SAN FRANCISCO EAST BAY AUTISM/ASPERGERS CONFERENCE
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Transcript of SAN FRANCISCO EAST BAY AUTISM/ASPERGERS CONFERENCE
SAN FRANCISCO EAST BAY AUTISM/ASPERGERS
CONFERENCE
DECEMBER 1-2, 2006
ALAMEDA COUNTY FAIRGROUNDS
PLEASANTON, CA
OVERVIEW:
BIOMEDICAL TESTING AND
TREATMENT OF AUTISM
Jaquelyn McCandless, M.D.
SUMMARY DAN! ASD BIO-MEDICAL TREATMENTS
• 1) DIETARY RESTRICTION• 2) NUTRIENT THERAPY• 3) GUT PATHOGEN TREATMENT• 4) METHYLATION STRATEGIES• 5) DETOXIFICATION (CHELATION)• 6) IMMUNE ENHANCEMENT• 7) ANTI-VIRAL TREATMENT• 8) HBOT, NEUROFEEDBACK
WORLDWIDE ASD EPIDEMIC• FROM 2001-04, 1026% INCREASE IN FULL-
DIAGNOSIS ASD SCHOOL AGE CHILDREN PER US DEPT OF EDUCATION.
• OVER 2 MILLION CHILDREN IN US HAVE ASD, OVER 6 MILLION HAVE ADD/ADHD, OVER 2 MILLION TAKE RITALIN
• INCIDENCE OF CLASSIC 1:10,000 TO ACQUIRED (“REGRESSIVE”) ASD 1:150
• RATIO - BOUS:GIRLS 4:1 for ASD, ADD/ADHD, LEARNING/BEHAVIOR
AUTISM (ASD) CHARACTERISTICSAUTISM SPECTRUM INCLUDES:
AUTISM, HFA, ASPERGER’S, PDD, ADD/ADHD
● FAILURE TO BOND● LACK OF SOCIAL INTERACTION● AVOIDANCE OF EYE-TO-EYE
CONTACT ● DIFFICULTIES IN LANGUAGE
DEVELOPMENT● REPETITIVE BEHAVIORS CALLED
“STIMMING”
ASD BIO-MEDICALLY
• GENETIC PREDISPOSITION – ALLERGIES, AUTOIMMUNITY, FAMILY HISTORY
• WEAKENED IMMUNE SYSTEM, FREQUENT INFECTIONS/ANTIBIOTICS 1st YEAR
• GUT INFLAMMATION, PATHOGENS• IMPAIRED NUTRITIONAL STATUS
INABILITY TO EXCRETE THEREFORE ACCUMULATE HEAVY METALS IN THEIR BODIES
BASIC EVALUATION
HISTORY, PHYSICAL EXAM
BASIC GENERAL LAB SCREENCBC, URINALYSIS
SERUM CHEMISTRIES
THYROID PANEL
IRON PANEL
BASIC DIAGNOSTIC TESTS
FOR GUT:
URINE ORGANIC ACIDSCOMPREHENSIVE STOOL STUDY
FOR NUTRIENT STATUS:ORGANIC ACIDS, AMINO ACIDSRBC MINERALS, FATTY ACIDS VITAMIN PANEL
CLINICAL HISTORY: EARLY INDICATIONS OF
GUT DYSFUNCTION
1) FAMILIAL DIGESTIVE DIGESTIVE DYSFUNCTIONS
2) INABILITY TO BREAST FEED3) PERSISTENT COLIC IN INFANCY
4) FREQUENT INFECTIONS (E.G. EAR) LEADING TO FREQUENT
ANTIBIOTICS 5) REACTION TO CERTAIN
VACCINATIONS
GASTROINTESTINAL PATHOLOGY SYMPTOMS REPORTED BY PARENTS
• PERSISTENT DIARRHEA AND/OR CONSTIPATION, BLOATING, GAS AND ABDOMINAL PAIN
• SELF-RESTRICTION OF DIET
• NIGHT WAKING – REFLUX
• GREATER ALLERGIC SUSCEPTIBILITIES
G.I. HEALTH: TREATMENTS PARENTS CAN DO
• ELIMINATE SUGARS AND JUNK FOOD FOR EVERYONE IN THE FAMILY
• READ LABELS ON FOODS, GET EDUCATED ABOUT TOXINS IN BOTH FOOD AND
WATER
• GF/CF/SF OR SCD DIET
• ENZYMES AND PROBIOTICS
• BASIC NUTRIENT SUPPLEMENTATION
G.I. HEALING TREATMENTS THAT REQUIRE A
PHYSICIAN
• LAB TESTING FOR GUT PATHOGENS
• ANTI-FUNGAL PRESCRIPTIONS RX
• ANTI-BACTERIAL PRESCRIPTION RX (CLOSTRIDICA AND OTHER)
• SECRETIN, VIT M-B12 INJECTABLES
• IMMUNOGLOBULIN, IV OR ORAL, ENDOSCOPY
METABOLIC IMBALANCES IN AUTISM SPECTRUM DISORDER
• MULTIPLE NUTRITIONAL DEFICIENCIES• ELEVATED IgG ANTIBODIES
GLUTEN/CASEIN• IMBALANCE GUT BACTERIAL FLORA• URINE BACTERIAL/FUNGAL BYPRODUCTS• MYELIN SHEATH INJURY IN BRAIN• EVIDENCE OF IMMUNE IMPAIRMENTS• METHYLATION DISORDERS• INABILITY TO EXCRETE TOXINS/METALS
ASD CAUSATION MODELS
• 1) SIMPLY GENETIC?
• 2) GUT HEALTH: MEASLES, GLUTEN/CASEIN INTOLERANCE, ENZYME DEFICIENCY, FUNGAL OVERGROWTH MODEL
• 3) TOXIC CHEMICALS/HEAVY METALS –VACCINATIONS, AMALGAMS/FISH
• 4) AUTOIMMUNITY, VIRAL MODEL
GENETICS AS CAUSE?
• RESEARCH HAS BEEN UNABLE TO IDENTIFY A SPECIFIC CHROMOSOME OR LOCATION ON A GENE THAT IS THE SITE OF A PRIMARY AUTISM DEFECT.
• GENETIC SUSCEPTIBILITY PROBABLE
GUT HEALTH: TREATMENTS THAT PARENTS CAN DO
• ELIMINATE SUGARS AND JUNK FOOD FOR EVERYONE IN FAMILY
• READ LABELS ON FOODS, GET EDUCATED ABOUT TOXINS IN BOTH FOOD AND WATER
• GF/CF/SCD DIET• ENZYMES AND PROBIOTICS• BASIC NUTRIENT
SUPPLEMENTATION
GUT HEALTH TREATMENTS THAT REQUIRE A
DOCTOR
• LAB TESTING FOR GUT PATHOGENS
• ANTI-FUNGAL PRESCRIPTIONS
• ANTI-BACTERIAL PRESCRIPTIONS (FOR CLOSTRIDIA AND OTHERS)
• SECRETIN, VIT M-B12 INJECTIONS
• IMMUNOGLOBULIN, IV OR ORAL
• ENDOSCOPY-ANTI-INFLAMMATORIES
WAKEFIELD: INFLAMMATORY BOWEL DISEASE IN AUTISM• GUT BIOPSIES, 1998: MEASLES VIRUS
DETECTED IN DENDRITIC CELLS AND MATURE LYMPHOCYTES IN 75/91 ASD CHILDREN VS 5/70 CONTROLS WITH LYMPHOID NODULAR HYPERPLAXIA
• NEW: 2006 BUIE, KRIGSMAN VALIDATE WAKEFIELD’S FINDINGS: INCREASED GI INFLAMMATION IN ASD’S WITH 87% BIOPSIES SHOWING VACCINE STRAIN MEASLES IN GUT
GUT MEASLES ASSESSMENT
• HISTORY, MMR RESPONSE• GUT ISSUES
• RUBEOLA ANTIBODIES TEST• BRAIN AUTO-ANTIBODIES TEST
• ENDOSCOPY• BIOPSY, CSF ANALYSIS
• PCR (POLMERASE CHAIN)
MEASLES AND BRAIN VIRAL AUTO-ANTIBODIES IN ASD
• SINGH 1998: 70% OF AUTISTIC SERA HAD ANTI-MYELIN BASIC PROTEIN ANTIBODIES, NONE IN NT CHILDREN.
• 57% ASD HAD ANTI-NEURON-AXON FILAMENT PROTEIN, NONE IN NT KIDS
• HIGHER ANTI-MEASLES ABS THAN NT KIDS, MUMPS AND RUBELLA NOT DIFFERENT FROM NT’S
GUT MEASLES TREATMENT
• DIETARY RESTRICTION • ENZYMES• GENERAL IMMUNE ENHANCEMENT• METHYLATION • DECREASE HEAVY METALS• HEAL LEAKY GUT• ANTI-OXIDANTS• LIVER SUPPORT• ANTI-INFLAMMATORIES• HIGH DOSE VIT A PROTOCOL
HIGH-DOSE VITAMIN A FOR GUT MEASLES
BAKER - McCANDLESS PROTOCOL200,000-400,000IU ORAL 2 DAYS EVERY SIX
MONTHS IF 3 OF 5 POSITIVE:1) HISTORY OF REGRESSION AFTER MMR2) PERSISTENT GUT PROBLEMS, PAIN3) MORE THAN SLIGHTLY ELEVATED IgG
SERUM RUBEOLA ABS4) ELEVATED ANTI-MBP & ANTI-NF ABS
5) ENDOSCOPY SHOWS ILH, CSF/BIOPSY+, PCR VACCINE STRAIN MEASLES
ANTI-FUNGAL PRESCRIPTIONS (BASED on 40-50 # CHILD)
• DIFLUCAN (FLUCONAZOLE - PRIMARY ONE I USE) 4-5mg/kg/day for 3-4 weeks in divided doses
• NIZORAL (ITROCONAZOLE -GOOD FOR LOWERING TESTOSTERONE)
5mg/kg/day for 3 weeks in divided doses
• SPORANOX (USE WHEN RESISTANCE TO FLUCONAZOLE)75-100mg/day for 3-4 weeks
• NYSTATIN (TOPICAL – MANY YEAST OUTGROW), BENIGN INEXPENSIVE
250,000 units qid
ANTI-BACTERIAL PRESCRIPTIONS (Based on 50# child)
• FLAGYL (clostridia, parasites) 250mg BID for 10 days
• BIAXIN 125mg/BID (tonsillitis, sinusitis)
• GENTAMYCIN 40-80mg BID for 10 days
• VANCOMYCIN 1 gram/day in 1/4 gm QID doses 5-10 days
NEUTRACEUTICAL COMPANIES I USE MOST FREQUENTLY (U.S.)
• ECOLOGICAL FORMULAS 800-888-4585• KLAIRE LABS 866-216-6127• INTEGRATIVE THERAPEUTICS, INC. (NF FORMULAS/TYLER) 503-582-8386• THORNE RESEARCH 800-228-1966• VITAMIN RESEARCH 800-877-2447• KIRKMAN LABS 877-365-9265• PHYSIOLOGICS 800-765-6775
SUMMARY: RX GUT DISORDER
• RESTRICTIVE GF/CF/SF DIET, PROBIOTICS
• REMOVE OFFENDING FOODS PER IGG HYPERSENSTITIVITY TESTING
• REPLACE NUTRIENT DEFICIENCIES, ENZYMES
• TREAT FOR PATHOGEN OVERGROWTHWITH NATURAL & PRESCRIPTIVE
ANTI-FUNGALS, BACTERIALS
TREATMENTS BEYOND THE BASICS
“TRIO:” 1) GLUTATHIONE, TD-ORAL-IV
2) TTFD (ALLITHIAMINE – AUTHIA)
3) M-B12 SUBCUT INJECTIONS
“QUARTET:”
4) ADD FOLINIC ACID
METHYLCOBALAMIN• VIT B12 LEAST TOXIC, BEST TOLERATED
• UPTAKE FROM ORAL INTAKE LOW, PARTICULARLY IN GI INFLAMMATION.
• VIT B12 PLAYS KEY ROLE IN GSH STABILIZATION & REDUCTION STATUS FOR ENDOGENOUS ANTIOXIDANTS
• DIFFICULT TO TEST FOR DEFICIENCY• ULTRA HIGH DOSES MAY REGENERATE NERVES
GLUTATHIONE (GSH)
• NATURALLY OCCURING TRI-PEPTIDE – FROM CYSTEINE, GLUTATMIC ACID, GLYCINE
• PRESENT IN ALL LIVING CELLS, HIGHEST LEVEL FOUND IN LIVER
• INHIBITS FORMATION OF FREE RADICALS• DETOXIFIES HARMFUL COMPOUNDS. • DEFICIENCY INCREASES SENSITIVITY TO THIMEROSAL AND OTHER
PRO-OXIDANT AGENTS.
GLUTATHIONE, Cont’d. ENHANCE GSH LEVELS BY HELPING
BODY MANUFACTURE IT:
• VIT C, E, A-LIPOIC ACID (ALA), N-ACETYL CYSTEINE (NAC), SELENIUM, GLUTAMINE, AND SILYMARIN
• VITAMIN B12 HELPS MAINTAIN GLUTATHIONE IN ITS USEFUL REDUCED BIOLOGICAL STATE.
TTFD (ALLITHIAMINE)
• TTFD: THIAMINE TETRAHYDROFURFURL DISULFIDE, SYNTHETIC COUNTERPART TO ALLITHIAMINE, DERIVATIVE VIT B1 (THIAMINE), FOUND IN GARLIC.
• THIAMINE: WATER-SOLUBLE, REQUIRED METABOLISM PROTEINS, CARBS, FATS
• THIAMINE DEFICIENCY IN ALCOHOLISM, MALNUTRITION, USE OF CERTAIN DRUGS
TTFD, CONT’D
• GENTLE CHELATOR FOR ARSENIC, CADMIUM, ALUMINUM, LESS FOR HG
• NON-TOXIC, NO PRESCRIPTION NEEDED, TRANSDERMAL CREAM TWICE DAILY
“TRIO – QUINTET” DOSES
1) GLUTATHIONE (GSH)150 MG BID ORAL, 125 MB BID
TRANSDERMAL, 300-600MG IV WEEKLY OR BI-WEEKLY OR MONTHLY
2) ALLITHIAMINE (TD-TTFD) 50 MG 2X DAILY (COMPOUNDED OR AUTHIA)
3) METHYLCOBALAMIN (INJECTABLE M-B12) CONC 25-MG/ML, 64.5 MCG/KG 2X/WEEK
4) FOLINIC ACID, 400-MCG TWICE DAILY
TOXICITY
• TOXIC CHEMICALS
• HEAVY METALS
• GLUTATHIONE
• VACCINATIONS
• AMALGAMS, FISH INGESTION
DETOXIFICATION OF HEAVY METALS
• DMSA—ORAL, TD, NEW - SUPPOSITORIES
• DMPS—ORAL, TD, IV
• CaEDTA--- IV, SUPPOSITORY
• TTFD (AUTHIA) - TD
VIRAL-IMMUNE ISSUES IN AUTISM
• EVIDENCE OF EFFECTS OF PSYCHOTROPIC VIRUSES IN AUTISM & OTHER DEVELOPMENTAL DELAY DISORDERS
• POSITIVE RESPONSES TO ANTI-VIRAL TREATMENTS IN AUTISM
0.11±0.12
0.17±0.15
0.21±0.19
0.13±0.140.15±0.11
0.18±0.17
0.28±0.30
0.45±0.33
0.61±0.38
0.32±0.29
0.54±0.49
0.73±0.62
0
0.2
0.4
0.6
0.8
1
IgG IgM IgA IgG IgM IgA
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ANTIBODIES AGAINST MBP AND NEUROFILAMENTS IN CONTROLS AND CHILDREN WITH AUTISM .
MBP NFP
37
HEALTHY IMMUNITY
• BALANCE BETWEEN Th1 - Th2, SWITCHES BACK AND FORTH AS NEEDED
• INABILITY TO RESPOND ADEQUATELY TO Th1 – CHRONIC INFECTION & CANCER
• OVERACTIVE Th2 RESPONSE – PLAYS ROLE IN AUTOIMMUNITY AND ALLERGIES
UNHEALTHY IMMUNITY
FAILURE OF THE Th1 ARM & OVERACTIVE Th2 ARM:
AIDS, CANCER
CFS (FATIGUE)
CANDIDIASIS
MULTIPLE ALLERGIES
MCS (CHEMICAL)
AUTISM
Th1/Th2 BALANCETh1 – CELLULAR IMMUNITY,
DIRECTS NK T-CELLS AND MACROPHAGES TO ATTACK
ABNORMAL CELLS AND PATHOGENS INSIDE THE CELL
Th2- HUMORAL IMMUNITY, CREATES ANTIBODIES TO NEUTRALIZE
FOREIGN INVADERS OUTSIDE CELL
IMMUNE-ENHANCING
• OMEGA-3 FATTYACIDS• GLUTATHIONE• METHYLCOBALAMIN/FOLINIC• DIETARY RESTRICTION• PROBIOTICS• VITAMIN C, E, A, CO-Q-10• ANTI-FUNGALS• ANTI-VIRALS
NATURAL ANTI-VIRALS
• LAURICIDIN (ENVELOPED VIRUSES)• GARLIC, OLIVE LEAF EXTRACT• GLUTAMINE, PROBIOTICS• BLACK ELDERBERRY• OIL OF OREGANO• IP- 6 (INOSITOL HEXAPHOSPHATE) • GRAPEFRUIT SEED EXTRACT• PROTEASE ENZYMES (VIRASTOP)• HEALTHY LIFE STYLE
ANTI-VIRAL PRESCRIPTIVES
GENERAL IMMUNITY:ORAL, IM, IV IMMUNOGLOBULINS
LOW-DOSE NALTREXONEACTOS
ANTI-VIRALS: VALTREX (PRIMARY ONE I USE)
FAMVIR ACYCLOVIR FOR SMALL CHILDREN
LIFE-STYLE ANTI-VIRAL MESSAGES
• EAT LOTS OF FRESH VEGETABLES
• DON’T SMOKE
• GET ENOUGH SLEEP
• DON’T EAT JUNK FOOD
• DON’T DRINK TOO MUCH ALCOHOL
• NURTURE YOUR RELATIONSHIPS
• DO WORK YOU BELIEVE IN
• LAUGH AT YOURSELF
• IF VACCINATE, GET HG-FREE!!!!
SUMMARY DAN! ASD BIO-MEDICAL TREATMENTS
• 1) DIETARY RESTRICTION• 2) NUTRIENT THERAPY• 3) GUT PATHOGEN TREATMENT• 4) METHYLATION STRATEGIES• 5) DETOXIFICATION (CHELATION)• 6) IMMUNE ENHANCEMENT• 7) ANTI-VIRAL TREATMENT• 8) HBOT, NEUROFEEDBACK