Salbutamol
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Transcript of Salbutamol
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Salbutamol
Presented By: Ameer hamza shaheedBPD-01093126
Submitted to: Sir Irfan
Clinical pharmacology
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SalbutamolDrug name (generic):
SalbutabolTherapeutic class:
Bronchodilator Agent Adrenergic beta-Agonists Tocolytic agent
Pharmacological class: Sympathomimetic (beta2-adrenergic agonist)
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Chemical name (IUPAC):
4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol
Chemical structure:
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Empirical formula:
C13H21NO3
Pregnancy category: C
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Physical properties:
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Odour : Odourless
Solubilty: Sparingly soluble in water; soluble in ethanol (96%); slightly soluble in ether.
Colour: A white or almost white, crystalline powder
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Pharmacodynamic
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Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD.
Salbutamol is formulated as a racemic mixture of the R- and S-isomers.
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S-isomer:
R-isomer:
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Mechanism of Action
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Salbutamol is a beta(2)-adrenergic agonist and thus it stimulates beta(2)-adrenergic receptors.
Salbutamol increases cAMP production by activating adenylate cyclase.
Increased intracellular cyclic AMP increases the activity of cAMP-dependent protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular calcium concentrations.
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Mechanism of Action
A lowered intracellular calcium concentration leads to a smooth muscle relaxation and bronchodilation.
Increased cyclic AMP concentrations are also inhibits the release of bronchoconstrictor mediators such as histamine, leukotreine from the mast cells in the airway.
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Pharmacokinetics
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Pharmacokinetics Bioavailability :oral bioavailability 50%Half life : half life is 4 hours (Taken from rang & dell page 168)
Onset of Action:oral: 30 minutes, Inhalation : 5-15 minutes
Duration of action :
8 to 12 hours(page 361 R&D)
Metabolism : It is subject to first pass metabolism in the liver
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Pharmacokinetics
Exretion : Readily excreated in the urine as metabolite and unchanged drug Some excreate in faeces.
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Reference Martindale 35th edition page 1016
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Clinical uses and Side Effects
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f55555555555555555fffffffffffffffffffffff1fffffffffff5Female reproductive
system Relaxation of uterus (during pregnancy)
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Reference From nurses drug hand book page 37
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Drug Intrections
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Contraindication& precaution
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Doses
Acute bronchospasm:1 or 2 inhalation of salbutamol i.e 100 microgram 3 or 4 time dailySevere attack of bronchospasm:250 microgram i.v insolution form 10 microgram/mlPremature labour.I.V infusion 200 microgram with 5% gluse used for dilution.
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Products for Salbutamol available in market
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Brand name Manufacturer Name
Dosage Forms
Ventoline GSK Injection: 0.5 mg Syrupe: 60 mlTablet : 8 mg
Respoline Munawar pharma Tablet : 2 mg
Aeroline Ankaz Syrupe : 60 , 450 MLTablet : 2 , 4 MG
Salbutamol Nawab sons Syrupe : 60 ML
Asmatol Siza Injection : 0.5 MGTablets : 4 MG
Ventomol Venus Tablets : 2 & 3 MG
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Reference
Taken from martindale 35th edition page 1016
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Reference Pharmaguid page # 1159
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Thank you