Santé, Neurosciences et Vieillissement AVRIST_Sherrard12.pdf · Santé, Neurosciences et...
Transcript of Santé, Neurosciences et Vieillissement AVRIST_Sherrard12.pdf · Santé, Neurosciences et...
Santé,NeurosciencesetVieillissement
• Ageing:mechanisms– UMRBiologicalAdapta=onandAgeing(B2A)
» PrBertrandFriguet,UPMC
– DHUFAST(FightagainstAgeingandSTress)» PrJeanMariani,DrChris7anNeri,UPMC
• Brainageing– Normalandpathology
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Chronicdisorders
Interest/interac=onswithJapan
• Mechanismsofageing:lifestyle/genes– Predic=vemarkersoflongevity(100yrolds)
» DrChris7anNeri– Pa=entcohortsDHU+Keio&Kyushuuniversi=es
» powerofstudy
• Neuroscience:cogni=vedecline– Whysovariable?– Capacitytomodify
» Delay/slow/reverse?– Psychosocial/technical?
» General/specificinput» People,domo7cs,brains7mula7on
Precisely-phenotypedcohortsforthestudyofstressresilience
(IledeFranceandna=onal/interna=onalcohorts)
CogDisCo (Marc Verny) 1000 patients, +500 patients/year IADL + MRI 80%, PET 20%
UPOG (Jacques Boddaert) 900 patients, +600 patients/year 340 parameters
AGER (Eric Pautas) Standardized questionnaire 150 parameters; starting 1500-2000 Patients/yr
Cognitive decline, brain proteostasis neuroinflammation (imaging) Post surgery trauma and immune response survival distribution at 6 months and beyond
Acute geriatrics