medicines and magnets: the Surgical Sciences prevention and treatment of stroke University of Otago

16 July Majd Dameh PhD final presentation: School of Pharmacy Insights into the availability and use of antibiotics without prescription from community pharmacies: two case studies

20 July Aarti Patel Quality of Medicines in South Africa School of Pharmacy

27 July Assoc Prof Brendan McCane Analysing x-ray images Head of Department Computer Science University of Otago

3 August Prof John Tagg Probiotics rule – an update on the Department of consequences associated with Microbiology/BLIS knowingly ingesting BLIS – University of Otago producing bacteria

10 August Dr Craig Bunt Formulation of bio-control agents University of Auckland

17 August Prof Ian Tucker Some insights into the pharma School of Pharmacy market

24 August Teerawan Rattanapak PhD 6 month presentation: School of Pharmacy Transdermal delivery of peptide vaccines by using lipid vesicles

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24 August Michael Bagge PhD 6 month presentation: School of Pharmacy Medicines in the context of older peoples’ lives

31 August Anshul Awasthi PhD final presentation: School of Pharmacy Investigation of role and function of GLIPR1 in gliomas and melanomas

7 September Dr Susan Heydon A historian in a school of pharmacy School of Pharmacy

14 September Louise Ho PhD final presentation: School of Pharmacy From non-destructive film coating quality analysis to dissolution prediction using Terahertz pulsed imagining

21 September Nicky Thomas PhD 6 month presentation: School of Pharmacy Design and characterization of oral lipid based formulations

28 September Dr June Tordoff Just part of my life – medicines- School of Pharmacy taking in people 75 years and older in New Zealand

30 September James Oughton Medsafe investigation and Senior Advisor & Border enforcement team – experiences as a Control Pharmacists, pharmacist Investigation & Enforcement Compliance Management, Medsafe, Sector Accountability & Funding Directorate, Ministry of Health

5 October Sarah Gordon PhD final presentation: School of Pharmacy Chitosan hydrogels containing particulate antigen as vaccine delivery systems

19 October Hee-Ji Lee PhD final presentation: Probiotic School of Pharmacy bacteria and their role in sulfasalazine metabolism

2 November Dr Anja Graf Post-RSL: Research experiences School of Pharmacy during a mini-sabbatical in Denmark

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9 November Shakila Rizwan PhD final presentation: School of Pharmacy Cubosomes as antigen delivery systems

16 November Dr Philip Taday Recent development in Terahertz Applications Group Leader pulsed technology in the TeraView Ltd pharmaceutical setting United Kingdom

18 November Dr Herman Offerhaus Coherent anti-stokes Raman Lecturer, Optical Sciences scattering (CARS) microscopy Group, Department of Applied Physics Twente University The Netherlands

30 November Roger Willet Real and financial return and risk in Department of Business & engineering asset management Accountancy University of Otago

2 December Gong Chen School of Pharmacy PhD final presentation: Effect of ketocholate derivatives on the transport and pharmacokinetics of methotrexate

14 December Prof Ann Daly Pharmacogenetics of drug-induced Institute of Cellular Medicine liver injury Newcastle University United Kingdom

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School of Pharmacy SEmINar ProgrammE 2010

Date Speaker title of Presentation

1 February Julia Korell PhD 6 month presentation: School of Pharmacy Design of survival studies for red blood cells

8 February Dr Joel Tyndall HtrA – a new potential drug target in School of Pharmacy Chlamydia trachomatis

15 February Summer students School of Pharmacy • Thomas Choi Solubilisation capacity and dissolution/precipitation characteristics of ‘hybrid’type lipid based formulations • Sharon Yang Formulation of sustained release thermosensitive chitosan hydrogels • Sashika Samaranayaka Direct to consumer advertising of medicines in New Zealand

22 February Summer students School of Pharmacy • Sarah Shan Investigating the efficacy of the Aseptic Production Unit at Dunedin Hospital • Alex Park Pulmonary drug delivery systems: Recent developments and prospects • Finna Shen Development of a dosing regimen for N-acetyl cysteine for the treatment of paracetamol poisoning • Sarah Walker Medicines, pharmacy and primary health care services in the Himalayan region

24 February Summer students School of Pharmacy • Harry Zheng Comparing the impact of pharmacist-led medication reviews in Australia and the UK: Home Medicines Review (HMR) and the Medicines Use Review (MUR) • Ben Liu Ether and ester derivatives of cholic acid as permeation enhancers • Sarah Bushby Insulin kinetics in the brushtail possum

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• Benny Pan Investigating poisoning exposure in schools and pre-schools • Anson Lui Solid state characterisation of drug- polymer mixes

16 March Karla Meledandri The development of colloidal carrier Department of Chemistry systems with turnable properties University of Otago

22 March Madlen Hubert PhD 6 month presentation: School of Pharmacy Formulation and immunological characterisation of novel carbohydrate containing immune- pharmaceuticals

22 March Freda Feng PhD 6 month presentation: School of Pharmacy Transport of ketotifen and norketotifen into brain

26 March Dr Kirsten Graeser Formulation development for Lab Head preclinical studies – concepts and Roche points to consider Basel, Switzerland

29 March Vlad Syzov PhD 6 month presentation: School of Pharmacy Imaging of solid dispersions – a comparison of analytical techniques

29 March Miriam Haaser PhD 6 month presentation: School of Pharmacy Chemical analysis using Raman and Terahertz pulsed imaging

30 March Prof Duncan Craig In search of lost drugs: characterising Head, School of Pharmacy drug-polymer dispersions for University of East Anglia improving bioavailability Norwich, United Kingdom

1 April Len Stevenson HSNO compliance and what it means School of Pharmacy for your laboratory

8 April Len Stevenson HSNO compliance and what it means School of Pharmacy for your laboratory (repeated)

12 April Ross Law Director, Corporate Personal perspectives on today’s Strategic Services pharmaceutical industry Quintiles Transnational

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19 April Dr Rhiannon Braund Pharmaceuticals – disposal practices School of Pharmacy and environmental aspects in New Zealand

26 April Prof Ian Tucker Delivering drugs to the brain School of Pharmacy

3 May Pummy Krittaphol PhD final presentation: School of Pharmacy The influence of gut microbiota and probiotics on selenium metabolism in the rat: in vitro and in vivo studies

10 May Lin Yang PhD final presentation: School of Pharmacy Drug delivery to brain: effect of bile salts on drug transport across the brain barrier

17 May Lipika Chatterjee PhD final presentation: School of Pharmacy Investigations on sustained release Eudragit® RLPO matrices prepared by direct compression

24 May Dr Igor Meglinski Bio-photonics: current progress in Department of Physics biomedical applications University of Otago

31 May Dr Susan Heydon Changing patterns in medicines use School of Pharmacy in the Mt Everest region of Nepal

3 June Pavan Kumar PhD final presentation: School of Pharmacy Application of pharmacometric methods to clinical toxicology studies

14 June Alexandra Kafka PhD final presentation: School of Pharmacy Pharmaceutical nanotechnology for biocontrol of the brushtail possum in New Zealand

21 June Paulina Guzman PhD 6 month presentation: School of Pharmacy Protein characterisation through IR and fluorescence

5 July Dan Wright PhD 6 month presentation: School of Pharmacy The application of population PKPD to dose individualisation

5 July Ernieda MD Hatah PhD 6 month presentation: School of Pharmacy Examining medicine use reviews (MUR) service in New Zealand

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19 July Prof Thomas Rades Post RSL School of Pharmacy

26 July Alfred Tong PhD 6 month presentation: School of Pharmacy Pharmaceuticals in the environment: significance and disposal practices for unused pharmaceuticals

2 August Madhu Shankar PhD 6 month presentation: School of Pharmacy Validating essential enzymes as targets for new broad-spectrum antifungal compounds

16 August Dr Stephen Moratti Chitosan hydrogels for surgery and Senior Research Fellow drug release Department of Chemistry

6 September Albert Nguyen PhD final presentation: School of Pharmacy The expression of recombinant Tex31 from Conus textile: a model for heterologous expression of the CAP proteins in E. coli

20 September Prof Stephen Duffull Uppsala and pharmacy School of Pharmacy

27 September Bevan Clayton-Smith The contribution of prescription Research Fellow medication towards the health and Te Pumanawa Hauora well-being of older Mäori Research Centre for Mäori Health & Development, School of Mäori Studies, Massey University

4 October Prof Alan Musgrave Strict empiricism versus explanation Department of Philosophy in science University of Otago

11 October Abhishek Gulati PhD 6 month presentation: School of Pharmacy Development and evaluation of a clotting time test for monitoring enoxaparin therapy

18 October Chakradhar Lagishetty PhD 6 month presentation: School of Pharmacy Identification of biomarkers of aging to describe changes in drug clearance in the elderly

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8 November Bettina Zadehvakili PhD 6 month presentation: School of Pharmacy Design, synthesis and structure activity relationship studies of some novel glutathione peroxidase mimics

22 November Hesham Al-Sallami CoaguSim: a novel teaching tool for School of Pharmacy pharmacy education

29 November Maria Stubbe The language of prescribing – Wellington School exploring medication talk in video- of Medicine recorded health interactions

2 December Ulrike Zimper PhD final presentation: School of Pharmacy Milling behaviour of drugs

6 December Ellen Ou PhD 6 month presentation: School of Pharmacy Preformulation of Puha (Sonchus oleraceus L.) as an antioxidant nutritional supplement

13 December Sara Hanning PhD 6 month presentation: School of Pharmacy A formulation for the persistent dry mouth

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SErvIcE ExTErNal To ThE uNIvErSITy

Olaf BorkMember of: Controlled Release Society New Zealand Chapter of the Controlled Release Society

rhiannon BraundMember of: Australasian Pharmaceutical Science Association American Society of Health-System Pharmacists Controlled Release Society New Zealand College of Pharmacists (Fellow) Pharmaceutical Society of New Zealand Inc. (President)Peer reviewer of: Expert Review of Clinical Pharmacology Journal of the American Pharmacists Association Pharmacy World and Science (now IJCP) International Journal of Pharmacy Practice New Zealand Medical Journal Community Pharmacy, textbook by Paul Rutter Programme Contributor, New Zealand Police DARE

kate chesneyIntern Mentor and Committee Member of Otago Branch of the Pharmaceutical Societyof New Zealand Inc.

carolyn coulterMember of: Pharmaceutical Society of New Zealand Inc. New Zealand College of Pharmacists Pharmacy Defence Association New Zealand Hospital Pharmacists Association

Stephen DuffullMember of: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Australasian Pharmaceutical Science Association Pharmaceutical Society of NZ New Zealand Hospital Pharmacists’ Association The Royal Society of New Zealand The New Zealand College of Pharmacists (Associate) HRC SCOTT CommitteeEditorial Board of: Drug Metabolism and Pharmacokinetics Journal of Pharmacokinetics and Pharmacodynamics Clinical Pharmacokinetics Advances in Pharmacological Sciences (Associate Editor) Pharmaceutical Statistics, Special Edition (Executive Editor)

112

James greenMember of: Linguistics Society of New Zealand International Association of Language and Social Psychology Australasian Pharmaceutical Science Association American Academy on Communication in Healthcare European Health Psychology Society

Sarah HookMember of: Health Research Council Biomedical Assessing Committee Australasian Society for Immunology Australasian Pharmaceutical Science Association Academy of Pharmaceutical Sciences of Great Britain American Association of Pharmaceutical ScientistsReviewer of: Journal of Pharmacy and Pharmacology Journal of the Controlled Release FEBS Letters Immunology Journal of Drug Targeting International Journal of Pharmaceutics Bioconjugate Chemistry Vaccine Journal of Pharmaceutical Science Expert Reviews in Clinical Pharmacology Journal of Lipid Research AAPS Journal Biomaterials European Journal of Pharmaceutics and Biopharmaceutics Molecular Immunology Molecular Pharmaceutics Acta Biomaterialia Reviewer for Funding Bodies: Health Research Council Association for International Cancer Research Cancer Society of New Zealand Foundation for Research Science and Technology Lotteries Health Wellington Medical Research Foundation Canterbury Medical Research Foundation

113

arlene McDowellVeterinary Committee, Controlled Release Society (Chair)Member of: The Australasian Wildlife Management Society Controlled Release Society New Zealand Local Chapter of the Controlled Release Society Australasian Pharmaceutical Science Association Ecology Research Theme, University of Otago The Wildlife SocietyEditorial Board of Controlled Release Society NewsletterReviewer of: Australian Mammalogy Current Drug Delivery New Zealand Journal of Zoology Biopolymers: Peptide Science Willdlife Research Journal of Pharmaceutical Sciences Journal of Pharmacy and Pharmacology

natalie MedlicottMember of: College of Pharmacists Pharmaceutical Society of New Zealand New Zealand Chapter of the Controlled Release Society American Association of Pharmaceutical Scientists Australasian Pharmaceutical Sciences AssociationMember of the Pharmacy Council Working Party on ProfessionalismExternal Examiner for International Medical University, Kuala Lumpur, Malaysia Member of Pharmacy Reference group for the Implementation of the Strategy for MäoriHealth Reviewer of: Editorial Board Drug Delivery and Translational Research Journal Editorial Board Journal of Pharmaceutical and Biomedical Analysis Editorial Board Journal of Pharmacy and Pharmacology

Pauline norrisMember of: International Network for the Rational Use of Drugs Sociological Association of Aotearoa New Zealand Australasian Pharmaceutical Sciences Association Health Services Research Association of Australia and New Zealand Research Grant Assessing Committee, Health Research Council, 2010 Scientific Committee, International Social Pharmacy Workshop conference, Lisbon,

Portugal, 2010 and Invited Chair, Patient perspectives and Social/cultural issues session The International Advisory Board of Journal of Medicine Use in Developing Countries Pharmacy World and Science (Editorial Advisory Board) Research in Social and Administrative Pharmacy (Editorial Advisory Board) Health, Risk and Society (International Editorial Advisor)

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thomas radesMember of: Academy of Pharmaceutical Sciences Australasian Pharmaceutical Science Association International Association for Pharmaceutical Technology Controlled Release Society New Zealand Local Chapter of the Controlled Release Society United Kingdom and Ireland Chapter of the Controlled Release Society German Pharmaceutical Society European Association of Pharma Biotechnology (Founding member) New Zealand Institute of Chemistry (Fellow) Microscopy New Zealand Otago Medical Sciences Research Society Pharmaceutical Solid State Research Cluster (Director) Royal Society of New ZealandSymposium organizer of the Eleventh International Workshop on Physical Characterization of

Pharmaceutical Solids, Detecting Process Induced Transformations in Solid State Formulations, Stamford, Ct, USA, June, 2009

Co-organiser and presenter APS workshop: Poorly soluble drugs: How can we improve dissolution, solubility and

bioavailability, Aston, Birmingham, United Kingdom, August, 2009Symposium organizer 12th International Workshop on Physical Characterization of Pharmaceutical Solids,

Solid State Characterisation Methods and Physical Stability of API Dispersions, Lille, France, June, 2010

Editorial Board member of: Journal of Pharmacy and Pharmacology Journal of Pharmaceutical Sciences International Journal of Pharmaceutics Pharmaceutics Pharmaceuticals Current Drug Delivery Journal of Liposome Research Journal of Biomaterials Science, Polymer Edition Pharmaceutical Technology Asia Pharmaceutical Technology Europe The Journal of Controlled Release DiePharmazieReviewer of 27 scientific international peer-reviewed journals

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Dorothy SavilleReviewer for: International Journal of Pharmaceutics International Journal of Pharmacy Journal of Pharmacy Science Pharmacy Research Current Drug DeliveryReviewed abstracts and revisions for Controlled Release Society Reviewed research papers

clare Strachan Member of: New Zealand Local Chapter of the Controlled Release Society Australasian Pharmaceutical Science Association American Association of Pharmaceutical Scientists Pharmaceutical Solid State Research Cluster (Founding member) Society of Physical Pharmacy, Finland Pharmaceutical Society of Finland New Zealand Pharmacy Council, registered pharmacist New Zealand Pharmacy Education and Research Foundation grant review panel,

2010Editorial Board member of Pharmaceutical Technology EuropeReviewer of 20 scientific international peer-reviewed journals

June tordoffMember of: Pharmaceutical Society of New Zealand New Zealand College of Pharmacy Practice Royal Pharmaceutical Society of Great Britain New Zealand HealthCare Pharmacists Association Australasian Society for Clinical Pharmacology and ToxicologyZenith Technology Biomedical Ethics CommitteeBest Practice Advocacy Centre Incorporated SocietyReviewer of: Journal of Primary Health Care American Journal of Pharmaceutical Education Research in Social and Administrative Pharmacy Pediatrics Health Policy Pharmacy World and Science New Zealand Medical Journal New Zealand Student Medical Journal

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Ian TuckerMember of: The Royal Society of New Zealand American Association of Pharmaceutical Scientists Australasian Pharmaceutical Science Association Controlled Release Society (Fellow) International Microencapsulation Society Otago Branch - Pharmaceutical Society of New Zealand Otago Medical Research Foundation Otago Medical School Research Society Pharmaceutical Society of New Zealand New Zealand College of Pharmacists (Fellow) New Zealand Registered Pharmacist Board of the New Zealand Pharmacy Education Research Foundation St Margaret’s College CouncilEditorial Board member of: Journal of Microencapsulation Drug Delivery Science and Technology International Journal of Pharmaceutics Therapeutic DeliveryReviewer of: International Journal of Pharmaceutics Journal Pharmacy and Pharmacology Abstracts for international Controlled Release Society annual conference

Joel tyndallMember of: Associate Investigator, Maurice Wilkins Centre, 2010 American Chemical Society Association of Molecular Modellers of Australasia International Proteolysis Society New Zealand Institute of Chemistry New Zealand Institute of Chemistry Otago Branch Committee Pharmacy

Representative, 2010 Society of Crystallographers in Australia and New ZealandReviewer for: Biochemistry Journal of Medicinal Chemistry Chemical Biology & Drug Design Recent Patent Reviews on Anti -Cancer Drug Discovery Biochimica et Biophysica Acta – Proteins and Proteomics Bioorganic & Medicinal Chemistry Endocrine reviews Biological Chemistry Cancer Therapy PLoSOne FEMS Immunology & Medical Microbiology

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Hu ZhangMember of: American Association of Pharmaceutical Scientists Australasian Pharmaceutical Science Association New Zealand Local Chapter of the Controlled Release Society Australasian Society of Clinical and Experimental Pharmacologists and ToxicologistsReviewer of: Food and Chemical Toxicology Journal of Chromatography B Pharmacology Biochemistry & Behaviour

SCHOOL OF PHARMACYREPORT 2OO9/2O1O

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