SAMPLE - Integrative Oncology Essentials€¦ · * The RDA (Recommended Daily Allowance) was first...

Patient: Doe, JonAccession ID: 0000000000

Provider: Sample Provider, MD

10401 Town Park Drive, Houston, TX 770721(800) 227-5227 | [email protected] | www.spectracell.com

SAMPLE

What we measure:

We have measured the functional levels of 31 micronutrients, from vitamins and minerals to fatty acids and metabolites, as well as an overall measurement of antioxidant capacity and immune function to provide you with a powerful tool for optimal health, performance, and insight into

any health condition. We provide your unique nutrient status in the following areas:

VITAMINS & MINERALSDiscover your body’s unique vitamin and mineral requirements and the disparities that exist within your makeup.

AMINO ACIDSLearn how well your amino acids, the building block of protein, are functioning within your cells.

ANTIOXIDANT STATUS & IMMUNE FUNCTIONUnderstand your body’s ability to manageoxidative stress and your immune response toinfections and disease.

ENERGY, FAT AND METABOLISMKnow how well your body ismetabolizing micronutrients forenergy production.

Your body is unique and your story is too. Virtually all metabolic and developmental processes that take place in thebody require micronutrients and strong evidence suggests that subtle vitamin, mineral, and antioxidant deficiencies can

contribute to degenerative processes. These cellular deficiencies may suggest the underlying cause of a myriad of unwantedsymptoms and, if corrected, can optimize physical and mental health performance.

Welcome to your Micronutrient Profile, Jon!

The SpectraCell AdvantageSuperior insights, earlier interventions, customized treament plans.

Proprietary

Only SpectraCell offers the patented Spectrox® (reflects antioxidant capacity) and Immunidex (an overall measure of immune

function).

Long-term

This test measures intracellular micronutrient function over a period of 4-6 months, extending

beyond static serum measurements.

Functional

We measure the functional level and capabilityof nutrients present within your white bloodcells, where metabolism takes place and

where micronutrients do their job.

PATIENTNAMEDoe, Jon

AGE48

DOB6/7/1970

GenderMale

Patient ID00-000-00000

PROVIDER

123 S. Any Street ANYWHERE, TX 77000

Address

00000000Account ID

Sample Provider, MDCLIENT NAME

SPECIMENACCESSION ID0000000000

DATE COLLECTED

DATE RECEIVED03/01/2019DATE REPORTED03/18/2019

02/28/2019

ORDER ID0000-00000000000-000000

SpectraCell Laboratories, Inc. Laboratory Director: Jonathan Stein, Ph.D. CLIA#45D0710715Result of 6


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Spectrox®Total Antioxidant Function

ImmunidexTotal Immune Function

DeficientValues in this area represent a deficiency and may require nutrient repletion or dietary changes

BorderlineValues in this area represent a borderline deficiency and may indicate a need for nutrient repletion or dietary changes

NormalValues in this area represent a normal result

Spectrox®

Total Antioxidant Function is a measurement of overall antioxidant function. The patient’s cells are oxidatively challenged and the cell’s ability to resist damage is determined.

Immunidex

Total Immune Function is an indication of the patient’s T-Lymphocyte’s response to mitogen stimulation relative to the response of a control population. An average or poor growth response may improve with correction of the nutritional deficiencies determined by the micronutrient testing.

Functional Deficiencies

Borderline DeficienciesBorderline Provider CommentsAsparagine

Calcium

Folate

Fructose

Glutathione

Immunidex

Inositol

Pantothenate

Serine

Spectrox

Vitamin B2

Zinc

Abnormal Suggested Supplementation * Provider CommentsCholine 1000 mg b.i.d. (2000 mg daily) of Choline from Choline Bitartrate, Citrate or Chloride salts

Oleic Acid 2-3 tbsp olive oil daily for repletion of Oleic Acid. Deficiency of Oleic Acid suggests impaired synthesis of unsaturated

Vitamin A 10,000 IU of Vitamin A and 25,000 IU beta-carotene for 6 months and then retest.

Vitamin B12 1000 mcg daily (methylcobalamin or adenosylcobalamin) (consider injectable forms)

* The RDA (Recommended Daily Allowance) was first published in 1968 primarily for use in nutritional labeling of packaged foods. The DRI (Dietary Reference Intake), published in 1997, serves as replacements for the former RDA, although the actual values are generally within an order of magnitude, and are also primarily for use in nutritional labeling and fortification of packaged foods. In most cases, neither the RDA nor the DRI will be adequate to replete a nutrient in people who demonstrate a functional cellular deficiency of said nutrient. An evidence based approach was used to develop clinically relevant repletion recommendations, consisting of data from published studies and clinician expertise. However, the information presented is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment.

Results At-A-Glance



PATIENT: Doe, Jon PROVIDER: Sample Provider, MD DATE REPORTED: 03/18/2019 ACCESSION ID: 0000-00000000000-000000

SAMPLE

55

Micronutrients Patient Results ReferenceRange

PatientResult

Interpretation

B-VITAMINS

Vitamin B1 >78% 86

Vitamin B2 >53% 55

Vitamin B3 >80% 87

Vitamin B6 >54% 60

Vitamin B12 >14% 13 Deficient

Folate >32% 33 Borderline

Pantothenate >7% 11 Borderline

Biotin >34% 42

AMINO ACIDS AND METABOLITES

Serine >30% 34 Borderline

Glutamine >37% 43

Asparagine >39% 42 Borderline

Choline >20% 19 Deficient

Inositol >58% 62 Borderline

Carnitine >46% 59

Oleic Acid >65% 65 Deficient

OTHER VITAMINS & MINERALS

Vitamin D3 >50% 68

Vitamin A >70% 70 Deficient

Vitamin K2 >30% 56

Manganese >50% 72

Calcium >38% 41 Borderline

Zinc >37% 42 Borderline

Copper >42% 54

Magnesium >37% 43

CARBOHYDRATE METABOLISM

Fructose >34% 39 Borderline

Glucose-Insulin Interaction >39 53

Chromium >40% 47

ANTIOXIDANTS

Glutathione >42% 46 Borderline

Cysteine >41% 48

Coenzyme Q10 >86% 92

Selenium >74% 82

Vitamin E >84% 91

Lipoic Acid >81% 92

Vitamin C >40% 60

The reference ranges listed in the above table are valid for male and female patients 12 years of age or older.DeficientValues in this area represent a deficiency and may require nutrient repletion or dietary changes






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Other Vitamins & Minerals

B-Complex Vitamins




Amino Acids & Metabolites




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Immunidex - Total Immune Function

Total Immune Function is an indication of the patient’s T-Lymphocyte’s response to mitogen stimulation relative to the response of a control population. An average or poor growth response may improve with correction of the nutritional deficiencies determined by the micronutrient testing.

Total Immune Function value above 65%indicates a strong response, a measurement of cell mediatedimmune function

Total Immune Function value between 40% and 65%indicates an average response.

Total Immune Function value below 40%may indicate a weakened cell mediated immuneresponse

Spectrox® - Total Antioxidant Function

Total Antioxidant Function is a measurement of overall antioxidant function. The patient’s cells are oxidatively challenged and the cell’s ability to resist damage is determined.

Total Antioxidant Function value above 65%indicates a desirable status. Since antioxidants are protective nutrients, the most desired status would be the greatest ability to resist oxidative stress.

Total Antioxidant Function value between 40%-65%indicates an average ability to resist oxidative stress.

Total Antioxidant Function value below 40%indicates poor antioxidant function resulting in reduced ability to resist oxidative stress.

Fructose SensitivityThis assay measures changes in the patient’s lymphocyte growth response to a fructose challenge. Significant reduction in cell growth capacity is indicative of poor ability to metabolize fructose. This can be due to nutritional deficiencies of necessary cofactors in the fructose metabolizing pathway (e.g. copper, zinc) or may be due to genetic factors.

Carbohydrate Metabolism

Glucose-Insulin InteractionThe patient’s cells are challenged with glucose and their ability to grow in the presence or absence of insulin is determined. A significant decrease of cell growth is indicative of reduced ability to metabolize glucose.

Individual Antioxidants







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Overview of Test MethodologyCellular Function = Performance, Not Just Potential

Lymphocyte Proliferation Assay

Routine turnaround time for the Micronutrient assay is 10-14 business days.

SpectraCell Laboratories, Inc. Laboratory Director: Jonathan Stein, Ph.D. CLIA#45D0710715Supplemental Page 1 of 7


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Krebs Cycle Energy Production



SAMPLE

Methylation CycleDetoxification, Cellular Adaptability, Gene Regulation

Tryptophan

Tyrosine

Tetrahydrobiopterin(BH4) Tetrahydrofolate(THF)

NEUROTRANSMITTER SYNTHESIS

FOLATE CYCLE

METHIONINECYCLE

5,10 Methylene-THF

5- Formyl-THF(folinic acid)

SerotoninDihydrobiopterin

(BH2)

Dopamine

5-Methy- THF(L-Methylfolate)

Homocysteine

Cystathionine

Taurine

α -ketobutyrate

Methionine

S-Adenosylmethionine(SAM)

S-Adenosylhomocysteine(SAH)

TRANSSULFURATION




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Supplemental InformationCellular Function = Performance, Not Just Potential



PATIENT: Doe, Jon PROVIDER: Sample Provider, ND DATE REPORTED: 03/18/2019 ACCESSION ID: 0000-00000000000-000000

SAMPLE





SAMPLE

Jane Doe

Date Collected: 8/15/2016

OmegaCheck Report

SAMPLE

Patient Name: Batch Number:Patient DOB: Gender: Accession Number:Physician Date Received:

Report Date:

HHLLLH

nits

Linoleic Acid 24.6 H 20.0 % by wt

Arachidonic Acid 8.8 9.0 % by wt

% by wt

% by wt

Cleveland HeartLab measures a number of omega-6 fatty acids with AA and LA being the two most abundant forms reported.

Omega-6 total 36.1

DHA 2.0 L > 4.0

% by wt

8/23/20168/16/2016

DPA 0.8 L > 1.0

EPA 0.8 L > 2.0 % by wt

Omega-3 total 3.6 % by wt

Omega-6/Omega-3 Ratio 10.0 H 4.5

FDoe, Jane

Arachidonic Acid/EPA Ratio

In Range Out of Range Flag**

5.0

11.0 H 5.0

% by wt

The risk categories for OmegaCheck are based on the top (75th percentile) and the bottom (25th percentile) quartiles of the CHL reference population. Consumption of foods rich in omega-3 fatty acids or supplements containing omega-3 fatty acids (EPA, DHA or DPA) may increase omega-3 fatty acid levels measured by OmegaCheck, and decrease the risk of sudden death due to cardiovascular disease.* The totality of the scientific evidence demonstrates that when consumption of fish oils is limited to 3 g/day or less of EPA and DHA, there is no significant risk for increased bleeding time beyond the normal range. A daily dosage of 1 gram of EPA and DHA lowers the circulating triglycerides by about 7-10% within 2 to 3 weeks. *Albert CM et al. N Engl J Med. 2001 346 1113-1118.

OmegaCheck™ Report

3/3/1969

Relative Risk

≥ 5.5

Optimal Range nits Previous

Result Date

OmegaCheck(Whole Blood: EPA DPA DHA)(1) L HIGH

Relative Risk

Optimal Range

Previous Result Date

Laboratory Director: Deborah H. Sun, PhD, DABCC, FACBOmegaCheck is performed by Cleveland HeartLab, Inc. 6701 Carnegie Ave. Suite 500 Cleveland, Ohio 44103 CLIA 36D1032987 CAP 7190119

**Flags: H Out of Range High L Out of Range Low CH Critical High CL Critical Low

> 4.0

Flag**Result

(1) This test is performed by a Liquid Chromatography-Tandem Mass Spectrometry (LC/MS/MS) method. This test was developed and its performance characteristics determined by the Cleveland HeartLab, Inc. It has not been cleared or approved by the .S. FDA. The Cleveland HeartLab is regulated under Clinical Laboratory Improvement Amendments (CLIA) as qualified to perform high-complexity testing. This test is used for clinical purposes. It should not be regarded as investigational or for research.

Arachidonic Acid/EPA Ratio 11.0

DHA 2.0DPA 0.8 > 1.0 % by wtEPA 0.8 > 2.0 % by wtOmega-6/Omega-3 Ratio 10.0 4.5

Linoleic Acid 24.6 20.0 % by wt% by wt

FATTY ACIDS

3.6

OUT OF RANGE RESULTS SUMMARY SAMPLE

OmegaCheck™

Clinical Significance•

•••

•

••

OmegaCheck™ References1.

2.3.

4.

5.

6.

7.8.

9.

10.

11.

12.

13.14.

Albert CM et al. Blood levels of long-chain n-3 fatty acids and the risk of sudden death. N Engl J Med. 2002 346: 1113-1118.

Engstrom K et al. Effect of low-dose aspirin in combination with stable fish oil on whole blood production of eicosanoids. Prostaglandins Leukot Essent Fatty Acids. 2001 64: 291-297.Balk E et al. Effects of omega-3 fatty acids on cardiovascular risk factors and intermediate markers of cardiovascular disease. Evid Rep Technol Assess 2004: Mar(93): 1-6.Musa-Veloso K et al. Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid dose-dependently reduce fasting serum triglycerides. Nutrition Reviews. 2010 68: 155-167.Kastelein JJP et al. Omega-3 free fatty acids for the treatment of severe hypertriglyceridemia: The EpanoVa fOr Lowering Very high tyriglyceridEs (EVOLVE) trial. J Clin Lipidol. 2014 8: 94-106.

Harris WS and von Schacky C. The Omega-3 Index: A new risk factor for death from coronary heart disease Prev Med. 2004 39: 212-220.

Schmitz G. The opposing effects of n-3 and n-6 fatty acids. Prog Lipid Res. 2008 47: 147-155.Saito et al. Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: Sub-analysis of primary prevention cases from Japan EPA Lipid Intervention Study (JELIS). Atherosclerosis. 2008 200: 135-140.Marchioli R et al. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction. Time-course analysis of the results of the Gruppo-Italiano per lo Studio della Sopravvievenza nell’Infarto Miocardio (GISSI)-Prevenzione. Circulation. 2002: 105 1897-1903.Pottala JV et al. Blood eicosapentaenoic and docosahexaenoic acids predict all-cause mortality in patients with stable coronary heart disease: The Heart and Soul Study. Circ Cardiovasc Qual Outcomes. 2010 3: 406-412.

OmegaCheck™ ReportComponent Summaries

This information is provided for educational purposes.

Omega-3 and omega-6 fatty acids are polyunsaturated long chain fatty acids (P FA) required by the body for proper functioning, normal growth and the formation of neural synapses and cellular membranes. Omega-3 and -6 fatty acids are considered essential and obtained primarily from dietary sources.

Simopoulos AP. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med. 2009 233: 674-688.

de Lorgeril M et al. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet. 1994 343: 1454-1459.

Consider omega-3 fatty acid supplementation – If currently taking, consider adjusting dosage and retest in 1-2 months.Assess lifestyle habits – Consider diet/exercise/weight reduction efforts if appropriate.

Treatment Considerations –These treatment considerations are for educational purposes only. Specific treatment plans should be provided and reviewed by the treating practitioner.

Kesavulu MM et al. Effect of ω-3 fatty acids on lipid peroxidation and antioxidant enzyme status in type 2 diabetic patients. Diabetes Metab. 2002 28: 20-26.James MJ et al. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr. 2000 71: 343s-348s.

Three of the most important omega-3 fatty acids are eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA). Omega-3 fatty acids are primarily obtained from food sources, such as oily fish. They have antioxidant (1), anti-inflammatory (2) and anti-thrombotic (3) effects, and can help to reduce triglyceride levels (4-6). Two of the most important omega-6 fatty acids are arachidonic acid (AA) and linoleic acid (LA). Omega-6 fatty acids are obtained from animal sources and plant oils, and have pro-inflammatory (2,7) and pro-thrombotic (7) properties at high levels.

Consumption of omega-3 fatty acids reduces the occurrence of major acute cardiac events in healthy individuals or patients with cardiovascular risk factors or who have cardiovascular disease (8-14).Consumption of omega-3 fatty acids leads to a reduction in triglycerides (4-6) and non-HDL (6), as well as Lp-PLA2 levels (6).A high intake of omega-6 fatty acid precursors can interfere with the absorption of omega-3 fatty acids (8).The mean omega-6:omega-3 ratio of the standard American diet is approximately 10:1 (8). A diet with an omega-6:omega-3 fatty acid ratio of 4:1 or less may reduce total mortality up to 70% over 2 years (11).

Assess dietary intake of omega-3 and omega-6 fatty acids – Dietary sources of omega-3 fatty acids include fatty fishes, such as salmon or sardines, nuts and plant oils. Foods high in omega-6 fatty acids include red meat, poultry, eggs, plant oils, and nuts.

SAMPLE

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